LOCUS       NM_008673               1564 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus N-acetyl transferase 1 (Nat1), mRNA.
ACCESSION   NM_008673
VERSION     NM_008673.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1564)
  AUTHORS   Zhang,T., Fu,W., Zhang,H., Li,J., Xing,B., Cai,Y., Zhang,M.,
            Liu,X., Qi,C., Qian,L., Hu,X., Zhu,H., Yang,S., Zhang,M., Liu,J.,
            Li,G., Li,Y., Xiang,R., Qi,Z., Hu,J., Li,Y., Zou,C., Wang,Q.,
            Jin,X., Pang,R., Li,P., Liu,J., Zhang,Y., Wang,Z., Zhu,Z.J.,
            Shan,B. and Yuan,J.
  TITLE     Spermidine mediates acetylhypusination of RIPK1 to suppress
            diabetes onset and progression
  JOURNAL   Nat Cell Biol 26 (12), 2099-2114 (2024)
   PUBMED   39511379
REFERENCE   2  (bases 1 to 1564)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1564)
  AUTHORS   Zou,C., Mifflin,L., Hu,Z., Zhang,T., Shan,B., Wang,H., Xing,X.,
            Zhu,H., Adiconis,X., Levin,J.Z., Li,F., Liu,C.F., Liu,J.S. and
            Yuan,J.
  TITLE     Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial
            Necroptosis and Abeta Accumulation in Alzheimer's Disease
  JOURNAL   Cell Rep 33 (10), 108447 (2020)
   PUBMED   33296651
  REMARK    GeneRIF: Reduction of mNAT1/hNAT2 Contributes to Cerebral
            Endothelial Necroptosis and Abeta Accumulation in Alzheimer's
            Disease.
REFERENCE   4  (bases 1 to 1564)
  AUTHORS   Denis,R.G.P., Busi,F., Castel,J., Morel,C., Zhang,W., Bui,L.C.,
            Sugamori,K.S., Prokopec,S.D., Boutros,P.C., Grant,D.M.,
            Rodrigues-Lima,F., Luquet,S. and Dupret,J.M.
  TITLE     A readout of metabolic efficiency in arylamine
            N-acetyltransferase-deficient mice reveals minor energy metabolism
            changes
  JOURNAL   FEBS Lett 593 (8), 831-841 (2019)
   PUBMED   30883722
  REMARK    GeneRIF: metabolic efficiency in arylamine
            N-acetyltransferase-deficient mice
REFERENCE   5  (bases 1 to 1564)
  AUTHORS   Hussain,Z., Uyama,T., Kawai,K., Binte Mustafiz,S.S., Tsuboi,K.,
            Araki,N. and Ueda,N.
  TITLE     Phosphatidylserine-stimulated production of
            N-acyl-phosphatidylethanolamines by Ca2+-dependent
            N-acyltransferase
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (5), 493-502 (2018)
   PUBMED   29447909
  REMARK    GeneRIF: Ca(2+)-dependent N-acyltransferase absolutely required
            Calcium for its activity and the activity was enhanced by
            phosphatidylserine.
REFERENCE   6  (bases 1 to 1564)
  AUTHORS   Martell,K.J., Levy,G.N. and Weber,W.W.
  TITLE     Cloned mouse N-acetyltransferases: enzymatic properties of
            expressed Nat-1 and Nat-2 gene products
  JOURNAL   Mol Pharmacol 42 (2), 265-272 (1992)
   PUBMED   1513324
REFERENCE   7  (bases 1 to 1564)
  AUTHORS   Martell,K.J., Vatsis,K.P. and Weber,W.W.
  TITLE     Molecular genetic basis of rapid and slow acetylation in mice
  JOURNAL   Mol Pharmacol 40 (2), 218-227 (1991)
   PUBMED   1875909
REFERENCE   8  (bases 1 to 1564)
  AUTHORS   Karolyi,J., Erickson,R.P., Liu,S. and Killewald,L.
  TITLE     Major effects on teratogen-induced facial clefting in mice
            determined by a single genetic region
  JOURNAL   Genetics 126 (1), 201-205 (1990)
   PUBMED   2227380
REFERENCE   9  (bases 1 to 1564)
  AUTHORS   Mattano,S.S., Erickson,R.P., Nesbitt,M.N. and Weber,W.W.
  TITLE     Linkage of Nat and Es-1 in the mouse and development of strains
            congenic for N-acetyltransferase
  JOURNAL   J Hered 79 (6), 430-433 (1988)
   PUBMED   3209851
REFERENCE   10 (bases 1 to 1564)
  AUTHORS   Ebihara,S., Marks,T., Hudson,D.J. and Menaker,M.
  TITLE     Genetic control of melatonin synthesis in the pineal gland of the
            mouse
  JOURNAL   Science 231 (4737), 491-493 (1986)
   PUBMED   3941912
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122867.4.
            
            [WARNING] On Feb 6, 2025 this sequence was replaced by NM_008673.3.
            
            On Feb 5, 2019 this sequence version replaced NM_008673.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U35885.1, BC137747.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1564              AC122867.4         165690-167253
FEATURES             Location/Qualifiers
     source          1..1564
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.38 cM"
     gene            1..1564
                     /gene="Nat1"
                     /gene_synonym="Nat-1"
                     /note="N-acetyl transferase 1"
                     /db_xref="GeneID:17960"
                     /db_xref="MGI:MGI:97279"
     exon            1..1564
                     /gene="Nat1"
                     /gene_synonym="Nat-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1081..1086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nat1"
                     /gene_synonym="Nat-1"
                     /note="hexamer: AATAAA"
     regulatory      1090..1095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nat1"
                     /gene_synonym="Nat-1"
                     /note="hexamer: AATATA"
     polyA_site      1103
                     /gene="Nat1"
                     /gene_synonym="Nat-1"
     polyA_site      1108
                     /gene="Nat1"
                     /gene_synonym="Nat-1"
                     /note="major polyA site"
ORIGIN      
        1 gggaccatgg acatcgaagc atactttgaa aggattggtt acaagaactc agtgaataaa
       61 ttggacttag ccacattaac tgaagttctt cagcaccaga tgcgagcagt tccttttgag
      121 aatcttaaca tgcattgtgg agaagccatg catctggatt tacaggacat ttttgaccac
      181 atagtaagga agaagagagg tggatggtgt ctccaggtta atcatctgct gtactgggct
      241 ctgaccaaaa tgggctttga aaccacaatg ttgggaggat atgtttacat aactccagtc
      301 agcaaatata gcagtgaaat ggtccacctt ctagtacagg tgaccatcag tgacaggaag
      361 tacattgtgg attccgccta tggaggctcc taccagatgt gggagcctct ggaattaaca
      421 tctgggaagg atcagcctca ggtgcctgcc atcttccttt tgacagagga gaatggaacc
      481 tggtacttgg accaaatcag aagagagcag tatgttccaa atgaagaatt tgttaactca
      541 gacctccttg aaaagaacaa atatcgaaaa atctactcct ttactcttga gccccgagtt
      601 atcgaggatt ttgaatatgt gaatagctat cttcagacat cgccagcatc tgtgtttgta
      661 agcacatcgt tctgttcctt gcagacctcg gaaggggttc actgtttagt gggctccacc
      721 tttacaagta ggagattcag ctataaggac gatgtagatc tggttgagtt taaatatgtg
      781 aatgaggaag aaatagaaga tgtactgaaa accgcatttg gcatttcttt ggagagaaag
      841 tttgtgccca aacatggtga actagttttt actatttagg gtaaggagca aaattgttct
      901 ccattgttat ttcatagtct taaaccttct aaacatatgc aaatgtatcc ataacagaaa
      961 tcacccagtc caatgctgac caactaatga cttgttgtat cttctatttc ctagatttta
     1021 taaaacgaaa tcctactcct cctgtcattt caccaataaa aatagcgtca gttatacttg
     1081 aataaaataa atatattaat ggatgtaaca acaatccttt caatattaat caacaaaaat
     1141 tacttaatga agatgtggaa atctttggag ccatattgac ttgtagtaga agcctcccac
     1201 catcatttta ttgttgaact cacataaaaa gtggttgaat atgaataatc agagaatagc
     1261 aggtataaaa ttcagccaga ataaatctga tgtccatggt ttacaagaaa ccacattcac
     1321 aacttaggat cagaataaag caaagaagaa tgagacatca tttcagattc aggtaactta
     1381 ccagtcctca aaacagaact caagccagtg cacccgggct ctgtgagtgg gtgccaagac
     1441 aacgacatgg cttagaattt cttccagagc taattgtgca gacgtagttc cttttacatt
     1501 ggattttttt caaactatga gaatacttta gaattatgca attgatttat acattatata
     1561 atac
//
