LOCUS       NM_172607               1890 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus nicotinate phosphoribosyltransferase (Naprt), mRNA.
ACCESSION   NM_172607
VERSION     NM_172607.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1890)
  AUTHORS   Membrez,M., Migliavacca,E., Christen,S., Yaku,K., Trieu,J.,
            Lee,A.K., Morandini,F., Giner,M.P., Stiner,J., Makarov,M.V.,
            Garratt,E.S., Vasiloglou,M.F., Chanvillard,L., Dalbram,E.,
            Ehrlich,A.M., Sanchez-Garcia,J.L., Canto,C., Karagounis,L.G.,
            Treebak,J.T., Migaud,M.E., Heshmat,R., Razi,F., Karnani,N.,
            Ostovar,A., Farzadfar,F., Tay,S.K.H., Sanders,M.J., Lillycrop,K.A.,
            Godfrey,K.M., Nakagawa,T., Moco,S., Koopman,R., Lynch,G.S.,
            Sorrentino,V. and Feige,J.N.
  TITLE     Trigonelline is an NAD+ precursor that improves muscle function
            during ageing and is reduced in human sarcopenia
  JOURNAL   Nat Metab 6 (3), 433-447 (2024)
   PUBMED   38504132
REFERENCE   2  (bases 1 to 1890)
  AUTHORS   Nomura,M., Ohuchi,M., Sakamoto,Y., Kudo,K., Yaku,K., Soga,T.,
            Sugiura,Y., Morita,M., Hayashi,K., Miyahara,S., Sato,T.,
            Yamashita,Y., Ito,S., Kikuchi,N., Sato,I., Saito,R., Yaegashi,N.,
            Fukuhara,T., Yamada,H., Shima,H., Nakayama,K.I., Hirao,A.,
            Kawasaki,K., Arai,Y., Akamatsu,S., Tanuma,S.I., Sato,T.,
            Nakagawa,T. and Tanuma,N.
  TITLE     Niacin restriction with NAMPT-inhibition is synthetic lethal to
            neuroendocrine carcinoma
  JOURNAL   Nat Commun 14 (1), 8095 (2023)
   PUBMED   38092728
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1890)
  AUTHORS   Yaku,K., Palikhe,S., Izumi,H., Yoshida,T., Hikosaka,K., Hayat,F.,
            Karim,M., Iqbal,T., Nitta,Y., Sato,A., Migaud,M.E., Ishihara,K.,
            Mori,H. and Nakagawa,T.
  TITLE     BST1 regulates nicotinamide riboside metabolism via its
            glycohydrolase and base-exchange activities
  JOURNAL   Nat Commun 12 (1), 6767 (2021)
   PUBMED   34799586
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1890)
  AUTHORS   Amici,A., Grolla,A.A., Del Grosso,E., Bellini,R., Bianchi,M.,
            Travelli,C., Garavaglia,S., Sorci,L., Raffaelli,N., Ruggieri,S.,
            Genazzani,A.A. and Orsomando,G.
  TITLE     Synthesis and Degradation of Adenosine 5'-Tetraphosphate by
            Nicotinamide and Nicotinate Phosphoribosyltransferases
  JOURNAL   Cell Chem Biol 24 (5), 553-564 (2017)
   PUBMED   28416276
  REMARK    GeneRIF: Synthesis and Degradation of Adenosine 5'-Tetraphosphate
            by Nicotinamide and Nicotinate Phosphoribosyltransferases
REFERENCE   5  (bases 1 to 1890)
  AUTHORS   Hara,N., Yamada,K., Shibata,T., Osago,H., Hashimoto,T. and
            Tsuchiya,M.
  TITLE     Elevation of cellular NAD levels by nicotinic acid and involvement
            of nicotinic acid phosphoribosyltransferase in human cells
  JOURNAL   J Biol Chem 282 (34), 24574-24582 (2007)
   PUBMED   17604275
  REMARK    GeneRIF: NA elevates cellular NAD levels through NAPRT function
            and, thus, protects the cells against stress, partly due to lack of
            feedback inhibition of NAPRT but not NamPRT by NAD
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK033661.1.
            
            On Apr 5, 2007 this sequence version replaced NM_172607.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033661.1, AY214331.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1890              AK033661.1         4-1893
FEATURES             Location/Qualifiers
     source          1..1890
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 35.05 cM"
     gene            1..1890
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /note="nicotinate phosphoribosyltransferase"
                     /db_xref="GeneID:223646"
                     /db_xref="MGI:MGI:2442664"
     exon            1..465
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1856
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /EC_number="6.3.4.21"
                     /note="NAPRTase; nicotinate phosphoribosyltransferase
                     domain-containing protein 1; nicotinate
                     phosphoribosyltransferase domain containing 1"
                     /codon_start=1
                     /product="nicotinate phosphoribosyltransferase"
                     /protein_id="NP_766195.2"
                     /db_xref="CCDS:CCDS27552.1"
                     /db_xref="GeneID:223646"
                     /db_xref="MGI:MGI:2442664"
                     /translation="MEMELDSEGRMVVRPLLTDLYQATMALGYWRAGRACEAAEFELF
                     FRHCPFGGSFALSAGLQDCMRFLRAFRLRDADVQFLASVLPPDTDPAFFEHLRALDCS
                     GVTVRALPEGSLAFPGVPLLQVSGPLLLVQLLETPLLCLVSYASLVATNAARLRLIAG
                     PDKKLLEMGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFVTS
                     FSGSEVPPDPMLAPASSEGPTVDLPARVNLWLKRVCLYLGLEEQEPHPGERAAFVAYA
                     LAFPRAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAKEIRGI
                     FRTAGAQFQMPWLESVPIAVSNNIDESELMRLAQKGSEVNVIGIGTSVVTCPKQPSMG
                     CVYKLVSVGGQPRIKLTEDPEKQTLPGSKAAFRFLGPDGSLLLDLLQLAEEPPPKAGQ
                     ELRVWPRGTQEPCTVKPAQVEPLLRLYLQQGQLCEPLPSLDESRRFAQQSLSLLRPAH
                     KQLQSPAVYPVALSEKLRALVDSLSARGPL"
     exon            466..593
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..676
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..807
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..923
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1120
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1261
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1346
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1427
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1530
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1685
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1793
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1890
                     /gene="Naprt"
                     /gene_synonym="9130210N20Rik; Naprt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaacgtaag aaccattctg aggggcaagc ggctagttgg agtccaggag actgggatgg
       61 gggtgtgcca gtcgcctatc ttgctggttt gagtccctgc aactactagc agattaggcg
      121 gctcgctccg cccacttctg ccgggaaagg ccctcctttc gtgtgagttg gttctctgga
      181 ccagtgccgt agggggtgga gtagggcgcc attagtcggg agcctgtgta ccccgcggaa
      241 tggagatgga gctggacagc gaggggcgca tggtggtgcg gccgctgctc accgacctct
      301 atcaggctac catggcgctg ggctactggc gtgcgggccg ggcgtgcgag gcagcagagt
      361 tcgagctctt cttccgccac tgccctttcg gaggctcctt cgccctttcc gctggcttgc
      421 aggactgtat gcgctttctt cgcgccttcc gtctgcggga tgcagatgtg cagttcctgg
      481 cttcggtact acccccagac actgaccctg cgttcttcga gcaccttcga gcccttgatt
      541 gctctggggt gaccgtgcgg gctctgccag agggttccct cgccttccct ggtgtgccgc
      601 ttctgcaggt gtccgggcct cttcttctgg tacagctgct agagactcca ctgctgtgtc
      661 tggtcagcta cgctagcctc gtagccacca atgctgctcg gctacgcttg attgcagggc
      721 cggataagaa actactagag atgggtttgc ggcgagctca gggtcccgac gggggtttca
      781 cggcctcaat ttacagctac ctgggtggct ttgacagcag cagcaacaca cttgctggac
      841 aactgagagg tgtaccggtg gcagggaccc tggcccactc ctttgtcact tcattttcgg
      901 gtagtgaggt accccccgac ccgatgttgg ctccagcttc tagtgagggc cccacagtgg
      961 acctgcctgc cagggtaaat ttgtggctga agcgtgtgtg cctctacttg gggctagagg
     1021 agcaggagcc acacccaggg gagcgcgcag catttgtggc ctatgctctg gcctttcccc
     1081 gggctttcca gggcctgcta gattcctaca gtgtacgcag gagtggcctt cctaacttcc
     1141 tggcagtagc cctggcactg ggggagcttg gctacagagc agtgggtgtg aggctggaca
     1201 gcggtgacct gcttcagcag gctaaagaga tccgtggcat ctttcgaact gctggtgccc
     1261 aattccagat gccctggcta gagtctgttc ccattgcagt cagcaacaac attgacgaga
     1321 gtgagctgat gaggctagcc cagaagggca gtgaggtgaa tgtcattggc attggcacca
     1381 gtgtggtcac ttgtcccaaa cagccttcta tgggctgtgt ctacaagctg gtgtctgtag
     1441 gaggccagcc tcgaatcaag ctgacagagg accctgagaa gcaaacactg ccagggagca
     1501 aggctgcctt ccggttccta ggccccgatg ggtctttgct actggaccta ctgcagttag
     1561 cagaagagcc cccgcccaag gctgggcagg aactgagggt ttggcctcgg gggacccagg
     1621 agccctgcac tgtgaagcca gcccaagtgg agccattgct gcgactctac ctgcaacagg
     1681 gacagctgtg tgagccactg ccatctctgg atgagtccag acgctttgcc cagcagtccc
     1741 tgagcctcct ccgccctgca cataagcagc tgcagagccc tgcagtgtat ccggtcgcac
     1801 tgtcagagaa gcttcgggca ctggtggaca gtttgagtgc tcgaggtccc ctgtgaaaaa
     1861 agtcataaat aacacggctc tgttcccacc
//
