LOCUS       NM_008669               1856 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus N-acetyl galactosaminidase, alpha (Naga), transcript
            variant 1, mRNA.
ACCESSION   NM_008669
VERSION     NM_008669.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1856)
  AUTHORS   Harper,J., Mould,A., Andrews,R.M., Bikoff,E.K. and Robertson,E.J.
  TITLE     The transcriptional repressor Blimp1/Prdm1 regulates postnatal
            reprogramming of intestinal enterocytes
  JOURNAL   Proc Natl Acad Sci U S A 108 (26), 10585-10590 (2011)
   PUBMED   21670299
REFERENCE   4  (bases 1 to 1856)
  AUTHORS   Tajima,Y., Kawashima,I., Tsukimura,T., Sugawara,K., Kuroda,M.,
            Suzuki,T., Togawa,T., Chiba,Y., Jigami,Y., Ohno,K., Fukushige,T.,
            Kanekura,T., Itoh,K., Ohashi,T. and Sakuraba,H.
  TITLE     Use of a modified alpha-N-acetylgalactosaminidase in the
            development of enzyme replacement therapy for Fabry disease
  JOURNAL   Am J Hum Genet 85 (5), 569-580 (2009)
   PUBMED   19853240
  REMARK    GeneRIF: Use of a modified Naga in the development of enzyme
            replacement therapy for Fabry disease is reported.
REFERENCE   5  (bases 1 to 1856)
  AUTHORS   Hentges,K.E., Yarlagadda,S.P. and Justice,M.J.
  TITLE     Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia
            virus insertions at Lvis22
  JOURNAL   Genomics 80 (2), 204-212 (2002)
   PUBMED   12160734
REFERENCE   6  (bases 1 to 1856)
  AUTHORS   Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J.,
            Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     High-throughput sequence identification of gene coding variants
            within alcohol-related QTLs
  JOURNAL   Mamm Genome 12 (8), 657-663 (2001)
   PUBMED   11471062
REFERENCE   7  (bases 1 to 1856)
  AUTHORS   Wang,A.M., Ioannou,Y.A., Zeidner,K.M. and Desnick,R.J.
  TITLE     Murine alpha-N-acetylgalactosaminidase: isolation and expression of
            a full-length cDNA and genomic organization: further evidence of an
            alpha-galactosidase gene family
  JOURNAL   Mol Genet Metab 65 (2), 165-173 (1998)
   PUBMED   9787108
REFERENCE   8  (bases 1 to 1856)
  AUTHORS   Herrmann,T., Schindler,D., Tabe,H., Onodera,O., Igarashi,S.,
            Polack,A., Zehnpfennig,D. and Shoji,Tsuji.
  TITLE     Molecular cloning, structural organization, sequence, chromosomal
            assignment, and expression of the mouse
            alpha-N-acetylgalactosaminidase gene
  JOURNAL   Gene 211 (2), 205-214 (1998)
   PUBMED   9602128
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104325.28.
            
            On Aug 25, 2022 this sequence version replaced NM_008669.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF079458.1, AK077116.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC104325.28        187668-187698       c
            32-108              AC104325.28        187154-187230       c
            109-244             AC104325.28        186303-186438       c
            245-416             AC104325.28        185686-185857       c
            417-594             AC104325.28        184759-184936       c
            595-689             AC104325.28        184413-184507       c
            690-851             AC104325.28        183702-183863       c
            852-1049            AC104325.28        181249-181446       c
            1050-1193           AC104325.28        179571-179714       c
            1194-1856           AC104325.28        178461-179123       c
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.56 cM"
     gene            1..1856
                     /gene="Naga"
                     /note="N-acetyl galactosaminidase, alpha"
                     /db_xref="GeneID:17939"
                     /db_xref="MGI:MGI:1261422"
     exon            1..31
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            32..108
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1340
                     /gene="Naga"
                     /EC_number="3.2.1.49"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; alpha-N-acetylgalactosaminidase;
                     alpha-galactosidase B"
                     /codon_start=1
                     /product="alpha-N-acetylgalactosaminidase isoform 1
                     precursor"
                     /protein_id="NP_032695.3"
                     /db_xref="CCDS:CCDS27686.1"
                     /db_xref="GeneID:17939"
                     /db_xref="MGI:MGI:1261422"
                     /translation="MLQKTVLLLALVAQVLMLENGLLRTPPMGWLAWERFRCNIDCVE
                     DPKNCISERLFMEMADRLAQDGWRDLGYVYLNIDDCWIGGRDASGRLIPDPKRFPHGI
                     AFLADYAHSLGLKLGIYEDMGKMTCMGYPGTTLDKVELDAETFAEWKVDMLKLDGCFS
                     SSRERAEGYPKMAAALNATGRPIAFSCSWPAYEGGLPPKVNYTEVSRVCNLWRNYKDI
                     QDSWKSVLSILDWFVRHQDVLQPVAGPGHWNDPDMLLIGNFGLSFDESRAQMALWTVL
                     AAPLLMSTDLRTISPQNMDILQNPLMIKINQDPLGIQGRRILKSKSHIEVFKRYLSNQ
                     ASALVFFSRRTDMPFRFHCSLLELNYPKGRVYEGQNVFTGDIFSGLQTEVNFTVIINP
                     SGVVMWYLYPIKDLGISTMMSHW"
     exon            109..244
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            245..416
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            417..594
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            595..689
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            690..851
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1049
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1193
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1856
                     /gene="Naga"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1834..1839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naga"
                     /note="hexamer: AATAAA"
     polyA_site      1856
                     /gene="Naga"
                     /note="major polyA site"
ORIGIN      
        1 acggcttacc gcggactgag cgagcgcgag gttcagcata taaagctgct aagagcagat
       61 tcgagtgggt cctgagattt gactccaagg caatgttgca gaagacagtg ctcttactgg
      121 ccctggtggc tcaggtactg atgctggaga atgggctact gcggactcca cccatgggct
      181 ggctggcctg ggaacgcttc cgctgtaaca tcgactgtgt ggaggacccg aagaactgca
      241 tcagtgaacg gctctttatg gagatggcgg acagactggc ccaggatgga tggcgggacc
      301 tgggctatgt atacctcaac atcgatgact gctggattgg tgggcgtgac gcctcaggcc
      361 gcctaattcc tgatcccaag cgcttccctc acgggattgc cttcctagct gactatgctc
      421 actctttggg tctgaagctg ggcatctatg aggacatggg caaaatgacc tgcatgggtt
      481 accctggtac caccctagac aaagtggagc tggacgcgga aaccttcgcg gagtggaagg
      541 tggacatgct gaagttggat ggctgtttct ccagctccag agaacgtgca gaggggtacc
      601 ccaagatggc tgctgccctg aacgccacgg gccgtcccat tgccttttct tgcagctggc
      661 cagcctatga agggggccta ccccccaagg tgaactacac cgaggtttcc agggtctgca
      721 atctctggcg caactataaa gacatccagg actcctggaa gagtgtgctg tccatcctgg
      781 actggtttgt gagacaccag gatgtactgc agccggtggc gggtcctggg cactggaatg
      841 acccagacat gctgctcatc gggaactttg gcctgagctt cgatgaatcc cgggcacaaa
      901 tggccctgtg gacagtgctc gcagcccccc tcctcatgtc cacggacctg cgtaccatct
      961 cccctcagaa tatggacatt cttcagaacc cactcatgat caaaatcaat caggacccct
     1021 taggcatcca gggacgcagg atcttaaaga gcaaatccca tatcgaagtg ttcaagaggt
     1081 atctgtctaa ccaggccagt gccctggttt tcttcagccg caggacagac atgcctttcc
     1141 gctttcattg ctccctcttg gaactaaact accccaaagg cagagtgtat gagggccaga
     1201 acgtcttcac aggagatatc ttcagtggtc tccagactga agtcaacttc actgtgatca
     1261 tcaatccttc gggggttgtg atgtggtacc tctatcccat caaagacctg gggatatcca
     1321 cgatgatgtc ccactggtga ggacccaaga atgacaggct acggcagccc cactgagcct
     1381 ggaccacgga gccttgacag gccaaggaca tggcagggct ctgtcctcca caggctgctt
     1441 ggtgatgtga cctccacccc ccaaagtgca tttgcagggc ccaggttcaa tgccaggtcc
     1501 agctgaagca ggggccttct tggaagcttg gaactcttgg gacagtttcc tgtggccttc
     1561 cggcctctgc ccctacacag ctctgcagat ttcactcggc cagcctcccg agccccccgc
     1621 aggcagggtc ctgatgccca ctggactcca gcctctgact ttgctgactc agaaatcagg
     1681 atttggaatt tttaaaatta agaagagaga cctgactcct tgccaggaat tctcagaatc
     1741 atgtgattag ccttcctcct ggagaaggcc tttgcagttg ataccctgag ggagtgaagg
     1801 aggaatcaga gaccttagct ccctcaggtc gctaataaag ctgttttttt ttttaa
//
