LOCUS       NM_025294               4159 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus N-acetyltransferase domain containing 1 (Natd1), mRNA.
ACCESSION   NM_025294
VERSION     NM_025294.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4159)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4159)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4159)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 4159)
  AUTHORS   Yan,J., Bi,W. and Lupski,J.R.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
REFERENCE   5  (bases 1 to 4159)
  AUTHORS   Cannon,J.P., Colicos,S.M. and Belmont,J.W.
  TITLE     Gene trap screening using negative selection: identification of two
            tandem, differentially expressed loci with potential hematopoietic
            function
  JOURNAL   Dev Genet 25 (1), 49-63 (1999)
   PUBMED   10402672
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY196792.1, AK004720.2 and AK080453.1.
            
            On Jul 16, 2009 this sequence version replaced NM_025294.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080453.1, AK004720.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BY196792.1         1-2
            3-1003              AK004720.2         2-1002
            1004-2006           AK080453.1         1005-2007
            2007-2165           AK004720.2         2006-2164
            2166-4159           AK080453.1         2167-4160
FEATURES             Location/Qualifiers
     source          1..4159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.93 cM"
     gene            1..4159
                     /gene="Natd1"
                     /gene_synonym="F3-2; Gm16515; Gtlf3b"
                     /note="N-acetyltransferase domain containing 1"
                     /db_xref="GeneID:24083"
                     /db_xref="MGI:MGI:1344388"
     exon            1..164
                     /gene="Natd1"
                     /gene_synonym="F3-2; Gm16515; Gtlf3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..400
                     /gene="Natd1"
                     /gene_synonym="F3-2; Gm16515; Gtlf3b"
                     /note="gene trap locus F3b; protein GTLF3B; gene trap
                     locus protein F3b; gene trap locus protein F3-2;
                     N-acetyltransferase domain-containing protein 1"
                     /codon_start=1
                     /product="protein NATD1"
                     /protein_id="NP_079570.1"
                     /db_xref="CCDS:CCDS24802.1"
                     /db_xref="GeneID:24083"
                     /db_xref="MGI:MGI:1344388"
                     /translation="MAHATPPSALEQGGPIRVEHDRQRRQFSVRLNGCHDRAVLLYEY
                     VGKRIVDLQHTEVPDAYRGRGIAKHLAKAALDFVVEEDLKAHLTCWYIQKYVKENPLP
                     QYLERLQP"
     exon            165..283
                     /gene="Natd1"
                     /gene_synonym="F3-2; Gm16515; Gtlf3b"
                     /inference="alignment:Splign:2.1.0"
     exon            284..4159
                     /gene="Natd1"
                     /gene_synonym="F3-2; Gm16515; Gtlf3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3323..3328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Natd1"
                     /gene_synonym="F3-2; Gm16515; Gtlf3b"
                     /note="hexamer: ATTAAA"
     polyA_site      3349
                     /gene="Natd1"
                     /gene_synonym="F3-2; Gm16515; Gtlf3b"
                     /note="major polyA site"
ORIGIN      
        1 ttctccggcc cgcgccgccg aagagtcagt tcgctgcggc ccgcggtccc cagtgtcggc
       61 gcgcgcgatg gcgcacgcta ccccgccgag cgcactggag cagggcggcc ccatccgcgt
      121 ggagcacgac cgccaacgcc gccagttctc cgtgcgcctc aacggatgtc atgaccgagc
      181 tgtcctgctc tatgagtatg tgggcaagcg gatcgtggac ctgcaacaca cagaggtccc
      241 agatgcttac cgtgggcgtg gcattgccaa gcacctggcc aaggctgccc tggacttcgt
      301 ggtggaggaa gacctgaagg cccacctcac ctgctggtac atccagaagt atgtcaagga
      361 gaaccctctg ccacagtacc tggagcgcct acagccatga ccctggccac tgtgtgcagg
      421 agtgcaccct gtgggccttc tgtgtgggcc tcagccagct catgtgctct caggaacctg
      481 ttcccatggg gacaggctca gagttatttt tgcaaggaca cccgtctgca gccttcatcc
      541 aggattctgg ggaccagctg ctggttgtgg atatgtgaaa agccagagtg ggacgaaggg
      601 caggccaagt ggtcaagacc cgcttcccac agaggtcctc cagctctgct gaggtggtcc
      661 tcctaccagc tgcacatctc ctctggcctg gctactgggt ccctgctctg atcagcaaga
      721 gggtgacgta gagtccctgc caccacctcc tggcatcaat gtcctttctg caaatgagga
      781 gggtgttcct ggagccaaga agaacaacag gaaccctgtg tgccagcttc ccaaggtgga
      841 ggtgccaagc cttagccaca accagtgcta accctttctc tgtctcagac ttgcgtgccc
      901 tggcacaggc agtgggacgg cggcagaggg cagccaatcc tggcatgtga gagagccgag
      961 gattcagctc tggcccaggc ccatctgagc atgcacacca acacatgagc acaagaggcg
     1021 ggtcaggtac ccacactcca cactgtttgg cttctcatgt ggttccctgt cagagggact
     1081 cccttctcat gcattcacct acaggagcca gcccagaggc ttagtgtggt ctgctgagca
     1141 gcccagtacc cttagccctc gctgaccttc agctggactt gtcagggcct ttcttgtggg
     1201 tcaccttcaa gatggatgag atggtggcac acaagatcca tttcacatct tttgtactcc
     1261 tggcttctga ccatctcccc actgctgctt aggctactcc agacatctgt gcacagacac
     1321 cttcccactc tgcaggagta ctgaaatctg gaccagaaag ccatgcatcc tggctgggag
     1381 gtcttaagtt cagaaccctt gggcctcact caccactgca gtcatgggca cagaccctta
     1441 tggtccccac actcagcatc tccctacctc ctgcacctct ggctcttacc cggttcttga
     1501 tgctcctctt ccagcctcct agagttctag gataacccag catactcctc actactgcct
     1561 ccctcctctg ccaccccatt ctgtctgaca gggactcttc ggggtccaga gaaacccctg
     1621 ggcctctagg aagacattgc tgactgctct gacagctgcg gtggcagtgt gtccacaata
     1681 cagtacttga atgagggccc tgagtcatgt ggacccaaga agagtggctg ggcttcctcc
     1741 gtgggcttgt ctcaagttcc tgcagggtgg cctgagcatt cctcactgcc ttggcagcct
     1801 taaagtccca ctgactgtgc cccggaggct tcatagcctt gcggtgtagc aataactata
     1861 tctctgcctc ttcctcctgg ccaatactgc ccaactgggc cactctggtg ctatcccatc
     1921 tgcctccccc tacccctcaa cacctgttcc acgtcctgag tcactccaag agcctggtta
     1981 ggcactggca ctctagacat catgttcctt caataggtct gtgcagtgct cagacctcac
     2041 cctaggcttt ctcttccttg cccagtctac acaggcagta actcatgtgc ctttcctact
     2101 ctgaacctgc caccagtagt atctgggcca aggctggtct tgggacctgc atcccctcac
     2161 ttttctgact tttgaataca ttgcatgatc ctgttggtca ctgacaaaag actaaggcac
     2221 agtgaggtca ggggccccca gagcgaagaa atagggcaag ataggttgtg taggaagtgg
     2281 ttctccctgg tgcccagcct atttgttggt cctccaatgc ctgcatagtt ggacagctcc
     2341 actgcgggga gtctaggctc caaaggctgc cagagcctga ctgaggtctc ctagcacaac
     2401 agtgccaaca agcttcggga tcccagccca ggtctgggga actttgccat ctgtatccct
     2461 ccatactacc tgaacctcag agttttaccc tagaggccac actcctcatt gctgggcaac
     2521 agctttacag ggattcctag aagtcatggt gccatactag cctctgattc gtgagctgct
     2581 ctttgccctc aagttggtca ttcagggttc ctgacagaac tgttggtaag cacaggagca
     2641 gtgcaagtgt tccaagatgg gagcacgtgg aatctgctca tgcagtcctc cttacacggg
     2701 acctaaccca caagggccag ggtagctagt ggaccgagtg caaggcacag cagtcaggct
     2761 ctgtggtctc accccctcct taattctcat gcaattccca agagacacca cttactgggc
     2821 ctgtcctgca gttgaaggga cagggtcaga ttaagtgggt caccagcctg caacccacac
     2881 aactagacag cccaggatct aaacccagtc cctgacccct cggtagtccc cagcttgtgt
     2941 attgtggtca gatgtctact tgggaaacaa atgacctcag taatacatag ataacatttc
     3001 tagaagtttc cttactcctt tgaagggctg aaatgaggat ctgtcttgag ttgcaaggta
     3061 cacatggcca gcattcagaa gtctggctta tgaacaggag cactcccctg gagcacctgg
     3121 ccactcacct gttgttcctc agatcaggac ttgggctggt tcgagtcctc ccacatgtcc
     3181 ttttactagt ctcagggtcc tgcttccagc tcattgccct aagtttcata cacgagatcc
     3241 tgtgaggctg tggcttgaac ctttaactac aacctcgggg atcacattta tgggttttag
     3301 ctgtgtccca tggcttcaag atattaaaga tgcttttctg gttgtcaaag gtgctctctg
     3361 cttttctctc ggtgccttgg gaagagcagt tgacagtgtt atttctgtca ctcttcagtg
     3421 ctgtcctcaa tctctgcacc ctagactagc tgggaggccc tggctagagc cacaggggtg
     3481 gccatcgggt cttccaggct ttgccttcaa agccagtgat tactgtggca cttattaatc
     3541 tagcgtggga tgtcacggca gaaccaagat tgaacattct gtaaaggata gattggttct
     3601 aggattccca aggctagagg gtccaaggtc aagggtcaca tctggctttt tgctacactg
     3661 tctgtggcaa agagcaagga aggttagcca gacacccttc acagtaacaa tgcagtaatg
     3721 gttaacccat gcctaagggc agagctagca ctcatgacct agaaacctct gaaaggcccc
     3781 acctttggcc accactgcac tgcttcagtg catggccttt ctggtacatg ttgcactcca
     3841 cgtgaggttt taggggtcca ttttccccag cattagaatc atgtcctggt ggggacagat
     3901 cagcaatccc gtgtttacaa ctttgggcaa ctttccagga agtcagtccc aataccagca
     3961 atgtcagcct gcaccgaaga acgaagagca ctcaggtact gatgtgggat ttagggcaga
     4021 gaacttctga aaatgttaaa attctcaaag ttcctcagat tacaggaagc tggaggaata
     4081 tcaacaccat aatcacgtgg cctctgaggg ttctccctga agaacaaatt ccaggagtta
     4141 cgatattctt aacacacac
//
