LOCUS       NM_025898               2402 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus N-ethylmaleimide sensitive fusion protein attachment
            protein alpha (Napa), mRNA.
ACCESSION   NM_025898
VERSION     NM_025898.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2402)
  AUTHORS   Liu,F., He,R., Xu,X., Zhu,M., Yu,H. and Liu,Y.
  TITLE     Munc18c accelerates SNARE-dependent membrane fusion in the presence
            of regulatory proteins alpha-SNAP and NSF
  JOURNAL   J Biol Chem 300 (3), 105782 (2024)
   PUBMED   38395304
  REMARK    GeneRIF: Munc18c accelerates SNARE-dependent membrane fusion in the
            presence of regulatory proteins alpha-SNAP and NSF.
REFERENCE   2  (bases 1 to 2402)
  AUTHORS   Rodriguez-Perez,L.M., Lopez-de-San-Sebastian,J., de Diego,I.,
            Smith,A., Roales-Bujan,R., Jimenez,A.J. and Paez-Gonzalez,P.
  TITLE     A selective defect in the glial wedge as part of the
            neuroepithelium disruption in hydrocephalus development in the
            mouse hyh model is associated with complete corpus callosum
            dysgenesis
  JOURNAL   Front Cell Neurosci 18, 1330412 (2024)
   PUBMED   38450283
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2402)
  AUTHORS   Bustamante-Barrientos,F.A., Mendez-Ruette,M., Molina,L., Koning,T.,
            Ehrenfeld,P., Gonzalez,C.B., Wyneken,U., Henzi,R. and Batiz,L.F.
  TITLE     Alpha-SNAP (M105I) mutation promotes neuronal differentiation of
            neural stem/progenitor cells through overactivation of AMPK
  JOURNAL   Front Cell Dev Biol 11, 1061777 (2023)
   PUBMED   37113766
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2402)
  AUTHORS   de Paola,M., Miro,M.P., Ratto,M., Batiz,L.F. and Michaut,M.A.
  TITLE     Pleiotropic effects of alpha-SNAP M105I mutation on oocyte biology:
            ultrastructural and cellular changes that adversely affect female
            fertility in mice
  JOURNAL   Sci Rep 9 (1), 17374 (2019)
   PUBMED   31758001
  REMARK    GeneRIF: Pleiotropic effects of alpha-SNAP M105I mutation on oocyte
            biology: ultrastructural and cellular changes that adversely affect
            female fertility in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2402)
  AUTHORS   Arcos,A., de Paola,M., Gianetti,D., Acuna,D., Velasquez,Z.D.,
            Miro,M.P., Toro,G., Hinrichsen,B., Munoz,R.I., Lin,Y.,
            Mardones,G.A., Ehrenfeld,P., Rivera,F.J., Michaut,M.A. and
            Batiz,L.F.
  TITLE     alpha-SNAP is expressed in mouse ovarian granulosa cells and plays
            a key role in folliculogenesis and female fertility
  JOURNAL   Sci Rep 7 (1), 11765 (2017)
   PUBMED   28924180
  REMARK    GeneRIF: results showed that alpha-SNAP protein is highly expressed
            in granulosa cells and its expression is modulated by gonadotropin
            stimuli.
            Erratum:[Sci Rep. 2020 Mar 25;10(1):5691. doi:
            10.1038/s41598-020-61863-w.. PMID: 32214131]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2402)
  AUTHORS   Advani,R.J., Bae,H.R., Bock,J.B., Chao,D.S., Doung,Y.C.,
            Prekeris,R., Yoo,J.S. and Scheller,R.H.
  TITLE     Seven novel mammalian SNARE proteins localize to distinct membrane
            compartments
  JOURNAL   J Biol Chem 273 (17), 10317-10324 (1998)
   PUBMED   9553086
REFERENCE   7  (bases 1 to 2402)
  AUTHORS   McMahon,H.T., Missler,M., Li,C. and Sudhof,T.C.
  TITLE     Complexins: cytosolic proteins that regulate SNAP receptor function
  JOURNAL   Cell 83 (1), 111-119 (1995)
   PUBMED   7553862
REFERENCE   8  (bases 1 to 2402)
  AUTHORS   Mann,M., Latham,K.E. and Varmuza,S.
  TITLE     Identification of genes showing altered expression in
            preimplantation and early postimplantation parthenogenetic embryos
  JOURNAL   Dev Genet 17 (3), 223-232 (1995)
   PUBMED   8565329
REFERENCE   9  (bases 1 to 2402)
  AUTHORS   Puschel,A.W., O'Connor,V. and Betz,H.
  TITLE     The N-ethylmaleimide-sensitive fusion protein (NSF) is
            preferentially expressed in the nervous system
  JOURNAL   FEBS Lett 347 (1), 55-58 (1994)
   PUBMED   8013662
REFERENCE   10 (bases 1 to 2402)
  AUTHORS   Bronson,R.T. and Lane,P.W.
  TITLE     Hydrocephalus with hop gait (hyh): a new mutation on chromosome 7
            in the mouse
  JOURNAL   Brain Res Dev Brain Res 54 (1), 131-136 (1990)
   PUBMED   2364541
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050623.1, AK078019.1 and BY631159.1.
            
            On Feb 14, 2018 this sequence version replaced NM_025898.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.234284.1, AK005372.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1547              AK050623.1         2-1548
            1548-2393           AK078019.1         543-1388
            2394-2402           BY631159.1         402-410
FEATURES             Location/Qualifiers
     source          1..2402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.74 cM"
     gene            1..2402
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /note="N-ethylmaleimide sensitive fusion protein
                     attachment protein alpha"
                     /db_xref="GeneID:108124"
                     /db_xref="MGI:MGI:104563"
     exon            1..195
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..985
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /note="N-ethylmaleimide-sensitive factor attachment
                     protein alpha; hydrocephaly with hop gait"
                     /codon_start=1
                     /product="alpha-soluble NSF attachment protein"
                     /protein_id="NP_080174.1"
                     /db_xref="CCDS:CCDS20843.1"
                     /db_xref="GeneID:108124"
                     /db_xref="MGI:MGI:104563"
                     /translation="MDNSGKQAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEI
                     YARAANMFKMAKNWSAAGNAFCQAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAIN
                     CLMRAIEIYTDMGRFTIAAKHHISIAEIYETELVDVEKAIAHYEQSADYYKGEESNSS
                     ANKCLLKVAGYAAQLEQYQKAIDIYEQVGTSAMDSPLLKYSAKDYFFKAALCHFCIDM
                     LNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTEAVKEYDSISRLDQWL
                     TTMLLRIKKTIQGDEEDLR"
     exon            196..275
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            276..392
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            393..439
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            440..517
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            518..573
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            574..658
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            659..763
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            764..832
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            833..883
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /inference="alignment:Splign:2.1.0"
     exon            884..2402
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1524..1529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /note="hexamer: AATAAA"
     polyA_site      1548
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /note="major polyA site"
     regulatory      2374..2379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /note="hexamer: AATAAA"
     polyA_site      2397
                     /gene="Napa"
                     /gene_synonym="1500039N14Rik; a-SNAP; hyh; RA81;
                     SNAP-alpha; SNAPA; SNARE"
                     /note="major polyA site"
ORIGIN      
        1 aacgcagcgg gcggagctcc gctgagtgcg cggtgtccgg ggcctgtgag tcgtcgccag
       61 gctgtgtcgg gcctgagccg agcagctgcg cgacgtcatg gacaactccg ggaagcaggc
      121 tgaggctatg gcgctgctgg ctgaagcgga gcgcaaggtg aagaactcgc agtccttctt
      181 ctccggcctc tttggaggct catccaaaat agaggaagca tgcgagatct atgccagagc
      241 ggcgaacatg ttcaagatgg ccaagaactg gagcgctgct gggaacgctt tctgccaggc
      301 tgcccaacta cacctacagc tccaaagcaa gcacgatgca gccacctgct ttgtggacgc
      361 tggcaatgct ttcaagaaag ctgaccccca agaggccatt aactgtctga tgagagcaat
      421 tgagatctat acagacatgg gcagattcac aatcgcagcc aagcaccaca tctccatcgc
      481 tgagatctat gagacagaac tggtggatgt agagaaggcc atcgcccact atgagcaatc
      541 tgcagactac tacaaaggag aagagtccaa cagctcagcc aacaagtgtc tgctgaaggt
      601 ggctggctac gccgcacagc tggagcagta ccagaaggct atcgacatct atgagcaggt
      661 ggggaccagt gccatggaca gtcccctcct caagtacagc gccaaagact acttcttcaa
      721 ggcggccctc tgccacttct gcattgacat gctcaacgcc aagctcgctg ttcagaagta
      781 tgaggagctc ttcccggcct tctcggattc ccgggaatgc aagctgatga aaaagctgct
      841 ggaagcccat gaggaacaga atgtggacag ctacacagag gcggtgaagg aatatgactc
      901 catctccaga ctggaccagt ggcttaccac catgcttctg cgcataaaga agaccattca
      961 gggtgacgag gaggacctgc gctaggcctc cagccactgc cttccaccca tctgtctatc
     1021 acagaggtgg agccagcacc tcccaccagg agtctgaagg agtgggtgca atgtgggcca
     1081 cattctccag caccaggcga gctctcctgg atggctggtc acccgctgcg tccttcaccc
     1141 tgccgtttat ttaagccccc agaggtgccc tcctgccctg gaaagtccac ctggacagat
     1201 tctccaattc agacttctgt gtgcttcagg aaccagaggt cagggtctgg tcccatctcc
     1261 tgaccagcag tgtactaagg ctgtttccat atctcctacc ttgtccccta gcagagataa
     1321 gaacacaggt agctctgaga cttgctctcc ctggctgggg gtaacctctg cccctggagc
     1381 cttcccttgt tcctacaatg ccaacctctc aggttagacc cagccctgga gctcatgggg
     1441 tgccttggcc ctgccctgcg cacctgcttc tctccatgca tccaggtcta tcgacctgaa
     1501 gctgcagctg gcccaaaaag gacaataaaa cctgccactt ttgcatgagc ctcttgagct
     1561 gtccctttga ccctcggtgc ccttcccttt ggaccttggc tgtcctggag gagttggagg
     1621 tttctgcagc tgagcctcag aaccagagtg ctttctagaa gctgtggact ggcccaagat
     1681 gacgggagcc tcatacccat ttcaccctgc agggggtctg ccagggctgg cctccttcca
     1741 tgggattgcc ctgactgaag cagacagcct aggagaaaaa gttggccttc cacacatctc
     1801 gctctgctcc cctgtccctc cagtgtcccc aacagcttca ttcagttgat aatttggccc
     1861 tcagctttgg agaaccctga ggctggaggc tgacaacttt ttttaccatg ggattgccaa
     1921 gaagccttgt gagaatgtcc cagcctgctg ctctggttag gctgaggtta ataccctggt
     1981 gttgtggaag cttcctaagt ggctcagata catactaggg ttgaaaacat ggtttctaag
     2041 tttctacatg agtcagaagc aacctgaaga gaagaaaccg cacagctggg aaaatgggga
     2101 gagcttagtg tgtaagaaca cttactacaa cagacaggag gacccaaggt cagatattca
     2161 gcacccatgc taaaaacact ggtttgacca catgaacacg tgagtctgca aggtggggca
     2221 gtgactactg ctagagcctg gtggccagaa gcctggcagc agcttcaaca aaaggaccct
     2281 gtctcaaagg aataagagtg acagaatatg accagataac tgtcttcctg tgtatatggg
     2341 tatgcacaag atacatctat tacatacaca aataataaaa acgagaggcc atgccaacct
     2401 gc
//
