LOCUS       NM_001126182            4782 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus NLR family, apoptosis inhibitory protein 2 (Naip2),
            transcript variant 2, mRNA.
ACCESSION   NM_001126182
VERSION     NM_001126182.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4782)
  AUTHORS   Mitchell,P.S., Roncaioli,J.L., Turcotte,E.A., Goers,L.,
            Chavez,R.A., Lee,A.Y., Lesser,C.F., Rauch,I. and Vance,R.E.
  TITLE     NAIP-NLRC4-deficient mice are susceptible to shigellosis
  JOURNAL   Elife 9, e59022 (2020)
   PUBMED   33074100
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4782)
  AUTHORS   Zhao,Y., Shi,J., Shi,X., Wang,Y., Wang,F. and Shao,F.
  TITLE     Genetic functions of the NAIP family of inflammasome receptors for
            bacterial ligands in mice
  JOURNAL   J Exp Med 213 (5), 647-656 (2016)
   PUBMED   27114610
  REMARK    GeneRIF: These results provide definitive genetic evidence for the
            important physiological function of NAIPs in antibacterial defense
            and inflammatory damage-induced lethality in mice.
REFERENCE   3  (bases 1 to 4782)
  AUTHORS   Rauch,I., Tenthorey,J.L., Nichols,R.D., Al Moussawi,K., Kang,J.J.,
            Kang,C., Kazmierczak,B.I. and Vance,R.E.
  TITLE     NAIP proteins are required for cytosolic detection of specific
            bacterial ligands in vivo
  JOURNAL   J Exp Med 213 (5), 657-665 (2016)
   PUBMED   27045008
  REMARK    GeneRIF: Naip1 is uniquely required to detect T3SS needle protein
            and Naip2 is uniquely required to detect T3SS inner rod protein,
            but neither Naip1 nor Naip2 is required for detection of flagellin.
REFERENCE   4  (bases 1 to 4782)
  AUTHORS   Suzuki,S., Franchi,L., He,Y., Munoz-Planillo,R., Mimuro,H.,
            Suzuki,T., Sasakawa,C. and Nunez,G.
  TITLE     Shigella type III secretion protein MxiI is recognized by Naip2 to
            induce Nlrc4 inflammasome activation independently of Pkcdelta
  JOURNAL   PLoS Pathog 10 (2), e1003926 (2014)
   PUBMED   24516390
  REMARK    GeneRIF: activation of caspase-1 by Shigella is triggered by the
            rod protein MxiI that interacts with Naip2 to induce activation of
            the Nlrc4 inflammasome independently of the Pkcdelta kinase
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4782)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4782)
  AUTHORS   Endrizzi,M., Huang,S., Scharf,J.M., Kelter,A.R., Wirth,B.,
            Kunkel,L.M., Miller,W. and Dietrich,W.F.
  TITLE     Comparative sequence analysis of the mouse and human Lgn1/SMA
            interval
  JOURNAL   Genomics 60 (2), 137-151 (1999)
   PUBMED   10486205
REFERENCE   7  (bases 1 to 4782)
  AUTHORS   Yaraghi,Z., Diez,E., Gros,P. and MacKenzie,A.
  TITLE     cDNA cloning and the 5'genomic organization of Naip2, a candidate
            gene for murine Legionella resistance
  JOURNAL   Mamm Genome 10 (7), 761-763 (1999)
   PUBMED   10384056
REFERENCE   8  (bases 1 to 4782)
  AUTHORS   LaCasse,E.C., Baird,S., Korneluk,R.G. and MacKenzie,A.E.
  TITLE     The inhibitors of apoptosis (IAPs) and their emerging role in
            cancer
  JOURNAL   Oncogene 17 (25), 3247-3259 (1998)
   PUBMED   9916987
  REMARK    Review article
REFERENCE   9  (bases 1 to 4782)
  AUTHORS   Yaraghi,Z., Korneluk,R.G. and MacKenzie,A.
  TITLE     Cloning and characterization of the multiple murine homologues of
            NAIP (neuronal apoptosis inhibitory protein)
  JOURNAL   Genomics 51 (1), 107-113 (1998)
   PUBMED   9693038
REFERENCE   10 (bases 1 to 4782)
  AUTHORS   Scharf,J.M., Damron,D., Frisella,A., Bruno,S., Beggs,A.H.,
            Kunkel,L.M. and Dietrich,W.F.
  TITLE     The mouse region syntenic for human spinal muscular atrophy lies
            within the Lgn1 critical interval and contains multiple copies of
            Naip exon 5
  JOURNAL   Genomics 38 (3), 405-417 (1996)
   PUBMED   8975718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY154503.1, AY147001.1 and CT030167.8.
            
            On Sep 24, 2013 this sequence version replaced NM_001126182.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY147001.1, AF135490.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY154503.1         2-31
            31-3956             AY147001.1         1-3926
            3957-3957           CT030167.8         128730-128730       c
            3958-4782           AY147001.1         3928-4752
FEATURES             Location/Qualifiers
     source          1..4782
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.01 cM"
     gene            1..4782
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /note="NLR family, apoptosis inhibitory protein 2"
                     /db_xref="GeneID:17948"
                     /db_xref="MGI:MGI:1298226"
     exon            1..96
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            97..138
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            139..710
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            711..810
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            811..892
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            893..944
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1064
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1164
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1246
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1304
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..3548
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3716
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..3869
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..3956
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            3957..4121
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
     exon            4122..4782
                     /gene="Naip2"
                     /gene_synonym="Birc1b; Naip-rs6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttttctctgc ccccttgctg ctgatgcact gtgaccagct ggcttcctgc tcctgccaag
       61 ccttctgtgc caccttgaga tacagatctt catactgaaa ccacccgagg aagaagcagg
      121 aacctgactg aactgaagaa aaatggcagc ccagggagaa gccgttgagg agataatttg
      181 tgagtttgat gacgacttgg tctctgagct ctctactctt ctcagagtgg atgcactttc
      241 agtcttgaag agacaacaag aagaagacca taaaacacga atgaaaatga agaaaggttt
      301 taactcacag atgcgcagtg aagccaaacg actaaagact tttgagacct atgacaagtt
      361 cagatcatgg acgccacagg agatggcagc tgctgggttt taccacacag gggtgaaact
      421 tggggttcag tgcttttgct gtagcttgat cctcttttcc accagactca ggaaacttcc
      481 catagagaac cacaagaaat tacgaccaga atgtgagttc cttctgggca aagatgttgg
      541 taacattggc aagtatgaca tccgggttaa gagtccagag aagatgctga gaggtgacaa
      601 agcaaggtac catgaagagg aggcaagact ggagtccttt gaggactggc cattttatgc
      661 ccatgggaca tcaccacgtg tactctcagc agctggcttt gtctttacag gtaaaaggga
      721 cactgtgcag tgtttctcct gtggtggatg cttgggcaac tgggaagaag gagatgatcc
      781 ctggaaggag catgccaagt ggttccccaa atgtgaattt cttcaaagta agaagtcccc
      841 agaggaaatt acccaatatg tacaaagcta tgaaggattt cttcatgtaa cgggagaaca
      901 ttttgtgaat tcctgggtca gaagagaatt acctatggta tcagcttact gcaatgacag
      961 cgtcttcgct aatgaagaac taaggatgga cacgtttaag gactggcccc acgaatcacc
     1021 cggggctgtt gaagctctgg tcaaagcagg ccttttctac acaggcaaaa gggacattgt
     1081 ccagtgtttt tcctgtggag gatgtatgga gaagtgggca gaaggtgaca acccaataga
     1141 agatcacacc aagttttttc ccaactgtgt gtttctccaa accctgaagt cctctgcaga
     1201 agtgattcca gcccttcaga gccactgtgc acttccagaa gccatggaaa ccacaagtga
     1261 aagcaaccat gatgatgcag cagcagttca ttctacagtg gtggatgttt ctccaagtga
     1321 agcccaggaa cttgaacctg catccagctt ggtgtctgtt ctctgtagag accaggacca
     1381 cagtgaagcc caagggcgtg gatgtgcatc cagtgggacc tatcttccct ccacagactt
     1441 gggtcagagt gaagcccagt ggcttcaaga ggccaggagt ctgagtgagc agctgagaga
     1501 cacctacacc aaagctactt tccgccacat gaacttgcca gaagtgtact ccagcctcgg
     1561 cactgaccat ttgctcagct gcgatgtgtc catcatttca aagcacatca gccagccagt
     1621 gcaagggtcc ctgacgatcc ctgaggtctt ctccaatctc aactctgtca tgtgtgtgga
     1681 gggggaagct ggcagtggaa agacaacctt cctgaagagg atagcttttc tctgggcatc
     1741 aggatgctgc cccctgttgt acaggttcca gctggtcttc tacctctccc ttagttccat
     1801 cacaccaggc caggaactgg ccaaaatcat ctgtgcccaa ctcctagggg caggaggctg
     1861 cattagtgaa gtgtgtctga gcagcatcat ccagcagtta caacaccagg tgctgttcct
     1921 gttggatgac tacagtgggc tggcctcact cccccaagcc ctacacacac tgattacaaa
     1981 aaactacttg tcacggacct gcttattgat cgctgtgcat acaaacaagg tcaggggcat
     2041 ccgcccatac ctagatacga gtctagagat caaagagttt cccttctata atactgtctc
     2101 tgtgttacgg aagctttttt cacatgacat aatgcgtgta cgaaaattta taaattactt
     2161 tggatttcat gaagagttgc agggaattca caagacaccc ctcttcgtgg cagcagtatg
     2221 tactgactgg tttaaaaatc catctgacca gccctttcag gatgtggcac ttttcaaggc
     2281 ctatatgcaa tacttgtcct taaagcacaa aggtgcagct aagcctctcc aggccacagt
     2341 gtcctcatgt gggcagctgg ccttgacagg gcttttctca tcgtgctttg agttcaatag
     2401 tgataacctg gcagaggcag gagttgatga agatgaagag ctcaccacct gcttgatgag
     2461 caaattcacc gcccagagac tgaggccagt ctaccggttt ttaggtcctc tgttccagga
     2521 gtttcttgct gccgtgaggt tgactgaact cctgagttca gataggcagg aagaccaaga
     2581 tctgggactt tattatttga gacaaattaa ctcacctcta aaggctatga gcatctacca
     2641 cacttttttg aaatatgtct ccagccaccc ttcatcaaag gcagcgccaa cagttgtatc
     2701 tcatttgctt cagttggtgg atgagaaaga gtcactggag aacatgtctg aaaatgagga
     2761 ttacatgaag ctccatccag aagctttgct gtggattgag tgtcttagag gattgtggca
     2821 gctgtctcct gaatcttttt ctttgttcat ttcagaaaac ttattgcgca tttgtctaaa
     2881 ctttgctcat gaaagcaaca cagttgctgc atgttctcca gttattttgc agttccttcg
     2941 agggagaaca ctggatttga aagttttgag tttacagtac ttttgggacc atccagaaac
     3001 cttgttgtta ttgaagagta ttaagatctc attaaatgga aataactggg tacagagaat
     3061 cgatttttca ctcatagaaa aatcttttga aaaagtacag ccaccaacta tagatcagga
     3121 ctatgccatt gcctttcaac ctataaatga agtccagaaa aatttatctg aaaagaaaca
     3181 cataataaag aagtatgagg atatgaaaca ccagatccca ctaaatatta gtactggcta
     3241 ctggaaactg tcccccaagc catacaagat ccccaagctg gaagttcaag tgaccaacac
     3301 aggtccagca gatcaagcac tgctccaggt cctcatggaa gtcttctcag cttcacagag
     3361 tattgagttc cgtttatccg acagcagtgg cttccttgaa agcatccgcc cagctctgga
     3421 gctgagtaag gcctctgtca ccaagtgttc catgtccagg ctggagctca gcagagaaga
     3481 tcagaagctg cttctcaccc tgcctaccct gcagtctctc gaggtctcag agacaaacca
     3541 gttaccagat cagctcttcc ataacttgca caagttcctg ggcctgaaag aactgtgtgt
     3601 gagactagat agcaagccgg atgtgctctc agtccttcct ggagagttcc caaacctcca
     3661 tcacatggag aagttatcca tcagaacctc cacggagtct gacctctcca aactagttaa
     3721 gttgattcag aactctccaa atctccatgt tttccatctg aagtgtaatt tcctttcgaa
     3781 ttgtgagcct ctcatgactg tgcttgcttc ctgcaagaaa ctcagagaga ttgagttttc
     3841 tggacgatgc tttgaagcca tgacctttgt caacattttg ccaaattttg tttttctgaa
     3901 gatattgaat cttagagacc aacaattccc agataaagaa acatcagaaa agtttgccca
     3961 ggctctgggt tctctcagga acctggagaa actgttcgtt cccactgggg acgggattca
     4021 ccaagtggcc aaactgattg tccggcagtg tctgcagctc ccatgtctcc gagttcttgt
     4081 ctttgcagag actctggatg acgacagtgt actggaaatt gccaagggag caaccagggg
     4141 aggcttccaa aaacttgaga acttagacct tacactgaat cacaagatta cagaggaagg
     4201 atacagaaat ttctttcaag tcctggacaa cctgccaaac ctgaaaaacc tggacatttc
     4261 caggcatatc ccagaatgca ttcaaattca ggccatcact gtcaaggctc tgggtcagtg
     4321 tgtgtcccga ctgcccagcc tcaccaggct cgggatgctc agttggctcc tggatgaaga
     4381 ggacataaaa gtgattaatg atgtgaagga aagacaccct cagtccaaac gcttgactgt
     4441 tcactggagg tgggtagtgc cattctctcc tgtcattcag aagtgaagga tgaagtggaa
     4501 gattactggc aggtccaaaa acctgatttt ctagtacatt tcactctaga caggcatggt
     4561 gcaatcctag tacttaggag cctgagcagg gggatcaaga gtttgagccg gggctggaga
     4621 gatggcccag tgcttaagag caccgtgatc ttctagaggt cctgagttca attctcagca
     4681 accacatggt ggttcacaac catctgtaat gggatctgat gccctcttct ggtatgtctg
     4741 aagatggcta cagtgtactc atatacatta aataaatctt tt
//
