LOCUS       NM_001163564            2990 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus nuclear assembly factor 1 ribonucleoprotein (Naf1),
            mRNA.
ACCESSION   NM_001163564 XR_032374 XR_032626
VERSION     NM_001163564.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2990)
  AUTHORS   Stanley,S.E., Gable,D.L., Wagner,C.L., Carlile,T.M.,
            Hanumanthu,V.S., Podlevsky,J.D., Khalil,S.E., DeZern,A.E.,
            Rojas-Duran,M.F., Applegate,C.D., Alder,J.K., Parry,E.M.,
            Gilbert,W.V. and Armanios,M.
  TITLE     Loss-of-function mutations in the RNA biogenesis factor NAF1
            predispose to pulmonary fibrosis-emphysema
  JOURNAL   Sci Transl Med 8 (351), 351ra107 (2016)
   PUBMED   27510903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116731.9 and AK144735.1.
            
            On or before Jul 25, 2009 this sequence version replaced
            XR_032626.1, XR_032374.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144735.1, SRR7974084.29700.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-754               AC116731.9         36087-36840         c
            755-2990            AK144735.1         2-2237
FEATURES             Location/Qualifiers
     source          1..2990
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.18 cM"
     gene            1..2990
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /note="nuclear assembly factor 1 ribonucleoprotein"
                     /db_xref="GeneID:234344"
                     /db_xref="MGI:MGI:2682306"
     exon            1..830
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1944
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /note="nuclear assembly factor 1 homolog"
                     /codon_start=1
                     /product="H/ACA ribonucleoprotein complex non-core subunit
                     NAF1"
                     /protein_id="NP_001157036.1"
                     /db_xref="CCDS:CCDS52562.1"
                     /db_xref="GeneID:234344"
                     /db_xref="MGI:MGI:2682306"
                     /translation="MEVVEAAAQLQTLKFGGSGQGSAAPQPPEDRREAPPPGVQPPPP
                     APSSDPGGRPPPLPAPSSDPGGRPPPLPAPNSDPGGRPPPLPAPSSDPGGRPPPLPAP
                     NSDPGGRPPPLPAPSSDPGGRPPPLPAPNSDPGGRPPPPPAPSSDPGGRPPPPPAPNW
                     DAGGRPPPPPAPNSDPGGRPTPPLPALNWDAGGRPPPPGGAWVTGRNAAEPPPVLQAS
                     DSSDSDSDSETDSDSSSSSSSSSSSSSSCVSFPPVLSDGDEDFQLEKENKNFPLKTKD
                     ELLLNELPSVEELTVILPEDIALKPLGKVSSIIEQLVIIESVTNIPPVNEDTVIFKSD
                     RQAAGKIFEIFGPVAHPFYVLRFNSSDHIESKGIKINDTMYFAPSMKDFTQYIFTEKL
                     KQDRGSDASWKNDQEPPPEVLDFSDDEKEKEAKQRKKSQIQGRKKLKSELNESGEDFG
                     EVHENWNAYSSSEHSKGYHHREFSRGFARGRYSRRSHGRPPPQQYYNSDHMASQESLG
                     FTPQRQDNPVMPHYPFPPPMFDMHNFPLPPPPPPPPPPPPSMGWAAPSMASHPVLNLP
                     YSMPPPPLPPPPPPPPPSPGENNSSHFGPYF"
     exon            831..993
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1087
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1170
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1331
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1383
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1486
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..2990
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2964..2969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /note="hexamer: AATAAA"
     polyA_site      2984
                     /gene="Naf1"
                     /gene_synonym="Gm174"
                     /note="major polyA site"
ORIGIN      
        1 tcccggaagt cccgtgaatg atgccggggg cgtgtcctca ggtcggtccg cgtgcggtta
       61 cctgagaaac gcgcgggctt cagcgtggcc gagttggcta gcttggcttc tgaggagacc
      121 ctcgcgctgc tctgcggccc gggcggcgcc atggaggtgg tggaggccgc cgcgcagctg
      181 cagacgctca agttcggcgg ctccggccag gggtcggcag caccgcagcc acctgaggat
      241 cgccgggagg ccccgccgcc gggggtgcag ccgccgccgc cagccccgag ctcggatccc
      301 ggcggaagac caccgccgct gccagccccg agctcggatc ccggcggaag accaccgccg
      361 ctgccagccc cgaactcgga tcccggcgga agaccaccgc cgctgccagc cccgagctcg
      421 gatcccggcg gaagaccacc gccgctgcca gccccgaact cggatcccgg cggaagacca
      481 ccgccgctgc cagccccgag ctcggatccc ggcggaagac caccgccgct gccagccccg
      541 aactcggatc ccggcggaag accaccgccg ccgccagccc cgagctcgga tcccggcgga
      601 agaccaccgc cgccgccagc cccgaactgg gatgcgggcg gaagaccacc accgccgcca
      661 gccccgaact cggatcccgg cggaagaccg actccgccgc tgccagccct gaactgggat
      721 gcgggcggaa gaccaccgcc gccgggcggg gcctgggtca ccggccggaa cgccgcggag
      781 ccgccgccag tgctgcaggc ctcggactcc tcggactcgg attcggacag tgaaacagat
      841 tcagatagct ccagctcctc ctcttcgtcg tcctcttcat cttcatcctg tgtatcattt
      901 cctcctgtgt tgtcagatgg agatgaggat tttcaacttg agaaagaaaa taagaatttt
      961 cctcttaaaa caaaagatga attgcttctt aatgaactac cttctgttga agaactcact
     1021 gtaattctgc ctgaagacat tgcactaaag cctcttggga aggtttcaag cattattgaa
     1081 caattagtaa taattgagtc tgtgactaac atacctccag ttaatgagga tactgtcatt
     1141 ttcaaaagtg atcgacaagc agcagggaag atatttgaga tatttggacc tgttgcccat
     1201 ccattttatg tgttacggtt taattcatca gatcacattg agagtaaagg tatcaaaata
     1261 aatgacacga tgtattttgc tccatcaatg aaagacttca ctcaatatat attcacagaa
     1321 aagctcaaac aggacagagg atcggacgct tcttggaaga atgatcagga accccctcca
     1381 gaagtcttgg acttcagtga cgatgagaaa gaaaaagaag ccaaacagag aaaaaaatct
     1441 cagattcaag gccgcaaaaa actcaaatct gaattgaatg agtcaggtga agattttggt
     1501 gaagtgcatg agaattggaa tgcttatagc tcttcagaac attcaaaagg atatcaccac
     1561 agggaattct caagaggctt tgcgaggggt agatactctc gaagaagcca tggcaggcct
     1621 ccacctcagc agtactataa ctcagaccat atggcatctc aagagagttt gggatttaca
     1681 cctcagagac aagataatcc tgtcatgccc cactatcctt ttcccccgcc catgtttgat
     1741 atgcataact ttccacttcc gcccccaccc ccacccccgc ctccgccccc accaagcatg
     1801 gggtgggctg cacctagcat ggcctctcat cctgtgctta acttaccata ctccatgccc
     1861 ccaccacctc ttcctccacc acctccacct ccccctccct ctcctgggga aaataattct
     1921 tctcattttg ggccttattt ttagttgtat gcttgtattt cagagaaata tgataaaaaa
     1981 gaaaatttaa catatattgt agaactagat tattttttat aaaaacattg taaaatacta
     2041 aatcaaatga ctcagttgta cattcatata tatttttaat aactcagttg taagctcata
     2101 tatatttgta acctttatga aatgatattg ctagggaaag ttcatctcat tcttaggaaa
     2161 ctccagttca tgtaataatt aaatacaatg ttgtctcatg tcctctgcta cccacagcag
     2221 gtaaacagcg tgcatagtga tggttatgac acagggttca tcatggccgc tgatacactg
     2281 aacaccgatg gaaaacttga cacttggttt ataagtgcaa gaattctttt tttatttaca
     2341 cattgaagac tttattgaaa atatttctaa taataaccac tattttgtgt ggtttagctc
     2401 actttaccaa ataaaataga gcaaatagag cacatcttga gaagtctaat tatatattac
     2461 ttcataactt aatcattaat caggtatagg catttattta atatacatta gaactatgat
     2521 tcaattttta attttattga cctactaaag gcaaaagaat aagttgtctg ctcccttcct
     2581 gtaataacag ggtctaaaat cacttggagt cctaaaaaca agcaaactca catgtttgag
     2641 ttcttctgct cctgaatttg ttattttttt gatacttgct tctattacct tttatatata
     2701 tatggttatc ctagtgcaaa aattcattag acttgattcc cttaagcaag ttagaagtgt
     2761 gaaggaggaa gacattggct gaagctctca taatactagt gggttagtag tcactgtgca
     2821 ttgacagact tgtgttgtct atgtagctgt cagttagtta gaaagcttta ctgttccact
     2881 gtgtacatta aggcatgtgt tggtatatat gtgtattctg tgtctagtca caggctctcc
     2941 agtacctgac atgtgtaacg tgtaataaag gcatattaaa tgactgagtg
//
