LOCUS       NM_001357361             692 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus nanos C2HC-type zinc finger 3 (Nanos3), transcript
            variant 2, mRNA.
ACCESSION   NM_001357361 XM_006530981
VERSION     NM_001357361.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 692)
  AUTHORS   Mikami,N., Nguyen,C.L.K., Osawa,Y., Kato,K., Ishida,M.,
            Tanimoto,Y., Morimoto,K., Murata,K., Kang,W., Sugiyama,F., Ema,M.,
            Takahashi,S. and Mizuno,S.
  TITLE     Deletion of Exoc7, but not Exoc3, in male germ cells causes severe
            spermatogenesis failure with spermatocyte aggregation in mice
  JOURNAL   Exp Anim 73 (3), 286-292 (2024)
   PUBMED   38325858
REFERENCE   2  (bases 1 to 692)
  AUTHORS   Capriati,M., Hao,C., D'Cruz,S.C., Monfort,C., Chevrier,C.,
            Warembourg,C. and Smagulova,F.
  TITLE     Genome-wide analysis of sex-specific differences in the
            mother-child PELAGIE cohort exposed to organophosphate metabolites
  JOURNAL   Sci Rep 13 (1), 8003 (2023)
   PUBMED   37198424
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 692)
  AUTHORS   Ogonuki,N., Kyogoku,H., Hino,T., Osawa,Y., Fujiwara,Y., Inoue,K.,
            Kunieda,T., Mizuno,S., Tateno,H., Sugiyama,F., Kitajima,T.S. and
            Ogura,A.
  TITLE     Birth of mice from meiotically arrested spermatocytes following
            biparental meiosis in halved oocytes
  JOURNAL   EMBO Rep 23 (7), e54992 (2022)
   PUBMED   35587095
REFERENCE   4  (bases 1 to 692)
  AUTHORS   Inoue,H., Sakurai,T., Hasegawa,K., Suzuki,A. and Saga,Y.
  TITLE     NANOS3 suppresses premature spermatogonial differentiation to
            expand progenitors and fine-tunes spermatogenesis in mice
  JOURNAL   Biol Open 11 (4) (2022)
   PUBMED   35394008
  REMARK    GeneRIF: NANOS3 suppresses premature spermatogonial differentiation
            to expand progenitors and fine-tunes spermatogenesis in mice.
REFERENCE   5  (bases 1 to 692)
  AUTHORS   Agrimson,K.S., Minkina,A., Sadowski,D., Wheeler,A., Murphy,M.W.,
            Gearhart,M.D., Bardwell,V.J. and Zarkower,D.
  TITLE     Lrh1 can help reprogram sexual cell fate and is required for
            Sertoli cell development and spermatogenesis in the mouse testis
  JOURNAL   PLoS Genet 18 (2), e1010088 (2022)
   PUBMED   35192609
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 692)
  AUTHORS   Lolicato,F., Marino,R., Paronetto,M.P., Pellegrini,M., Dolci,S.,
            Geremia,R. and Grimaldi,P.
  TITLE     Potential role of Nanos3 in maintaining the undifferentiated
            spermatogonia population
  JOURNAL   Dev Biol 313 (2), 725-738 (2008)
   PUBMED   18089289
  REMARK    GeneRIF: Potential role of Nanos3 in maintaining the
            undifferentiated spermatogonia population is reported.
REFERENCE   7  (bases 1 to 692)
  AUTHORS   Seki,Y., Yamaji,M., Yabuta,Y., Sano,M., Shigeta,M., Matsui,Y.,
            Saga,Y., Tachibana,M., Shinkai,Y. and Saitou,M.
  TITLE     Cellular dynamics associated with the genome-wide epigenetic
            reprogramming in migrating primordial germ cells in mice
  JOURNAL   Development 134 (14), 2627-2638 (2007)
   PUBMED   17567665
REFERENCE   8  (bases 1 to 692)
  AUTHORS   Suzuki,A., Tsuda,M. and Saga,Y.
  TITLE     Functional redundancy among Nanos proteins and a distinct role of
            Nanos2 during male germ cell development
  JOURNAL   Development 134 (1), 77-83 (2007)
   PUBMED   17138666
REFERENCE   9  (bases 1 to 692)
  AUTHORS   DiMagno,M.J., Williams,J.A., Hao,Y., Ernst,S.A. and Owyang,C.
  TITLE     Endothelial nitric oxide synthase is protective in the initiation
            of caerulein-induced acute pancreatitis in mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 287 (1), G80-G87 (2004)
   PUBMED   14962849
  REMARK    GeneRIF: eNOS is the main isoform influencing the initiation of
            caerulein-induced AP. eNOS-derived NO exerts a protective effect
            through actions on nonacinar cell types, most likely endothelial
            cells, to produce greater pancreatic microvascular blood flow.
REFERENCE   10 (bases 1 to 692)
  AUTHORS   Tsuda,M., Sasaoka,Y., Kiso,M., Abe,K., Haraguchi,S., Kobayashi,S.
            and Saga,Y.
  TITLE     Conserved role of nanos proteins in germ cell development
  JOURNAL   Science 301 (5637), 1239-1241 (2003)
   PUBMED   12947200
  REMARK    GeneRIF: cloning and functional analyses of nanos2 and nanos3;
            demonstrated an evolutionarily conserved function of nanos proteins
            in germ cell development [nanos2] [nanos3]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159266.3.
            
            On Oct 26, 2017 this sequence version replaced XM_006530981.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119514.1, ERR3363658.3242804.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               AC159266.3         168324-168801       c
            479-692             AC159266.3         166008-166221       c
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.45 cM"
     gene            1..692
                     /gene="Nanos3"
                     /gene_synonym="nos3"
                     /note="nanos C2HC-type zinc finger 3"
                     /db_xref="GeneID:244551"
                     /db_xref="MGI:MGI:2675387"
     exon            1..478
                     /gene="Nanos3"
                     /gene_synonym="nos3"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..546
                     /gene="Nanos3"
                     /gene_synonym="nos3"
                     /note="isoform 2 is encoded by transcript variant 2; nanos
                     homolog 3"
                     /codon_start=1
                     /product="nanos homolog 3 isoform 2"
                     /protein_id="NP_001344290.1"
                     /db_xref="CCDS:CCDS90425.1"
                     /db_xref="GeneID:244551"
                     /db_xref="MGI:MGI:2675387"
                     /translation="MGTFNLWTDYLGLARLVGALHKEEELDVRLDPKPEPKPSSESQQ
                     ASKESSAAPERLCSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATQEHA
                     HTRRFCPLTSQGYTSVYCYTTRNSAGKKLTRPDKAKTQDAGHRLGGEAAAGSKSGRKP
                     PGPSPSACCPSTTA"
     exon            479..692
                     /gene="Nanos3"
                     /gene_synonym="nos3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctctgctcc tctgcccagc catggggact ttcaatcttt ggacagatta cctaggtctg
       61 gcaagactgg ttggggctct gcataaggaa gaggagcttg atgtaaggct ggatcccaaa
      121 ccagagccca agccaagttc agaaagccag caagccagca aggaatcctc tgcagctcct
      181 gaacgcttat gttcattctg caaacacaat ggcgagtccc gtgccatcta tcagtcccat
      241 gtcctgaagg atgaggcagg gcgggtgctg tgtcccattt tgcgggatta tgtgtgtccc
      301 cagtgtgggg ccactcagga gcatgcccac actcgacgct tttgcccact caccagccag
      361 ggctacactt ctgtctactg ctacaccacc cggaattctg caggcaaaaa gctgacccgg
      421 cctgacaagg caaagacaca ggatgctggc caccgccttg gaggagaagc agcagcaggt
      481 tccaaaagtg gcaggaagcc ccctggacct tcaccctcgg cctgctgtcc ctccactacg
      541 gcctaggagc ttggagtggg gaggaccatg gtggcatcgt tgccaagggt ctggacacag
      601 gcatgctgga gactggacct tgcttaggac tgaggctggc cacagtcttg tcagcgatca
      661 ccttccccac ccctacttgt ggtgttgcct ca
//
