LOCUS       NM_026086               1392 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus N-acetylneuraminic acid phosphatase (Nanp), mRNA.
ACCESSION   NM_026086
VERSION     NM_026086.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1392)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1392)
  AUTHORS   Abeln,M., Albers,I., Peters-Bernard,U., Flachsig-Schulz,K.,
            Kats,E., Kispert,A., Tomlinson,S., Gerardy-Schahn,R.,
            Munster-Kuhnel,A. and Weinhold,B.
  TITLE     Sialic acid is a critical fetal defense against maternal complement
            attack
  JOURNAL   J Clin Invest 129 (1), 422-436 (2019)
   PUBMED   30382946
REFERENCE   3  (bases 1 to 1392)
  AUTHORS   Maliekal,P., Vertommen,D., Delpierre,G. and Van Schaftingen,E.
  TITLE     Identification of the sequence encoding
            N-acetylneuraminate-9-phosphate phosphatase
  JOURNAL   Glycobiology 16 (2), 165-172 (2006)
   PUBMED   16237198
REFERENCE   4  (bases 1 to 1392)
  AUTHORS   Schwarzkopf,M., Knobeloch,K.P., Rohde,E., Hinderlich,S.,
            Wiechens,N., Lucka,L., Horak,I., Reutter,W. and Horstkorte,R.
  TITLE     Sialylation is essential for early development in mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5267-5270 (2002)
   PUBMED   11929971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083086.1 and AL808125.11.
            
            On Apr 25, 2009 this sequence version replaced NM_026086.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083086.1, AK005566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-499               BC083086.1         1-499
            500-500             AL808125.11        197427-197427       c
            501-1392            BC083086.1         501-1392
FEATURES             Location/Qualifiers
     source          1..1392
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.83 cM"
     gene            1..1392
                     /gene="Nanp"
                     /gene_synonym="1600031M04Rik; Hdhd4"
                     /note="N-acetylneuraminic acid phosphatase"
                     /db_xref="GeneID:67311"
                     /db_xref="MGI:MGI:1914561"
     exon            1..143
                     /gene="Nanp"
                     /gene_synonym="1600031M04Rik; Hdhd4"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..800
                     /gene="Nanp"
                     /gene_synonym="1600031M04Rik; Hdhd4"
                     /EC_number="3.1.3.29"
                     /note="haloacid dehalogenase-like hydrolase domain
                     containing 4; neu5Ac-9-Pase; haloacid dehalogenase-like
                     hydrolase domain-containing protein 4"
                     /codon_start=1
                     /product="N-acylneuraminate-9-phosphatase"
                     /protein_id="NP_080362.1"
                     /db_xref="CCDS:CCDS16864.1"
                     /db_xref="GeneID:67311"
                     /db_xref="MGI:MGI:1914561"
                     /translation="MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEE
                     AEIICDKVQVKLSKECFHPYSTCITDVRTSHWEEAIQETKGGADNRKLAEECYFLWKS
                     TRLQHMILADDVKAMLTELRKEVRLLLLTNGDRQTQREKIEACACQSYFDAIVIGGEQ
                     KEEKPAPSIFYHCCDLLGVQPGDCVMVGDTLETDIQGGLNAGLKATVWINKSGRVPLT
                     SSPMPHYMVSSVLELPALLQSIDCKVSMSV"
     exon            144..1375
                     /gene="Nanp"
                     /gene_synonym="1600031M04Rik; Hdhd4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1333..1338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nanp"
                     /gene_synonym="1600031M04Rik; Hdhd4"
                     /note="hexamer: ATTAAA"
     polyA_site      1364
                     /gene="Nanp"
                     /gene_synonym="1600031M04Rik; Hdhd4"
                     /note="major polyA site"
ORIGIN      
        1 cgcatgcgcg gcgcggcaga agcggctcgc gcgctgcttg ggttgccgag gctatggggc
       61 tgagtcgggt ccgcgcggtc ttctttgacc tggacaacac actcatcgac acggccgggg
      121 cgagcaggag aggcatgttg gaggtaataa agctcttaca gtcaaaatac cactacaaag
      181 aagaggctga aatcatctgt gataaagttc aagttaaact gagcaaggag tgctttcatc
      241 cctatagtac atgcattaca gatgtgagga cttcacactg ggaagaagca atccaggaaa
      301 ccaaaggagg tgctgacaat aggaaattgg cggaggaatg ttatttcctg tggaaatcta
      361 cacgcttaca gcacatgatc ctagcagacg atgtcaaagc catgctcact gaacttcgaa
      421 aagaggtccg cctgctcctg ttaacaaatg gtgacagaca gactcagagg gaaaagatcg
      481 aggcctgcgc ctgccagtct tactttgatg ccattgttat tggcggagaa cagaaggaag
      541 agaaaccagc accttccata ttttatcact gctgtgatct tcttggagtg cagccaggtg
      601 actgtgtgat ggttggtgac acactggaaa ccgatataca aggaggcctc aatgcaggac
      661 tgaaagctac ggtctggata aacaagagtg gaagagtgcc gctgacatca tcacccatgc
      721 ctcactatat ggtttcttct gtgctagaat tacctgctct cttgcaaagc atagattgca
      781 aagtcagcat gtctgtgtaa atacagaaga gcgcagggac catgttcaga gccagtttcc
      841 agcgttagaa ctaagggaag ctaaggtgtt cctgtatatt tggttctatt ctaagaataa
      901 tgtgagcgag gaattcatag tcccctgtga agatcctccc aaccctgctg ctgttgataa
      961 ccataggctt gtgttcatat ccgaaatcca ggtattaatc gtgtagtcca aaaaacttga
     1021 agaaaggcaa aatagcttat atgatgatat acaaatactg gtttctagag tagaaattga
     1081 tttttttaaa aaaaatagat attctaaaat agagattcag gcagctgaat cgggacaata
     1141 taagtactaa atcatacaaa tcgagacatt tcatagtgaa attttgcata ttttaggcaa
     1201 atttgttata aatattgtgc ctactttcaa tgtatgtgtt cttaatctgt tatctaattt
     1261 ttctgcatga cttttggagg gctgaatttt ctgtggcgtg aacatgacat tgttatagtt
     1321 tggtgaaaaa ctattaaaaa tcaaaccgtg gtgctttttt cccacactgt tttcaaaaaa
     1381 aaaaaaaaaa aa
//
