LOCUS       NM_015781               2765 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus nucleosome assembly protein 1-like 1 (Nap1l1),
            transcript variant 2, mRNA.
ACCESSION   NM_015781
VERSION     NM_015781.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2765)
  AUTHORS   Liang,X., Tang,Z., Zhang,Y., Sun,Y. and Wang,J.
  TITLE     NAP1L1 promotes the growth of colon cancer by activating HDGF/DDX5
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (9), 1234-1243 (2022)
   PUBMED   36148951
  REMARK    GeneRIF: NAP1L1 promotes the growth of colon cancer by activating
            HDGF/DDX5.
REFERENCE   2  (bases 1 to 2765)
  AUTHORS   Dominguez,F., Shiliaev,N., Lukash,T., Agback,P., Palchevska,O.,
            Gould,J.R., Meshram,C.D., Prevelige,P.E., Green,T.J., Agback,T.,
            Frolova,E.I. and Frolov,I.
  TITLE     NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya
            Virus nsP3 Protein Is Bivalent and Requires Phosphorylation
  JOURNAL   J Virol 95 (16), e0083621 (2021)
   PUBMED   34076483
  REMARK    GeneRIF: NAP1L1 and NAP1L4 Binding to Hypervariable Domain of
            Chikungunya Virus nsP3 Protein Is Bivalent and Requires
            Phosphorylation.
REFERENCE   3  (bases 1 to 2765)
  AUTHORS   Qiao,H., Li,Y., Feng,C., Duo,S., Ji,F. and Jiao,J.
  TITLE     Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and
            Differentiation in the Developing Brain
  JOURNAL   Cell Rep 22 (9), 2279-2293 (2018)
   PUBMED   29490266
  REMARK    GeneRIF: These findings reveal an essential role for the Nap1l1
            histone chaperone in cortical neurogenesis during early embryonic
            brain development.
REFERENCE   4  (bases 1 to 2765)
  AUTHORS   Yan,Y., Yin,P., Gong,H., Xue,Y., Zhang,G., Fang,B., Chen,Z., Li,Y.,
            Yang,C., Huang,Z., Yang,X., Ge,J. and Zou,Y.
  TITLE     Nucleosome Assembly Protein 1-Like 1 (Nap1l1) Regulates the
            Proliferation of Murine Induced Pluripotent Stem Cells
  JOURNAL   Cell Physiol Biochem 38 (1), 340-350 (2016)
   PUBMED   26824453
  REMARK    GeneRIF: Nap1l1 promotes the proliferation of iPSC attributable to
            G2/M transition caused by downregulation of p27 and p21, and
            upregulation of cyclin B1, the activation of AKT or ERK is involved
            in the process.
REFERENCE   5  (bases 1 to 2765)
  AUTHORS   Takahashi,N., Hozumi,Y., Tanaka,T., Okada,M., Iseki,K., Hayasaka,K.
            and Goto,K.
  TITLE     Cellular expression and localization of DGKzeta-interacting
            NAP1-like proteins in the brain and functional implications under
            hypoxic stress
  JOURNAL   Histochem Cell Biol 142 (5), 461-471 (2014)
   PUBMED   24893663
  REMARK    GeneRIF: The molecular interaction between DGKzeta and Nap1l1 was
            attenuated after hypoxic stress.
REFERENCE   6  (bases 1 to 2765)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   7  (bases 1 to 2765)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   8  (bases 1 to 2765)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2765)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 2765)
  AUTHORS   Kato,K.
  TITLE     A Collection of cDNA Clones with Specific Expression Patterns in
            Mouse Brain
  JOURNAL   Eur J Neurosci 2 (8), 704-711 (1990)
   PUBMED   12106288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136161.1, AK011301.1 and BF458793.1.
            
            On Dec 14, 2017 this sequence version replaced NM_015781.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.227398.1, AK136161.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1481              AK136161.1         2-1482
            1482-2742           AK011301.1         700-1960
            2743-2765           BF458793.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..2765
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 58.67 cM"
     gene            1..2765
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /note="nucleosome assembly protein 1-like 1"
                     /db_xref="GeneID:53605"
                     /db_xref="MGI:MGI:1855693"
     exon            1..125
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            126..162
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1321
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nucleosome assembly protein-1; brain protein DN38;
                     NAP-1-related protein"
                     /codon_start=1
                     /product="nucleosome assembly protein 1-like 1 isoform 2"
                     /protein_id="NP_056596.1"
                     /db_xref="CCDS:CCDS36058.1"
                     /db_xref="GeneID:53605"
                     /db_xref="MGI:MGI:1855693"
                     /translation="MADIDNKEQSELDQDLEDVEEVEEEETGEETKIKARQLTVQMMQ
                     NPQILAALQERLDGLVDTPTGYIESLPKVVKRRVNALKNLQVKCAQIEAKFYEEVHDL
                     ERKYAVLYQPLFDKRFEIINAIYEPTEEECEWKPDEEDEVSEELKEKAKIEDEKKDEE
                     KEDPKGIPEFWLTVFKNVDLLSDMVQEHDEPILKHLKDIKVKFSDAGQPMSFVLEFHF
                     EPNDYFTNEVLTKTYRMRSEPDDSDPFSFDGPEIMGCTGCQIDWKKGKNVTLKTIKKK
                     QKHKGRGTVRTVTKTVSNDSFFNFFAPPEVPENGDLDDDAEAILAADFEIGHFLRERI
                     IPRSVLYFTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPKKDQNPAECKQQ"
     exon            163..248
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..351
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            352..493
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..574
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..703
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..775
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..915
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1061
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1081
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1204
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1234
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1285
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1351
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..2748
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1453..1458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /note="hexamer: AATAAA"
     polyA_site      1482
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /note="major polyA site"
     regulatory      2720..2725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /note="hexamer: AATAAA"
     polyA_site      2748
                     /gene="Nap1l1"
                     /gene_synonym="D10Ertd68e; NAP-1"
                     /note="major polyA site"
ORIGIN      
        1 cttttttagc gccatctgct cgcggcgccg cctcctgctc ctcccgccgc cgccgctgcc
       61 gccgccctga gtcactgcct gcgcagctcc cgccgcccgg ctccgcgtcc gagcctcctg
      121 gaacgacatt tggagttctt acaagatggc cgacattgac aacaaagaac agtctgaact
      181 tgatcaagat ttggaagatg ttgaagaagt agaagaagaa gaaacgggtg aagaaacaaa
      241 aatcaaagca cgtcagctaa ctgttcagat gatgcaaaat cctcagattc ttgcagctct
      301 tcaggaaaga cttgatggtc tggtagacac accaacagga tacattgaaa gcttgcctaa
      361 ggtagtcaaa agacgagtga atgctctcaa gaatcttcag gttaaatgtg cacagataga
      421 agccaaattc tatgaggaag ttcatgatct cgagaggaag tatgctgttc tctatcagcc
      481 tttatttgat aagcgatttg agatcattaa tgcaatctat gaacctacag aagaagaatg
      541 cgagtggaaa ccagatgagg aggatgaagt ttcggaggag ctgaaagaaa aggccaagat
      601 tgaagatgag aaaaaggatg aagaaaaaga agacccgaaa ggaattcctg aattttggtt
      661 gacagtgttt aagaatgttg acttgctcag tgacatggtt caggaacatg atgaacctat
      721 tctgaagcac ttgaaagata ttaaagtgaa gttttcggat gctggccagc ctatgagttt
      781 tgtcttagaa tttcactttg aacccaatga ctatttcaca aatgaagtgt taacaaagac
      841 ttacaggatg cggtcagagc cagatgattc tgaccccttt tcttttgacg gaccagagat
      901 tatgggctgt acagggtgcc agatagattg gaaaaaagga aagaatgtta ctttgaaaac
      961 cattaagaag aagcagaaac acaaggggcg tgggacagtt cgtactgtga ctaaaacagt
     1021 ttccaatgat tctttcttta atttttttgc tcctcctgaa gttcctgaga atggcgatct
     1081 ggatgatgat gctgaggcga tactggctgc agactttgaa attggtcact ttttacgtga
     1141 gcgcataatc ccaagatcag tgctgtactt cactggagag gctatcgagg acgatgacga
     1201 tgattatgat gaagaaggtg aagaagctga cgaggaaggg gaagaagaag gagatgagga
     1261 aaacgatcca gactatgacc caaagaagga tcagaaccca gccgagtgca agcagcagtg
     1321 agcagtgact ggccttgagg acggccgccc tggcctacct tctgctttcc tggaaaagat
     1381 gaatatacat catatgaacc tattttgagt ttttctgttg tttgtttgcc taattttgtt
     1441 tttatagcct aaaataaaaa tatgacacag ttttagctct catgggatgc tgtctcggtt
     1501 tgtactgatt gaggctattg cagagggtta gttggaattc aggggtgcct agttttctat
     1561 attgaacaac gctggaggag ctaatacaca cgtgctttaa aaaaagtgat atgctctagt
     1621 ttgagcagaa aggtacagtt gtgcttgtta gaactgaaac ctttgtttgg actttgttta
     1681 ttctgtcctc aggaggatga ggagtgtcgg gagccatgct gtttatttac tgtgcataac
     1741 caagaatggg tgggactgtt gattcaacta cctcaactct gttaaggcat attggggtat
     1801 atctcacaaa ctctcagtct tacttgcaaa atgctcaaaa aattgggcct ctataccatg
     1861 agtgtgatat tcagcattat attcacacca agctttgatg attaaactgg agaatgaagt
     1921 ttaaacactt ctattctaga tctgagcatg tggctccaat tttagtggga aggaatgaaa
     1981 gtagtgtatg atttcaagag attgaagagt tttgggattt ttgagtttta ccccccttca
     2041 gatatttcaa gtgaccacat tataaaacac cctaaggtgg taacgaggca ggggaggatg
     2101 gcatgaagtt gcattaagtt tcagaccact gagagccaca tttaaaatac ctcaggctaa
     2161 ttactgttca ctttggggca ggagtaggtt ttgccagggt atagtaattg gattgcactc
     2221 caaggaaagt tcctattgtt aataaaattt acgtagagga gaaacgtttg tttgaggtgg
     2281 tagttctttc tgtgaggttt tagtattcga actcttagaa tgtgaacaca ttcgagagct
     2341 gacttcttcc tgagagtttt aactactgga aatccttaac caattatatt ttctttattt
     2401 tgagaatgat ttggttgctt tttcttagat ggtttctgct attttctgta atcatagttc
     2461 atctaaacac agcctatttt cgtgaacatt gaagtttgta acggaaagat aggatctcat
     2521 tttcagtgaa cttccagact agcgcactct tcccttccct ctgtaggaag tagctgttgc
     2581 caaagcgaag aggtagctgg ctcttgtata atgggaaagt gccgtgtgga gcttcagggg
     2641 tcagtgttta ttatgacatc tgtcagtccc caaatggttc tattctctac aagtctgaaa
     2701 tatgtaatct gaaatcctta ataaaattgg atctaatttt ataaaataaa aaaaaaaaaa
     2761 aaaaa
//
