LOCUS       NM_194064               1439 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nanos C2HC-type zinc finger 2 (Nanos2), mRNA.
ACCESSION   NM_194064
VERSION     NM_194064.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1439)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1439)
  AUTHORS   Singh,N., Singh,D., Bhide,A., Sharma,R., Bhowmick,S., Patel,V. and
            Modi,D.
  TITLE     LHX2 in germ cells control tubular organization in the developing
            mouse testis
  JOURNAL   Exp Cell Res 425 (1), 113511 (2023)
   PUBMED   36796745
REFERENCE   3  (bases 1 to 1439)
  AUTHORS   Hirano,T., Wright,D., Suzuki,A. and Saga,Y.
  TITLE     A cooperative mechanism of target RNA selection via
            germ-cell-specific RNA-binding proteins NANOS2 and DND1
  JOURNAL   Cell Rep 39 (11), 110894 (2022)
   PUBMED   35705038
  REMARK    GeneRIF: A cooperative mechanism of target RNA selection via
            germ-cell-specific RNA-binding proteins NANOS2 and DND1.
REFERENCE   4  (bases 1 to 1439)
  AUTHORS   Inoue,H., Sakurai,T., Hasegawa,K., Suzuki,A. and Saga,Y.
  TITLE     NANOS3 suppresses premature spermatogonial differentiation to
            expand progenitors and fine-tunes spermatogenesis in mice
  JOURNAL   Biol Open 11 (4) (2022)
   PUBMED   35394008
REFERENCE   5  (bases 1 to 1439)
  AUTHORS   Kong,X., Fei,Q., Pan,C., Jin,J., Zheng,J., Wu,D., Li,H. and
            Huang,X.
  TITLE     LncRNA HOTAIR promotes proliferation and suppresses apoptosis of
            mouse spermatogonium GC-1 cells by sponging miR-761 to modulate
            NANOS2 expression
  JOURNAL   In Vitro Cell Dev Biol Anim 58 (4), 295-306 (2022)
   PUBMED   35426065
REFERENCE   6  (bases 1 to 1439)
  AUTHORS   Suzuki,A. and Saga,Y.
  TITLE     Nanos2 suppresses meiosis and promotes male germ cell
            differentiation
  JOURNAL   Genes Dev 22 (4), 430-435 (2008)
   PUBMED   18281459
REFERENCE   7  (bases 1 to 1439)
  AUTHORS   Suzuki,A., Tsuda,M. and Saga,Y.
  TITLE     Functional redundancy among Nanos proteins and a distinct role of
            Nanos2 during male germ cell development
  JOURNAL   Development 134 (1), 77-83 (2007)
   PUBMED   17138666
REFERENCE   8  (bases 1 to 1439)
  AUTHORS   Tsuda,M., Kiso,M. and Saga,Y.
  TITLE     Implication of nanos2-3'UTR in the expression and function of
            nanos2
  JOURNAL   Mech Dev 123 (6), 440-449 (2006)
   PUBMED   16806845
  REMARK    GeneRIF: nanos2 plays a role in the maintenance and differentiation
            of gonocytes/spermatogonia in neonatal testes
REFERENCE   9  (bases 1 to 1439)
  AUTHORS   Vissers,Y.L., Hallemeesch,M.M., Soeters,P.B., Lamers,W.H. and
            Deutz,N.E.
  TITLE     NOS2 deficiency increases intestinal metabolism both in
            nonstimulated and endotoxemic mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 286 (5), G747-G751 (2004)
   PUBMED   14656712
  REMARK    GeneRIF: Both in baseline conditions and during endotoxemia, the
            absence of NOS2 upregulated NOS1 and/or NOS3, which increased
            intestinal metabolism.
REFERENCE   10 (bases 1 to 1439)
  AUTHORS   Tsuda,M., Sasaoka,Y., Kiso,M., Abe,K., Haraguchi,S., Kobayashi,S.
            and Saga,Y.
  TITLE     Conserved role of nanos proteins in germ cell development
  JOURNAL   Science 301 (5637), 1239-1241 (2003)
   PUBMED   12947200
  REMARK    GeneRIF: cloning and functional analyses of nanos2 and nanos3;
            demonstrated an evolutionarily conserved function of nanos proteins
            in germ cell development [nanos2] [nanos3]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC170864.2.
            
            On Jul 27, 2007 this sequence version replaced NM_194064.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB095972.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1439              AC170864.2         98000-99438         c
FEATURES             Location/Qualifiers
     source          1..1439
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.45 cM"
     gene            1..1439
                     /gene="Nanos2"
                     /gene_synonym="nos2"
                     /note="nanos C2HC-type zinc finger 2"
                     /db_xref="GeneID:378430"
                     /db_xref="MGI:MGI:2676627"
     exon            1..1439
                     /gene="Nanos2"
                     /gene_synonym="nos2"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..492
                     /gene="Nanos2"
                     /gene_synonym="nos2"
                     /note="NOS-2"
                     /codon_start=1
                     /product="nanos homolog 2"
                     /protein_id="NP_918953.2"
                     /db_xref="CCDS:CCDS20883.1"
                     /db_xref="GeneID:378430"
                     /db_xref="MGI:MGI:2676627"
                     /translation="MDLPPFDMWRDYFNLSQVVMDIIQSRKQRQEGEVAEEPNSRPQE
                     KSEQDLEGYPGCLPTICNFCKHNGESRHVYTSHQLKTPEGVVVCPILRHYVCPLCGAT
                     GDQAHTLKYCPLNSSQQSLYRRSGRNSAGRRVKR"
     regulatory      1419..1424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nanos2"
                     /gene_synonym="nos2"
                     /note="hexamer: AATAAA"
     polyA_site      1439
                     /gene="Nanos2"
                     /gene_synonym="nos2"
                     /note="major polyA site"
ORIGIN      
        1 aaaactcctg ctcctgccct ctgacctcac agcccctgct ccccagtccc tctccagtgc
       61 ccacagccac atttaagtgc catggaccta ccgccctttg acatgtggag agactacttt
      121 aacctgagcc aggtggtgat ggatataatt cagagccgga agcaaagaca ggagggtgag
      181 gtagctgagg agcccaactc caggccccag gagaagagtg agcaggacct ggagggctac
      241 cctggatgtc tgcctaccat atgcaacttc tgcaagcaca atggggagtc tcgtcacgtc
      301 tacacctcac accagctgaa gacgcctgaa ggggtggttg tgtgtcccat cctgaggcac
      361 tatgtgtgtc ctctatgtgg agccaccggc gaccaggctc atacactcaa gtattgtcca
      421 ctcaacagca gtcagcagtc tctctaccga cgcagtgggc gaaactcagc tggtcgcaga
      481 gtcaagcgat aattgagacc ctgtgaggta cctgtcaccc acaacccaca ccctcctgct
      541 tctgacccta gtcccctctg ctctgctcac ccagcccgct ggaggtcccc cgatctcaac
      601 gttttctgtg ccttcaggat cctgaaacac tgggaaatgc tggcagccca gactgtgtgt
      661 ctcagacatt cctggtactg tgagaaccct tctccatgga ccgtgtgagt cttggtggtt
      721 tcttttggat tgtgagggcc tggtgatgac ttctcggttc ctctctaaag atcccttggg
      781 ggggaggggt ccttggattt gctatcctat agagtcagtg tgctctgaca ggccagtctt
      841 cagaacctgg ggacagtgcc agagactgat cctgatcgtc actgccaaga agtggatgtt
      901 ggtactgact atgagaccat ccatctatct tcaccttttt tcagcatctg cagactcaaa
      961 cttctccatg gaccattcac gttcagctcc ttagttcctt gaacatggcc atgtccatca
     1021 ggaataagag gaaggttaca ggaactagag gagggttggg accctctggg aaggctgcca
     1081 gacctttgta acttcagact gcctcgggtg agcagaagcc cacagatttc acttcatcac
     1141 taaccatggt tcactctatt cctgccccca gccccactcg ttgatggatc cctgactccc
     1201 ggtgggtgag agacattctc tctcttctac ccatccaata tagttgagtg tgttacgtca
     1261 gtgtgtgtcc catggtgaga agagtctgag acctcatggg actgatgact gcttaggttt
     1321 taattttagg ggcagagaag aatgccagtt gggttttatg ctatctagga ggttggcttg
     1381 gaaatgggat gagggtggag gaggggtgtc tgctgctgaa taaagcgttg ttagtctac
//
