LOCUS       NM_023455               1073 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus N-acetyltransferase 8 (GCN5-related) (Nat8),
            transcript variant 2, mRNA.
ACCESSION   NM_023455 XM_006506535
VERSION     NM_023455.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1073)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1073)
  AUTHORS   Rigby,M.J., Lawton,A.J., Kaur,G., Banduseela,V.C., Kamm,W.E.,
            Lakkaraju,A., Denu,J.M. and Puglielli,L.
  TITLE     Endoplasmic reticulum acetyltransferases Atase1 and Atase2
            differentially regulate reticulophagy, macroautophagy and cellular
            acetyl-CoA metabolism
  JOURNAL   Commun Biol 4 (1), 454 (2021)
   PUBMED   33846551
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1073)
  AUTHORS   De Iaco,A., Verp,S., Offner,S., Grun,D. and Trono,D.
  TITLE     DUX is a non-essential synchronizer of zygotic genome activation
  JOURNAL   Development 147 (2) (2020)
   PUBMED   31806660
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1073)
  AUTHORS   Fu,J., Zhang,H., Zhuang,Y., Liu,H., Shi,Q., Li,D. and Ju,X.
  TITLE     The role of N-acetyltransferase 8 in mesenchymal stem cell-based
            therapy for liver ischemia/reperfusion injury in rats
  JOURNAL   PLoS One 9 (7), e103355 (2014)
   PUBMED   25057902
  REMARK    GeneRIF: Results show that Nat8 is down-regulated in liver
            ischemia/reperfusion injury and its upregulation prevents it
            suggesting its protective effect against liver injuries.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1073)
  AUTHORS   Popsueva,A.E., Luchinskaya,N.N., Ludwig,A.V., Zinovjeva,O.Y.,
            Poteryaev,D.A., Feigelman,M.M., Ponomarev,M.B., Berekelya,L. and
            Belyavsky,A.V.
  TITLE     Overexpression of camello, a member of a novel protein family,
            reduces blastomere adhesion and inhibits gastrulation in Xenopus
            laevis
  JOURNAL   Dev Biol 234 (2), 483-496 (2001)
   PUBMED   11397015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161888.5.
            
            On or before Apr 6, 2018 this sequence version replaced
            XM_006506535.3, NM_023455.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant (1). Variants 1 and 2 both encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB955458.1, ERR3363658.4088745.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC161888.5         109297-109398       c
            103-239             AC161888.5         108912-109048       c
            240-1073            AC161888.5         107506-108339       c
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.49 cM"
     gene            1..1073
                     /gene="Nat8"
                     /gene_synonym="0610037O16Rik; ATase2; CCNAT; Cml4"
                     /note="N-acetyltransferase 8 (GCN5-related)"
                     /db_xref="GeneID:68396"
                     /db_xref="MGI:MGI:1915646"
     exon            1..102
                     /gene="Nat8"
                     /gene_synonym="0610037O16Rik; ATase2; CCNAT; Cml4"
                     /inference="alignment:Splign:2.1.0"
     exon            103..239
                     /gene="Nat8"
                     /gene_synonym="0610037O16Rik; ATase2; CCNAT; Cml4"
                     /inference="alignment:Splign:2.1.0"
     exon            240..1073
                     /gene="Nat8"
                     /gene_synonym="0610037O16Rik; ATase2; CCNAT; Cml4"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..994
                     /gene="Nat8"
                     /gene_synonym="0610037O16Rik; ATase2; CCNAT; Cml4"
                     /EC_number="2.3.1.80"
                     /note="probable N-acetyltransferase CML4; camello-like
                     protein 4; camello-like 4; acetyltransferase 2;
                     cysteinyl-conjugate N-acetyltransferase;
                     N-acetyltransferase 8 (GCN5-related, putative)"
                     /codon_start=1
                     /product="N-acetyltransferase 8"
                     /protein_id="NP_075944.1"
                     /db_xref="CCDS:CCDS20301.1"
                     /db_xref="GeneID:68396"
                     /db_xref="MGI:MGI:1915646"
                     /translation="MASFRIRQFQERDYKQVVDVFSRGMEEHIPTAFRHLLTLPRTLL
                     LLAVVPLAIVLVSGSWFLAVVCIFFLFLFLWFLASKPWKNYVSKCLHTDMADITKSYL
                     SVRGSGFWVAESGGQVVGTVAARPVKDPPLGRKQLQLFRLSVSSQHRGQGIAKALTRT
                     VLQFARDQGYSDVVLVTGLLQQGAVTLYYSMGFQKTGESFVDILTWLVDVSLIHFIYP
                     LPSAQKYEL"
     regulatory      1040..1045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nat8"
                     /gene_synonym="0610037O16Rik; ATase2; CCNAT; Cml4"
                     /note="hexamer: AATAAA"
     polyA_site      1073
                     /gene="Nat8"
                     /gene_synonym="0610037O16Rik; ATase2; CCNAT; Cml4"
                     /note="major polyA site"
ORIGIN      
        1 ggtggacttt ggctccctgc ctcatcacaa gctcactcct tccccatggt tatcaaacac
       61 ctaggtgctc gccaaggaga cctctaccca ggggagccca gggaaccagc caatgaggca
      121 ccagcccacg tctattcttc agaggtgggg catggcctgg caggttctgg atgttatcag
      181 tgactgtggc cattttggac actcggctgt agtagcagct aagaggacag agagacaagg
      241 gctgcgaggc agcaatataa acagatctgg tgtctctcat ggatgctgag atttgagacg
      301 aagtttcccc atggcttctt ttcgcatccg ccagttccag gagagggact acaaacaggt
      361 cgtggatgtg ttctccaggg gcatggagga gcacataccc actgccttcc gccacttgct
      421 gacactgccc cgaaccctcc tgctcttagc tgtggtgccc cttgccatag tcctggtgtc
      481 tggctcctgg ttcctggctg ttgtatgcat tttctttctg ttcctattct tgtggttcct
      541 cgccagcaag ccctggaaga attatgtgtc caaatgttta cacacagaca tggctgacat
      601 caccaagtcc tacctgagtg tccgtggctc aggtttctgg gtggctgagt ctggggggca
      661 ggtggtgggt acagtggctg ctcggccagt caaggatcct ccgttaggga ggaagcagct
      721 gcagctcttt cgcctgtctg tgtcctcaca gcatcgagga caggggatag cgaaagcgct
      781 gaccagaact gtcctccagt ttgcaaggga ccagggttac agtgatgttg tccttgtgac
      841 tggccttttg cagcaaggtg ctgtgactct ctactacagc atgggcttcc agaagacagg
      901 tgaatccttc gtggacatac tcacatggct tgtggatgtt tctctaattc atttcatata
      961 cccactccct tctgctcaaa aatatgagtt gtgatctctc tcagtgtgtc tgtcagcctc
     1021 tggtttacta tgctgtggga ataaataacc cagagattgt ggtggacaaa tca
//
