LOCUS       NM_001411280            1387 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus N-acetylglucosamine kinase (Nagk), transcript variant
            4, mRNA.
ACCESSION   NM_001411280 XM_030255509
VERSION     NM_001411280.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1387)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1387)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 1387)
  AUTHORS   Stafford,C.A., Gassauer,A.M., de Oliveira Mann,C.C., Tanzer,M.C.,
            Fessler,E., Wefers,B., Nagl,D., Kuut,G., Sulek,K., Vasilopoulou,C.,
            Schwojer,S.J., Wiest,A., Pfautsch,M.K., Wurst,W., Yabal,M.,
            Frohlich,T., Mann,M., Gisch,N., Jae,L.T. and Hornung,V.
  TITLE     Phosphorylation of muramyl peptides by NAGK is required for NOD2
            activation
  JOURNAL   Nature 609 (7927), 590-596 (2022)
   PUBMED   36002575
  REMARK    GeneRIF: Phosphorylation of muramyl peptides by NAGK is required
            for NOD2 activation.
REFERENCE   4  (bases 1 to 1387)
  AUTHORS   Ripon,M.K.H., Lee,H., Dash,R., Choi,H.J., Oktaviani,D.F., Moon,I.S.
            and Haque,M.N.
  TITLE     N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1
            and promotes protein aggregate clearance
  JOURNAL   Cell Death Dis 11 (8), 619 (2020)
   PUBMED   32796833
  REMARK    GeneRIF: N-acetyl-D-glucosamine kinase binds dynein light chain
            roadblock 1 and promotes protein aggregate clearance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1387)
  AUTHORS   Nabeshima,R., Nishimura,O., Maeda,T., Shimizu,N., Ide,T.,
            Yashiro,K., Sakai,Y., Meno,C., Kadota,M., Shiratori,H., Kuraku,S.
            and Hamada,H.
  TITLE     Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and
            is associated with aberrant methylation at a subset of gene
            promoters
  JOURNAL   Elife 7, e36435 (2018)
   PUBMED   30070635
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1387)
  AUTHORS   Lee,H., Dutta,S. and Moon,I.S.
  TITLE     Upregulation of dendritic arborization by N-acetyl-D-glucosamine
            kinase is not dependent on its kinase activity
  JOURNAL   Mol Cells 37 (4), 322-329 (2014)
   PUBMED   24722415
  REMARK    GeneRIF: small domain, and not kinase activity, promotes
            dendritogenesis
REFERENCE   7  (bases 1 to 1387)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1387)
  AUTHORS   Bergfeld,A.K., Pearce,O.M., Diaz,S.L., Pham,T. and Varki,A.
  TITLE     Metabolism of vertebrate amino sugars with N-glycolyl groups:
            elucidating the intracellular fate of the non-human sialic acid
            N-glycolylneuraminic acid
  JOURNAL   J Biol Chem 287 (34), 28865-28881 (2012)
   PUBMED   22692205
REFERENCE   9  (bases 1 to 1387)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   10 (bases 1 to 1387)
  AUTHORS   Hinderlich,S., Berger,M., Schwarzkopf,M., Effertz,K. and Reutter,W.
  TITLE     Molecular cloning and characterization of murine and human
            N-acetylglucosamine kinase
  JOURNAL   Eur J Biochem 267 (11), 3301-3308 (2000)
   PUBMED   10824116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090647.6 and AC156283.6.
            
            On Aug 24, 2022 this sequence version replaced XM_030255509.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.519960.1,
                                           SRR7345562.1902754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC090647.6         1500-1681           c
            183-368             AC156283.6         149138-149323       c
            369-467             AC156283.6         148955-149053       c
            468-609             AC156283.6         148133-148274       c
            610-720             AC156283.6         147576-147686       c
            721-833             AC156283.6         146847-146959       c
            834-921             AC156283.6         145872-145959       c
            922-1019            AC156283.6         145042-145139       c
            1020-1098           AC156283.6         144654-144732       c
            1099-1387           AC156283.6         143674-143962       c
FEATURES             Location/Qualifiers
     source          1..1387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.96 cM"
     gene            1..1387
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /note="N-acetylglucosamine kinase"
                     /db_xref="GeneID:56174"
                     /db_xref="MGI:MGI:1860418"
     exon            1..182
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            183..368
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1286
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /EC_number="2.7.1.60"
                     /EC_number="2.7.1.59"
                     /note="isoform 4 is encoded by transcript variant 4;
                     N-acetyl-D-glucosamine kinase; GlcNAc kinase; muramyl
                     dipeptide kinase; N-acetyl-D-mannosamine kinase"
                     /codon_start=1
                     /product="N-acetyl-D-glucosamine kinase isoform 4"
                     /protein_id="NP_001398209.1"
                     /db_xref="GeneID:56174"
                     /db_xref="MGI:MGI:1860418"
                     /translation="MYCSTPIELIGTDQCVERINEMVDRAKQKAGVDPLVPLRSLGLS
                     LSGGEQEDAVRLLIEELRHRFPNLSENYLITTDAAGSIATATPDGGIVLISGTGSNCR
                     LINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHDIGHVKQAMFD
                     YFQVPDRLGILTHLYRDFDKCKFAGFCQKIAEGAHQGDPLSRYIFRKAGEMLGRHVVA
                     VLPEIDPVLFQGELGLPILCVGSVWKSWELLKEGFLLALTLGREQQAQNSFSSFTLMK
                     LRHSSALGGASLGARHIGYHLPMDYSINAIAFYSYTF"
     exon            369..467
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            468..609
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            610..720
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            721..833
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            834..921
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1019
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1098
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1387
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1362..1367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /note="hexamer: AATAAA"
     polyA_site      1387
                     /gene="Nagk"
                     /gene_synonym="Gnk"
                     /note="major polyA site"
ORIGIN      
        1 gggagcgaag tcacggctag ggtcgaggtt gctacggcgg accagcggtg gcaacggtag
       61 tatggccgcg ctttatggtg gcgtggaagg gtgagcgctg gatcggccga aggctgtccg
      121 tccgggagcg gcgggtcagg gggcggcggc ccacaccatg cccggtgcct ttgtgctcca
      181 cggggaggca cacggtccaa agtcctttta ctttctgagg atgggcagat cctggcagaa
      241 gcagatggac tgagcacaaa ccactgggta aaaaaaaaaa aaaaaaaaaa aaaaaaagaa
      301 gaagaaagca agccatcctg aggggaccag agaacttggc cttcatgtac tgttcaactc
      361 cgatagagct gattggcaca gaccagtgtg tggagaggat caatgagatg gtggacaggg
      421 ccaaacagaa ggctggagtg gatcctctgg tgccccttcg aagcctgggc ctgtccctga
      481 gtggtgggga gcaggaggat gcagtgaggc tcctgattga ggagttgagg caccgctttc
      541 ccaacctgag tgaaaactac ttaatcacca cggatgcagc aggttccatc gccacagcca
      601 caccggacgg tgggattgtg ctcatctctg gaacaggctc caactgtagg cttatcaacc
      661 ctgatggctc cgagagtggc tgtggaggct ggggccacat gatgggagac gagggctcag
      721 cctactggat tgcacaccaa gctgtgaaaa ttgtgtttga ttccatcgac aacctggagg
      781 cagctcctca tgatattggc catgtcaagc aggccatgtt cgactatttc caggtgccag
      841 atcggcttgg aatcctcacc catttgtata gggactttga taaatgcaag tttgctggat
      901 tttgccagaa aattgcagaa ggtgcacatc agggagaccc tctttccagg tacatcttca
      961 ggaaggctgg agagatgctg ggcagacatg ttgtggcagt attgccagag attgacccgg
     1021 ttttgttcca aggggagctt ggcctcccca ttctgtgtgt gggctcagtg tggaagagct
     1081 gggagctcct gaaggaaggc tttctcctgg cgctgacgct gggccgagag cagcaggcac
     1141 agaactcctt ctccagcttc accctgatga agttgcggca ttcttctgca ttggggggtg
     1201 ccagcctggg ggccaggcac attggatacc accttcccat ggactacagt atcaatgcca
     1261 ttgccttcta ttcctatacc ttctagagtc tgtccccctg cccaaccagc caacaccgag
     1321 agctgggaga ctttcctttt taaaaaacac atatggaaga aaataaatgc actttactcc
     1381 ttcccta
//
