LOCUS       NM_021524               4547 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus nicotinamide phosphoribosyltransferase (Nampt), mRNA.
ACCESSION   NM_021524
VERSION     NM_021524.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4547)
  AUTHORS   Hattori,K., Kobayashi,K., Azuma-Suzuki,R., Iwasa,K., Higashi,S.,
            Hamaguchi,T., Saito,Y., Morifuji,M. and Nabeshima,Y.I.
  TITLE     Nicotinamide phosphoribosyl transferase in mammary gland epithelial
            cells is required for nicotinamide mononucleotide production in
            mouse milk
  JOURNAL   Biochem Biophys Res Commun 728, 150346 (2024)
   PUBMED   38972085
  REMARK    GeneRIF: Nicotinamide phosphoribosyl transferase in mammary gland
            epithelial cells is required for nicotinamide mononucleotide
            production in mouse milk.
REFERENCE   2  (bases 1 to 4547)
  AUTHORS   Qi,N., Franczyk,M.P., Yamaguchi,S., Kojima,D., Hayashi,K.,
            Satoh,A., Ogiso,N., Kanda,T., Sasaki,Y., Finck,B.N., DeBosch,B.J.
            and Yoshino,J.
  TITLE     Adipocyte-specific inactivation of NAMPT, a key NAD+ biosynthetic
            enzyme, causes a metabolically unhealthy lean phenotype in female
            mice during aging
  JOURNAL   Am J Physiol Endocrinol Metab 327 (1), E81-E88 (2024)
   PUBMED   38809511
  REMARK    GeneRIF: Adipocyte-specific inactivation of NAMPT, a key NAD[+]
            biosynthetic enzyme, causes a metabolically unhealthy lean
            phenotype in female mice during aging.
REFERENCE   3  (bases 1 to 4547)
  AUTHORS   Iwatani,Y., Hayashi,H., Oba,H., Oba,M., Sawamura,A., Moriyama,Y.
            and Takagi,N.
  TITLE     Possible involvement of NAMPT in neuronal survival in cerebral
            ischemic injury under high-glucose conditions through the
            FoxO3a/LC3 pathway
  JOURNAL   Biomed Pharmacother 176, 116778 (2024)
   PUBMED   38788601
  REMARK    GeneRIF: Possible involvement of NAMPT in neuronal survival in
            cerebral ischemic injury under high-glucose conditions through the
            FoxO3a/LC3 pathway.
REFERENCE   4  (bases 1 to 4547)
  AUTHORS   Chen,Y., Wang,T., Liang,F., Han,J., Lou,Z., Yu,Y., Li,J., Zhan,T.,
            Gu,Y., Dong,L., Jiang,B., Zhang,W., Wu,M. and Lu,Y.
  TITLE     Nicotinamide phosphoribosyltransferase prompts bleomycin-induced
            pulmonary fibrosis by driving macrophage M2 polarization in mice
  JOURNAL   Theranostics 14 (7), 2794-2815 (2024)
   PUBMED   38773984
  REMARK    GeneRIF: Nicotinamide phosphoribosyltransferase prompts
            bleomycin-induced pulmonary fibrosis by driving macrophage M2
            polarization in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4547)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4547)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 4547)
  AUTHORS   Revollo,J.R., Grimm,A.A. and Imai,S.
  TITLE     The NAD biosynthesis pathway mediated by nicotinamide
            phosphoribosyltransferase regulates Sir2 activity in mammalian
            cells
  JOURNAL   J Biol Chem 279 (49), 50754-50763 (2004)
   PUBMED   15381699
  REMARK    GeneRIF: NAD biosynthesis mediated by Nampt regulates the function
            of Sir2alpha and plays an important role in controlling various
            biological events in mammals
REFERENCE   8  (bases 1 to 4547)
  AUTHORS   Kitani,T., Okuno,S. and Fujisawa,H.
  TITLE     Growth phase-dependent changes in the subcellular localization of
            pre-B-cell colony-enhancing factor
  JOURNAL   FEBS Lett 544 (1-3), 74-78 (2003)
   PUBMED   12782293
REFERENCE   9  (bases 1 to 4547)
  AUTHORS   Rongvaux,A., Shea,R.J., Mulks,M.H., Gigot,D., Urbain,J., Leo,O. and
            Andris,F.
  TITLE     Pre-B-cell colony-enhancing factor, whose expression is
            up-regulated in activated lymphocytes, is a nicotinamide
            phosphoribosyltransferase, a cytosolic enzyme involved in NAD
            biosynthesis
  JOURNAL   Eur J Immunol 32 (11), 3225-3234 (2002)
   PUBMED   12555668
  REMARK    GeneRIF: Pre-B-cell colony-enhancing factor, whose expression is
            up-regulated in activated lymphocytes, is a nicotinamide
            phosphoribosyltransferase, a cytosolic enzyme involved in NAD
            biosynthesis.
REFERENCE   10 (bases 1 to 4547)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT572998.9, BY068469.1, AK086415.1 and CV561474.1.
            
            On Sep 3, 2009 this sequence version replaced NM_021524.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018358.1, AF234625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CT572998.9         114035-114044
            11-170              BY068469.1         2-161
            171-1339            AK086415.1         2-1170
            1340-1840           CV561474.1         197-697
            1841-4547           CT572998.9         144363-147069
FEATURES             Location/Qualifiers
     source          1..4547
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.74 cM"
     gene            1..4547
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /note="nicotinamide phosphoribosyltransferase"
                     /db_xref="GeneID:59027"
                     /db_xref="MGI:MGI:1929865"
     exon            1..292
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1711
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /EC_number="2.4.2.12"
                     /note="pre-B-cell colony-enhancing factor 1 homolog"
                     /codon_start=1
                     /product="nicotinamide phosphoribosyltransferase"
                     /protein_id="NP_067499.2"
                     /db_xref="CCDS:CCDS25871.1"
                     /db_xref="GeneID:59027"
                     /db_xref="MGI:MGI:1929865"
                     /translation="MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKT
                     ENSKVRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWN
                     YILEKYDGHLPIEVKAVPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPIT
                     VATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGT
                     DTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSV
                     VSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPV
                     TENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKKWSIENVSFGSGGALLQKLTR
                     DLLNCSFKCSYVVTNGLGVNVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDL
                     EEYGHDLLHTVFKNGKVTKSYSFDEVRKNAQLNIEQDVAPH"
     exon            293..449
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /inference="alignment:Splign:2.1.0"
     exon            450..553
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /inference="alignment:Splign:2.1.0"
     exon            554..682
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /inference="alignment:Splign:2.1.0"
     exon            683..841
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /inference="alignment:Splign:2.1.0"
     exon            842..978
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1204
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1324
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1465
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1600
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..4547
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2257..2262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /note="hexamer: AATAAA"
     polyA_site      2278
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /note="major polyA site"
     regulatory      2776..2781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /note="hexamer: ATTAAA"
     polyA_site      2786
                     /gene="Nampt"
                     /gene_synonym="1110035O14Rik; NAmPRTase; Pbef; Pbef1;
                     Visfatin"
                     /note="major polyA site"
ORIGIN      
        1 cggagccgcc gggaaagccg ccggagcgcg ctgggcaggg gagcgcgcta gcctccaccg
       61 ccgcgtcacg gacctgcccg ccctcccggc ccctccccgc gctccgttcc ctgctctccc
      121 gcccccctgc gagcgagcgg tgacttaagc aacggagcgc agcgaagccc atttttctcc
      181 ttgctcgcag ccgcgccggg cagctcgtgg cgcggcgtct ccgctccggc ccgagatgaa
      241 tgctgcggca gaagccgagt tcaacatcct gctggccacc gactcgtaca aggttactca
      301 ctataaacaa tacccaccca acacaagcaa agtttattcc tactttgaat gccgtgaaaa
      361 gaagacagaa aactccaaag taaggaaggt gaaatacgag gaaacagtat tttatgggtt
      421 gcagtacatt cttaataagt acttaaaagg taaagtagtg accaaagaga aaatccagga
      481 ggccaaagaa gtgtacagag aacatttcca agatgatgtc tttaacgaaa gaggatggaa
      541 ctacatcctt gagaaatacg atggtcatct cccgattgaa gtaaaggctg ttcccgaggg
      601 ctctgtcatc cccagaggga acgtgctgtt cacagtggaa aacacagacc cagagtgcta
      661 ctggcttacc aattggattg agactattct tgttcagtcc tggtatccaa ttacagtggc
      721 cacaaattcc agagaacaga agaaaatact ggccaaatat ttgttagaaa cctctggtaa
      781 cttagatggt ctggaataca agttacatga ctttggttac agaggagtct cttcgcaaga
      841 gactgctggc ataggggcat ctgctcattt ggttaacttt aaaggaacag atactgtggc
      901 gggaattgct ctaattaaaa aatactatgg gacaaaagat cctgttccag gctattctgt
      961 tccagcagca gagcacagta ccataacggc ttgggggaaa gaccatgaga aagatgcttt
     1021 tgaacacata gtaacacagt tctcatcagt gcctgtgtct gtggtcagcg atagctatga
     1081 catttataat gcgtgtgaga aaatatgggg tgaagacctg agacatctga tagtatcgag
     1141 aagtacagag gcaccactaa tcatcagacc tgactctgga aatcctcttg acactgtatt
     1201 gaaggtctta gatattttag gcaagaagtt tcctgttact gagaactcaa aaggctacaa
     1261 gttgctgcca ccttatctta gagtcattca aggagatggc gtggatatca atactttaca
     1321 agagattgta gagggaatga aacaaaagaa gtggagtatc gagaatgtct ccttcggttc
     1381 tggtggcgct ttgctacaga agttaacccg agacctcttg aattgctcct tcaagtgcag
     1441 ctatgttgta accaatggcc ttggggttaa tgtgtttaag gacccagttg ctgatcccaa
     1501 caaaaggtca aaaaagggcc ggttatcttt acataggaca ccagcgggga actttgttac
     1561 acttgaagaa ggaaaaggag accttgagga atatggccat gatcttctcc atacggtttt
     1621 caagaatggg aaggtgacaa aaagctactc atttgatgaa gtcagaaaaa atgcacagct
     1681 gaacatcgag caggacgtgg cacctcatta ggcttcatgt ggccgggttg ttatgtgtgc
     1741 agtgtgtgta tacatacatg cacgtatgtg tgcgcctgtg cgtatgtact aacatgttca
     1801 ttgtacagat gtgtgggttc gtgtttatga tacactgcag ccagattatt tgttggttta
     1861 tggacatact gcccttttta tttttctccc agtgtttaga tgatctcaga ttagaaaaca
     1921 cttacaacca tgtacaagat taatgctgaa gcaagctttt cagggtcctt tgctaataga
     1981 tagtaatcca atctggtgtt gatcttttca caaataacaa accaagaaac ttttatatat
     2041 aactacagat cacataaaac agatttgcat aaaattacca tgcctgcttt atgtttatat
     2101 ttaacttgta tttttgtaca aacgagattg tgtaagatat atttaaagtt tcagtgattt
     2161 accagtctgt ttccaacttt tcatgatttt tatgagcaca gactttcaag aaaatacttg
     2221 aaataaatta cattgccttt tgtccattaa tcagcaaata aaacatggcc ttaaccaagt
     2281 tgtttgtggt gttgtacatt tgcaaattat gtcaggacag acagacaccc aacagagttc
     2341 cgaacatcac tgcccttgta gagtatgcag cagtcattct ccgtggaaga gaagaatggt
     2401 tcttacgcga atgtttaggc attgtacagt tctgtgccct ggtcagtgta tgtaccagtg
     2461 atgccaaatc ccaaaggcct gttctgcaat tttatatgtt ggatattgcc tgtggctcta
     2521 atatgcacct caagatttta agaagataat gtttttagag agaatttctg cttccactat
     2581 agaatatata cataaatgta aaatattgaa agtggaagta gtgtatttta aagtaattac
     2641 acttctgaat ttatttttca tattctatag ttggtatgtc ttaaatgaat tgctggagtg
     2701 ggtagtgagt gtacttattt taaatgtttt gattctgtta tattttcatt aagtttttta
     2761 aaaattaaat tggatattaa actgtatgga catcatttat taattttaag ttaaaccctc
     2821 agtaactaat atttaagtaa gttcttgatg ttatccccag tggaaagcct gattcttaat
     2881 agaagaatct taatacagag atttagctaa atttaagata ctcatcctca aaatgtttat
     2941 agcgatttac tgctaggtcc tgagtcagcc attgcactca acaagacacc agtctctttg
     3001 aggtgactcc taggtcacct gtaggtgaca ctacacagtt ctaagccaag gttggccagc
     3061 caacttcata ctgcttcttc atttttagtt acacactgtc taaggatgtt tcccacttcg
     3121 gtggcagaaa tagagtagtt acaatagaga ccagatagtc ctcaaagcct ggaatgttca
     3181 ctaaacacaa tcacagagag ctcgctagcc tgtgttctaa gaaaaggagc atgcgtttgc
     3241 attttaagag agatgttggt ttttctggga agggaggaag ttgaatttta cagagtacct
     3301 cttgttcttt ctcatttaag aatctgataa tagaaaactg atttagaaaa gttttcacaa
     3361 cttgccatta agatagaata ttaaaagcca tacatcatgt aaaacaattt catgaggaac
     3421 catatgaggt gaattagagg ggttagcagg tgatcctaag acttggaaca gtaagcatta
     3481 ctcattttta gtaatcttta ttttgtaata catgaaaaaa atcttaaact gactttaaaa
     3541 agtggaactt gagtagtgtg gtcatggtgt atacactaca atgcctgtaa tcccagaaat
     3601 gaggtagaca cagggatcgg aaaccaacat cattcttgac tacataacaa attttaggct
     3661 agcccgcact acctggctca agaaaaaatg tacctgagat tagtagtact gcagagacat
     3721 gtcctgcatg ggtataggca tagccagtac ctgagacttt atacacagga ggtttgttaa
     3781 gttcaaaacc agtctgagct taaatagacc cttgagtctc ctcctcttca caaaggcttg
     3841 tagagtacta cacaaaaccc attggtgtca tactacaagc agtgtttttg tgttgtgtga
     3901 attccaccgg ctgcacatgc cagttttgtt tagaagcatg tagtataaac tagtagcttc
     3961 catttgtgca cagaatgggt ctagagatgg aaggagtcat gtctcttggc tccagtcccc
     4021 ttggaacggg ttcattttgg atttctgtca cttagcagta tttggccatc ccccttctga
     4081 gtaccaaatg gttaacatga atgtcaaatt gagttgattt gcgtgtcacc cttagattgg
     4141 actagctctt aagacactag atttgcagtt gacattagtc ccctcaattc ataactttga
     4201 agtaggcagt agaatttgtg ttatttgtac cctctactta aagtaaaagg tttttatgag
     4261 tagccttcct ttcttgaaat gaaaagaaaa aaaagctttt ttagtgaaat ccatcatgga
     4321 aaattagaga aaaatagcaa gatgtttgtt gttgtattta ccatacctta gaactcacac
     4381 ttaaactagt attttgtagt tttacattcc tttttaactc attcagtgga gaatatcaga
     4441 ctttctccca agttgtatgt taagtcaatt ctaataatgt actcagcatc aaagacaaac
     4501 atgtaataaa catggaaata aagtttagtt ctgttagtga aatgtta
//
