LOCUS       NM_153126               3830 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus N-acetyltransferase 10 (Nat10), mRNA.
ACCESSION   NM_153126
VERSION     NM_153126.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3830)
  AUTHORS   Li,W.P., Mao,X.T., Xie,J.H., Li,J.Y., Liu,B.Q., Wu,L.X., Yang,B.,
            Li,Y.Y. and Jin,J.
  TITLE     N-acetyltransferase 10 is implicated in the pathogenesis of cycling
            T cell-mediated autoimmune and inflammatory disorders in mice
  JOURNAL   Nat Commun 15 (1), 9388 (2024)
   PUBMED   39477944
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3830)
  AUTHORS   Gao,S., Shen,R., Li,J., Jiang,Y., Sun,H., Wu,X., Li,X., Miao,C.,
            He,M., Wang,J. and Chen,W.
  TITLE     N-acetyltransferase 10 mediates cognitive dysfunction through the
            acetylation of GABABR1 mRNA in sepsis-associated encephalopathy
  JOURNAL   Proc Natl Acad Sci U S A 121 (36), e2410564121 (2024)
   PUBMED   39190359
  REMARK    GeneRIF: N-acetyltransferase 10 mediates cognitive dysfunction
            through the acetylation of GABABR1 mRNA in sepsis-associated
            encephalopathy.
REFERENCE   3  (bases 1 to 3830)
  AUTHORS   Liu,D., Kuang,Y., Chen,S., Li,R., Su,F., Zhang,S., Qiu,Q., Lin,S.,
            Shen,C., Liu,Y., Liang,L., Wang,J., Xu,H. and Xiao,Y.
  TITLE     NAT10 promotes synovial aggression by increasing the stability and
            translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis
  JOURNAL   Ann Rheum Dis 83 (9), 1118-1131 (2024)
   PUBMED   38724075
  REMARK    GeneRIF: NAT10 promotes synovial aggression by increasing the
            stability and translation of N4-acetylated PTX3 mRNA in rheumatoid
            arthritis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3830)
  AUTHORS   Qu,Z., Pang,X., Mei,Z., Li,Y., Zhang,Y., Huang,C., Liu,K., Yu,S.,
            Wang,C., Sun,Z., Liu,Y., Li,X., Jia,Y., Dong,Y., Lu,M., Ju,T.,
            Wu,F., Huang,M., Li,N., Dou,S., Jiang,J., Dong,X., Zhang,Y., Li,W.,
            Yang,B. and Du,W.
  TITLE     The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes
            cardiomyocyte ferroptosis to exacerbate cardiac I/R injury
  JOURNAL   Redox Biol 72, 103145 (2024)
   PUBMED   38583415
  REMARK    GeneRIF: The positive feedback loop of the NAT10/Mybbp1a/p53 axis
            promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R
            injury.
REFERENCE   5  (bases 1 to 3830)
  AUTHORS   Ma,W., Tian,Y., Shi,L., Liang,J., Ouyang,Q., Li,J., Chen,H.,
            Sun,H., Ji,H., Liu,X., Huang,W., Gao,X., Jin,X., Wang,X., Liu,Y.,
            Yu,Y., Guo,X., Tian,Y., Yang,F., Li,F., Wang,N. and Cai,B.
  TITLE     N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of
            ac4C modification to promote heart regeneration
  JOURNAL   Nat Commun 15 (1), 2137 (2024)
   PUBMED   38459019
  REMARK    GeneRIF: N-Acetyltransferase 10 represses Uqcr11 and Uqcrb
            independently of ac4C modification to promote heart regeneration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3830)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3830)
  AUTHORS   Balmus,G., Larrieu,D., Barros,A.C., Collins,C., Abrudan,M.,
            Demir,M., Geisler,N.J., Lelliott,C.J., White,J.K., Karp,N.A.,
            Atkinson,J., Kirton,A., Jacobsen,M., Clift,D., Rodriguez,R.,
            Adams,D.J. and Jackson,S.P.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Targeting of NAT10 enhances healthspan in a mouse model of human
            accelerated aging syndrome
  JOURNAL   Nat Commun 9 (1), 1700 (2018)
   PUBMED   29703891
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3830)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 3830)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 3830)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX537331.2.
            
            On Jan 10, 2022 this sequence version replaced NM_153126.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034516.1, SRR13422603.104031.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               BX537331.2         125309-125483       c
            176-298             BX537331.2         121931-122053       c
            299-390             BX537331.2         121429-121520       c
            391-562             BX537331.2         118319-118490       c
            563-685             BX537331.2         116840-116962       c
            686-747             BX537331.2         114482-114543       c
            748-862             BX537331.2         112446-112560       c
            863-970             BX537331.2         112239-112346       c
            971-1104            BX537331.2         108546-108679       c
            1105-1198           BX537331.2         107524-107617       c
            1199-1297           BX537331.2         107304-107402       c
            1298-1434           BX537331.2         104013-104149       c
            1435-1559           BX537331.2         99126-99250         c
            1560-1710           BX537331.2         98635-98785         c
            1711-1807           BX537331.2         98004-98100         c
            1808-1924           BX537331.2         97179-97295         c
            1925-2026           BX537331.2         96414-96515         c
            2027-2101           BX537331.2         96233-96307         c
            2102-2218           BX537331.2         95567-95683         c
            2219-2352           BX537331.2         94770-94903         c
            2353-2401           BX537331.2         94508-94556         c
            2402-2498           BX537331.2         92260-92356         c
            2499-2609           BX537331.2         92063-92173         c
            2610-2782           BX537331.2         90976-91148         c
            2783-2902           BX537331.2         90380-90499         c
            2903-3001           BX537331.2         89924-90022         c
            3002-3075           BX537331.2         89349-89422         c
            3076-3159           BX537331.2         88452-88535         c
            3160-3830           BX537331.2         85518-86188         c
FEATURES             Location/Qualifiers
     source          1..3830
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.43 cM"
     gene            1..3830
                     /gene="Nat10"
                     /note="N-acetyltransferase 10"
                     /db_xref="GeneID:98956"
                     /db_xref="MGI:MGI:2138939"
     exon            1..175
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            176..298
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..3265
                     /gene="Nat10"
                     /note="novel putative ATPase domain containing protein;
                     18S rRNA cytosine acetyltransferase"
                     /codon_start=1
                     /product="RNA cytidine acetyltransferase"
                     /protein_id="NP_694766.1"
                     /db_xref="CCDS:CCDS16480.1"
                     /db_xref="GeneID:98956"
                     /db_xref="MGI:MGI:2138939"
                     /translation="MNRKKVDNRIRILIENGVAERQRSLFVVVGDRGKDQVVILHHML
                     SKATVKARPSVLWCYKKELGFSSHRKKRMRQLQKKIKSGTLNLKQDDPFELFVAATNI
                     RYCYYNETHKILGNTFGMCVLQDFEALTPNLLARTVETVEGGGLVVILLRTMNSLKQL
                     YTMTMDVHSRYRTEAHQDVVGRFNERFILSLASCKKCLVIDDQLDILPISSHVASIEA
                     LPPQAPDENLSPAALELLELKESLQDTQPVGVLVDCCKTLDQAKAVLKFIEGISEKTL
                     RSTVALTAARGRGKSAALGLAIAGAVAFGYSNIFVTSPSPDNLHTLFEFVFKGFDALQ
                     YQEHLDYEIVQSLNPEFNKAVIRVNVFREHRQTIQYIHPADAVKLGQAELVVIDEAAA
                     IPLPLVKSLLGPYLVFMASTINGYEGTGRSLSLKLIQQLRQQSAQSQVSTTAENKTTT
                     TARLASARTLHEVSLQESIRYAPGDAVEKWLNDLLCLDCLNITRIVSGCPLPEACELY
                     YVNRDTLFCYHKASEVFLQRLMALYVASHYKNSPNDLQMLSDAPAHHLFCLLPPVPPT
                     QNALPEVLAVVQVCLEGEISRQSILNSLSRGKKASGDLIPWTVSEQFQDPDFGGLSGG
                     RVVRIAVHPDYQGMGYGSRALQLLQMYYEGKFPCLEEKVLETPQEIRTVSSEAVSLLE
                     EVITPRKDLPPLLLKLNERPAERLDYLGVSYGLTPRLLKFWKRAGFVPVYLRQTPNDL
                     TGEHSCIMLKTLADEDEAEQGAWLAAFWKDFRRRFLALLSYQFSTFSPALSLNIIQNR
                     NVAKSALPALGREHLEALFLPYDLKRLEMYSRNMVDYHLIMDLIPAISRLYFLNQLGD
                     LSLSAAQSALLLGIGLQHKSVDQLEKEIELPSGQLMGLFNRIIRKVVKLFNDVQEKAI
                     EEQMVAVKDVVMEPTMKTLSDDLDEAAKEFQEKHKKEVGKLKDMDLSQYVIRGDDEEW
                     NEVLSKAGQNASIVSLKSDKKRKLETKQEPKQSKKLKKRDNNRKDMKLKRKK"
     exon            299..390
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            391..562
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            563..685
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            686..747
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            748..862
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            863..970
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1104
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1198
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1297
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1434
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1559
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1710
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1807
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1924
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2026
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2101
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2218
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2352
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2401
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2498
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2609
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2782
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2902
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3001
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3075
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3159
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3830
                     /gene="Nat10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3808..3813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nat10"
                     /note="hexamer: AATAAA"
     polyA_site      3830
                     /gene="Nat10"
                     /note="major polyA site"
ORIGIN      
        1 gagcacttgc ccacgtgctg tctgccactt aagcggattc acgtgcagcg gcggccccgg
       61 cgtagctcag ctgtgtagaa ttttctccag cagattggtc agcctgggta gcaactcggt
      121 gtcttcacgt gcttccgttg tgcagctgcc tggtgtcggc cggagcaggg cgcagtgata
      181 gcttttcatc atgaatcgga agaaggtgga taaccgaatt cgaattctca ttgagaatgg
      241 cgtagctgag cggcagaggt ctctttttgt tgtagttggg gatcgaggaa aagatcaggt
      301 ggttattctt catcatatgt tgtccaaggc aactgtgaag gctcggccct cagtcctgtg
      361 gtgttataag aaagagctgg gatttagcag tcaccggaag aagaggatgc ggcagctaca
      421 gaagaaaata aagagtggga ccttgaactt aaagcaagat gacccctttg agctttttgt
      481 agcagccaca aacattcgct actgctacta caatgaaacc cacaagattc tgggcaatac
      541 tttcggcatg tgtgtcctcc aggattttga agcgttaact ccgaacttgt tggccagaac
      601 tgtagaaaca gtagaaggtg gtggactggt ggtcatcctc ctgcggacca tgaactcgct
      661 taagcagctg tacacgatga ctatggatgt gcattccagg tacaggactg aggcccatca
      721 ggacgtggtg ggaagattta acgagaggtt tattctctct ctggcctctt gtaagaagtg
      781 tctggtcatt gacgatcagc tcgacatcct gcccatctcc tcccacgtgg ccagcattga
      841 agccttacct cctcaggccc cggatgagaa tctcagtcct gctgctctgg agctgctgga
      901 gttgaaagag agcttgcagg acactcagcc cgtgggtgtt ctggtggact gctgcaagac
      961 cctggaccag gccaaagctg tcttgaaatt cattgagggg atctcggaga agactctaag
     1021 gagtactgta gccctcaccg ctgcccgagg aaggggcaag tctgcggccc tgggcctggc
     1081 tatcgctgga gcagtggcat tcgggtattc caatattttt gttacctccc caagcccgga
     1141 taacctccac acgctgtttg aatttgtatt taaaggattt gatgctctgc agtatcagga
     1201 gcatctggat tatgagattg tacagtcgct gaaccccgag tttaataaag cggtgatcag
     1261 ggtcaatgtg ttccgagagc acagacagac tattcagtac atccaccctg cagatgctgt
     1321 gaaactgggc caggctgagc tggttgtgat agatgaagct gccgctattc ccctccccct
     1381 ggtgaagagc ctgcttgggc cctacctggt tttcatggca tctactatca atggctacga
     1441 gggcactggc cggtcactgt ccctcaagct cattcaacaa ctccgtcagc agagtgccca
     1501 gagccaggtc agcaccactg ctgagaacaa gaccacaacg acagccagac tggcctcagc
     1561 tcgaaccttg catgaggttt ccctccaaga gtcaatccga tacgcccctg gggatgcagt
     1621 ggagaagtgg cttaatgacc tgctgtgcct ggattgcctc aacatcaccc gcatcgtttc
     1681 cggctgcccc ttgcctgagg cctgtgagct ctactatgtt aacagagata ccctcttttg
     1741 ctaccacaag gcctctgaag ttttcctcca gcggctcatg gctctctatg tggcttctca
     1801 ttacaagaac tctcccaacg acctgcagat gctctcagac gctcctgctc accacctctt
     1861 ctgcctcctg ccacctgtgc cccccaccca gaatgccctg cctgaagtgc ttgcagttgt
     1921 ccaggtgtgc cttgagggag agatttctcg tcagtccatt ttgaatagcc tctctcgagg
     1981 caagaaggct tctggggacc tgattccatg gacagtgtcg gaacagtttc aagatccaga
     2041 ctttggaggc ctttctggtg gacgggttgt tcgaattgct gttcacccag attatcaagg
     2101 gatgggatat ggcagccgag cgctgcagct gctgcagatg tattatgaag gcaagttccc
     2161 ttgtctggag gaaaaagtct tggagacacc acaagaaatc cgcaccgtga gcagtgaggc
     2221 tgtcagcttg ttggaagaag ttattactcc ccggaaggat ctgcccccct tgctcctcaa
     2281 gttgaatgag aggcctgcag agcgcctgga ttacctgggg gtttcctatg ggctgacccc
     2341 caggcttctc aagttctgga aacgagctgg atttgttcct gtctatttga gacagacccc
     2401 aaacgacctg actggggaac actcgtgcat tatgctgaag acgctggccg atgaggatga
     2461 ggctgagcag ggagcttggc tggcagcatt ttggaaagat ttccgaagac ggttcctggc
     2521 cttgctgtca taccagttca gcaccttctc tcctgccctg tctctgaaca tcattcagaa
     2581 caggaacgta gccaagtcag ccctgccagc cctaggccgg gagcatctgg aggcactttt
     2641 ccttccctat gacctgaagc gtctagagat gtactctcgg aacatggtcg attaccacct
     2701 catcatggat cttatcccag ccatttcccg cttgtacttc ctgaaccagc taggagacct
     2761 gtccctgtcg gctgcccagt cggctcttct cttgggaatt ggcctacagc acaagtctgt
     2821 ggatcagctg gaaaaggaga ttgagctgcc ctcaggccag ttgatggggc ttttcaaccg
     2881 gatcatccgc aaagttgtga agctgttcaa tgatgtgcag gaaaaggcta ttgaggagca
     2941 gatggtggca gtgaaggatg tggtcatgga gcccactatg aagaccctga gtgatgacct
     3001 ggatgaagca gcaaaggaat tccaggagaa acacaagaag gaagtcggga agctgaagga
     3061 catggacctc tctcaatatg taattcgtgg ggacgatgaa gagtggaatg aagttttgag
     3121 caaagcaggg cagaatgcct ccattgttag tttgaaaagt gacaagaaaa ggaaactgga
     3181 aacaaaacaa gaacccaaac agagcaagaa gttgaagaag agagataaca acagaaagga
     3241 tatgaaactg aagcgaaaga agtagtgagg tgaggagatg ccagacttct gagctgtgct
     3301 ctgctgggcc aggccaggca gcagtgtgga cagtgacagt gacagtgaca agggccttca
     3361 gcaaaggcag gcaccatcgt tccatctgta tgcccgccgt gactgaagac aaagtcactc
     3421 ttgaacaggc tgcttagaac ttggtgtggg caaagctctg gcattgtcag gggctgtcgt
     3481 tccacccagg tcagtctcac tttggcttgc tcccactgtg gctgctgtgc tggctcctgg
     3541 cctccctgtg ctccagcaca cggctttctg gaggcacacg ctgcctcact gcagacctgt
     3601 cccgacactg aggctgggtc agcaggacct ctcctgctcc tcccttctat gtctgcctgc
     3661 ggcaggtctg ctgtcctcag cgtcccagga aaggcttagg taggctgcaa catctgagcc
     3721 ccagatgcct tttggttgcc tcttcatttg ggagagacta tcgagaaaga ctcttactac
     3781 aaaaatgagg ggagagagaa tatttttaat aaatgatgtc ttggaaggac
//
