LOCUS       NP_001162049             290 aa            linear   ROD 16-JUN-2024
DEFINITION  arylamine N-acetyltransferase 2 [Mus musculus].
ACCESSION   NP_001162049
VERSION     NP_001162049.1
DBSOURCE    REFSEQ: accession NM_001168577.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 290)
  AUTHORS   Denis,R.G.P., Busi,F., Castel,J., Morel,C., Zhang,W., Bui,L.C.,
            Sugamori,K.S., Prokopec,S.D., Boutros,P.C., Grant,D.M.,
            Rodrigues-Lima,F., Luquet,S. and Dupret,J.M.
  TITLE     A readout of metabolic efficiency in arylamine
            N-acetyltransferase-deficient mice reveals minor energy metabolism
            changes
  JOURNAL   FEBS Lett 593 (8), 831-841 (2019)
   PUBMED   30883722
  REMARK    GeneRIF: metabolic efficiency in arylamine
            N-acetyltransferase-deficient mice
REFERENCE   2  (residues 1 to 290)
  AUTHORS   Yang,C.L., Zheng,X.L., Ye,K., Sun,Y.N., Lu,Y.F., Ge,H. and Liu,H.
  TITLE     Effects of microRNA-217 on proliferation, apoptosis, and autophagy
            of hepatocytes in rat models of CCL4-induced liver injury by
            targeting NAT2
  JOURNAL   J Cell Physiol 234 (4), 3410-3424 (2019)
   PUBMED   30417525
  REMARK    GeneRIF: miR-217 inhibits proliferation adn promotes apoptosis and
            autophagy in hepatocytes in CCL4-induced liver injury through
            targeting NAT2 expression.
REFERENCE   3  (residues 1 to 290)
  AUTHORS   Wang,P., Shehu,A.I., Lu,J., Joshi,R.H., Venkataramanan,R.,
            Sugamori,K.S., Grant,D.M., Zhong,X.B. and Ma,X.
  TITLE     Deficiency of N-acetyltransferase increases the interactions of
            isoniazid with endobiotics in mouse liver
  JOURNAL   Biochem Pharmacol 145, 218-225 (2017)
   PUBMED   28888949
  REMARK    GeneRIF: This study illustrated that deficiency of NAT1/2 decreases
            isoniazid (INH) acetylation, but increases the interactions of INH
            with endobiotics in the liver.
REFERENCE   4  (residues 1 to 290)
  AUTHORS   Ramirez-Alcantara,V. and Montrose,M.H.
  TITLE     Acute murine colitis reduces colonic 5-aminosalicylic acid
            metabolism by regulation of N-acetyltransferase-2
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 306 (11), G1002-G1010
            (2014)
   PUBMED   24742986
  REMARK    GeneRIF: It was concluded that an acute colonic inflammation
            impairs the expression and function of NAT2 enzyme, thereby
            diminishing the capacity for 5-aminosalisylic acid metabolism by
            colonic mucosa.
REFERENCE   5  (residues 1 to 290)
  AUTHORS   Laurieri,N., Dairou,J., Egleton,J.E., Stanley,L.A., Russell,A.J.,
            Dupret,J.M., Sim,E. and Rodrigues-Lima,F.
  TITLE     From arylamine N-acetyltransferase to folate-dependent acetyl CoA
            hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and
            its homologue (MOUSE)NAT2
  JOURNAL   PLoS One 9 (5), e96370 (2014)
   PUBMED   24823794
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 290)
  AUTHORS   Vatsis,K.P., Weber,W.W., Bell,D.A., Dupret,J.M., Evans,D.A.,
            Grant,D.M., Hein,D.W., Lin,H.J., Meyer,U.A., Relling,M.V. et al.
  TITLE     Nomenclature for N-acetyltransferases
  JOURNAL   Pharmacogenetics 5 (1), 1-17 (1995)
   PUBMED   7773298
  REMARK    Review article
REFERENCE   7  (residues 1 to 290)
  AUTHORS   Kelly,S.L. and Sim,E.
  TITLE     Arylamine N-acetyltransferase in Balb/c mice: identification of a
            novel mouse isoenzyme by cloning and expression in vitro
  JOURNAL   Biochem J 302 (Pt 2) (Pt 2), 347-353 (1994)
   PUBMED   7545952
REFERENCE   8  (residues 1 to 290)
  AUTHORS   Martell,K.J., Levy,G.N. and Weber,W.W.
  TITLE     Cloned mouse N-acetyltransferases: enzymatic properties of
            expressed Nat-1 and Nat-2 gene products
  JOURNAL   Mol Pharmacol 42 (2), 265-272 (1992)
   PUBMED   1513324
REFERENCE   9  (residues 1 to 290)
  AUTHORS   Martell,K.J., Vatsis,K.P. and Weber,W.W.
  TITLE     Molecular genetic basis of rapid and slow acetylation in mice
  JOURNAL   Mol Pharmacol 40 (2), 218-227 (1991)
   PUBMED   1875909
REFERENCE   10 (residues 1 to 290)
  AUTHORS   Ebihara,S., Marks,T., Hudson,D.J. and Menaker,M.
  TITLE     Genetic control of melatonin synthesis in the pineal gland of the
            mouse
  JOURNAL   Science 231 (4737), 491-493 (1986)
   PUBMED   3941912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007583.1 and AC122867.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012972.2, AK007583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.38 cM"
     Protein         1..290
                     /product="arylamine N-acetyltransferase 2"
                     /EC_number="2.3.1.5"
                     /EC_number="2.3.1.118"
                     /note="N-acetyl transferase 2; NAT-2; arylamide acetylase
                     2; N-acetyltransferase type 2; N-hydroxyarylamine
                     O-acetyltransferase"
                     /calculated_mol_wt=33570
     Region          20..280
                     /region_name="Acetyltransf_2"
                     /note="N-acetyltransferase; pfam00797"
                     /db_xref="CDD:395644"
     CDS             1..290
                     /gene="Nat2"
                     /coded_by="NM_001168577.1:35..907"
                     /db_xref="CCDS:CCDS22338.1"
                     /db_xref="GeneID:17961"
                     /db_xref="MGI:MGI:109201"
ORIGIN      
        1 mdieayferi gyqstrskld lktlteilqh qiraipfenl nihcgesmel sleaifdqiv
       61 rkkrggwclq vnhllywalt klgfettmlg gyvfntpank yssgmihllv qvtisgkdyi
      121 vdagfgrsyq mwepleltsg kdqpqvpaif rlteengtwy ldqirreqyv pnqefinsdl
      181 leknkyrkiy sftleprtie dfesmntylq tspasvftsk sfcslqtpeg vhclvgstlt
      241 yrrfsykdnv dlvefkslte eeiedvlrti fgvslerklv pkhgdrffti
//
