LOCUS       NM_008670               5361 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus NLR family, apoptosis inhibitory protein 1 (Naip1),
            mRNA.
ACCESSION   NM_008670
VERSION     NM_008670.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5361)
  AUTHORS   An,Y., Zhai,Z., Wang,X., Ding,Y., He,L., Li,L., Mo,Q., Mu,C.,
            Xie,R., Liu,T., Zhong,W., Wang,B. and Cao,H.
  TITLE     Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4
            inflammasome activation in macrophages attenuates ulcerative
            colitis
  JOURNAL   J Adv Res 52, 219-232 (2023)
   PUBMED   37586642
  REMARK    GeneRIF: Targeting Desulfovibrio vulgaris flagellin-induced
            NAIP/NLRC4 inflammasome activation in macrophages attenuates
            ulcerative colitis.
REFERENCE   2  (bases 1 to 5361)
  AUTHORS   Ataide,M.A., Manin,G.Z., Oliveira,S.S., Guerra,R.O. and
            Zamboni,D.S.
  TITLE     Inflammasome activation and CCR2-mediated monocyte-derived
            dendritic cell recruitment restrict Legionella pneumophila
            infection
  JOURNAL   Eur J Immunol 53 (2), e2249985 (2023)
   PUBMED   36427489
  REMARK    GeneRIF: Inflammasome activation and CCR2-mediated monocyte-derived
            dendritic cell recruitment restrict Legionella pneumophila
            infection.
REFERENCE   3  (bases 1 to 5361)
  AUTHORS   Piao,X., Miura,R., Miyake,S., Komazawa-Sakon,S., Koike,M.,
            Shindo,R., Takeda,J., Hasegawa,A., Abe,R., Nishiyama,C., Mikami,T.,
            Yagita,H., Uchiyama,Y. and Nakano,H.
  TITLE     Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and
            TNFR1-independent cell death is crucial for normal epidermal
            differentiation
  JOURNAL   J Allergy Clin Immunol 143 (1), 213-228 (2019)
   PUBMED   29596938
REFERENCE   4  (bases 1 to 5361)
  AUTHORS   Svandova,E.B., Vesela,B., Lesot,H., Poliard,A. and Matalova,E.
  TITLE     Expression of Fas, FasL, caspase-8 and other factors of the
            extrinsic apoptotic pathway during the onset of interdigital tissue
            elimination
  JOURNAL   Histochem Cell Biol 147 (4), 497-510 (2017)
   PUBMED   27709293
REFERENCE   5  (bases 1 to 5361)
  AUTHORS   Zhao,Y., Shi,J., Shi,X., Wang,Y., Wang,F. and Shao,F.
  TITLE     Genetic functions of the NAIP family of inflammasome receptors for
            bacterial ligands in mice
  JOURNAL   J Exp Med 213 (5), 647-656 (2016)
   PUBMED   27114610
  REMARK    GeneRIF: These results provide definitive genetic evidence for the
            important physiological function of NAIPs in antibacterial defense
            and inflammatory damage-induced lethality in mice.
REFERENCE   6  (bases 1 to 5361)
  AUTHORS   Yaraghi,Z., Korneluk,R.G. and MacKenzie,A.
  TITLE     Cloning and characterization of the multiple murine homologues of
            NAIP (neuronal apoptosis inhibitory protein)
  JOURNAL   Genomics 51 (1), 107-113 (1998)
   PUBMED   9693038
REFERENCE   7  (bases 1 to 5361)
  AUTHORS   Diez,E., Beckers,M.C., Ernst,E., DiDonato,C.J., Simard,L.R.,
            Morissette,C., Gervais,F., Yoshida,S.I. and Gros,P.
  TITLE     Genetic and physical mapping of the mouse host resistance locus
            Lgn1
  JOURNAL   Mamm Genome 8 (9), 682-685 (1997)
   PUBMED   9271671
REFERENCE   8  (bases 1 to 5361)
  AUTHORS   DiDonato,C.J., Chen,X.N., Noya,D., Korenberg,J.R., Nadeau,J.H. and
            Simard,L.R.
  TITLE     Cloning, characterization, and copy number of the murine survival
            motor neuron gene: homolog of the spinal muscular
            atrophy-determining gene
  JOURNAL   Genome Res 7 (4), 339-352 (1997)
   PUBMED   9110173
REFERENCE   9  (bases 1 to 5361)
  AUTHORS   DiDonato,C.J., Nadeau,J.H. and Simard,L.R.
  TITLE     The mouse neuronal apoptosis inhibitory protein gene maps to a
            conserved syntenic region of mouse chromosome 13
  JOURNAL   Mamm Genome 8 (3), 222 (1997)
   PUBMED   9069126
REFERENCE   10 (bases 1 to 5361)
  AUTHORS   Scharf,J.M., Damron,D., Frisella,A., Bruno,S., Beggs,A.H.,
            Kunkel,L.M. and Dietrich,W.F.
  TITLE     The mouse region syntenic for human spinal muscular atrophy lies
            within the Lgn1 critical interval and contains multiple copies of
            Naip exon 5
  JOURNAL   Genomics 38 (3), 405-417 (1996)
   PUBMED   8975718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF135491.1 and AF007769.1.
            
            On Sep 15, 2006 this sequence version replaced NM_008670.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF135491.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1981              AF135491.1         1-1981
            1982-3325           AF007769.1         2079-3422
            3326-4682           AF135491.1         3326-4682
            4683-4704           AF007769.1         4780-4801
            4705-5361           AF135491.1         4706-5362
FEATURES             Location/Qualifiers
     source          1..5361
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.18 cM"
     gene            1..5361
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /note="NLR family, apoptosis inhibitory protein 1"
                     /db_xref="GeneID:17940"
                     /db_xref="MGI:MGI:1298223"
     exon            1..67
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            68..109
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..680
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..4324
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /note="neuronal apoptosis inhibitory protein 1;
                     baculoviral IAP repeat-containing 1a"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 1a"
                     /protein_id="NP_032696.2"
                     /db_xref="CCDS:CCDS26729.1"
                     /db_xref="GeneID:17940"
                     /db_xref="MGI:MGI:1298223"
                     /translation="MAEHGESSEDRISEIDYEFLPELSALLGVDAVQLAKSQEEEEHK
                     ERMKMKKGFNSQMRSEAKRLKTFETYDTFRSWTPQEMAAAGFYHTGVKLGVQCFCCSL
                     ILFGNSLRKLPIERHKKLRPECEFLQGKDVGNIGKYDIRVKSPEKMLRGGKARYHEEE
                     ARLESFEDWPFYAHGTSPRVLSAAGFVFTGKRDTVQCFSCGGSLGNWEEGDDPWKEHA
                     KWFPKCEFLQSKKSSEEIAQYIQGYEGFVHVTGEHFVNSWVRRELPMVSAYCNDSVFA
                     NEELRMDTFKDWPHESPVAVDALVRAGLFYTGKKGIVQCFSCGGCMEKCTEGDDPIQE
                     HNKFFPNCVFLQTPKSSAEVIPALQSHCALPEAMETTSESNHDDPAAVHSTVVGLGRS
                     EAQWFQEARSLSEQLRDNYTKATFRHMNLPEVCSSLGTDHLIGCDVSIISKHISQPVQ
                     GALTIPEVFSNLSSVMCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSS
                     ITPDQGLANIICAQLLGAGGCISEVCLSSIIQQLQHQVLFLLDDYSGLASLPQALHTL
                     ITKNYLSRTCLLIAVHTNRVRGIRSYLDTSLEIKEFPLSNTVYILKKFFSHNIKRLLE
                     FMVYFGQNEDLQGIHKTPLFVAAVCTDWFENPSDQPFQDMALFKSYMQYLSLKHKGAA
                     KPLQATVSSCGQLALTGLFSSCFEFNSDDLAEAGVDEDEELTTCLMSKFTAQRLRPVY
                     RFLGPLFQEFLAAMRLTELLSSDRQEDQDLGLYYLRQINSPLKALTTYNNFLKYVFSH
                     PSSKAGPTVVSHLLHLVDETELLENTYKNEDYVNHPPGTSRIMKGLKELWLLSPEYYS
                     SFVSEHLLRIALNFAYESNTVAECSPFILQFLRGRTLALKVLNLQYFRDHPESLLLVK
                     SLEVSINGNKVPKVVDYSVMEKSFETLQPPTIDQDYASAFEQMKEHEKNLSENEETIK
                     SIKNIFPLQPPKISSGYWKLSPKPCKIPRLEVGVTNMGPADQALLQVLMEVFSASQSI
                     EFRLSDSSGFLESIRPALELSKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETN
                     QLPDQLFHNLHKFLGLKELCVRLDGKPDVLSVLPGEFPNLLHMEKLSIRTSMESDLSK
                     LVKLIQNSPNLHVFHLKCDFLSNCDSLMAVLASCKKLREIEFSGRCFEAMPFVNILPN
                     FISLKILNLISQQFPDKETSEKFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQL
                     PCLRVLAFHYILDNDSVIEIARVATSGGFQKLEKLDLSMNHKITEEGYRNFFQALDNL
                     PNLQNLNICRHIPECIQVQATTVKALGQCVSRLPSLTRLHMLSWLLDEEDMKVINDVK
                     ERHPQSKRLIIFWKWIVPFSPVVLE"
     exon            681..780
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..862
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..914
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1034
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1134
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1216
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1274
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..3386
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3554
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3707
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3794
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3959
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..5361
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaccggta gactctgatc cttctaccaa accttccgtg ccatggtgga atttatccct
       61 tcaaattgaa accacctgag gaagaagcag gagcctgact gaactgaaga aaatggctga
      121 gcatggggag tcctccgagg atcggatttc tgagattgat tatgaatttc tccctgagct
      181 ctctgctctt ctcggggtgg atgcagttca gctggcaaag agccaagaag aagaagagca
      241 taaagaacgg atgaaaatga agaaaggttt taactcacag atgcgcagtg aagccaaacg
      301 actaaagacc tttgagacct atgacacgtt cagatcatgg acgccacagg agatggcagc
      361 tgctgggttt taccacacag gggtgaaact tggggttcag tgcttttgct gtagcttgat
      421 cctctttggc aatagcctca ggaagcttcc catagagaga cacaagaaat tacgtccaga
      481 atgtgagttc cttcagggaa aagatgttgg taacattggc aagtatgaca tccgggtgaa
      541 gagtccagag aagatgctga gaggtggcaa agccaggtac catgaagagg aggccagact
      601 ggagtccttt gaggactggc cattttatgc ccatgggaca tcaccacgtg tactctcagc
      661 agctggcttt gtctttacag gtaaaaggga cactgtgcag tgtttttcct gtggcggaag
      721 cttgggcaac tgggaagaag gagatgaccc ctggaaggag catgccaagt ggttccccaa
      781 atgtgaattt cttcaaagta agaaatcttc agaggaaatt gcccagtata tccaaggcta
      841 tgagggattt gttcatgtaa cgggagaaca ttttgtgaat tcctgggtca gaagagaatt
      901 acctatggta tcagcttact gcaacgacag cgtcttcgct aatgaagaac taaggatgga
      961 cacgtttaag gactggcccc acgaatcacc tgtggctgtt gatgctttgg tcagagctgg
     1021 ccttttctac acaggcaaaa agggcattgt ccagtgtttt tcctgtggag gatgtatgga
     1081 gaagtgcaca gaaggtgacg acccaataca agagcacaac aagttttttc ccaactgtgt
     1141 atttctccaa accccgaagt cctctgcaga agtgattcca gcccttcaga gccactgtgc
     1201 acttccagaa gccatggaaa ccacaagtga aagcaaccac gatgatccag cagcagttca
     1261 ttctacagtg gtgggcttgg gtaggagtga agcccagtgg tttcaagagg ccaggagtct
     1321 gagtgagcag ctaagagaca actacactaa agccactttt cgccacatga acttgccaga
     1381 agtgtgctcc agccttggca ctgaccactt gatcggctgc gatgtgtcca tcatttcaaa
     1441 gcacatcagc cagcctgtgc aaggggccct gacgatccct gaggtcttct ccaatctcag
     1501 ctctgtcatg tgtgtggagg gggaaactgg cagtggaaag acaaccttcc tgaagaggat
     1561 agcttttctc tgggcatcag gatgctgccc cttgttgtac aggttccagc tggtcttcta
     1621 cctctccctt agttccatca caccagacca gggactggcc aacatcatct gtgcccaact
     1681 cctaggggca ggaggctgca ttagtgaagt gtgtctgagc agcatcatcc agcagttaca
     1741 acaccaggtg ctgttcctgt tggatgacta cagtgggctg gcctcactcc cccaagccct
     1801 acatacactg attacaaaaa actacttgtc acggacctgc ttattgatcg ctgtgcatac
     1861 aaacagggtc aggggcatcc gctcatacct agatacgagt ctagagatca aagagtttcc
     1921 cttgtccaat actgtctata tattaaagaa gttcttctcc cataatataa aacgtctact
     1981 agagtttatg gtttattttg gacagaatga agatttacag ggaattcaca agacccccct
     2041 cttcgtggca gcagtatgta ctgactggtt tgaaaatcca tctgaccagc cctttcagga
     2101 tatggcactt ttcaagtcct acatgcaata cctgtcctta aagcacaaag gtgcagctaa
     2161 gcctctccaa gccaccgtgt cctcatgtgg gcagctggcc ttgacagggc ttttctcatc
     2221 atgctttgag ttcaatagtg atgacctggc agaggcagga gttgatgaag atgaagagct
     2281 caccacctgc ttgatgagca aattcaccgc ccagagactg aggccagtct accggttttt
     2341 aggtccgctg ttccaggagt ttcttgctgc catgagactg actgaacttc tgagttcaga
     2401 taggcaggaa gaccaagatc tgggacttta ttatttgaga caaattaact cacccttgaa
     2461 ggctttgacc acctacaaca attttttgaa gtatgtcttt agccatccgt catcaaaggc
     2521 agggccaaca gttgtatctc atttgcttca cttggtggat gagacagagt tgctggagaa
     2581 tacctataaa aatgaggatt atgtaaatca ccctccagga acttcccgaa taatgaaggg
     2641 acttaaggaa ctgtggctgt tatctcctga atattactct tcatttgttt cagaacattt
     2701 attgcgcatt gctctaaact ttgcttatga aagcaacact gttgctgaat gttctccatt
     2761 tattttgcag ttccttagag ggagaacact ggctttgaaa gtactgaatt tacaatactt
     2821 tagggaccac ccagaaagcc tgttactggt gaagagttta gaagtctcga taaatggaaa
     2881 taaagtgcca aaagttgtag attattcagt catggaaaaa agttttgaaa cattacagcc
     2941 accaactata gatcaggact atgcatccgc ctttgaacaa atgaaggaac atgaaaaaaa
     3001 tttatctgaa aatgaagaga ccataaagag tattaagaac atcttcccct tacagccacc
     3061 taaaataagc tctggctatt ggaaactgtc ccccaagcca tgcaagatcc ctaggctgga
     3121 agttggagtg accaacatgg gtccagcaga tcaagcactg ctccaggtcc tcatggaagt
     3181 cttctcagct tcacagagta ttgagttccg tttatccgac agcagtggct tccttgaaag
     3241 catccgccca gctctggagc tgagtaaggc ctctgtcacc aagtgttcca tgtccaggct
     3301 ggagctcagc agagcagaac aggagctgct tctcaccctg cctgccctgc agtctctcga
     3361 ggtctcagag acaaaccagt taccagatca gctcttccat aacttgcaca agttcctggg
     3421 cctgaaagaa ctgtgtgtga gactagatgg caaaccggat gtgctctcag tccttcctgg
     3481 agagttccca aacctccttc acatggagaa gttatccatc cgaacctcca tggagtctga
     3541 cctctccaaa ctagttaaat tgattcagaa ctctccaaat ctccatgttt tccatctgaa
     3601 atgtgatttc ctttcgaatt gtgactctct catggctgtg cttgcttcct gcaagaaact
     3661 cagagagatt gagttttctg gacgatgctt tgaagccatg ccctttgtta acattttgcc
     3721 aaattttatt tctctgaaga tattaaatct tataagccaa caattcccag ataaggaaac
     3781 atcagaaaag tttgcccagg ctctgggttc tctcaggaac ctggaggaac tgctcgttcc
     3841 cactggagac gggattcacc aagtggccaa attgattgtc cggcagtgtc tgcagcttcc
     3901 gtgtctccga gttcttgcct ttcactacat cttggacaat gacagtgtga ttgaaattgc
     3961 cagggtggca accagtggag gtttccagaa actcgagaag ttagatcttt ccatgaatca
     4021 caagattacc gaggaaggat atagaaattt ctttcaagcc ctggacaacc tgccaaactt
     4081 gcagaatctg aacatctgca gacatatccc agaatgcatt caagttcagg ccaccactgt
     4141 caaggctctg ggtcaatgtg tgtcccgact gcccagcctc actaggctgc acatgctcag
     4201 ttggctcctg gatgaagagg acatgaaagt gattaatgat gtgaaggaaa gacaccccca
     4261 gtccaaacgc ttgattatct tctggaaatg gatagtcccg ttctctcctg ttgtcctgga
     4321 gtaaaggatg ctcctgaaga ctactgatag ttcagaatac cagatttcct aaaacacttt
     4381 actttagctg ggcatggtgg tacacacctg tactttcaac atttaggaca ctgatgtgca
     4441 agaatcaaga agttcagacc agatccagtt tcacagctaa agacacaact atccatccta
     4501 ctaaagaata tttattaagt gtgcagactg ctaatttttt ttcagaagtc tgcatgccca
     4561 ctattgaatt cagtagctat attgctcaat gccttggcag tccttatttg gtcttcctgt
     4621 ctgaagacta gagcctcagt cacgttcata tagagaactg tcaatgccaa ggtcaacagg
     4681 aaggcgctgg gaaaggaaca tcgatctatg tagaagccac atccggaagt agtatttgat
     4741 aggtgctggg gtagtgcaag aggaacagca aaacagcttt agaactcacg gaacgcagtc
     4801 tcctggttag cacaaactca tgggtgggtc tccgagagaa ctatgggtcc tgagagcttc
     4861 atggtgtcat agagatttgc tctgcttgct gccttctcac tgtgttactc ataatctatg
     4921 agttttatga actctctagg gggcttaaca acccctcact gggcagtgtc attgtcactc
     4981 acagcagcag tgcttgatct tcaagatcaa tgattcaatc accacccttg gaaagaactt
     5041 agaaatgtac attgttagaa atgaccacca gtcttaagaa tttggagaag tagattgtca
     5101 gtaaagttag gttaagatgt ttttgttaat ggctctgatg ttgaaaaatc ttagaaatca
     5161 aatagaaatt cagaaaagcc cacttttgat tattgatcaa gggatgtttt caagatcagg
     5221 aacaagaaca atggcagctc agctagcact ggctgatgtg actcttgctg aagctgggct
     5281 gatgatcgag gtgataatta atgtcttgta cccaatgttc ccctcacctt tctgataaga
     5341 tttaataaaa agttgtcccc g
//
