LOCUS       NM_019632               4364 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus N-ethylmaleimide sensitive fusion protein attachment
            protein beta (Napb), transcript variant 1, mRNA.
ACCESSION   NM_019632 NM_019627
VERSION     NM_019632.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4364)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4364)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 4364)
  AUTHORS   Burgalossi,A., Jung,S., Meyer,G., Jockusch,W.J., Jahn,O.,
            Taschenberger,H., O'Connor,V.M., Nishiki,T., Takahashi,M., Brose,N.
            and Rhee,J.S.
  TITLE     SNARE protein recycling by alphaSNAP and betaSNAP supports synaptic
            vesicle priming
  JOURNAL   Neuron 68 (3), 473-487 (2010)
   PUBMED   21040848
  REMARK    GeneRIF: analysis of alpha- and betaSNAP deletion mutant neurons
            shows that the two N-Ethylmaleimide-Sensitive Factor cofactors
            support synaptic vesicle priming by determining the availability of
            free SNARE components
            Erratum:[Neuron. 2012 Feb 9;73(3):620]
REFERENCE   4  (bases 1 to 4364)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   5  (bases 1 to 4364)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 4364)
  AUTHORS   Lang,J.
  TITLE     Molecular mechanisms and regulation of insulin exocytosis as a
            paradigm of endocrine secretion
  JOURNAL   Eur J Biochem 259 (1-2), 3-17 (1999)
   PUBMED   9914469
  REMARK    Review article
REFERENCE   7  (bases 1 to 4364)
  AUTHORS   Gotte,M. and von Mollard,G.F.
  TITLE     A new beat for the SNARE drum
  JOURNAL   Trends Cell Biol 8 (6), 215-218 (1998)
   PUBMED   9695844
  REMARK    Review article
REFERENCE   8  (bases 1 to 4364)
  AUTHORS   Advani,R.J., Bae,H.R., Bock,J.B., Chao,D.S., Doung,Y.C.,
            Prekeris,R., Yoo,J.S. and Scheller,R.H.
  TITLE     Seven novel mammalian SNARE proteins localize to distinct membrane
            compartments
  JOURNAL   J Biol Chem 273 (17), 10317-10324 (1998)
   PUBMED   9553086
REFERENCE   9  (bases 1 to 4364)
  AUTHORS   Puschel,A.W., O'Connor,V. and Betz,H.
  TITLE     The N-ethylmaleimide-sensitive fusion protein (NSF) is
            preferentially expressed in the nervous system
  JOURNAL   FEBS Lett 347 (1), 55-58 (1994)
   PUBMED   8013662
REFERENCE   10 (bases 1 to 4364)
  AUTHORS   Kato,K.
  TITLE     Finding new genes in the nervous system by cDNA analysis
  JOURNAL   Trends Neurosci 15 (9), 319-323 (1992)
   PUBMED   1382328
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844519.9 and AL928638.7.
            
            On Oct 25, 2022 this sequence version replaced NM_019632.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038362.1, AK083184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AL844519.9         6135-6288           c
            155-234             AL928638.7         113152-113231       c
            235-351             AL928638.7         109794-109910       c
            352-398             AL928638.7         107636-107682       c
            399-476             AL928638.7         107423-107500       c
            477-532             AL928638.7         103747-103802       c
            533-617             AL928638.7         103538-103622       c
            618-722             AL928638.7         100850-100954       c
            723-791             AL928638.7         99408-99476         c
            792-842             AL928638.7         98660-98710         c
            843-4364            AL928638.7         94462-97983         c
FEATURES             Location/Qualifiers
     source          1..4364
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 73.53 cM"
     gene            1..4364
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /note="N-ethylmaleimide sensitive fusion protein
                     attachment protein beta"
                     /db_xref="GeneID:17957"
                     /db_xref="MGI:MGI:104562"
     exon            1..154
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..953
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /note="brain protein I47; brain protein 14; SNAP-beta;
                     N-ethylmaleimide-sensitive factor attachment protein beta"
                     /codon_start=1
                     /product="beta-soluble NSF attachment protein"
                     /protein_id="NP_062606.1"
                     /db_xref="CCDS:CCDS16842.1"
                     /db_xref="GeneID:17957"
                     /db_xref="MGI:MGI:104562"
                     /translation="MDNAGKEREAVQLMAEAEKRVKASHSFLRGLFGGNTRIEEACEM
                     YTRAANMFKMAKNWSAAGNAFCQAAKLHMQLQSKHDSATSFVDAGNAYKKADPQEAIN
                     CLNAAIDIYTDMGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSS
                     ANKCLLKVAAYAAQLEQYQKAIEIYEQVGANTMDNPLLKYSAKDYFFKAALCHFIVDE
                     LNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRLDQWL
                     TTMLLRIKKSIQGDGEGDGDLK"
     exon            155..234
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            235..351
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            352..398
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            399..476
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            477..532
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            533..617
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            618..722
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            723..791
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            792..842
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            843..4364
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4342..4347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /note="hexamer: AATAAA"
     polyA_site      4364
                     /gene="Napb"
                     /gene_synonym="b-SNAP; Brp14; E161; I47; SNARE"
                     /note="major polyA site"
ORIGIN      
        1 agtcgtcccg ggagcctagc tagtcagcag aggaggcttt ggctgcagcg ggtgacatgg
       61 acaacgcagg gaaggagcga gaagcggtcc agcttatggc ggaggccgag aagcgagtga
      121 aggcttccca ctctttcctc cgagggttgt tcggaggaaa cacaagaata gaagaggcat
      181 gtgaaatgta taccagagct gcaaatatgt tcaagatggc caagaactgg agtgctgcag
      241 ggaatgcgtt ttgtcaagct gccaaactcc acatgcagct ccagagcaag catgactctg
      301 ctaccagctt tgtggatgct ggaaatgcgt acaagaaagc agaccctcaa gaggctatca
      361 actgcttaaa tgcagccatc gacatttaca cagacatggg gaggttcaca atcgcagcca
      421 agcaccatat caccattgcc gagatctatg agactgagct cgtggacatt gagaaggcta
      481 ttgcacacta tgaacaatct gctgattact acaaaggaga ggaatctaac agctctgcca
      541 acaagtgtct gctgaaggtg gcagcctacg ctgcacagct ggagcagtac cagaaagcca
      601 tcgagatcta tgagcaggtg ggagcaaaca ccatggataa ccccttgttg aagtacagtg
      661 caaaggatta cttcttcaag gccgcgctct gccacttcat agtggatgag ctgaacgcaa
      721 agcttgctct ggagaaatac gaggaaatgt ttccagcatt tacggactcc agagaatgta
      781 aattattgaa gaaacttcta gaagctcatg aggaacagaa cagtgaagcg tacactgaag
      841 cagtgaagga gtttgactca atatcacgtt tggatcagtg gctgaccacc atgttgcttc
      901 gtatcaagaa gtccatccaa ggggatggag aaggagatgg agacctcaag tgaagtgctg
      961 acatctttgt ggcatgcagc tcattccttt ttattttgtc ttcgggcaga gccgtctttg
     1021 taaataagcc agccacacag tttatgtatt gttttagctc accatgtctg tgtcatgtga
     1081 gaatcggagg cttctattca gtttgtggtc atgacaacca aagtacatca tgcgagtatc
     1141 tgagtcctca tagttttctg agaagtactg ccaaatcttt ttcccgttct tttgatattt
     1201 tcagggccca tggttaatgt tgccacgttt tgtgttttct tttttcttga actctggtcc
     1261 tcaacccagt tttatagatg cttagcaaag accctgtgca ttggtatctg gatgcaacct
     1321 ttatacaagt gacttagttt agggtgctta ttaggaataa gtttgtaatt cagtagaaac
     1381 tgtttggctt tcctttatag ctactttgaa ggtgttagtg atgtttcttg ttttgcaaaa
     1441 tatgctcaca tgtgcatgac aaacactgac aacagctagg atctgctaac atcacttgaa
     1501 gctggtaggt cctggggtcc tgtttgtttg gatggatgtc aaggtagatt tccttggttt
     1561 tgttttaact tacacacaca cacacacaca cacacacaca cacacacaca cacataaaac
     1621 ctgtgagatg gaattttccc tttctctaga gactgtttcc acttttagct ggagtgggaa
     1681 tcccttcata tttgccttaa accatcttta gctggcatct cctttattca cacatccata
     1741 tatgctcctc acattgtctt ctgggccaca gtcatgccaa gcttgagcag agttggacag
     1801 aaaattccag ctgaatatgt gtggtgatgt ccatttgtcg gacatggtgg ttaaatgtta
     1861 tcagtgtagc ataagagttt gtgttatccc tggttagata agagcctcac ttgtatttga
     1921 gggtctgtga cttatttcat ttgcgtgtat gagctctgat gtcctatttg gtttacataa
     1981 gacgtatgct ctgttatttg agatgttgat gctccctgct actttatatg ctgatacagt
     2041 actgtagaca tgaccttgct ccctgggtcc cctttgctga gagactttta tgctgggatg
     2101 atttgtgctt gaagagcctg tgttactagg cctgtctcat tgccctattg tgctgctatc
     2161 atgtgacaat gaaactcctg attatccagg taaaaatggc cctggaatgg tgttttcatc
     2221 tttggatggc cctagactag ggttggaggc ttttaccatg cagtagagta gtagctttgc
     2281 ccaggcccag ggctaaacga gaagagttgg aggactgatg agaaagtccg ttctttcaaa
     2341 agtgaaacaa agtagcaaaa gggggctaga gagatggtta ctcttccaga ggacccaagt
     2401 ttgatttcta gcacccatgt tgggtggctc aaaaccacct gtaaacccag gaattccagt
     2461 gccctccttt gccttccaca agcatgtgcg tgcagataaa cacatacagg caaatgaaat
     2521 ctacacatat atgcaagcaa gacactcatt tgtaaaataa taaatcttat tattttaaaa
     2581 agaaaaaagg aaatgaagca gaaactggcc ccatgagaac aggtggtagg tgtctgtcag
     2641 gcccctgtca tggtggtaac agggtgtaaa tgcaggaagc cgagaggcct ttgcatgtct
     2701 gaaacagagg gaatgtgccc tagaatctga tgagagctcc tttttccttc catgccttta
     2761 ggggtttctg tatgatagct ggctatacca aaggtaaaag ttgcaatgga accttgttga
     2821 tactgcttga ctccactaga ctctctaatg taaagacaaa aagtgagtta ctggggctag
     2881 agatgcctca tttgctcttt cagaggaccc agggttaaag tcccagaatt tatatggggg
     2941 ctcacagctg tctataactc cagtcctaag agatccacca tcctcttttt gcctccactg
     3001 gtaccaggca tgcatgtgat gctcacgcat acatgcagac aaaacatgca tacacttaaa
     3061 aataaaaaaa tttaaaactg taatgtatag gaaagagagt tactgctttg ttcacggcca
     3121 gccacaggca gccttggaaa tgaggtatgg aaatggctct aagtcagttc cagcagaaga
     3181 gcatctgaac actggccagc ctctgttctc tgcctcccag ttcagtcttc tgatgcgacc
     3241 atttaaagtg agacccacat ggtgtcttac ggggcactgt ggtttacctt tcatcatggc
     3301 tccctaacac acctccatga agaagtgttg ggttgttaaa gtagtgtttg gattactttg
     3361 ctgcttgtaa agaaacttac tcacttattt gcttttcctg aagttaaatg ctgggccagg
     3421 catcatgaac acttgtaatc ccgcagtatc tacaaggtga agggaggagg attgctgtga
     3481 ggttgaggcc agcctggact ccctagtgaa ttccaggcca gcctaagtta atgtgagact
     3541 ccatctatct caaaaaacca accaaccaac caaccaaaaa aaaaaaagga ctgaaaggct
     3601 gaggtgagtc cctgttgagt ttattttgtc tcagcacttg ggaggctgag gcaagaggaa
     3661 cgtgattcca gactaagcta agtcagacca tctaaaaaaa aaaaaaatac aaagaacaca
     3721 cttttggcag aagataaaag aatgaggacc atgtccggac aggagtatgc aagcttactc
     3781 ccttcaaatg tcccgcagac acagagcaat gcattctctc aagatgtcca ggctttaggc
     3841 tttcatggtc tctagaatat tgtgaccaaa acgcaacgat tgttatagtt ctcatatttg
     3901 agtgcatctg gagataattc atagttatgg cagttaatat ttcttacaga aaagttttcc
     3961 ttttgtggca acatttttat agcttgtgtg aattcctttt ttttttttta atgacataaa
     4021 acagtatttt tgcacagttg taaccatgtg tgatggtgtc actataacca aagtatatgc
     4081 accagccctt gtgcatttat tgttccctct ggtattgtgc acttaaaatg tccaaattca
     4141 aacctctgta actgtggaga atctggcagc agcacagcat gcccgtgacc tgcctgctac
     4201 agtgtgagct gtgaccagta agcaggcact gtaaagtcct aagttgctct caggcaaggg
     4261 agtccattac aaaaacaaat cgtgtaacaa taaatctatc ttagctaaaa gaacgtttgt
     4321 tttatgtgaa cctgtacagt aaataaagtg gaagttatcg gtaa
//
