LOCUS       NP_032696               1403 aa            linear   ROD 28-APR-2025
DEFINITION  baculoviral IAP repeat-containing protein 1a [Mus musculus].
ACCESSION   NP_032696
VERSION     NP_032696.2
DBSOURCE    REFSEQ: accession NM_008670.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1403)
  AUTHORS   An,Y., Zhai,Z., Wang,X., Ding,Y., He,L., Li,L., Mo,Q., Mu,C.,
            Xie,R., Liu,T., Zhong,W., Wang,B. and Cao,H.
  TITLE     Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4
            inflammasome activation in macrophages attenuates ulcerative
            colitis
  JOURNAL   J Adv Res 52, 219-232 (2023)
   PUBMED   37586642
  REMARK    GeneRIF: Targeting Desulfovibrio vulgaris flagellin-induced
            NAIP/NLRC4 inflammasome activation in macrophages attenuates
            ulcerative colitis.
REFERENCE   2  (residues 1 to 1403)
  AUTHORS   Ataide,M.A., Manin,G.Z., Oliveira,S.S., Guerra,R.O. and
            Zamboni,D.S.
  TITLE     Inflammasome activation and CCR2-mediated monocyte-derived
            dendritic cell recruitment restrict Legionella pneumophila
            infection
  JOURNAL   Eur J Immunol 53 (2), e2249985 (2023)
   PUBMED   36427489
  REMARK    GeneRIF: Inflammasome activation and CCR2-mediated monocyte-derived
            dendritic cell recruitment restrict Legionella pneumophila
            infection.
REFERENCE   3  (residues 1 to 1403)
  AUTHORS   Piao,X., Miura,R., Miyake,S., Komazawa-Sakon,S., Koike,M.,
            Shindo,R., Takeda,J., Hasegawa,A., Abe,R., Nishiyama,C., Mikami,T.,
            Yagita,H., Uchiyama,Y. and Nakano,H.
  TITLE     Blockade of TNF receptor superfamily 1 (TNFR1)-dependent and
            TNFR1-independent cell death is crucial for normal epidermal
            differentiation
  JOURNAL   J Allergy Clin Immunol 143 (1), 213-228 (2019)
   PUBMED   29596938
REFERENCE   4  (residues 1 to 1403)
  AUTHORS   Svandova,E.B., Vesela,B., Lesot,H., Poliard,A. and Matalova,E.
  TITLE     Expression of Fas, FasL, caspase-8 and other factors of the
            extrinsic apoptotic pathway during the onset of interdigital tissue
            elimination
  JOURNAL   Histochem Cell Biol 147 (4), 497-510 (2017)
   PUBMED   27709293
REFERENCE   5  (residues 1 to 1403)
  AUTHORS   Zhao,Y., Shi,J., Shi,X., Wang,Y., Wang,F. and Shao,F.
  TITLE     Genetic functions of the NAIP family of inflammasome receptors for
            bacterial ligands in mice
  JOURNAL   J Exp Med 213 (5), 647-656 (2016)
   PUBMED   27114610
  REMARK    GeneRIF: These results provide definitive genetic evidence for the
            important physiological function of NAIPs in antibacterial defense
            and inflammatory damage-induced lethality in mice.
REFERENCE   6  (residues 1 to 1403)
  AUTHORS   Yaraghi,Z., Korneluk,R.G. and MacKenzie,A.
  TITLE     Cloning and characterization of the multiple murine homologues of
            NAIP (neuronal apoptosis inhibitory protein)
  JOURNAL   Genomics 51 (1), 107-113 (1998)
   PUBMED   9693038
REFERENCE   7  (residues 1 to 1403)
  AUTHORS   Diez,E., Beckers,M.C., Ernst,E., DiDonato,C.J., Simard,L.R.,
            Morissette,C., Gervais,F., Yoshida,S.I. and Gros,P.
  TITLE     Genetic and physical mapping of the mouse host resistance locus
            Lgn1
  JOURNAL   Mamm Genome 8 (9), 682-685 (1997)
   PUBMED   9271671
REFERENCE   8  (residues 1 to 1403)
  AUTHORS   DiDonato,C.J., Chen,X.N., Noya,D., Korenberg,J.R., Nadeau,J.H. and
            Simard,L.R.
  TITLE     Cloning, characterization, and copy number of the murine survival
            motor neuron gene: homolog of the spinal muscular
            atrophy-determining gene
  JOURNAL   Genome Res 7 (4), 339-352 (1997)
   PUBMED   9110173
REFERENCE   9  (residues 1 to 1403)
  AUTHORS   DiDonato,C.J., Nadeau,J.H. and Simard,L.R.
  TITLE     The mouse neuronal apoptosis inhibitory protein gene maps to a
            conserved syntenic region of mouse chromosome 13
  JOURNAL   Mamm Genome 8 (3), 222 (1997)
   PUBMED   9069126
REFERENCE   10 (residues 1 to 1403)
  AUTHORS   Scharf,J.M., Damron,D., Frisella,A., Bruno,S., Beggs,A.H.,
            Kunkel,L.M. and Dietrich,W.F.
  TITLE     The mouse region syntenic for human spinal muscular atrophy lies
            within the Lgn1 critical interval and contains multiple copies of
            Naip exon 5
  JOURNAL   Genomics 38 (3), 405-417 (1996)
   PUBMED   8975718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF135491.1 and AF007769.1.
            
            On Sep 15, 2006 this sequence version replaced NP_032696.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF135491.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1403
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.18 cM"
     Protein         1..1403
                     /product="baculoviral IAP repeat-containing protein 1a"
                     /note="neuronal apoptosis inhibitory protein 1;
                     baculoviral IAP repeat-containing 1a"
                     /calculated_mol_wt=158594
     Region          63..128
                     /region_name="BIR"
                     /note="Inhibitor of Apoptosis domain; pfam00653"
                     /db_xref="CDD:459891"
     Region          63..128
                     /region_name="BIR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWK5.3)"
     Site            order(89,94,96,103..105,107,111,116,120..121)
                     /site_type="active"
                     /note="peptide binding groove [active]"
                     /db_xref="CDD:237989"
     Site            order(97,100,117,124)
                     /site_type="other"
                     /note="Zn2+ binding site [ion binding]"
                     /db_xref="CDD:237989"
     Region          159..229
                     /region_name="BIR"
                     /note="Baculoviral inhibition of apoptosis protein repeat;
                     smart00238"
                     /db_xref="CDD:197595"
     Region          162..228
                     /region_name="BIR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWK5.3)"
     Site            order(189,194,196,203..205,207,211,216,220..221)
                     /site_type="active"
                     /note="peptide binding groove [active]"
                     /db_xref="CDD:237989"
     Site            order(197,200,217,224)
                     /site_type="other"
                     /note="Zn2+ binding site [ion binding]"
                     /db_xref="CDD:237989"
     Region          279..346
                     /region_name="BIR"
                     /note="Baculoviral inhibition of apoptosis protein repeat
                     domain; Found in inhibitors of apoptosis proteins (IAPs)
                     and other proteins. In higher eukaryotes, BIR domains
                     inhibit apoptosis by acting as direct inhibitors of the
                     caspase family of protease enzymes; cd00022"
                     /db_xref="CDD:237989"
     Region          281..346
                     /region_name="BIR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QWK5.3)"
     Site            order(307,312,314,321..323,325,329,334,338..339)
                     /site_type="active"
                     /note="peptide binding groove [active]"
                     /db_xref="CDD:237989"
     Site            order(315,318,335,342)
                     /site_type="other"
                     /note="Zn2+ binding site [ion binding]"
                     /db_xref="CDD:237989"
     Region          450..>766
                     /region_name="NACHT"
                     /note="Predicted NTPase, NACHT family domain [Signal
                     transduction mechanisms]; COG5635"
                     /db_xref="CDD:444362"
     Region          464..617
                     /region_name="NACHT"
                     /note="NACHT domain; pfam05729"
                     /db_xref="CDD:428606"
     Site            470..477
                     /site_type="other"
                     /note="Walker A/P-loop"
                     /db_xref="CDD:213179"
     Site            502..505
                     /site_type="other"
                     /note="Q-loop/lid"
                     /db_xref="CDD:213179"
     Site            526..534
                     /site_type="other"
                     /note="ABC transporter signature motif"
                     /db_xref="CDD:213179"
     Site            547..551
                     /site_type="other"
                     /note="Walker B"
                     /db_xref="CDD:213179"
     Region          766..872
                     /region_name="NLRC4_HD"
                     /note="NLRC4 helical domain; pfam17889"
                     /db_xref="CDD:436120"
     Region          <1118..>1329
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          1132..1156
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1157..1182
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1183..1236
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1237..1261
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1262..1293
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1294..1322
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1323..1355
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     CDS             1..1403
                     /gene="Naip1"
                     /gene_synonym="Birc1a; D13Lsd1; Naip; Naip-rs1"
                     /coded_by="NM_008670.2:113..4324"
                     /db_xref="CCDS:CCDS26729.1"
                     /db_xref="GeneID:17940"
                     /db_xref="MGI:MGI:1298223"
ORIGIN      
        1 maehgessed riseidyefl pelsallgvd avqlaksqee eehkermkmk kgfnsqmrse
       61 akrlktfety dtfrswtpqe maaagfyhtg vklgvqcfcc slilfgnslr klpierhkkl
      121 rpeceflqgk dvgnigkydi rvkspekmlr ggkaryheee arlesfedwp fyahgtsprv
      181 lsaagfvftg krdtvqcfsc ggslgnweeg ddpwkehakw fpkceflqsk ksseeiaqyi
      241 qgyegfvhvt gehfvnswvr relpmvsayc ndsvfaneel rmdtfkdwph espvavdalv
      301 raglfytgkk givqcfscgg cmekctegdd piqehnkffp ncvflqtpks saevipalqs
      361 hcalpeamet tsesnhddpa avhstvvglg rseaqwfqea rslseqlrdn ytkatfrhmn
      421 lpevcsslgt dhligcdvsi iskhisqpvq galtipevfs nlssvmcveg etgsgkttfl
      481 kriaflwasg ccpllyrfql vfylslssit pdqglaniic aqllgaggci sevclssiiq
      541 qlqhqvlfll ddysglaslp qalhtlitkn ylsrtcllia vhtnrvrgir syldtsleik
      601 efplsntvyi lkkffshnik rllefmvyfg qnedlqgihk tplfvaavct dwfenpsdqp
      661 fqdmalfksy mqylslkhkg aakplqatvs scgqlaltgl fsscfefnsd dlaeagvded
      721 eelttclmsk ftaqrlrpvy rflgplfqef laamrltell ssdrqedqdl glyylrqins
      781 plkalttynn flkyvfshps skagptvvsh llhlvdetel lentyknedy vnhppgtsri
      841 mkglkelwll speyyssfvs ehllrialnf ayesntvaec spfilqflrg rtlalkvlnl
      901 qyfrdhpesl llvkslevsi ngnkvpkvvd ysvmeksfet lqpptidqdy asafeqmkeh
      961 eknlseneet iksiknifpl qppkissgyw klspkpckip rlevgvtnmg padqallqvl
     1021 mevfsasqsi efrlsdssgf lesirpalel skasvtkcsm srlelsraeq ellltlpalq
     1081 slevsetnql pdqlfhnlhk flglkelcvr ldgkpdvlsv lpgefpnllh meklsirtsm
     1141 esdlsklvkl iqnspnlhvf hlkcdflsnc dslmavlasc kklreiefsg rcfeampfvn
     1201 ilpnfislki lnlisqqfpd ketsekfaqa lgslrnleel lvptgdgihq vaklivrqcl
     1261 qlpclrvlaf hyildndsvi eiarvatsgg fqklekldls mnhkiteegy rnffqaldnl
     1321 pnlqnlnicr hipeciqvqa ttvkalgqcv srlpsltrlh mlswlldeed mkvindvker
     1381 hpqskrliif wkwivpfspv vle
//
