LOCUS       NM_008674               1395 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus N-acetyltransferase 3 (Nat3), mRNA.
ACCESSION   NM_008674 XM_977468
VERSION     NM_008674.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1395)
  AUTHORS   Sugamori,K.S., Brenneman,D., Wong,S., Gaedigk,A., Yu,V.,
            Abramovici,H., Rozmahel,R. and Grant,D.M.
  TITLE     Effect of arylamine acetyltransferase Nat3 gene knockout on
            N-acetylation in the mouse
  JOURNAL   Drug Metab Dispos 35 (7), 1064-1070 (2007)
   PUBMED   17403913
  REMARK    GeneRIF: Generated Nat3 knockout mouse, showing that Nat3 is
            unlikely to play a significant role in the N-acetylation of
            arylamines either in wild-type mice or in mice lacking Nat1 and
            Nat2 activities.
REFERENCE   2  (bases 1 to 1395)
  AUTHORS   Boukouvala,S., Price,N. and Sim,E.
  TITLE     Identification and functional characterization of novel
            polymorphisms associated with the genes for arylamine
            N-acetyltransferases in mice
  JOURNAL   Pharmacogenetics 12 (5), 385-394 (2002)
   PUBMED   12142728
REFERENCE   3  (bases 1 to 1395)
  AUTHORS   Rodrigues-Lima,F. and Dupret,J.M.
  TITLE     In silico sequence analysis of arylamine N-acetyltransferases:
            evidence for an absence of lateral gene transfer from bacteria to
            vertebrates and first description of paralogs in bacteria
  JOURNAL   Biochem Biophys Res Commun 293 (2), 783-792 (2002)
   PUBMED   12054539
REFERENCE   4  (bases 1 to 1395)
  AUTHORS   Fakis,G., Boukouvala,S., Buckle,V., Payton,M., Denning,C. and
            Sim,E.
  TITLE     Chromosome mapping of the genes for murine arylamine
            N-acetyltransferases (NATs), enzymes involved in the metabolism of
            carcinogens: identification of a novel upstream noncoding exon for
            murine Nat2
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 134-138 (2000)
   PUBMED   11060463
REFERENCE   5  (bases 1 to 1395)
  AUTHORS   Stanley,L.A., Copp,A.J., Pope,J., Rolls,S., Smelt,V., Perry,V.H.
            and Sim,E.
  TITLE     Immunochemical detection of arylamine N-acetyltransferase during
            mouse embryonic development and in adult mouse brain
  JOURNAL   Teratology 58 (5), 174-182 (1998)
   PUBMED   9839355
REFERENCE   6  (bases 1 to 1395)
  AUTHORS   Fretland,A.J., Doll,M.A., Gray,K., Feng,Y. and Hein,D.W.
  TITLE     Cloning, sequencing, and recombinant expression of NAT1, NAT2, and
            NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator
            inbred mouse: functional characterization of the activation and
            deactivation of aromatic amine carcinogens
  JOURNAL   Toxicol Appl Pharmacol 142 (2), 360-366 (1997)
   PUBMED   9070359
REFERENCE   7  (bases 1 to 1395)
  AUTHORS   Kelly,S.L. and Sim,E.
  TITLE     Arylamine N-acetyltransferase in Balb/c mice: identification of a
            novel mouse isoenzyme by cloning and expression in vitro
  JOURNAL   Biochem J 302 (Pt 2) (Pt 2), 347-353 (1994)
   PUBMED   7545952
REFERENCE   8  (bases 1 to 1395)
  AUTHORS   Kelly,S.L. and Sim,E.
  TITLE     Arylamine N-acetyl transferase in mice
  JOURNAL   Biochem Soc Trans 20 (2), 106S (1992)
   PUBMED   1397516
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077364.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_977468.1, NM_008674.1.
            
            Sequence Note: An in-frame AUG is located 51 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it is not conserved and is in a weak Kozak
            sequence context.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077364.1, BB618160.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849384,
                                           SAMN00849387 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1395
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.39 cM"
     gene            1..1395
                     /gene="Nat3"
                     /note="N-acetyltransferase 3"
                     /db_xref="GeneID:17962"
                     /db_xref="MGI:MGI:102537"
     exon            1..69
                     /gene="Nat3"
                     /inference="alignment:Splign:2.1.0"
     exon            70..232
                     /gene="Nat3"
                     /inference="alignment:Splign:2.1.0"
     exon            233..1395
                     /gene="Nat3"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1111
                     /gene="Nat3"
                     /EC_number="2.3.1.5"
                     /note="NAT-3; arylamide acetylase 3; N-acetyltransferase
                     type 3"
                     /codon_start=1
                     /product="arylamine N-acetyltransferase 3"
                     /protein_id="NP_032700.1"
                     /db_xref="CCDS:CCDS22339.1"
                     /db_xref="GeneID:17962"
                     /db_xref="MGI:MGI:102537"
                     /translation="MDIEAYFERIGYQKSSNKLDLQTLTEILQHQIRAIPFENLNIHC
                     GKTMELSLEDTFHQIVRKKRGGWCLQVNHLLYWALAMIGFETTMLGGCVYVPSACKYS
                     NTMIHLLLQVTISGKTYIVDSAFPFSCQLWEPLELTSGKDQPQVPAIFHLREENGTWY
                     LEQTKRQEYVSNQEFIDSNFLEKNTHRKIYSFTLEPRTIEDFWSISTYYQVSRTSVMT
                     NTSLCSLHTKDGVHGLMGTILAYKKFNYKDNIDLVEFKTLKEEEIEEVLKSVFGIHLE
                     TKLVPKCGNVFFTI"
     regulatory      1375..1380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nat3"
                     /note="putative"
     polyA_site      1395
                     /gene="Nat3"
                     /note="putative"
ORIGIN      
        1 ggaaggggag acctaagatg gaggaacaag agtgaaggaa gccggctggt acttcctgga
       61 ggtggccaga ctgaattatc agactatgaa caaacgctgt agaagagcca ccagggttgc
      121 tgtgctccag cctcttgtca caggaactat cagccttcag ggacccagac atgaaaggag
      181 agtagcagat ggacaggcgg tggctgtcag gcgcttagag aggacacagc tggggaccat
      241 ggacattgaa gcatactttg aaagaattgg ttaccagaag tccagcaaca aactggactt
      301 gcagacatta actgaaatcc ttcagcatca gatacgggct attccttttg agaacttgaa
      361 catccattgt gggaaaacca tggaactgag cttagaggac acctttcatc aaattgtgag
      421 gaagaagcgg ggagggtggt gtcttcaagt caaccatctt ctctactggg ctctggccat
      481 gatagggttt gagaccacaa tgttaggagg atgtgtttat gtcccttcag cctgcaagta
      541 tagtaacact atgatacacc ttctactaca ggtgaccatc agtggcaaaa catatattgt
      601 agatagtgca ttcccatttt cctgccagct atgggagcct ctggagttga catctgggaa
      661 ggatcagcct caggttcctg ccatcttcca cctgagagaa gagaatggaa cctggtacct
      721 ggaacaaact aaaagacaag aatatgtttc aaaccaagaa ttcattgatt ctaattttct
      781 tgagaagaac acacatcgaa aaatatattc ttttactctt gaaccacgaa cgattgaaga
      841 tttctggagt ataagtacat actaccaggt atctcgaaca tctgtgatga caaacacatc
      901 actttgttcc ctacatacca aagacggagt ccatggctta atgggcacca ttcttgccta
      961 taagaagttc aattataagg acaatataga tctggtagag tttaagactc tgaaggaaga
     1021 agaaatagaa gaagtcctga agagtgtttt tggaattcac ttggagacaa agcttgtgcc
     1081 caaatgtggc aatgtctttt ttactattta gagtaataag gggaaatgat ctttaatgtt
     1141 tctatatgca cttattcttt catgaaaaac aatcaaatta tgcaaaatta ggtgacagac
     1201 tgagaagcct tgagatatca tcacaaagtt catcaatgat tgactggtat atcaacatct
     1261 gtcccctaca ttatggtaag aaaatcatag acatcaaata gctctttctg caaaattaac
     1321 catttatgta actaaatgac ttttgaagaa atgtgccatt aaaaatgtaa tcgcaataaa
     1381 agtgctttaa tgatg
//
