LOCUS       NM_019542               1194 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus N-acetylglucosamine kinase (Nagk), transcript variant
            1, mRNA.
ACCESSION   NM_019542
VERSION     NM_019542.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1194)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1194)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 1194)
  AUTHORS   Stafford,C.A., Gassauer,A.M., de Oliveira Mann,C.C., Tanzer,M.C.,
            Fessler,E., Wefers,B., Nagl,D., Kuut,G., Sulek,K., Vasilopoulou,C.,
            Schwojer,S.J., Wiest,A., Pfautsch,M.K., Wurst,W., Yabal,M.,
            Frohlich,T., Mann,M., Gisch,N., Jae,L.T. and Hornung,V.
  TITLE     Phosphorylation of muramyl peptides by NAGK is required for NOD2
            activation
  JOURNAL   Nature 609 (7927), 590-596 (2022)
   PUBMED   36002575
  REMARK    GeneRIF: Phosphorylation of muramyl peptides by NAGK is required
            for NOD2 activation.
REFERENCE   4  (bases 1 to 1194)
  AUTHORS   Ripon,M.K.H., Lee,H., Dash,R., Choi,H.J., Oktaviani,D.F., Moon,I.S.
            and Haque,M.N.
  TITLE     N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1
            and promotes protein aggregate clearance
  JOURNAL   Cell Death Dis 11 (8), 619 (2020)
   PUBMED   32796833
  REMARK    GeneRIF: N-acetyl-D-glucosamine kinase binds dynein light chain
            roadblock 1 and promotes protein aggregate clearance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1194)
  AUTHORS   Nabeshima,R., Nishimura,O., Maeda,T., Shimizu,N., Ide,T.,
            Yashiro,K., Sakai,Y., Meno,C., Kadota,M., Shiratori,H., Kuraku,S.
            and Hamada,H.
  TITLE     Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and
            is associated with aberrant methylation at a subset of gene
            promoters
  JOURNAL   Elife 7, e36435 (2018)
   PUBMED   30070635
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1194)
  AUTHORS   Lee,H., Dutta,S. and Moon,I.S.
  TITLE     Upregulation of dendritic arborization by N-acetyl-D-glucosamine
            kinase is not dependent on its kinase activity
  JOURNAL   Mol Cells 37 (4), 322-329 (2014)
   PUBMED   24722415
  REMARK    GeneRIF: small domain, and not kinase activity, promotes
            dendritogenesis
REFERENCE   7  (bases 1 to 1194)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1194)
  AUTHORS   Bergfeld,A.K., Pearce,O.M., Diaz,S.L., Pham,T. and Varki,A.
  TITLE     Metabolism of vertebrate amino sugars with N-glycolyl groups:
            elucidating the intracellular fate of the non-human sialic acid
            N-glycolylneuraminic acid
  JOURNAL   J Biol Chem 287 (34), 28865-28881 (2012)
   PUBMED   22692205
REFERENCE   9  (bases 1 to 1194)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   10 (bases 1 to 1194)
  AUTHORS   Hinderlich,S., Berger,M., Schwarzkopf,M., Effertz,K. and Reutter,W.
  TITLE     Molecular cloning and characterization of murine and human
            N-acetylglucosamine kinase
  JOURNAL   Eur J Biochem 267 (11), 3301-3308 (2000)
   PUBMED   10824116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090647.6 and AC156283.6.
            
            On Aug 24, 2022 this sequence version replaced NM_019542.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004689.1, AJ242909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC090647.6         1592-1681           c
            91-175              AC156283.6         149239-149323       c
            176-274             AC156283.6         148955-149053       c
            275-416             AC156283.6         148133-148274       c
            417-527             AC156283.6         147576-147686       c
            528-640             AC156283.6         146847-146959       c
            641-728             AC156283.6         145872-145959       c
            729-826             AC156283.6         145042-145139       c
            827-905             AC156283.6         144654-144732       c
            906-1194            AC156283.6         143674-143962       c
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.96 cM"
     gene            1..1194
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /note="N-acetylglucosamine kinase"
                     /db_xref="GeneID:56174"
                     /db_xref="MGI:MGI:1860418"
     exon            1..90
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            91..175
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            176..274
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            275..416
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            417..527
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            528..640
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            641..728
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            729..826
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            827..905
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1194
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1169..1174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /note="hexamer: AATAAA"
     polyA_site      1194
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /note="major polyA site"
ORIGIN      
        1 gggagcgaag tcacggctag ggtcgaggtt gctacggcgg accagcggtg gcaacggtag
       61 tatggccgcg ctttatggtg gcgtggaagg gggaggcaca cggtccaaag tccttttact
      121 ttctgaggat gggcagatcc tggcagaagc agatggactg agcacaaacc actggctgat
      181 tggcacagac cagtgtgtgg agaggatcaa tgagatggtg gacagggcca aacagaaggc
      241 tggagtggat cctctggtgc cccttcgaag cctgggcctg tccctgagtg gtggggagca
      301 ggaggatgca gtgaggctcc tgattgagga gttgaggcac cgctttccca acctgagtga
      361 aaactactta atcaccacgg atgcagcagg ttccatcgcc acagccacac cggacggtgg
      421 gattgtgctc atctctggaa caggctccaa ctgtaggctt atcaaccctg atggctccga
      481 gagtggctgt ggaggctggg gccacatgat gggagacgag ggctcagcct actggattgc
      541 acaccaagct gtgaaaattg tgtttgattc catcgacaac ctggaggcag ctcctcatga
      601 tattggccat gtcaagcagg ccatgttcga ctatttccag gtgccagatc ggcttggaat
      661 cctcacccat ttgtataggg actttgataa atgcaagttt gctggatttt gccagaaaat
      721 tgcagaaggt gcacatcagg gagaccctct ttccaggtac atcttcagga aggctggaga
      781 gatgctgggc agacatgttg tggcagtatt gccagagatt gacccggttt tgttccaagg
      841 ggagcttggc ctccccattc tgtgtgtggg ctcagtgtgg aagagctggg agctcctgaa
      901 ggaaggcttt ctcctggcgc tgacgctggg ccgagagcag caggcacaga actccttctc
      961 cagcttcacc ctgatgaagt tgcggcattc ttctgcattg gggggtgcca gcctgggggc
     1021 caggcacatt ggataccacc ttcccatgga ctacagtatc aatgccattg ccttctattc
     1081 ctataccttc tagagtctgt ccccctgccc aaccagccaa caccgagagc tgggagactt
     1141 tcctttttaa aaaacacata tggaagaaaa taaatgcact ttactccttc ccta
//
