LOCUS       NM_001190357            1330 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus NAD(P)HX dehydratase (Naxd), transcript variant 2,
            mRNA.
ACCESSION   NM_001190357
VERSION     NM_001190357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1330)
  AUTHORS   Marbaix,A.Y., Tyteca,D., Niehaus,T.D., Hanson,A.D., Linster,C.L.
            and Van Schaftingen,E.
  TITLE     Occurrence and subcellular distribution of the NADPHX repair system
            in mammals
  JOURNAL   Biochem J 460 (1), 49-58 (2014)
   PUBMED   24611804
REFERENCE   2  (bases 1 to 1330)
  AUTHORS   Vats,K.R., Ishwad,C., Singla,I., Vats,A., Ferrell,R., Ellis,D.,
            Moritz,M., Surti,U., Jayakar,P., Frederick,D.R. and Vats,A.N.
  TITLE     A locus for renal malformations including vesico-ureteric reflux on
            chromosome 13q33-34
  JOURNAL   J Am Soc Nephrol 17 (4), 1158-1167 (2006)
   PUBMED   16565260
REFERENCE   3  (bases 1 to 1330)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 1330)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY270677.1, AK012456.1 and BC030080.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            exon in the 5' UTR and 5' coding region, compared to variant 1.
            This results in a shorter protein (isoform 2) with a distinct
            N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021955.1, AK009254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               BY270677.1         1-118
            119-1241            AK012456.1         59-1181
            1242-1330           BC030080.1         837-925
FEATURES             Location/Qualifiers
     source          1..1330
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..1330
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /note="NAD(P)HX dehydratase"
                     /db_xref="GeneID:69225"
                     /db_xref="MGI:MGI:1913353"
     exon            1..121
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1065
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /EC_number="4.2.1.93"
                     /note="isoform 2 is encoded by transcript variant 2;
                     carbohydrate kinase domain-containing protein;
                     ATP-dependent NAD(P)HX dehydratase; ATP-dependent
                     (S)-NAD(P)H-hydrate dehydratase; carbohydrate kinase
                     domain containing"
                     /codon_start=1
                     /product="ATP-dependent (S)-NAD(P)H-hydrate dehydratase
                     isoform 2"
                     /protein_id="NP_001177286.1"
                     /db_xref="CCDS:CCDS57604.1"
                     /db_xref="GeneID:69225"
                     /db_xref="MGI:MGI:1913353"
                     /translation="MGVRCVAIRACGGVLQRALSLHTAHATKDMENLFQLVRNIVPAL
                     TSKKHKGQDGRIGIVGGCQEYTGAPYFAGISALKVGADLTHVFCAREAAPVIKSYSPE
                     LIVHPVLDSSNAVEEVEKWLPRLHALVVGPGLGRDDLLLNNVRGILESTKARDIPVVI
                     DADGLWLVAQQPALIHSYHKAILTPNHVEFSRLWEAVLSSPMDSNDLKGSTLKLSQAL
                     GNITVVQKGEQDLISNGQQVLVCNQEGSSRRCGGQGDLLSGSLGVMVHWALRAGPEKT
                     NGSSPLLVAAWGACTLTRECNRQAFQKYGRSTTTTDMITEVGTAFSRLFTT"
     exon            122..272
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /inference="alignment:Splign:2.1.0"
     exon            273..318
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /inference="alignment:Splign:2.1.0"
     exon            319..407
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /inference="alignment:Splign:2.1.0"
     exon            408..516
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /inference="alignment:Splign:2.1.0"
     exon            517..567
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /inference="alignment:Splign:2.1.0"
     exon            568..672
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /inference="alignment:Splign:2.1.0"
     exon            673..793
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /inference="alignment:Splign:2.1.0"
     exon            794..914
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1307
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1307
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /note="major polyA site"
ORIGIN      
        1 gggcggagcc cagaagacca atggcggtgg cccggcgtcc gcgcggggac acctgggaac
       61 ccggaagtgc gctggaccgc catgggagtc cgctgtgtgg caatccgcgc ctgcggggga
      121 gttttacaga gagcactgtc tctccataca gcacatgcga caaaggacat ggagaacctt
      181 tttcagctgg tgagaaacat tgtgcctgct ctgacgtcga agaagcacaa ggggcaagat
      241 ggaagaatag gcatagtcgg gggctgccaa gagtacacag gagcaccata ttttgcagga
      301 atctcagcct tgaaagtggg tgcagatttg acccacgtgt tctgtgccag ggaggcagcg
      361 ccagtgatca agtcctacag cccagagctg atcgtccacc cagtccttga cagttccaat
      421 gctgttgagg aggtggagaa atggctcccc aggctgcatg cccttgtcgt gggacctggc
      481 ctaggtaggg atgaccttct tctcaacaat gtcaggggca ttttggaatc aaccaaggcc
      541 agggacatcc ctgtggtcat tgatgcggac ggcctgtggc tcgttgctca gcagccagcc
      601 ctcatccata gttaccacaa ggccattctc acccccaacc acgtggagtt cagcagactc
      661 tgggaagctg tgctcagtag tcctatggac agcaacgatc tcaagggctc cacactgaag
      721 ctcagccagg ccctggggaa catcacagtg gtccagaaag gagagcagga cctgatctcc
      781 aatggccagc aggtgcttgt gtgtaaccaa gaaggcagca gtcgcaggtg tggcgggcaa
      841 ggcgatctcc tgtcaggctc cctgggtgtc atggtgcact gggccctccg tgctggacca
      901 gagaaaacaa atggctccag cccactcctg gtggctgcct ggggcgcctg cacactcaca
      961 agggagtgta accggcaggc cttccagaag tacgggcgct ctacaaccac taccgacatg
     1021 atcacagagg taggaactgc cttcagcagg ctcttcacga cctgaacctg tgcagactgg
     1081 agtgacagac tgaatcctcc atttgcctag ccttgggctc agcagcactt ggaacagagg
     1141 atttacgacc taaccatgta ttctcactaa tgtagagttg atatgtcaac tacgacacta
     1201 atctggtctt tcaaggtttt cttggcttct cagaaatagc tgaaaagaaa atgagaataa
     1261 aattcccagc agcccaactg gatctgggct tgctctgaga caggaaaaaa aaaaaaaaaa
     1321 aaaaaaaaaa
//
