LOCUS       NP_001177286             327 aa            linear   ROD 04-JUN-2024
DEFINITION  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 2 [Mus
            musculus].
ACCESSION   NP_001177286
VERSION     NP_001177286.1
DBSOURCE    REFSEQ: accession NM_001190357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 327)
  AUTHORS   Marbaix,A.Y., Tyteca,D., Niehaus,T.D., Hanson,A.D., Linster,C.L.
            and Van Schaftingen,E.
  TITLE     Occurrence and subcellular distribution of the NADPHX repair system
            in mammals
  JOURNAL   Biochem J 460 (1), 49-58 (2014)
   PUBMED   24611804
REFERENCE   2  (residues 1 to 327)
  AUTHORS   Vats,K.R., Ishwad,C., Singla,I., Vats,A., Ferrell,R., Ellis,D.,
            Moritz,M., Surti,U., Jayakar,P., Frederick,D.R. and Vats,A.N.
  TITLE     A locus for renal malformations including vesico-ureteric reflux on
            chromosome 13q33-34
  JOURNAL   J Am Soc Nephrol 17 (4), 1158-1167 (2006)
   PUBMED   16565260
REFERENCE   3  (residues 1 to 327)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (residues 1 to 327)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY270677.1, AK012456.1 and BC030080.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            exon in the 5' UTR and 5' coding region, compared to variant 1.
            This results in a shorter protein (isoform 2) with a distinct
            N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021955.1, AK009254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..327
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     Protein         1..327
                     /product="ATP-dependent (S)-NAD(P)H-hydrate dehydratase
                     isoform 2"
                     /EC_number="4.2.1.93"
                     /note="carbohydrate kinase domain-containing protein;
                     ATP-dependent NAD(P)HX dehydratase; ATP-dependent
                     (S)-NAD(P)H-hydrate dehydratase; carbohydrate kinase
                     domain containing"
                     /calculated_mol_wt=35038
     Region          49..316
                     /region_name="YXKO-related"
                     /note="B.subtilis YXKO protein of unknown function and
                     related proteins. Based on the conservation of the ATP
                     binding site, the substrate binding site and the
                     Mg2+binding site and structural homology this group is a
                     member of the ribokinase-like superfamily; cd01171"
                     /db_xref="CDD:238576"
     Site            order(71,252,255)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:238576"
     Site            order(186,226,253..254,257,294)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:238576"
     CDS             1..327
                     /gene="Naxd"
                     /gene_synonym="0710008K08Rik; 2810407E01Rik; Carkd"
                     /coded_by="NM_001190357.1:82..1065"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS57604.1"
                     /db_xref="GeneID:69225"
                     /db_xref="MGI:MGI:1913353"
ORIGIN      
        1 mgvrcvaira cggvlqrals lhtahatkdm enlfqlvrni vpaltskkhk gqdgrigivg
       61 gcqeytgapy fagisalkvg adlthvfcar eaapviksys pelivhpvld ssnaveevek
      121 wlprlhalvv gpglgrddll lnnvrgiles tkardipvvi dadglwlvaq qpalihsyhk
      181 ailtpnhvef srlweavlss pmdsndlkgs tlklsqalgn itvvqkgeqd lisngqqvlv
      241 cnqegssrrc ggqgdllsgs lgvmvhwalr agpektngss pllvaawgac tltrecnrqa
      301 fqkygrsttt tdmitevgta fsrlftt
//
