LOCUS       NM_010870               5368 bp    mRNA    linear   ROD 07-MAY-2023
DEFINITION  Mus musculus NLR family, apoptosis inhibitory protein 5 (Naip5),
            mRNA.
ACCESSION   NM_010870 XM_916667
VERSION     NM_010870.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5368)
  AUTHORS   Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma BR,
            Balakrishnan A, Malireddi RKS, Geiger R, Zhu Q, Neale G and
            Kanneganti TD.
  TITLE     IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome
            Activation
  JOURNAL   Cell 173 (4), 920-933 (2018)
   PUBMED   29576451
REFERENCE   2  (bases 1 to 5368)
  AUTHORS   Yang X, Yang F, Wang W, Lin G, Hu Z, Han Z, Qi Y, Zhang L, Wang J,
            Sui SF and Chai J.
  TITLE     Structural basis for specific flagellin recognition by the NLR
            protein NAIP5
  JOURNAL   Cell Res 28 (1), 35-47 (2018)
   PUBMED   29182158
REFERENCE   3  (bases 1 to 5368)
  AUTHORS   Van Opdenbosch N, Van Gorp H, Verdonckt M, Saavedra PHV, de
            Vasconcelos NM, Goncalves A, Vande Walle L, Demon D, Matusiak M,
            Van Hauwermeiren F, D'Hont J, Hochepied T, Krautwald S, Kanneganti
            TD and Lamkanfi M.
  TITLE     Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress
            ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b
            and NLRC4
  JOURNAL   Cell Rep 21 (12), 3427-3444 (2017)
   PUBMED   29262324
REFERENCE   4  (bases 1 to 5368)
  AUTHORS   Tenthorey JL, Haloupek N, Lopez-Blanco JR, Grob P, Adamson E,
            Hartenian E, Lind NA, Bourgeois NM, Chacon P, Nogales E and Vance
            RE.
  TITLE     The structural basis of flagellin detection by NAIP5: A strategy to
            limit pathogen immune evasion
  JOURNAL   Science 358 (6365), 888-893 (2017)
   PUBMED   29146805
  REMARK    GeneRIF: Six distinct NAIP5 domains contact multiple conserved
            regions of flagellin, prying NAIP5 into an open and active
            conformation.
REFERENCE   5  (bases 1 to 5368)
  AUTHORS   Zhao Y, Shi J, Shi X, Wang Y, Wang F and Shao F.
  TITLE     Genetic functions of the NAIP family of inflammasome receptors for
            bacterial ligands in mice
  JOURNAL   J Exp Med 213 (5), 647-656 (2016)
   PUBMED   27114610
  REMARK    GeneRIF: These results provide definitive genetic evidence for the
            important physiological function of NAIPs in antibacterial defense
            and inflammatory damage-induced lethality in mice.
REFERENCE   6  (bases 1 to 5368)
  AUTHORS   Dietrich WF, Damron DM, Isberg RR, Lander ES and Swanson MS.
  TITLE     Lgn1, a gene that determines susceptibility to Legionella
            pneumophila, maps to mouse chromosome 13
  JOURNAL   Genomics 26 (3), 443-450 (1995)
   PUBMED   7607666
REFERENCE   7  (bases 1 to 5368)
  AUTHORS   Brieland J, Freeman P, Kunkel R, Chrisp C, Hurley M, Fantone J and
            Engleberg C.
  TITLE     Replicative Legionella pneumophila lung infection in
            intratracheally inoculated A/J mice. A murine model of human
            Legionnaires' disease
  JOURNAL   Am J Pathol 145 (6), 1537-1546 (1994)
   PUBMED   7992856
REFERENCE   8  (bases 1 to 5368)
  AUTHORS   Yamamoto Y, Klein TW and Friedman H.
  TITLE     Genetic control of macrophage susceptibility to infection by
            Legionella pneumophila
  JOURNAL   FEMS Microbiol Immunol 4 (3), 137-145 (1992)
   PUBMED   1575991
REFERENCE   9  (bases 1 to 5368)
  AUTHORS   .
  TITLE     29th national meeting. Society for Leukocyte Biology. Charleston,
            South Carolina, December 2-5, 1992. Program and abstracts
  JOURNAL   J Leukoc Biol Suppl 3, 1-63 (1992)
   PUBMED   1392410
REFERENCE   10 (bases 1 to 5368)
  AUTHORS   Yoshida S, Goto Y, Mizuguchi Y, Nomoto K and Skamene E.
  TITLE     Genetic control of natural resistance in mouse macrophages
            regulating intracellular Legionella pneumophila multiplication in
            vitro
  JOURNAL   Infect Immun 59 (1), 428-432 (1991)
   PUBMED   1987055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY204731.1, AF135492.1 and BC070433.1.
            
            [WARNING] On Dec 8, 2023 this sequence was replaced by NM_010870.3.
            
            On Jan 25, 2007 this sequence version replaced NM_010870.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF135492.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               BY204731.1         1-144
            145-944             AF135492.1         131-930
            945-4639            BC070433.1         759-4453
            4640-5368           BC070433.1         4455-5183
FEATURES             Location/Qualifiers
     source          1..5368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.05 cM"
     gene            1..5368
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /note="NLR family, apoptosis inhibitory protein 5"
                     /db_xref="GeneID:17951"
                     /db_xref="MGI:MGI:1298220"
     exon            1..89
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            90..781
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..4425
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /note="Legionella, susceptiblility 1; neuronal apoptosis
                     inhibitory protein 5; neuronal apoptosis inhibitory
                     protein, related sequence 3; baculoviral IAP
                     repeat-containing 1e"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 1e"
                     /protein_id="NP_035000.2"
                     /db_xref="CCDS:CCDS26727.1"
                     /db_xref="GeneID:17951"
                     /db_xref="MGI:MGI:1298220"
                     /translation="MAEHGESSEDRISEIDYEFLPELSALLGVDAFQVAKSQEEEEHK
                     ERMKMKKGFNSQMRSEAKRLKTFETYDTFRSWTPQEMAAAGFYHTGVRLGVQCFCCSL
                     ILFGNSLRKLPIERHKKLRPECEFLQGKDVGNIGKYDIRVKRPEKMLRGGKARYHEEE
                     ARLESFEDWPFYAHGTSPRVLSAAGFVFTGKRDTVQCFSCGGSLGNWEEGDDPWKEHA
                     KWFPKCEFLQSKKSSEEIAQYIQSYEGFVHVTGEHFVKSWVRRELPMVSAYCNDSVFA
                     NEELRMDMFKDWPQESPVGVEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEGDDPMED
                     HIKFFPECVFLQTLKSSAEVIPTLQSQYALPEATETTRESNHGDAAAVHSTVVDLGRS
                     EAQWFQEARSLSEQLRDNYTKATFRHMNLPEVCSSLGTDHLLSCDVSIISKHISQPVQ
                     EALTIPEVFSNLNSVMCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSS
                     ITPDQGLANIICAQLLGAGGCISEVCLSSSIQQLQHQVLFLLDDYSGLASLPQALHTL
                     ITKNYLSRTCLLIAVHTNRVRDIRLYLGTSLEIQEFPFYNTVSVLRKFFSHDIICVEK
                     LIIYFIDNKDLQGVYKTPLFVAAVCTDWIQNASAQDKFQDVTLFQSYMQYLSLKYKAT
                     AEPLQATVSSCGQLALTGLFSSCFEFNSDDLAEAGVDEDEKLTTLLMSKFTAQRLRPV
                     YRFLGPLFQEFLAAVRLTELLSSDRQEDQDLGLYYLRQIDSPLKAINSFNIFLYYVSS
                     HSSSKAAPTVVSHLLQLVDEKESLENMSENEDYMKLHPQTFLWFQFVRGLWLVSPESS
                     SSFVSEHLLRLALIFAYESNTVAECSPFILQFLRGKTLALRVLNLQYFRDHPESLLLL
                     RSLKVSINGNKMSSYVDYSFKTYFENLQPPAIDEEYTSAFEHISEWRRNFAQDEEIIK
                     NYENIRPRALPDISEGYWKLSPKPCKIPKLEVQVNNTDAADQALLQVLMEVFSASQSI
                     EFRLFNSSGFLESICPALELSKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETN
                     QLPEQLFHNLHKFLGLKELCVRLDGKPNVLSVLPREFPNLLHMEKLSIQTSTESDLSK
                     LVKFIQNFPNLHVFHLKCDFLSNCESLMAVLASCKKLREIEFSGRCFEAMTFVNILPN
                     FVSLKILNLKDQQFPDKETSEKFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQL
                     PCLRVLTFHDILDDDSVIEIARAATSGGFQKLENLDISMNHKITEEGYRNFFQALDNL
                     PNLQELNICRNIPGRIQVQATTVKALGQCVSRLPSLIRLHMLSWLLDEEDMKVINDVK
                     ERHPQSKRLIIFWKLIVPFSPVILE"
     exon            782..881
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            882..963
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1015
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1135
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1235
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1317
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1375
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..3487
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3655
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3808
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            3809..3895
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            3896..4060
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..5293
                     /gene="Naip5"
                     /gene_synonym="Birc1e; Lgn1; Naip-rs3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcccccttg ctgctgatgc tctgtgacca gctggcttcc tgatcctgcc aagccttcca
       61 tgccaccttg agatacagat cttcagagta tgaaccacgc ttgggaggag aaataaaccc
      121 caccccctgt gaagctttgg tcattgtgct catcataaga acatgagagc tgcctcgaac
      181 acccaacaac tgctcacctt tcccctttag aaaatggctg agcatgggga gtcctccgag
      241 gatcggattt ctgagattga ttatgaattt ctccccgagc tctctgctct tctcggggtg
      301 gatgcatttc aggtggcaaa gagccaagaa gaagaagagc ataaagaacg gatgaaaatg
      361 aagaaaggtt ttaactcaca gatgcgcagt gaagccaaac gactaaagac ctttgagacc
      421 tatgacacgt tcagatcatg gacgccacag gagatggcag ctgctgggtt ttaccacaca
      481 ggggtgagac ttggcgttca gtgcttttgc tgtagcttga tcctctttgg taacagcctc
      541 aggaagcttc ccatagagag acacaagaaa ttacgtccgg aatgtgagtt ccttcagggc
      601 aaagatgttg gtaacattgg caagtatgac atccgggtga agaggccaga gaagatgctg
      661 agaggtggca aagccaggta ccatgaagag gaggccagac tggagtcctt tgaggactgg
      721 ccattttatg cccatgggac atcaccacgt gtactctcag cagctggctt tgtctttaca
      781 ggtaaaaggg acactgtgca gtgtttctcc tgtggcggaa gcttgggcaa ctgggaagaa
      841 ggagatgacc cctggaagga gcatgccaag tggttcccca aatgtgaatt tcttcaaagt
      901 aagaaatcct cagaggaaat tgcccagtat attcaaagct acgagggatt tgttcatgta
      961 acgggagaac attttgtgaa gtcctgggtc agaagagaat tacctatggt atcagcttac
     1021 tgcaatgaca gtgtcttcgc taatgaagaa ctaaggatgg acatgtttaa ggactggccc
     1081 caagaatcac ctgtgggtgt tgaagctcta gtcagagcag gctttttcta cactggcaaa
     1141 aaggacattg tccggtgttt ttcctgtgga ggatgtttgg aaaagtgggc agaaggtgac
     1201 gacccaatgg aagatcacat caagtttttt cccgaatgtg tatttcttca aaccttgaag
     1261 tcctctgcag aagtaattcc aacccttcag agccaatatg cacttccaga agccacggaa
     1321 accacacgtg aaagcaacca tggtgatgca gcagcagttc attctacagt ggtggacttg
     1381 ggtaggagtg aagcccagtg gtttcaagag gccaggagtc tgagtgagca gctaagagac
     1441 aactacacta aagccacttt ccgccacatg aacttgccag aagtgtgctc cagccttggc
     1501 actgaccact tgctcagctg cgatgtgtcc atcatttcaa agcacatcag ccagcctgtg
     1561 caagaggccc tgacgatccc cgaggtcttc tccaatctca actctgtcat gtgtgtggag
     1621 ggggaaactg gcagtggaaa gacaaccttc ctgaagagga tagcttttct ctgggcatca
     1681 ggatgctgcc ccctgttgta caggttccag ctggtcttct atctctccct tagttccatc
     1741 acaccagatc agggactggc caacatcatc tgtgcccaac tcctaggggc aggaggttgc
     1801 attagtgaag tgtgtctgag cagcagcatc cagcagttac aacaccaggt gctgttcctg
     1861 ttggatgact acagtgggct ggcctcactc ccccaagccc tacacacact gattacaaaa
     1921 aactacttgt cacggacctg cttattgatc gctgtgcata caaacagggt cagagacatc
     1981 cgcctatacc taggtacaag tctagagatc caagagtttc ccttctataa tactgtctct
     2041 gtattacgga agtttttttc acatgacata atctgtgtgg aaaagcttat aatttacttt
     2101 attgataata aagatttaca gggagtttac aagacccctc tctttgtagc agcagtatgt
     2161 actgactgga ttcaaaatgc atctgcccag gataaatttc aagatgtgac acttttccag
     2221 tcctacatgc aatacctgtc cttaaaatac aaagctacag ctgagcctct ccaggccact
     2281 gtgtcctcat gtgggcagct ggccttgaca gggcttttct catcatgctt tgagttcaat
     2341 agtgatgacc tggcagaggc aggagttgat gaagatgaaa agcttaccac cctcttgatg
     2401 agcaaattca ccgcccagag actgagacca gtctaccggt ttttaggtcc tctgttccag
     2461 gagtttcttg ctgccgtgag gttgactgaa ctcctgagtt cagataggca ggaagaccaa
     2521 gatcttggac tttattattt gagacaaatc gactcacctc tgaaggcaat aaactccttt
     2581 aacatatttt tgtattatgt ctccagccac tcttcctcaa aggcagcgcc aacagttgta
     2641 tctcatttgc ttcagttggt ggatgagaaa gagtcactgg agaacatgtc tgaaaatgag
     2701 gattacatga agctccatcc acaaactttt ctatggtttc agtttgttag agggttgtgg
     2761 ctggtgtctc ctgaatcttc ctcttcattc gtttcagaac atttattgcg ccttgctcta
     2821 atctttgctt atgaaagcaa cacagttgct gaatgctctc catttatttt gcaattcctt
     2881 cgaggaaaaa cactggcttt aagagtactg aatttacagt actttaggga ccacccagaa
     2941 agcctgttac tgttgaggag cttaaaggtt tccataaatg gaaataaaat gtcatcttat
     3001 gtagattatt cattcaagac atattttgaa aacttacagc caccagctat agatgaggag
     3061 tatacatctg cctttgagca tataagtgaa tggaggagaa attttgctca agatgaggag
     3121 atcataaaaa actatgaaaa tatccgaccc agagccctac cagacatcag tgaagggtac
     3181 tggaaactgt cccccaagcc atgcaagatc cccaagctgg aagttcaagt gaacaacacg
     3241 gatgcagcag atcaagcact gctccaggtc ctcatggaag tcttctcagc ttcacagagt
     3301 attgagttcc gtttattcaa cagcagtggc ttccttgaaa gcatctgccc agctctggag
     3361 ctgagtaagg cctctgtcac caagtgttcc atgtccaggc tggagctcag cagagcagaa
     3421 caggagctgc ttctcaccct gcctgccctg cagtctctcg aggtctcaga gacaaaccag
     3481 ttaccagaac agctcttcca taacttgcac aagttcctgg gcctgaaaga actgtgtgtg
     3541 agactagatg gcaaaccgaa tgtgctctca gtccttccta gagagttccc aaacctcctt
     3601 cacatggaga agttatccat ccaaacctcc acggagtctg acctctccaa actagttaaa
     3661 ttcatccaga actttccaaa tctccatgtt ttccatctga aatgtgattt cctttcaaat
     3721 tgtgagtctc tcatggctgt gcttgcttcc tgcaagaaac tcagagagat tgagttttct
     3781 ggacgatgct ttgaagccat gacctttgtc aacattttgc caaattttgt ttctctgaag
     3841 atactgaatc ttaaagatca acaatttcca gataaggaaa cgtcagaaaa gtttgcccag
     3901 gctctgggtt ctctcaggaa cctggaggaa ctgctcgttc ccactgggga cgggattcac
     3961 caagtggcca aactgattgt ccggcagtgt ctgcagcttc cgtgcctccg agttctcacc
     4021 tttcacgaca tcttggacga tgacagtgtg attgaaattg ccagggcggc aaccagtgga
     4081 ggtttccaga aacttgagaa cttagatatt tccatgaatc acaagattac cgaggaagga
     4141 tatagaaatt tctttcaagc cctggacaac ttgccaaacc tacaagagct gaacatctgc
     4201 aggaatatcc caggacgcat tcaagttcag gccaccactg tcaaggctct gggtcaatgt
     4261 gtgtcccgac tgcccagcct catcagactg cacatgctca gttggctcct ggatgaagag
     4321 gacatgaaag tgattaatga tgtgaaggaa agacatcccc agtctaaacg cttgattatc
     4381 ttctggaaat tgatagtccc attctctcct gttatcctgg agtaaaggat gctcctgaag
     4441 actactgaca gttcagaata tctaaaactc ctaaaattct agctgaggtc agaaaagtat
     4501 gttgggccct cctgggtctg gagttataga tagttaagag tctccatttg ggtgctggtc
     4561 accaaacctt tatcctcagt aaaagctaca ggtgctctta aaccctgatc catctatccg
     4621 aaggctgata attttttttg aaaatctaca tgctcatcac tgagctacaa tgaacagtgc
     4681 ctttttagtc cttgtatatt tctcctgtct aaagactaga gtttccttca agttcataca
     4741 aggaaccttc caataccaag gtcaacagga aagggctggt gaaaggaaca ttgatctatg
     4801 taaagccaag acatcatagg agcactgggt ggaggatata catggtctgt ttatagattg
     4861 aatcagcctt gtacatgagg aagcatgtgt tgactttatc atggctgcag ctgactctct
     4921 ctccaggaga tgctctttag tctttgcagc acttttgcgt attcattagc cttgatgtgg
     4981 ttgtgcatct attgccaatg ggtgggggga tattgggctt agagaaaact gcttttgttt
     5041 atgagagttt ttgataattt tgcatgtact gtaatggcct tgtgattttc ttagaaactc
     5101 atggtcaggc tggagagatg gctcagtggt taagagcact gactgctctt ctgaaggtcc
     5161 tgagttcaaa tcccagcaac cacacggtgg ctcacaacca tctgtaatga gatctgatgc
     5221 cctgttctgg ggtgtctaaa gatggctaca gtgtacttac atagaataaa gaaataaaat
     5281 cttaaaaaag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     5341 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
