LOCUS       NM_026272               4426 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus nuclear prelamin A recognition factor (Narf), mRNA.
ACCESSION   NM_026272
VERSION     NM_026272.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4426)
  AUTHORS   Yang,Y., Chen,C., Zuo,Q., Lu,H., Salman,S., Lyu,Y., Huang,T.Y.,
            Wicks,E.E., Jackson,W. 3rd, Datan,E., Wang,R., Wang,Y., Le,N.,
            Zhu,Y., Qin,W. and Semenza,G.L.
  TITLE     NARF is a hypoxia-induced coactivator for OCT4-mediated breast
            cancer stem cell specification
  JOURNAL   Sci Adv 8 (49), eabo5000 (2022)
   PUBMED   36490339
  REMARK    GeneRIF: NARF is a hypoxia-induced coactivator for OCT4-mediated
            breast cancer stem cell specification.
REFERENCE   2  (bases 1 to 4426)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4426)
  AUTHORS   Le Dour,C., Wu,W., Bereziat,V., Capeau,J., Vigouroux,C. and
            Worman,H.J.
  TITLE     Extracellular matrix remodeling and transforming growth factor-beta
            signaling abnormalities induced by lamin A/C variants that cause
            lipodystrophy
  JOURNAL   J Lipid Res 58 (1), 151-163 (2017)
   PUBMED   27845687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM951066.1, AK081305.1 and BC016090.1.
            
            On Dec 28, 2007 this sequence version replaced NM_026272.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016090.1, AK076232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BM951066.1         1-17
            18-1724             AK081305.1         2-1708
            1725-4426           BC016090.1         1664-4365
FEATURES             Location/Qualifiers
     source          1..4426
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 85.12 cM"
     gene            1..4426
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /note="nuclear prelamin A recognition factor"
                     /db_xref="GeneID:67608"
                     /db_xref="MGI:MGI:1914858"
     exon            1..116
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1478
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /note="IOP2; iron-only hydrogenase-like protein 2"
                     /codon_start=1
                     /product="nuclear prelamin A recognition factor"
                     /protein_id="NP_080548.3"
                     /db_xref="CCDS:CCDS25772.1"
                     /db_xref="GeneID:67608"
                     /db_xref="MGI:MGI:1914858"
                     /translation="MKCEHCTRKECSKKSKTDDQENVSSDGAQPSDGASPAKESEEKG
                     EFHKLADAKIFLSDCLACDSCVTVEEGVQLSQQSAKDFLHVLNLNKRCDTSKHRVLVV
                     SVCPQSLPYFAAKFNLSVTDASRRLCGFLKSLGVHYVFDTTIAADFSILESQKEFVRR
                     YHQHSEEQRELPMLTSACPGWVRYAERVLGRPIIPYLCTAKSPQQVMGSLVKDYFARQ
                     QNLSPEKIFHVVVAPCYDKKLEALREGLSTTLNGARGTDCVLTSGEIAQIMEQSDLSV
                     KDIAVDTLFGDMKEVAVQRHDGVSSDGHLAHVFRHAAKELFGEHVEEITYRALRNKDF
                     HEVTLEKNGEVLLRFAAAYGFRNIQNMIQKLKKGKLPYHFVEVLACPRGCLNGRGQAQ
                     TEDGHTDRALLQQMEGIYSGIPVRPPESSTHVQELYQEWLEGTESPKVQEVLHTSYQS
                     LEPCTDGLDIKW"
     exon            117..215
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            216..359
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            360..492
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            493..627
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            628..746
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            747..876
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..940
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1078
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1236
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..4412
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3096..3101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3120
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
                     /note="major polyA site"
     polyA_site      4394
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
     polyA_site      4412
                     /gene="Narf"
                     /gene_synonym="4430402O11Rik"
ORIGIN      
        1 ggtcgctagc gggcggcagg cggcggtgtt ccagtcttcc ttactcctca cagcttaggc
       61 gcgtcggcct cctgccagtc ccactccaga tgaagtgtga gcactgcaca cgaaaggaat
      121 gtagtaaaaa atcaaaaact gatgaccagg agaatgtgtc cagtgatggg gcccagccaa
      181 gcgatggggc cagcccagcc aaggagagtg aagagaaggg agagttccat aaattggctg
      241 atgcaaaaat atttctgagt gactgcctgg catgtgacag ctgtgtgact gtggaggaag
      301 gtgtccagct ttctcagcag agtgccaagg acttccttca tgtcctgaat cttaataaga
      361 gatgtgatac ctcaaagcac agagttctgg ttgtgtctgt gtgtcctcag tctctacctt
      421 attttgctgc taaattcaac ctcagtgtca ctgatgcatc tagaaggctg tgtggcttcc
      481 tcaaaagtct tggggtgcac tatgtattcg acaccacaat cgctgcagat ttcagcattc
      541 tggagagtca gaaggagttt gtacgccggt atcaccaaca cagtgaggaa cagcgtgaac
      601 tgcccatgtt gacctctgcc tgtcctggtt gggtcagata tgctgagcgg gtgctgggtc
      661 gccccatcat cccatatctc tgtaccgcca agtcccccca gcaggtcatg ggctccttgg
      721 tgaaggatta ctttgccagg cagcagaatc tgtctccaga gaaaatcttc catgttgtcg
      781 tggctccttg ctatgataag aagctggaag ctcttcgaga gggactttcc actactttaa
      841 atggtgctcg gggcactgac tgtgtgctga catcaggtga aattgctcag ataatggagc
      901 aaagtgacct ctctgtgaaa gacattgctg tggatacttt gtttggagac atgaaggagg
      961 tggcagtcca gcgtcatgat ggagtgagtt cagatgggca tctggctcac gttttcagac
     1021 acgcagccaa ggagctgttt ggcgagcacg tggaggagat cacctaccgt gcactcagga
     1081 acaaagactt ccatgaggtt acccttgaga agaacgggga ggtcctactg cgctttgctg
     1141 cagcgtacgg ctttcgcaac attcagaaca tgatccagaa gctcaagaag ggcaaactcc
     1201 cataccactt tgtggaggtg ctcgcgtgtc ccagaggttg cttaaatggc agaggccaag
     1261 cacagacaga ggacggccac acagatcgtg cactgctgca gcaaatggaa gggatctact
     1321 ccggcatccc tgtgcggccc ccagagagca gtacacatgt gcaggagttg taccaggagt
     1381 ggctggaggg tactgaatct cccaaagtcc aggaggtgct gcacaccagc taccagagct
     1441 tggagccctg cacagacggc ctggatatca agtggtgaca aagcctgaag ggcaggaggg
     1501 gacagctctg agtggagagt ggtgggtgct tcaaggaaca acaggtccct acagctttgc
     1561 cagcgcttca ggacacagtt ttcatgtggt gctatctttg tagtgtgtga gggagtggaa
     1621 tgtttgcaca tgggagaggt attttccctc tctgcgtagc ctttcatccc aagattgtga
     1681 gaaagatccc aaagaggcca gggacagatc cctgatttgc aggtttaaaa aaaaaaatca
     1741 agatgtgttt ttagagaacc aagacccagg ggttgtgatc cacgagccta agattattgc
     1801 tgcagaaatg gaggcatcag gaaggccagg ctgctgtaca gtggataact atggccttca
     1861 gagaggccca gtcttctggc ccaatttggc tctttcattt gtatacattt ttttaaaaat
     1921 aattttgaat tctagggcca gcaagatggc ttattggtac caccattagt ttgatccatg
     1981 gagcccacat ggtggaagga gagaccaacg cctacaagct atcctctgac tttcacacag
     2041 gcacatggca tgcatatgta ccaccgagac cacaccccga aaataaccgt aaagaaaatt
     2101 acactagttt taagtcatag taacagtgag ccatattttt tatagtcctt gaaggccggc
     2161 agtcattaca gccctgggcc actggtgtgc ctgagtcatt cttttacttg acctgccatc
     2221 agcgttgagc tggactcacc tcagaagaaa ggctgctgag aatggcatgc atcacaccct
     2281 gcatttgatg caatgtatat ttaaaaataa acaagtagag aattaagagg gtggcccacc
     2341 taggctttgg ggttctaagg gtggtgcagc tcatagttac tgctgtgggg ccggaagaca
     2401 gagctgaggc tccgtggacc ctggaatggg tgaaccagct ttgtaatgtc cagcctcctc
     2461 taaactcctc cccagtgcct tttcatacaa ataggcctgg agcacctcct ctcctccaca
     2521 aagcccactg gtctgggata gcatcccttc agccctcact atgctaatgc gagcatgcct
     2581 taggggaaac agtatgtcca cacacagaaa tagctgcccg atggtgaaat tcacaaaatc
     2641 atgtgacaca tactagatag agtccaccca ggagataaag gggtttgatg aagcccctga
     2701 attttgctca gtgtgtgact gccttgaccc ttagtactgt cagctctatc acagtcccac
     2761 atgcctcatg tcttggtctt cctgtgagtc tgtctaggag tgtaactgga tatgttattg
     2821 taaaccagtg gttctcaact tgtgggctgt gtccccacaa aggggtcaca tatcagatat
     2881 ttacattata attcataaca gtagcaatac tacagttatg aagtagcaac agaataattt
     2941 tataattgtt gggggggtca ccagaacaga agaaactatt aaagggtcac agcataggaa
     3001 ggttgagaac cactactata aattatgatt tttttttttt ttttgctttc agtctatatg
     3061 ccttgggtat ccatccccaa agtaactggt tatggaataa acaatgcaat ggggtcttga
     3121 gtgtggcatt gaaggagtca gctgttctcc tgtcctggac tacaccccgc agtccgcctc
     3181 cctcaccagg ccccagcctg ggtgatgata cctttttccc agtccctctc taataggtca
     3241 ggagaaggtt cagaacacgg ggagtcagcg tgggaaggga ctgacttcct gcaaacttca
     3301 tggcaccacc catgatagca acataggcta ggggctaaga tgtgagatct atgaccttct
     3361 gtttcactga tgctaggccg tggccctgtg agcttttcaa gactacaggt gcctttctgt
     3421 cccagcactt ggagccagag gcaggtggat ctctgtgaat tagaggctag tctaggttac
     3481 agagtgagtt ccaggacagt caggaataca tagagcaacc ctgccttatc ccccaactcc
     3541 ctccccccta aaaacaaagc ccaaagcaat ggaagtatga agtgagcaag ttcttgacag
     3601 acaggaccca gtcaaagcat cacgacagtc agagtggaca acgtacgctg gtgcaggcat
     3661 gaggggcata acccaagctc ctatctgccc agtgctctgt tgtaccatgc ttctgctctg
     3721 cttgggcaga ggcccaatct tagtttgatt cctacctggc ccgagctgta tgggtttgca
     3781 ctactgtggg taaccgtgct tctacatgat gagattctgt ctcaaagact aaatttggtt
     3841 tctgttacag gtaatttaga aatagttctg tcagggcttg tgccatagtt caggagcagg
     3901 gcgtgtgcct agcatccatg ggcaccacat tcgttctcaa gatccacagt agcagaaagt
     3961 gacagggagg attgctgcat tctttagtac gttgtttgga ctgctgttaa gatctgactc
     4021 agtgtgtgcc ttacccatta ctggtcgaca tgtgggcttc ccaggtgcat cacaggtgag
     4081 ccaaccacag ggtttggggt tgcagctggc agctaggctg caggcgctgc cctgggtaca
     4141 ccactcacct gaggggcaca gctggccgga agggtaatca ggaagtgtgg ctccttttcc
     4201 acttggcata ttacatatgg ggctccctcc tgcatctaga gatgggaaac tgcctgaaga
     4261 acttactctg gtttaccatt tgagagagtg cagtcattta tgtcagagaa gacacctcgc
     4321 atctcactac tcatgaagca ccgtctcttc tgtggattca cggctcagct tgtaaacatt
     4381 gagttgaaat ggaagattta ttatgatttt taaaaaaaaa aaaaaa
//
