LOCUS       NM_001159637            3053 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus NAD kinase (Nadk), transcript variant 1, mRNA.
ACCESSION   NM_001159637
VERSION     NM_001159637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3053)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3053)
  AUTHORS   Oka,S.I., Byun,J., Huang,C.Y., Imai,N., Ralda,G., Zhai,P., Xu,X.,
            Kashyap,S., Warren,J.S., Alan Maschek,J., Tippetts,T.S., Tong,M.,
            Venkatesh,S., Ikeda,Y., Mizushima,W., Kashihara,T. and Sadoshima,J.
  TITLE     Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy
  JOURNAL   Circ Res 129 (1), 114-130 (2021)
   PUBMED   33928788
REFERENCE   3  (bases 1 to 3053)
  AUTHORS   Zhang,K., Kim,H., Fu,Z., Qiu,Y., Yang,Z., Wang,J., Zhang,D.,
            Tong,X., Yin,L., Li,J., Wu,J., Qi,N.R., Houten,S.M. and Zhang,R.
  TITLE     Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced
            Hepatic Steatosis in Mice
  JOURNAL   Gastroenterology 154 (1), 224-237 (2018)
   PUBMED   28923496
REFERENCE   4  (bases 1 to 3053)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   5  (bases 1 to 3053)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 3053)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   7  (bases 1 to 3053)
  AUTHORS   Lerner,F., Niere,M., Ludwig,A. and Ziegler,M.
  TITLE     Structural and functional characterization of human NAD kinase
  JOURNAL   Biochem Biophys Res Commun 288 (1), 69-74 (2001)
   PUBMED   11594753
REFERENCE   8  (bases 1 to 3053)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3053)
  AUTHORS   Tavtigian,S.V., Zabludoff,S.D. and Wold,B.J.
  TITLE     Cloning of mid-G1 serum response genes and identification of a
            subset regulated by conditional myc expression
  JOURNAL   Mol Biol Cell 5 (3), 375-388 (1994)
   PUBMED   8049528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ166231.1, AK147917.1, BF682935.1, AA197692.1, BF453238.1,
            AW455445.1 and BE950056.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170608.1, AK147917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               CJ166231.1         1-278
            279-1488            AK147917.1         256-1465
            1489-2030           BF682935.1         218-759
            2031-2119           AA197692.1         95-183
            2120-2628           BF453238.1         33-541
            2629-2843           AW455445.1         200-414             c
            2844-3053           BE950056.1         1-210               c
FEATURES             Location/Qualifiers
     source          1..3053
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 86.44 cM"
     gene            1..3053
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /note="NAD kinase"
                     /db_xref="GeneID:192185"
                     /db_xref="MGI:MGI:2183149"
     exon            1..165
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            166..370
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1511
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /EC_number="2.7.1.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     poly(P)/ATP NAD kinase; Putative inorganic
                     polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase)"
                     /codon_start=1
                     /product="NAD kinase isoform 1"
                     /protein_id="NP_001153109.1"
                     /db_xref="CCDS:CCDS19031.1"
                     /db_xref="GeneID:192185"
                     /db_xref="MGI:MGI:2183149"
                     /translation="MEMEQEKMNLSQELSADSASYNCSACHGDETWSYNHPIRGRAKS
                     RSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTIMHIQDPASQRLTWNK
                     SPKSVLVIKKIRDASLLQPFKELCIYLMEENNMIVYVEKKVLEDPAIVSDENFGPVKK
                     KFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFNF
                     ENFQSQVNQVIEGNAAVILRSRLKVRVVKEPRDKKTAIHNGLSENGLDTEGGKQAMQY
                     QVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMVHP
                     NVPAIMVTPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSI
                     SITTSCYPLPSICVCDPVSDWFESLAQCLHWNVRKKQAHFPEDEEDS"
     exon            371..454
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            455..584
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            585..693
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            694..779
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            780..882
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1022
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1122
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1280
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1363
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..3037
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1878..1883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1898
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /note="major polyA site"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
                     /note="hexamer: AATGAA"
     polyA_site      3023
                     /gene="Nadk"
                     /gene_synonym="4432404C02Rik"
ORIGIN      
        1 actgacagcc gcggcgcagc ggggcttggt ggtgccggtc tctggaccga gcggccatgg
       61 ggtggcgggc ggctgggtcg ctgagagcca ggtagcagta gggcagcagg gaccgcctgc
      121 tcggcccagc atgtagacgt ccacgcgggc gcgcggcagc cgacggcacc agagtttttc
      181 tcatatcaac tatggaaatg gaacaagaaa agatgaacct gagtcaggag ctgagtgccg
      241 actcagcctc ctacaactgc tcagcatgtc atggggatga gacctggagc tacaatcacc
      301 ctatccgggg ccgggccaag tctcggagcc tgtcagcctc acctgcccta ggcagcacca
      361 aggagttcag gaggacccgc tctctccatg gaccgtgccc agtgacaaca tttggaccaa
      421 aggcctgcgt gctgcagaac ccgcagacca tcatgcacat ccaggaccct gcaagtcaac
      481 ggttgacatg gaacaagtct cccaagagtg tgcttgtcat caaaaagatc cgagatgcca
      541 gcttactgca gcccttcaaa gagctctgca tatacctcat ggaggaaaac aacatgatcg
      601 tgtatgtgga aaagaaagtt ctggaagacc ctgctatagt gagtgatgaa aactttggac
      661 cagtgaagaa gaagttctgc acgttccgtg aagactatga tgacatttcc aaccagatag
      721 acttcatcat atgccttgga ggagatggca ccttgctcta tgcctcctca cttttccagg
      781 gcagtgtgcc tcctgtcatg gccttccacc ttggatccct gggctttctg acccccttca
      841 actttgagaa cttccaatcc caagtgaatc aggtgataga ggggaatgcc gctgtcatcc
      901 tgaggagccg gctgaaggtc agggtggtga aagagcccag agacaagaag acagccatcc
      961 acaacggcct cagtgaaaat ggtctggaca cagagggcgg aaaacaggct atgcaatacc
     1021 aggtcttaaa tgaagtggtg atcgacagag gcccctcctc atatctgtcc aacgtggatg
     1081 tctacctgga tggacacctt atcactactg tgcagggcga tggagtgatc gtgtccaccc
     1141 cgacgggcag cacagcatat gcagctgcag ccggggcctc catggtccac cccaacgtgc
     1201 cggccatcat ggttacaccc atctgccccc actcgctgtc attccggcct atcgtggtcc
     1261 ctgcaggggt cgagctgaag attatgctgt caccggaagc caggaacacg gcatgggtgt
     1321 cttttgatgg acggaagaga caggaaatcc gccatggaga cagcatcagc attaccacct
     1381 cctgctaccc gctgccctcc atctgtgtgt gcgaccctgt gagtgactgg ttcgagagcc
     1441 ttgcccagtg tctgcactgg aatgttcgaa agaagcaagc tcactttcca gaggatgagg
     1501 aggacagcta gactacattt cccagcttcc aacctgcgca gaccctcaag ctcttggggg
     1561 ccttccttct cttgctctcc tgctggcctt ctggctgacc tagccttgac aaaccacatg
     1621 gctgtccagg catctatgtc ctgcctgcct tgctgggaga gcttgggtct gccttttgca
     1681 gaacagatca gctttttaat gtttttaaaa cctctttttc atttctaaaa aagcaaaatg
     1741 agaactgggc tgggtgtcct acatctctcc catgggcccc cgtatccccc tgagattccc
     1801 aggtcaggaa ttcccataaa tcagtctgtt gaaattctga gggggtcaga atgaattgat
     1861 cttccttttg atactgaaat aaatgtctca gccagaaatc ttcttttaac tgcagtgctt
     1921 ttccacaggg cctgtacctt tccccctggc agctttgcta tgggtgggca aggcaagctt
     1981 gctttttgtg tttctggaga tggctaggtc cctctcagtc tggcccccag acctctgact
     2041 ccttccagag cagacagagg caacacttgg cacagccatc caacaacctc acattcctca
     2101 cacaacaggg cagcagcccc tggggacagt ttcaatcctg tatacacttt ttagaggtta
     2161 ttttaaactt tctgaagtga ttatgtacat attttcttgt acacactttg tgaagattta
     2221 gaggggactg cctgttgtcc agtgtttaca ttgtgtccag gacagggctc tgtgcttcca
     2281 ctcctccctt acacagtggc cacaagggtt ttgagaccag ctcactattg acatcaggct
     2341 cgtgggcccg ctctccttcc ataagaatct taggtttgat tccatctgaa cagcagccat
     2401 atggagcctg tgtgcgagat gcatggagcc atgtaatgca agtaacatta gcacgtgagt
     2461 gccacacagg ccgtgagtgc cacacacgcc ctagagcctt tgtggagtca gtggtcagcc
     2521 acgtcgtctc agctcgctag ctactttcag ttttgtcctc acctcttgca gcaggagtcg
     2581 gaaggaagga ctgcctgtcc tttgactggc ttttgtctcc tgcttctagg aaaggtttgt
     2641 cagtcagctg ctgtagaacc aaacccactg agctttccta cctgttaaag tcaggaccta
     2701 ctgagcaccc atggagccct aagtggtctg ggttcagtgc tgttatcatg gtgactcgtc
     2761 cccacggtct gtgctgttca tctgtgactg agcacagcag gcctctgcta tgatccagag
     2821 gagagcaggg tctgaagtgt gtgccacgca tctcaaaagc aagtgttgac aaatctagaa
     2881 gcagctgcca ccagactgat ctagaacaca tggagttttc acgtaaattc ttaatgtttc
     2941 atattgttaa tatcttaaaa ttttgttaat tgttaatgaa ggccttatta ctattttcag
     3001 attctttcaa taaataaact tgtttaaaaa aaattgaaaa aaaaaaaaaa aaa
//
