LOCUS       NM_053096               3280 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus N-acetyltransferase 8 (GCN5-related) family member 2
            (Nat8f2), mRNA.
ACCESSION   NM_053096
VERSION     NM_053096.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3280)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3280)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 3280)
  AUTHORS   Karmodiya,K., Anamika,K., Muley,V., Pradhan,S.J., Bhide,Y. and
            Galande,S.
  TITLE     Camello, a novel family of Histone Acetyltransferases that
            acetylate histone H4 and is essential for zebrafish development
  JOURNAL   Sci Rep 4, 6076 (2014)
   PUBMED   25123547
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3280)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3280)
  AUTHORS   Ding,Y., Ko,M.H., Pehar,M., Kotch,F., Peters,N.R., Luo,Y.,
            Salamat,S.M. and Puglielli,L.
  TITLE     Biochemical inhibition of the acetyltransferases ATase1 and ATase2
            reduces beta-secretase (BACE1) levels and Abeta generation
  JOURNAL   J Biol Chem 287 (11), 8424-8433 (2012)
   PUBMED   22267734
  REMARK    GeneRIF: Biochemical inhibition of the acetyltransferases ATase1
            and ATase2 reduces beta-secretase (BACE1) levels and Abeta
            generation.
REFERENCE   6  (bases 1 to 3280)
  AUTHORS   Popsueva,A.E., Luchinskaya,N.N., Ludwig,A.V., Zinovjeva,O.Y.,
            Poteryaev,D.A., Feigelman,M.M., Ponomarev,M.B., Berekelya,L. and
            Belyavsky,A.V.
  TITLE     Overexpression of camello, a member of a novel protein family,
            reduces blastomere adhesion and inhibits gastrulation in Xenopus
            laevis
  JOURNAL   Dev Biol 234 (2), 483-496 (2001)
   PUBMED   11397015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158684.7 and AK050449.1.
            
            On Sep 1, 2006 this sequence version replaced NM_053096.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039773.1, AK050449.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC158684.7         206949-207052       c
            105-837             AK050449.1         35-767
            838-3280            AC158684.7         203337-205779       c
FEATURES             Location/Qualifiers
     source          1..3280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.51 cM"
     gene            1..3280
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /note="N-acetyltransferase 8 (GCN5-related) family member
                     2"
                     /db_xref="GeneID:93673"
                     /db_xref="MGI:MGI:2136446"
     exon            1..104
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /inference="alignment:Splign:2.1.0"
     exon            105..249
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /inference="alignment:Splign:2.1.0"
     exon            250..3280
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1040
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /note="probable N-acetyltransferase CML2; camello-like
                     protein 2; camello-like 2; N-acetyltransferase-like
                     protein CML2"
                     /codon_start=1
                     /product="N-acetyltransferase family 8 member 2"
                     /protein_id="NP_444326.2"
                     /db_xref="CCDS:CCDS20302.1"
                     /db_xref="GeneID:93673"
                     /db_xref="MGI:MGI:2136446"
                     /translation="MAAYHIRQYQEKDHKRVLELFSSGMKELIPAAIRQMLTLPHSLL
                     LLPGVPVTIVLMSASWLLATLYSFLFLLCLWLIFWISCRNYVAKSLQADLADITKSYL
                     NAHGSFWVAESGDQVVGMVGAQPVKDPPLGKKQMQLFRLSVSSQHRGQGIAKALVRTV
                     LQFARDQGYSDVVLETGSVQHSAQALYQAMGFQKTGQYFVSISKKLMGLSILQFSYSL
                     PFASGPGYSGKYLKKGPIPC"
     regulatory      1190..1195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /note="hexamer: AATAAA"
     polyA_site      1211
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
     regulatory      1243..1248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /note="hexamer: AATAAA"
     polyA_site      1265
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
     regulatory      1308..1313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /note="hexamer: AATAAA"
     polyA_site      1335
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /note="major polyA site"
     regulatory      2009..2014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /note="hexamer: ATTAAA"
     polyA_site      2027
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
     regulatory      2229..2234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /note="hexamer: AATAAA"
     polyA_site      2252
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
     regulatory      2719..2724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
                     /note="hexamer: TATAAA"
     polyA_site      2744
                     /gene="Nat8f2"
                     /gene_synonym="Cml2"
ORIGIN      
        1 gccagaccag atctgcaccc tagaggttca ccaggctctg gtaggtttta ctggatgtca
       61 tcggaggcaa aggccatcct ggacatttgg atctgtcata ttagactgaa tcattccagt
      121 tgctggaaag aggatttgtt gaaacttgga cctgggaaca caggagtttt caactctggg
      181 ccctgaagag gaaacagaag atctcagaac agcacatctt tccacagtgt agaacctcag
      241 ttcccaaagg gctcagggaa gttatgcaag aaggtctgga tgtcccttgt gatcactgat
      301 acttgagagc cagaagtctc cccatggctg cttatcacat ccgacagtac caggagaagg
      361 accacaaaag ggtcctggaa ttgttctcca gcggcatgaa ggagcttatt cctgctgcca
      421 tccgacagat gctgacactg cctcattctc tcttgctctt acctggagtg cctgtgacca
      481 tagtattgat gtctgcctcc tggctcctgg ccacattata cagcttcctc tttctccttt
      541 gcctgtggct tattttctgg atttcttgca gaaattatgt ggctaaaagt ttgcaggcag
      601 atcttgctga catcaccaag tcttacctga atgcacatgg ctccttctgg gtggctgagt
      661 ctggagacca ggtagttggc atggtgggtg ctcagccagt caaggaccct ccattaggga
      721 agaagcagat gcagctcttt cgcctgtctg tgtcctcaca gcatcgagga cagggaatag
      781 caaaggcact ggtcagaact gtcctccagt ttgctcggga ccagggttac agtgatgttg
      841 tccttgagac tggcagtgtg caacatagtg ctcaggctct ctaccaggcc atgggcttcc
      901 agaagacagg ccagtacttt gtcagtataa gcaagaagtt aatgggtctt tctattcttc
      961 aattctctta ctctctccct tttgcttcag gaccagggta tagtgggaaa tatttaaaaa
     1021 aaggtcccat tccatgctag caccaggtac tctctggccc cagtggtctc actgcctcca
     1081 tggcttgtcc tatgtagcaa ctgcccatct tgaggatctc ttgctgggga ttgtaacctg
     1141 gtaaaatcaa aagtctagag gcttgtgatt tatcagtcag atttaaatta ataaattctc
     1201 aacccacaaa atgtccccac aatgaattca aaactcaatt gaaataaact gaggctacac
     1261 acctagatgg ggcaaacata ccctatttat tatttaatca tctatccaat aaattcccaa
     1321 tatatatggc tcccaggact gtgtgcttct ggcttctcat cctctcctat agttttgatt
     1381 ttgtctcctg ccctgtgtct cttcttctct ctaatatttc ctgttacaca aaggatgtga
     1441 tccttttttg atttgtgtgt ccagaaggct tcagttcact ctgctctagg aacaagccac
     1501 tcctggcagt ttcccagtac caatcccaag ggctcccttt gcactccttt cagatgcagc
     1561 catgctggtg gtgacctgtg ggtgttggct ccattctgcc tttttaagta tctctctttc
     1621 gtctttctag tgccatgata agatagcaca aaacccaact gagtccatcc tgcacacagt
     1681 tcacttagga atctgttagc tgtcagtatc agctaggtgg tctcaagact tcaaggcaag
     1741 caaccttgct gagctgaagt tccagcagct cacaggattt aaatctaaga cttgtgtaga
     1801 aatggagcct ccactggtag aggcacagca cagatcaggg tggctgcact gagagcactg
     1861 gagcaacgaa gcctgtaact tacacctaag ccacctctgt gcagagggag gaaggggacc
     1921 tctgatgcag tgagagtaac tttgaatggc ctctcctggt ggaatgatcc ctcctggcct
     1981 cttggtccca gtcttatggg aaagcacaat taaatgcatg aaatgtactt ggggattcat
     2041 gaagatgaaa tgggatcagg aattgtatga atatgtcacc ctagggaaaa tgcctggacc
     2101 aactggcact cgagtaggtt ggacatcagt gggcttccag tgctcctgga tttcctctgt
     2161 aaaaagttaa aatggcagtt caggagttgg aacagcactg tagagtggag aaaggcagtc
     2221 tcagaactaa taaagttgtt ggctgaagat gaccctgcta ggcataagag acttccagaa
     2281 ttgttaagga aaggcccaga gggacatcaa atcacagatg tggtttccac tgcttttggt
     2341 tgcatgttgg aactggagaa ctccttgctg aggacatgac ctgtttggtt tcaggacaca
     2401 gaagaatcaa cagagagtga cctggaacag ccttgtgtgc tcgctgggtt tctagtgcca
     2461 agaggctcga tccaggctgc tgagggacaa ttgtagagac agtcttgctc cctgtgctgt
     2521 gttgttactt gccgggaaga tgtatgttgt agtgttatag tggcattgtt atgtttgcac
     2581 acacatactt tctgattaag gcctccatag gtggatattc ccattgatta ttctaaatca
     2641 agacaaaatt atgtgatgtg caggccacag gccatagtaa gaagactagt actattgttt
     2701 tagtttttat taagcagata taaactttta tcagcttgcc ttcatttctt tttatgccca
     2761 atgactgctg taccagcatc acttgtaaag ggagcctttt tcacagtgag aggtagtcac
     2821 tccagagact cataatttcc ctgattgctg agcataactg actgatcctt tgatataatc
     2881 cgatattggg tcataaatgg aagaaaatgg atatacacaa acacacacac acacacacac
     2941 acacatcacc tgctccaagg cttggaagag ttatggaagc ggatgcataa agatttaaga
     3001 tctggagtgg gtgggatacc ctgtatctct ctggtctgaa ttgaaacttc cccttttagg
     3061 gggctgacag aggcccagga gactctggag agcgttcctc tctgatgtca cccaggcagt
     3121 aaacatttat cagcagagag aagcctctta ggaaccccag ggttggaggt ttgtaagtca
     3181 ttaccaatgc aatggccata ctgcctgggc aacccgtgct cctgtaagta atccctcagc
     3241 tgtgctcctg tgctccaata aactgtttca tcaaacttga
//
