LOCUS       NM_178421               3945 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus nanos C2HC-type zinc finger 1 (Nanos1), mRNA.
ACCESSION   NM_178421 XM_977064 XM_986182
VERSION     NM_178421.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3945)
  AUTHORS   Amadei,G., Zander,M.A., Yang,G., Dumelie,J.G., Vessey,J.P.,
            Lipshitz,H.D., Smibert,C.A., Kaplan,D.R. and Miller,F.D.
  TITLE     A Smaug2-Based Translational Repression Complex Determines the
            Balance between Precursor Maintenance versus Differentiation during
            Mammalian Neurogenesis
  JOURNAL   J Neurosci 35 (47), 15666-15681 (2015)
   PUBMED   26609159
  REMARK    GeneRIF: Both Nanos1 and Smaug2 function as a bimodal translational
            repression switch to control neurogenesis.
REFERENCE   2  (bases 1 to 3945)
  AUTHORS   Miles,W.O., Korenjak,M., Griffiths,L.M., Dyer,M.A., Provero,P. and
            Dyson,N.J.
  TITLE     Post-transcriptional gene expression control by NANOS is
            up-regulated and functionally important in pRb-deficient cells
  JOURNAL   EMBO J 33 (19), 2201-2215 (2014)
   PUBMED   25100735
REFERENCE   3  (bases 1 to 3945)
  AUTHORS   Glassmann,A., Topka,S., Wang-Eckardt,L., Anders,S., Weisheit,G.,
            Endl,E., Zimmer,A. and Schilling,K.
  TITLE     Basic molecular fingerprinting of immature cerebellar cortical
            inhibitory interneurons and their precursors
  JOURNAL   Neuroscience 159 (1), 69-82 (2009)
   PUBMED   19141316
REFERENCE   4  (bases 1 to 3945)
  AUTHORS   Kurokawa,H., Aoki,Y., Nakamura,S., Ebe,Y., Kobayashi,D. and
            Tanaka,M.
  TITLE     Time-lapse analysis reveals different modes of primordial germ cell
            migration in the medaka Oryzias latipes
  JOURNAL   Dev Growth Differ 48 (3), 209-221 (2006)
   PUBMED   16573738
REFERENCE   5  (bases 1 to 3945)
  AUTHORS   Haraguchi,S., Tsuda,M., Kitajima,S., Sasaoka,Y.,
            Nomura-Kitabayashid,A., Kurokawa,K. and Saga,Y.
  TITLE     nanos1: a mouse nanos gene expressed in the central nervous system
            is dispensable for normal development
  JOURNAL   Mech Dev 120 (6), 721-731 (2003)
   PUBMED   12834871
REFERENCE   6  (bases 1 to 3945)
  AUTHORS   Jaruzelska,J., Kotecki,M., Kusz,K., Spik,A., Firpo,M. and Reijo
            Pera,R.A.
  TITLE     Conservation of a Pumilio-Nanos complex from Drosophila germ plasm
            to human germ cells
  JOURNAL   Dev Genes Evol 213 (3), 120-126 (2003)
   PUBMED   12690449
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC085512.1 and BC056473.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_977064.1, XM_986182.1, NM_178421.2.
            
            Summary: This gene encodes a CCHC-type zinc finger protein that is
            a member of the nanos family. This protein co-localizes with the
            RNA-binding protein pumilio RNA-binding family member 2and may be
            involved in regulating translation as a post-transcriptional
            repressor. Mutations in a similar protein in human are associated
            with spermatogenic impairment. [provided by RefSeq, Sep 2015].
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1982              BC085512.1         1-1982
            1983-3116           BC056473.1         1670-2803
            3117-3395           BC085512.1         3117-3395
            3396-3945           BC056473.1         3083-3632
FEATURES             Location/Qualifiers
     source          1..3945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 56.52 cM"
     gene            1..3945
                     /gene="Nanos1"
                     /gene_synonym="NOS-1"
                     /note="nanos C2HC-type zinc finger 1"
                     /db_xref="GeneID:332397"
                     /db_xref="MGI:MGI:2669254"
     exon            1..3928
                     /gene="Nanos1"
                     /gene_synonym="NOS-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1083
                     /gene="Nanos1"
                     /gene_synonym="NOS-1"
                     /note="nanos 1"
                     /codon_start=1
                     /product="nanos homolog 1"
                     /protein_id="NP_848508.2"
                     /db_xref="CCDS:CCDS29941.1"
                     /db_xref="GeneID:332397"
                     /db_xref="MGI:MGI:2669254"
                     /translation="MEAFPWAPRSPRRARAPAPMALVPSARYVSASGPVHPQPFSSWN
                     DYLGLATLITRASDRGSPHEGPGPTAAGPTMGPPEDDEDDDGEEPEAGGRYLGGALEL
                     RALELCAGPAEPGLLEERFAELNPFAGRAAAVLLGCAPTASTTAAAASTAEVTPREEP
                     SPAWAAEPRLHAASGATAARLLKPELQVCVFCRNNKEAVALYTTHILKGPDGRVLCPV
                     LRRYTCPLCGASGDNAHTIKYCPLSKVPPPTVRPPPRSNRDSLPSKKLR"
     regulatory      3899..3904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nanos1"
                     /gene_synonym="NOS-1"
                     /note="hexamer: ATTAAA"
     polyA_site      3928
                     /gene="Nanos1"
                     /gene_synonym="NOS-1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcagcgc acggggcgca ggaaacgcgc ggggctggag aagagcgcgc gcccgcctcc
       61 gctccgcctc cgtccggggg cgcgggcgca gtggcccggg cggaggatcg cagggggcag
      121 ggccgagaca gcgaggaggg gcacaggaga aagcgggagc gataaaagga agcaaggctg
      181 ccctacccca cggcaggccg gcgggcaagc tcctgcgtcc cttccgtctg gcccttgccg
      241 gcggcggcgg cggggaggcg cgcggcccgc tgccggccca tggaggcttt cccttgggcg
      301 ccacgctcgc cccgccgcgc ccgcgccccc gcgcctatgg cgctcgtgcc cagcgcccgc
      361 tacgtgagcg cctcgggccc ggtgcacccg cagcccttca gctcctggaa cgactacctg
      421 gggcttgcca cgctcatcac cagggctagc gaccgcggct ccccgcatga ggggcccggg
      481 cccacggcgg cggggcccac gatggggccg cccgaggacg atgaagacga tgacggcgaa
      541 gagccggagg ccgggggccg ctacctgggc ggtgcgttgg aactgcgcgc actagagctg
      601 tgtgccggcc ccgctgagcc cgggttgctg gaggagcgct tcgctgagct gaacccgttt
      661 gcagggcgcg ccgccgcggt tctgctgggc tgcgcgccca ccgcctccac caccgccgcc
      721 gccgcatcca cggccgaagt gacgccgcgc gaagagccaa gccctgcgtg ggctgccgag
      781 cctcgtctgc acgcggcttc cggggcgacc gccgcacgtc tgctgaaacc ggagcttcag
      841 gtgtgtgtgt tttgccggaa caacaaggag gcggtggcgc tctacaccac acacatcctc
      901 aagggcccgg acggccgggt gctgtgcccg gtcttgcgcc gctacacgtg ccccctgtgc
      961 ggcgccagcg gcgacaacgc acataccatc aagtattgcc cgctctccaa agtgccaccg
     1021 cccaccgtcc gcccgccgcc gcgcagcaac agggacagcc tgcccagcaa gaagctgcgc
     1081 taggagcggg ctgcatcaag ctgtgtacac ctgaaacctg cgctcctctc ccttgcctca
     1141 atttgggaag tcgtcttgat tttacggaag ccgcaggagc gcagcacttt cttgtggagt
     1201 ggtcggtctc tgacgttgaa atcttgaatt ttgtccctag tttctaaaac gcgcatccag
     1261 aacggtgagg gctgagcggg tgtaccaccg gttgagttgc ggtgaatgag gcgctgttta
     1321 ctgtatacgt cggcctagtt taggtgcgca accgtatgaa attgtctctc atcttggatg
     1381 tttcgtttta tgaatggagg cactttataa cgtctaaagt atttttaata gcctctgaac
     1441 tgagtgtaaa actaacaatt gtatggaatg tcggcaaaat gacttttatt gtttgatgca
     1501 attaatttat tttagtttgt cattctaatt gcaggtaaag caacttagtg cacttcccag
     1561 tattgagagg gtgttcttcc tcgtggcttg tttctgtcct agatgggagg cttaaaggca
     1621 caatctgtag caggtagaat acagttcctt atccttttat gcatcagata ttctgaatta
     1681 gcaagtagtc tttccaatcc ttaaaattaa ctgtgccaag gcttaatcat atcgtgtaca
     1741 tatttggaaa cggtgctgtt tgagagacgt gtatttatac agtgacagta ttatgaatcc
     1801 attaatctcc ccagtaactc ctgcttagca ttttctctat gcactacccc gatggtccaa
     1861 ttctttgtgt ctgatgctaa gacatttcct cctcagaaag gaggaaacct atttagagca
     1921 gtgttaaccc accttgattg ctcaagttca gggttcctaa atagaaaatg gggaactata
     1981 atgcaataac tcgagttcca aaaggttcta ctctgggctg tttgcctttc aatttacaga
     2041 gggtgtgcca gaataaacca cttcaagtct gtctcattaa ctccctcttg gtggttccac
     2101 tattactgag acccttgtct gcttccagaa ccccaaaaga tcttcatgca aagttcctct
     2161 ttccagtact cctgtaaatc tatcatagtg agtgctggaa tatggcacaa aactacctac
     2221 catctagaca gaagaggcaa aggtaaaggt gaattaagat aaattcagcc atgcatcaac
     2281 accactatct gctaatacca gccaagagtt taagtatata atgtttgcaa tagtcagatt
     2341 tagctaggaa tactgggagt taggctagac tgcctttcgt attaagtagc aactttacag
     2401 caaacttact ttctgtataa aaagaggctg gtgtgaaaat acagctgtta gccctattgg
     2461 taaaagggag gactttcttc acaaggaaga aaactatccc tgttagttat agccccacat
     2521 tcactgggcc taggcctgaa tgtaataaaa cgttgttatt ttgctagaaa atatactact
     2581 tgttttgagg tgaagttttt caagtcaaca taaattcaca tcctctagct aatctgcctt
     2641 ttcaaaaagg tattctcaat gtcaaaagca aaatcaagtc agattgctgt aatcccatca
     2701 gatatttccc aaggcacgta tgtatggtgc cagtatttaa gcacatgagc tgaaccatga
     2761 ccacatgtac ctaatgccaa cttttaattt tcggcatctt accagaacta aaggctgctg
     2821 aaactggcat tcttgtccca tggtattgag agggctcttg gaaaatatca aactaagtag
     2881 ctgttatatt aacagggaga cagctgtcag aaaagcgctt ctaaacacaa ggacccaagt
     2941 tctatcccca gcatctacat aagggaatag tggtatgcct ataaccccag tgctcacgag
     3001 gcagaggcca gccacgctac atggatgggc tccaggtctg agtgaaaaac atgatctcat
     3061 aagctagatg gttgtctgaa gttggacctc cacattcatc tgcagatttg gggtaattta
     3121 agccaaaggt agctatgatt gcatcactgg ggacactagc aaggcagtct agctccaggt
     3181 atggaaaaac ccagattcaa aagaaacatc ttgtttgaag aaaaggagaa tatgattgag
     3241 tagggcaacc cttgacctct gacctccatg tgcttgcaca cagtagtgac cacacaaaac
     3301 tgtatcccac atggtgttct ccaacccatg ccaagtctgt gtttcccagc taacagatac
     3361 tgaaagtgta cagccaaaaa aaaaaaaaaa aaaaagaaaa agtacttgtt tttctagtgt
     3421 tctagagaaa ataaacttag ccctaaaaat aaccaatcct ttaatcctga cactcaggaa
     3481 gtagaggaag gcttggaatg caatgttata aaggttttgc aaaattgttt acagtagaca
     3541 tccaagttta gggccatggg tatagctcaa tgatagagca cttgcctaga atgcacaaaa
     3601 ccctagaatg ccattaaagg gacaaaaatg aaacttaaaa cccaaagttt catataacac
     3661 tttgataaag ttggcttctg cctaagaaag cactgtggat ctggctagac cacaaaaagg
     3721 gacagcattg taacagcttc accatgggca gaaaggcaca ggttgtgctg tgctttagcc
     3781 tgcatttgtc tatccaaact tgctagtttt atcggctttt tacttttttg tactttattt
     3841 ttcctataaa gtccttttca gaagttaaat ggctttgatt ataacttttg ttagatatat
     3901 taaaccaaaa ccatgtattt caaaactaaa aaaaaaaaaa aaaaa
//
