LOCUS       NM_173437              12767 bp    mRNA    linear   ROD 24-FEB-2025
DEFINITION  Mus musculus neuron navigator 1 (Nav1), transcript variant 2, mRNA.
ACCESSION   NM_173437
VERSION     NM_173437.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12767)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 12767)
  AUTHORS   Fu,W., Vasylyev,D., Bi,Y., Zhang,M., Sun,G., Khleborodova,A.,
            Huang,G., Zhao,L., Zhou,R., Li,Y., Liu,S., Cai,X., He,W., Cui,M.,
            Zhao,X., Hettinghouse,A., Good,J., Kim,E., Strauss,E., Leucht,P.,
            Schwarzkopf,R., Guo,E.X., Samuels,J., Hu,W., Attur,M., Waxman,S.G.
            and Liu,C.J.
  TITLE     Nav1.7 as a chondrocyte regulator and therapeutic target for
            osteoarthritis
  JOURNAL   Nature 625 (7995), 557-565 (2024)
   PUBMED   38172636
  REMARK    GeneRIF: Nav1.7 as a chondrocyte regulator and therapeutic target
            for osteoarthritis.
REFERENCE   3  (bases 1 to 12767)
  AUTHORS   Bagley,J.R., Tan,Y., Zhu,W., Cheng,Z., Takeda,S., Fang,Z.,
            Arslan,A., Wang,M., Guan,Y., Jiang,L., Jian,R., Gu,F., Parada,I.,
            Prince,D., Jentsch,J.D. and Peltz,G.
  TITLE     Neuron Navigator 1 (Nav1) regulates the response to cocaine in mice
  JOURNAL   Commun Biol 6 (1), 1053 (2023)
   PUBMED   37853211
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12767)
  AUTHORS   Powers,R.M., Daza,R., Koehler,A.E., Courchet,J., Calabrese,B.,
            Hevner,R.F. and Halpain,S.
  TITLE     Growth cone macropinocytosis of neurotrophin receptor and
            neuritogenesis are regulated by neuron navigator 1
  JOURNAL   Mol Biol Cell 33 (7), ar64 (2022)
   PUBMED   35352947
REFERENCE   5  (bases 1 to 12767)
  AUTHORS   Nelson,M.M., Hoff,J.D., Zeese,M.L. and Corfas,G.
  TITLE     Poly (ADP-Ribose) Polymerase 1 Regulates Cajal-Retzius Cell
            Development and Neural Precursor Cell Adhesion
  JOURNAL   Front Cell Dev Biol 9, 693595 (2021)
   PUBMED   34708032
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12767)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   7  (bases 1 to 12767)
  AUTHORS   Xie,Q., Yang,Y., Huang,J., Ninkovic,J., Walcher,T., Wolf,L.,
            Vitenzon,A., Zheng,D., Gotz,M., Beebe,D.C., Zavadil,J. and Cvekl,A.
  TITLE     Pax6 interactions with chromatin and identification of its novel
            direct target genes in lens and forebrain
  JOURNAL   PLoS One 8 (1), e54507 (2013)
   PUBMED   23342162
REFERENCE   8  (bases 1 to 12767)
  AUTHORS   Martinez-Lopez,M.J., Alcantara,S., Mascaro,C., Perez-Branguli,F.,
            Ruiz-Lozano,P., Maes,T., Soriano,E. and Buesa,C.
  TITLE     Mouse neuron navigator 1, a novel microtubule-associated protein
            involved in neuronal migration
  JOURNAL   Mol Cell Neurosci 28 (4), 599-612 (2005)
   PUBMED   15797708
  REMARK    GeneRIF: This is the first functional characterization of the mouse
            homologue, mouse neuron navigator 1 (mNAV1), whose expression is
            largely restricted to the nervous system during development; mNAV1
            associates with microtubules.
REFERENCE   9  (bases 1 to 12767)
  AUTHORS   Maes,T., Barcelo,A. and Buesa,C.
  TITLE     Neuron navigator: a human gene family with homology to unc-53, a
            cell guidance gene from Caenorhabditis elegans
  JOURNAL   Genomics 80 (1), 21-30 (2002)
   PUBMED   12079279
REFERENCE   10 (bases 1 to 12767)
  AUTHORS   Coy,J.F., Wiemann,S., Bechmann,I., Bachner,D., Nitsch,R., Kretz,O.,
            Christiansen,H. and Poustka,A.
  TITLE     Pore membrane and/or filament interacting like protein 1 (POMFIL1)
            is predominantly expressed in the nervous system and encodes
            different protein isoforms
  JOURNAL   Gene 290 (1-2), 73-94 (2002)
   PUBMED   12062803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122458.1, AK140435.1, CN455316.1, CB523329.1, AK153742.1 and
            AC016814.14.
            
            On Mar 12, 2009 this sequence version replaced NM_173437.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF307453.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-962               AK122458.1         239-1200
            963-1751            AK140435.1         938-1726
            1752-3024           AK122458.1         1990-3262
            3025-3248           CN455316.1         34-257
            3249-3668           AK122458.1         3316-3735
            3669-4173           CB523329.1         119-623
            4174-8962           AK153742.1         495-5283
            8963-12767          AC016814.14        181891-185695       c
FEATURES             Location/Qualifiers
     source          1..12767
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..12767
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /note="neuron navigator 1"
                     /db_xref="GeneID:215690"
                     /db_xref="MGI:MGI:2183683"
     exon            1..801
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..5663
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Steerin1; pore membrane and/or filament-interacting-like
                     protein 3"
                     /codon_start=1
                     /product="neuron navigator 1 isoform 2"
                     /protein_id="NP_775613.2"
                     /db_xref="CCDS:CCDS35720.1"
                     /db_xref="GeneID:215690"
                     /db_xref="MGI:MGI:2183683"
                     /translation="MLGSSVKSVQPEVELSGGSGSGGDEGADESRGASRKAAAADGRG
                     MLPKRAKAAGGSGSMAKASAAELKVFKSGSVDSRVPGGLPTSNLRKQKSLTNLSFLTD
                     SEKKLQLYEPEWSDDMAKAPKGLGKLGPKGRETPLMSKTLSKSEHSLFQPKGGSTGGA
                     KTPLAPLAPSLGKPSRIPRGPYAEVKPLSKAPEAAVSDDGKSDDELLSSKAKAQKGSG
                     TVPSAKGQEERAFLKVDPELVVTVLGDLEQLLFSQMLDPESQRKRTVQNVLDLRQNLE
                     ETMSSLRGSQVTHSSLEMPCYDSDDANPRSVSSLSNRSSPLSWRYGQSSPRLQAGDAP
                     SVGGSCRSEGPPAWYMHGERAHYSHTMPMRSPSKLSHISRLELVESLDSDEVDLKSGY
                     MSDSDLMGKTMTEDDDITTGWDESSSISSGLSDASDNLSSEEFNASSSLNSLPTTPTA
                     SRRSSTIVLRTDSEKRSLAESGLNWFSESEEKTPKKLEYDSGSLKMEPGTSKWRRERP
                     ESCDDASKGGELKKPISLGHPGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATD
                     KGKLAVKNTGLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGTATVMQ
                     TGSSATLSKIQKSSGIPVKPVNGRKTSLDVSNSVEPGFLAPGARSNIQYRSLPRPAKS
                     SSMSVTGRGGPRPVSSSIDPSLLSTKQGGLTPSRLKEPSKVASGRSTPAPVNQTDREK
                     EKAKAKAVALDSDNISLKSIGSPESTPKNQASHPPATKLAELPPTPLRATAKSFVKPP
                     SLANLDKVNSNSLDLPSSSDTHASKVPDLHAPSSSTGGPLPSCFTPSPAPILNINSAS
                     FSQGLELMSGFSVPKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSAPIPTPPTAPSE
                     EDTEELPWSGSPRAGQLDSSQRDRNTLPKKGLRYQLQSQEETKERRHSHTAGGLPESD
                     DQAELPSPPALSMSLSAKGQLTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQMGS
                     TLSLAERPKGMIRSGSFRDPTDDVHGSVLSLASSASSTYSSAEERMQSEQIRKLRREL
                     ESSQEKVATLTSQLSANANLVAAFEQSLVNMTSRLRHLAETAEEKDTELLDLRETIDF
                     LKKKNSEAQAVIQGALNASEATPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAK
                     KKKKKSWVYELRSSFNKAFSIKKGPKSASSYSDIEEIATPDSSAPSSPKLQHGSTETA
                     SPSIKSSTSSSVGTEVTETPAHSVPHTRLFQANEEEEPEKKEVSELRSELWEKEMKLT
                     DIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLKVAPGPSSGCTPGQVPGSSAL
                     SSPRRSLGLALSHPFSPSLTDTDLSPMDGISTCGSKEEVTLRVVVRMPPQHIIKGDLK
                     QQEFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGLSTESIHGYSLSHVKR
                     VLDAEPPEMPPCRRGVNNISVALKGLKEKCVDSLVFETLIPKPMMQHYISLLLKHRRL
                     VLSGPSGTGKTYLTNRLAEYLVERSGREVTDGIVSTFNMHQQSCKDLQLYLSNLANQI
                     DRETGIGDVPLVILLDDLSEAGSISELVNGALTCKYHKCPYIIGTTNQPVKMTPNHGL
                     HLSFRMLTFSNNVEPANGFLVRYLRRKLVESDSDVNANKEELLRVLDWVPKLWYHLHT
                     FLEKHSTSDFLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQKA
                     AWEDPVEWVRDTLPWPSAQQDQSKLYHLPPPSVGPHSTASPPEDRTVKDSTPNSLDSD
                     PLMAMLLKLQEAANYIESPDRETILDPNLQATL"
     exon            802..904
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1270
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1409
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1707
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..2398
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2833
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2875
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3024
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3195
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3248
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3272
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3350
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3434
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3546
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3668
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3677
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3874
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..4067
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            4068..4236
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            4237..4334
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4430
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            4431..4590
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            4591..4826
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            4827..4981
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            4982..5053
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            5054..5250
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            5251..5369
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            5370..5567
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     exon            5568..12767
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6483..6488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /note="hexamer: AATAAA"
     polyA_site      6509
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /note="major polyA site"
     regulatory      8972..8977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /note="hexamer: AATAAA"
     polyA_site      9007
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
     regulatory      9327..9332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /note="hexamer: AATAAT"
     polyA_site      9350
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
     regulatory      12736..12741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /note="hexamer: AATAAA"
     polyA_site      12759
                     /gene="Nav1"
                     /gene_synonym="9530089B19; 9930003A20Rik; C230080M11Rik;
                     Gm38399; mKIAA1151; Pomfil3; steerin-1; Unc53h1"
                     /note="major polyA site"
ORIGIN      
        1 acgcgcggat cgtccatgcg ctcctcgcag gcagaatgct gggcagcagc gtcaagagcg
       61 tgcagcccga ggtggagctg agcggcggca gcggcagcgg cggcgacgag ggcgcggacg
      121 agtctcgggg agccagcaga aaggcagccg cggcggacgg cagaggcatg ctgcccaagc
      181 gcgccaaggc ggcaggaggc agtggcagta tggccaaggc cagtgcagcg gagctgaagg
      241 tcttcaagtc cggcagcgtg gacagtcgtg tccccggcgg gctgcctacc tccaacctgc
      301 gcaaacagaa gtcgctcacc aacctctcgt ttctcacgga ctccgagaaa aagctgcagc
      361 tgtatgagcc tgagtggagt gatgatatgg ccaaagcacc caagggtttg ggcaaactgg
      421 ggcccaaggg ccgcgagact cctctgatgt ccaagacgct gtccaagtct gagcattcgc
      481 tcttccaacc caaaggtggc tcaaccggcg gcgccaagac cccactggct ccgctagcgc
      541 ccagcctagg caaacctagc cggattcctc ggggacccta tgcggaggtc aagcctctca
      601 gcaaggcgcc tgaggcagcg gtaagcgatg atggcaaatc ggatgacgaa ctgctttcca
      661 gcaaggctaa agcgcaaaag ggctcaggga ctgtgccctc tgccaagggc caggaggagc
      721 gggccttcct caaggtggac cccgagcttg tggttaccgt gctgggcgac ctagaacagc
      781 tactcttcag ccagatgcta gatccagagt cgcagagaaa gagaacagta cagaacgttc
      841 tggatctccg acagaacctg gaagaaacca tgtccagcct gcgaggctcc caggtgactc
      901 acagctccct ggagatgcct tgttacgaca gcgatgacgc caacccccga agcgtgtcca
      961 gtctctccaa ccgctcctct ccgctctctt ggcgctacgg ccagtctagt ccccggctgc
     1021 aggctggcga cgcaccctct gttgggggga gctgtcgttc cgaggggcca ccggcctggt
     1081 acatgcatgg cgagcgggca cactactccc acaccatgcc gatgcggagc cccagcaaac
     1141 tcagccacat ctctcgcctg gagttggtgg agtccctgga ctctgacgag gtggacctca
     1201 aatccggcta catgagtgac agtgacctca tgggcaagac catgacagaa gacgatgaca
     1261 tcacaacggg ctgggatgaa agcagctcca ttagcagtgg gctcagcgat gcctccgaca
     1321 acctcagctc agaagagttc aatgccagct cctcactcaa ctccctccca accactccca
     1381 ctgcctcccg caggagctcc actatagtgt tacgcacaga ctcggagaag cgctccctgg
     1441 cggagagtgg gctcaactgg ttcagtgagt cagaggagaa gacccctaaa aaactggagt
     1501 acgacagtgg tagcctgaag atggaacctg ggacttcaaa gtggcggaga gagagaccag
     1561 agagctgcga tgacgcatcc aagggcggag aactgaaaaa gcccatcagc ctgggacacc
     1621 cagggtcctt gaaaaagggc aagacccctc cggtggctgt cacctctccc atcactcaca
     1681 ccgcccagag tgccctcaaa gtcgcaggca aacctgaagg caaagctaca gacaagggta
     1741 aactcgcagt gaagaacact gggctacaac gctcctcttc tgatgctggc cgggaccgcc
     1801 tgagtgatgc taagaagccc ccctcaggca ttgctcggcc ctctacttca ggatcctttg
     1861 gttataagaa gcctccccct gctactggca cagccactgt catgcagacc ggtagctcag
     1921 ccaccctcag caagatccag aagtcctcag ggatccctgt gaagccagta aacgggcgca
     1981 agacgagttt agacgtgtcc aacagtgtag agcccggatt tctcgcccct ggagcacggt
     2041 ccaacatcca gtatcgcagc ctacccaggc cagccaagtc cagttctatg agtgtgactg
     2101 ggcgtggtgg acctcggcct gttagcagca gcattgaccc cagcctcctc agcaccaagc
     2161 agggtggcct tacaccctcc agactgaagg aaccttccaa ggtcgccagt ggtcggagca
     2221 ctccagcccc tgtcaatcag acagatcggg aaaaggagaa ggccaaagcc aaggctgtgg
     2281 ccctggactc agacaacatc tccttgaaga gcataggctc cccagaaagc actcccaaga
     2341 accaagcaag ccaccctcca gccaccaagt tagcagagct gccaccaacc cctctcaggg
     2401 ccacagctaa aagctttgtc aagccaccct cgctagccaa tctagacaaa gtcaactcca
     2461 acagtttgga tctaccatct tccagcgaca cccatgcttc caaggtccca gatctgcatg
     2521 ctccgagctc atcaactggg ggccctctcc cttcttgctt cactcccagc ccagcaccca
     2581 tcctcaatat taactcagcc agcttctccc agggcctgga gctaatgagt ggtttcagtg
     2641 tcccaaagga gacccgcatg taccccaaac tctcaggcct gcacaggagc atggagtccc
     2701 tccagatgcc aatgagcctg cccagtgcct tccccagcag cgcccccatc cctaccccac
     2761 ctactgcccc atcagaggaa gacacagaag agctgccctg gagtggaagc cccagggctg
     2821 gacaattgga cagcagtcag cgagatcgga ataccctccc caagaaaggg ctcaggtacc
     2881 agcttcagtc ccaggaggag accaaggaga ggcggcactc ccacactgcc ggtgggcttc
     2941 cagaatccga cgaccaggca gagctgccat ccccccctgc tctctccatg tccttgagtg
     3001 caaagggcca gcttaccaac atagtgagtc ccactgcggc caccacgcca agaatcaccc
     3061 gatccaacag catccccacc cacgaggcgg ccttcgagct gtacagcggc tcccaaatgg
     3121 ggagcaccct gtccctggcc gagagaccca agggaatgat tcggtcagga tccttccgag
     3181 accccacgga tgatgttcat ggctcggtgc tgtctctggc ctccagtgct tcttctacct
     3241 actcctcagc tgaggagagg atgcaatctg agcaaattcg gaagcttcgt agggagctgg
     3301 agtcgtccca ggaaaaggtg gccaccctga catctcagct gtctgccaac gctaacctag
     3361 tggccgcttt cgagcagagc ctggtgaata tgacatcccg cctgcgacac ctggcagaga
     3421 cggccgagga gaaggacacc gagctgttgg atttgcgaga aactatagac ttcctgaaga
     3481 aaaagaattc cgaggcccag gcagtcatcc agggagcgtt aaatgcctca gaagccacgc
     3541 ccaaagaact ccggatcaag aggcagaatt cctcagatag catctccagc ctcaacagca
     3601 tcaccagcca ttccagcatc ggcagcagca aagatgctga tgccaagaag aaaaagaaga
     3661 agagttgggt ttatgagctt cggagttcct tcaacaaagc cttcagtatt aaaaagggtc
     3721 ccaagtcagc ctcctcctac tctgacattg aagagattgc cacacctgac tcctcagccc
     3781 catcatcccc caaactccaa cacggctcca ctgagactgc ctccccctcc atcaagtcct
     3841 ccacctcatc ctctgtgggc accgaggtca ccgagacccc tgctcattca gtcccccaca
     3901 ctagactgtt ccaagccaat gaagaggagg agccagagaa gaaggaggta tcagaactgc
     3961 gctctgaact atgggaaaaa gagatgaagc tcacggatat ccggttggag gccctcaact
     4021 ctgcccacca gctggaccag cttcgggaga ccatgcacaa tatgcagttg gaggtggacc
     4081 tgctgaaagc agagaatgac cggctgaagg ttgcccccgg cccctcctca ggctgcactc
     4141 cagggcaggt ccctgggtca tcggctctgt cgtcccctcg acgttccctg ggccttgcac
     4201 tcagccatcc tttcagtcct agtctcacag acacagacct ctcacccatg gatggcatca
     4261 gcacctgtgg ttcaaaggaa gaggtgaccc tgcgggtggt ggtccggatg ccgccccagc
     4321 acatcatcaa aggggactta aagcagcagg agttcttcct gggttgcagc aaggtcagtg
     4381 gcaaagttga ctggaagatg ctggatgaag ccgttttcca agtgttcaag gactacattt
     4441 ctaaaatgga cccagcctca accctgggac tgagcactga gtccatacat ggctatagcc
     4501 tcagccacgt gaaacgagtg ctggatgctg agcccccaga gatgcctcct tgccgccgag
     4561 gtgtcaataa catatcagtc gctctcaaag gtctgaaaga gaagtgtgtc gacagcctgg
     4621 tgttcgagac gcttatcccc aagcccatga tgcagcacta catcagcctc ctgctcaagc
     4681 accggcgcct ggtgctctcc ggccccagtg gcaccggcaa gacctacttg accaatcggc
     4741 tagccgagta cctggtggag cgctccggcc gcgaggtcac ggatggcatc gtcagcactt
     4801 tcaacatgca ccagcagtct tgcaaggatc tgcaactgta cctctccaac ctagccaacc
     4861 agatagaccg ggaaacaggg ataggggatg tgcccttggt gatcctcctg gatgatctga
     4921 gtgaagcagg ctccatcagt gagctggtca atggggccct cacctgcaag tatcacaaat
     4981 gtccctacat tataggtacc accaatcagc ctgtaaaaat gacacccaac catggcttgc
     5041 acttgagctt caggatgctg accttctcga acaatgtgga accagccaat ggctttctgg
     5101 tccgttacct gcggaggaag ttggtagagt cagacagtga cgtcaatgct aacaaggaag
     5161 agctgcttcg ggtgctggac tgggtgccca agctgtggta tcacctccac accttcctgg
     5221 agaagcacag cacctcggac ttcctcattg gcccttgctt cttcctgtcc tgtcccattg
     5281 gcatcgagga cttccggacc tggttcattg acctgtggaa caattccatc atcccctatc
     5341 tacaggaagg agccaaggat gggatcaagg ttcatggaca gaaagctgct tgggaagacc
     5401 cggtggaatg ggtccgagac actcttccct ggccgtcggc ccaacaagac caatcaaagc
     5461 tctaccacct gcccccgcct tctgtgggcc cccacagcac tgcctcaccc ccggaggaca
     5521 ggacagtcaa agacagcact ccaaactccc tcgactcaga tcccctgatg gccatgctac
     5581 tgaaactcca agaagctgcc aactacattg agtcaccaga tcgagagact atcctggacc
     5641 ccaacctcca ggcgacactc tgagggcccg gcagtcactg tcaccctgga gggcagaagg
     5701 ctggcttcag catcattagc tctcctctgc cctcttcctt catagctctg gctcaccagc
     5761 ctcgccaaga gaacaggagg gaagaagagg gcaggaggag ggatgggttc tcggtgctga
     5821 acctttgaga acttcctact aggaattgga gggggtggag tttgagaact ccgtgcccct
     5881 taactacatt tgctggcctc ctcttacgac ttaggagaaa agatgattct ggtcttttct
     5941 tcaagttttg tttcacctac aaactcttgg gctttctggg gagggattcg gaagatataa
     6001 acagacaaac aaaaacaaac aaaccaacta cagcagttcc aagctcgttc tcacaaacac
     6061 ctctgagaca gtcacatgtg ggcaaatcta agggaggcag gaagctctac agactttctt
     6121 gcaaaccctt cccagttctg tcgacactgc caacaacctc cccgccagag acctggccag
     6181 agccaagaaa agagaagcat gtggtttaac agaaaaacaa aacaaaacaa aacaaaaaat
     6241 atatgtgtaa atcaacctgt agaaggtaaa aacggcaatg gaaaagatga agctggaagg
     6301 aggggcccag ttgccaagat ggaacgagag ctgccagatc ttgccttctg gatgacaaga
     6361 ggggacattg caagatggct gccagtctaa aacgtcacca gaccacaaga gtaacatcac
     6421 agccttcgaa gaaaggccac aagctgtctt tctgccctct aactgaacat gcatgaaaag
     6481 tcaataaacc ctacttttta atttttaaat ttttatttct attttttcct tccatttgcc
     6541 tatttatttg tccctcacct ccagtttcct cacatcaata agatacttgg gtttccttcc
     6601 aggggatagt tttgctttcc aagtgggttt tctttggaga atttaattct ataatattgg
     6661 tacaagttag acacctccca tgccactgtc cctggcatcc ttggggctta catgggacaa
     6721 gaaacattgg ctcataatag taagagaaga agaactcagt ctctttggtt ccttttgaga
     6781 aagcacatgt tctacctgga agctcaactg ccgtcctcca gcatggtaga tctaccccga
     6841 gcttcatctc ggactgggag gaaaaccaaa atactggaaa cacctgcctg tcttatggcc
     6901 tgttagggcc ctcactgcac tatttggatg gtagccactt tgcctgactg aatcaagatt
     6961 ccctagctag cccttattat ttgtttttga cagatgaata gtcacttata ggagatggag
     7021 caaccgtgtg acctgcttca gatcagaata aaaggctcaa agagtttgac ttggtggcca
     7081 atatctgcct tccaaagaga tctacgtctt gcagaagttg ccctcttcct aacccacact
     7141 ccttcatttg acaagtactt actgagtatt taaccgagta ccagtcacta cgtttttaaa
     7201 aaagacaaga cttggtcctt aagttcaagg tctaggaggc aatgttaatc tcctttaagt
     7261 aaccatccct ttattatctg gaccttgaaa atcatctgag agatgcaggt gaaggccaag
     7321 gagtcaatta aaagaagcct ttggttagat ctccaatatg ttgtaggcag aaggttgggg
     7381 atcagtttaa atgaagcctg aagaactgtg gaatcttgct tgtcttgagt gggaaaatct
     7441 acttctgtca tttctggaaa ccagtggaac caaattccag gttgagctgc ctcatgggct
     7501 aatgtgttag cgctctgcag tgcagggata tatactatac gtctggacct gagaatacgc
     7561 tcttcaggtt ccttagtagc acacgacgta ccagaatcta taccaagatt ctttaggcaa
     7621 actaacctgg gccattgttc cacccaacca aggaattacg tgcccctgac tcttaatagt
     7681 ctattttcat ttagatcctc aagaaggtct agcttgtccc ttttgtaccc atccaccccc
     7741 ggcaaaagct tctatattca cctggtagcc ccagggatga cagggtcctc tattctggag
     7801 actgttattg ctactgctgc taattccacg agctgtgaag atccccaact cagctgcaaa
     7861 atatgcaatt ctgtggtggg aagaggctga ctgtccgagg atggtgctga aatcactgcc
     7921 ttaaggtctt tgctgtgcag aatgagaagg cccccccaga gctgggtgtt ccaacttaga
     7981 aggaagggaa gactggatag gcctactttg gacataggtc tcttctgaac cctatccaaa
     8041 gctccagtac atggcaaggc tcagactttt gctaacatcc taacgcttga gcctttcacc
     8101 ctctttttct ggtgctgccc agccagtgcc ttctgacacg gatgttactg gctacttaag
     8161 aagaaggaaa gtaggaaatg ccttcttcca ttccaactgc ctcagactac agagagagtg
     8221 tctctgtggt aactatggat accatcgaga attttatttg ggtctgcagc aagttgattc
     8281 tggaggcctc gcatactttg acttcatttc tattcctggg atccaccacc ctcttctctc
     8341 agttgactgc tgcatttagt tcaggcctca aatagctgtc ctccaggaag tgcgttccca
     8401 tctagtgaag tgctctcgaa gcctacactt tccttctgga gcctgggacc ctgtttacag
     8461 ttgcacatct gggcccctca cagtaggatc aaccatctca aaaaaaaaag aaaaaaaaaa
     8521 gggatcatgg ttcggtggca atttcggaag gttgagcctc ctcatggtgc tataacccct
     8581 cgggatgctc atccagactt ctaagaagca aaaagcctga gctcctcctc actgcctaag
     8641 aatccatggc aaagagcaaa gccgcagcag tcctcccaac ctacacactt cttggttgag
     8701 actcctagga ctcctcagaa aggaaaaact gggtcccaca atctccaggc accttcagaa
     8761 gaatgcaatc tatcttaatt ctgcaacttt tgctattccc tttccttcca actcctgatt
     8821 ccatccctca ccaaagttgg ctggtgaaga acaacaacct ttggagggcc tcagctccag
     8881 gagaggctcg ccagagtccc ttgcacttgg ggatgaagac caataagttg tgttcaatgt
     8941 gtttgtttct cagtccctgc ctaagcacta aaataaaata ctctaggtat tggaggctgc
     9001 taagggacct gatgtctgtg catttttctg tctctgtcct tctctcttac acacgagcag
     9061 tttgttgtta tcttctgggg ctctgtggaa cattattttt gatacctgct ttctggtaac
     9121 tcgttggtgc ttgtttctgt ctctgtaaat ccttattcca gtgtctttca tgtagtctaa
     9181 tcatttggaa ggtagaggct ggcaaggaag gagaaggggg taaaagatca tggagagagc
     9241 ccacaagaaa actttcttgg ttggtaaaca tttgggtctt gagttaccaa ccttctaatc
     9301 tgtctattct gatggacata agacaaaata atgatttttt tcctcccctt ttcattttgt
     9361 gccgtgtggt ttttctagtt tacaagagtc gatgtggact tcatgtaccc atctccttcc
     9421 tgatggctct caaagatgag tcatgctatt cacaggagtg ccaccccctt ccaggactct
     9481 gaggatgaac tcttgtttcc tgtcctattc cagaaaagta gttaggctct cacaccacct
     9541 tccatcaccc cagatggaac ccattcccag cagccagcct gggcacagag gacacatgcc
     9601 tgatgaggtg atccaaatga cattaatgat cttttttatg gcataggggt ttgggagagg
     9661 aagttgtgct gatcacaaat ctaatccagg gttccagagt taaagtgact cagatggtta
     9721 atcaaagacc cttctcattc tgtagccttc cttcccatag tcctgtgcac tagctaaatc
     9781 gaagctggta aactggctcc gtgagccaac agcccccgtg gtaagaactg aaatggctgt
     9841 aacaacaggt tggctaatag agatggatag gatggatgca ccaacagctg ttggtacctt
     9901 gtttttcctt caactgttgg gtattgactc tagggtttct cataacactc agcaagtacc
     9961 caccactgag ctttctctct agcctttata ctaagttgtc cataatggct ctgaattcag
    10021 taaatattcc aagcaagctt tgaatttgat gatcacacac acacacacct ctcaagtaat
    10081 tggcatttca gcctgcatca ctgggctcag ctataataca ctctgtagta agaactatac
    10141 atgacagttc ccaacaagga ggcccaaaaa tgtgttacaa atggccaaag cctgaagacg
    10201 ttgttcttca tcactgaatc agccttatca atcttcaacc tgctcaggga taactgggcc
    10261 accagcttgg ctctccccac tgcccaggat acactggtat acactctagc cctggaagca
    10321 cgtgctgttc tagggaagat agactaaact ggaaagcagc agagttcaga aggaaaagga
    10381 gcagttgaac tttggaaacc gcagggagaa aacgacattt aaaaggttta cctacagcct
    10441 ggcatggtgg tacatgcctt taatctcagc acttgggagg cagaggcagg tggatttctg
    10501 agtttgagac caccctggtc tacagagtga gttccaggac agccagagct atacagagaa
    10561 accctgtctc gaaaaacaaa aacaaaacaa accaaaaacc aaaaaaaaaa aaaaaaaaaa
    10621 aaaaaaaaga ggttcaccta tttatgctag tccattccgg tttaacattc tggctgtttt
    10681 ccttaatgat tatgtcacag ggaacattct ccaacgtgat cctagaaggg gaacctctgg
    10741 ttcttgattc agcctttcaa tccatacagt ggtggcacta gatggatgtt ttcagacaag
    10801 caacagcaga atgtaggaat aaatgcgtta gggataaatt tcccaggctc taatccagat
    10861 ttaccaagtc aaacctttat ggcggtgtcc ggcaatgctt ttaacggttc tgtagtgaat
    10921 ccagtacata agagcccttg ctccaagatg gctgatgttt ggagaccccc ccccaaaaag
    10981 aaacatctac agtctgattc aaatgttaac atctcaaagt catttttctc atacttaggt
    11041 ttctgggagt taacagtgaa agctttgggg tggaagtcag ggaagctcgc agcctctagt
    11101 aggcaacttc ctgcctctga aatttctatc tggcaaacta tggggcttca gtggaggaat
    11161 tgtgttggag gtctcatttg aattgctgtt ttgacagctt ctttttctga taatagtgta
    11221 aaaaaaagga aaataaaatc taatttgcat ttctatgata aaatgttctc ctggcaacca
    11281 ccctctccct tctttaagtg gttaagagtt tgagagccta gccagaccct ccttccccag
    11341 agcagctgac agctgtgggg ctccagttac tgccagaaag gccatgtctc tgctccaccc
    11401 acaggagaga gttctgcaca gtgaaaataa cgttatctac gtccttaagt tcaaccttgc
    11461 cttttcccac accaggacct aagtacagta ctcagcaaat agaacaaaat aaaatcctct
    11521 ttaaaaaaat aaattttttt tttccagaaa gagcttcata gatttccaaa ctcacaaact
    11581 agttgctatg gccatggaag agttgagact ttgagaagtg gttttgtttc aaatttgtca
    11641 gttccccttc tataaaagca cttttgtgta gagtattaaa aatcactagt atcgggtctc
    11701 ctgagctcag ggactaagca ctggaaggag ggactaaagt ccaaggcgag caggagtaaa
    11761 acatttacac caaaataacc ctccttacca tccagccagc tcctgtggcc tcatcctgca
    11821 tcccagctcc tgtggcctca tcctgcatcc cagctcctgt ggcctcatcc tgcatcccag
    11881 ctcctgtgac ctcatcctgc ctccctgcat cccagctcct gtggcctcat cctgcatccc
    11941 agctcctgtg gcctcatcct gcatccctgc atcccagctc ctgtgacctc atcctgcctc
    12001 cctgcatccc agctcctgtg gcctcatcct gcatcccagc tcctgtggcc tcatcctgcc
    12061 tccctgcctc ccagctcctg tgacaccatc ctgcttccat ggcatttctc taagaaggaa
    12121 gataaaaaag agcaaactcc cacccagcag ccagtttccc atatagctct gctgcacccc
    12181 accccacttc ctaatgctgt tcggtttatt gcttttaaca aaacaaattt atagtgagtt
    12241 ccaggccctg gtggcttcct ttcctccccc tccctatcct gttttacaca gcactgctca
    12301 tgtaagagtc tgtttctcaa atgcacggca ttcctcaggt ggaggatggg caagaatgtt
    12361 cactttttaa aacttactgg gtagaaaaat cccaaaccag gatatgtgtg tgtctgtatg
    12421 tttgtcttat tttcttctca tttgaccctc accattccag tctgtcccct tttatacctg
    12481 atgtagaaaa ggcagaactg aatctggaaa gcaaattgtt gtatatagtt gcggtaacaa
    12541 tcacgaagag agctgggctg tcccctcagt aattcatttt aaatgaaaaa aaattggttg
    12601 aaaatgaaat ccatgccttg gccagctgaa atggccttcc tccatcgcca ctgaggctac
    12661 ccttccctgg gtcctctgcc gaccaggcat gtctccatcc agcagatttc atctgtttgc
    12721 tgccatttgc gtttcaataa agttatctcc tgtattgtcc tctggtt
//
