LOCUS       NM_025788               4332 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus nucleus accumbens associated 1, BEN and BTB (POZ)
            domain containing (Nacc1), mRNA.
ACCESSION   NM_025788
VERSION     NM_025788.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4332)
  AUTHORS   Deehan,M.A., Kothuis,J.M., Sapp,E., Chase,K., Ke,Y., Seeley,C.,
            Iuliano,M., Kim,E., Kennington,L., Miller,R., Boudi,A., Shing,K.,
            Li,X., Pfister,E., Anaclet,C., Brodsky,M., Kegel-Gleason,K.,
            Aronin,N. and DiFiglia,M.
  TITLE     Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with
            Underlying Synaptic Dysfunction
  JOURNAL   J Neurosci 44 (14), e1610232024 (2024)
   PUBMED   38388424
  REMARK    GeneRIF: Nacc1 Mutation in Mice Models Rare Neurodevelopmental
            Disorder with Underlying Synaptic Dysfunction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4332)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4332)
  AUTHORS   Wang,L., Peng,H.Y., Kishore Das,J., Kumar,A., Ren,Y., Ballard,D.J.,
            Xiong,X., Yang,W., Ren,X., de Figueiredo,P., Yang,J.M. and Song,J.
  TITLE     NAC1 confines virus-specific memory formation of CD4+ T cells
            through the ROCK1-mediated pathway
  JOURNAL   J Med Virol 95 (7), e28957 (2023)
   PUBMED   37465969
  REMARK    GeneRIF: NAC1 confines virus-specific memory formation of CD4[+] T
            cells through the ROCK1-mediated pathway.
REFERENCE   4  (bases 1 to 4332)
  AUTHORS   Ren,Y., Kumar,A., Das,J.K., Peng,H.Y., Wang,L., Balllard,D.,
            Xiong,X., Ren,X., Zhang,Y., Yang,J.M. and Song,J.
  TITLE     Tumorous expression of NAC1 restrains antitumor immunity through
            the LDHA-mediated immune evasion
  JOURNAL   J Immunother Cancer 10 (9) (2022)
   PUBMED   36150745
  REMARK    GeneRIF: Tumorous expression of NAC1 restrains antitumor immunity
            through the LDHA-mediated immune evasion.
REFERENCE   5  (bases 1 to 4332)
  AUTHORS   Choi,H., Park,H.J., Kim,H., Kim,J., Lee,Y.K. and Kim,J.
  TITLE     Nac1 facilitates pluripotency gene activation for establishing
            somatic cell reprogramming
  JOURNAL   Biochem Biophys Res Commun 518 (2), 253-258 (2019)
   PUBMED   31412978
  REMARK    GeneRIF: these results reveal the genome wide role for Nac1 in the
            contribution to the pluripotency circuitry and the regulation of
            the establishing pluripotent state.
REFERENCE   6  (bases 1 to 4332)
  AUTHORS   Mackler,S., Pacchioni,A., Degnan,R., Homan,Y., Conti,A.C.,
            Kalivas,P. and Blendy,J.A.
  TITLE     Requirement for the POZ/BTB protein NAC1 in acute but not chronic
            psychomotor stimulant response
  JOURNAL   Behav Brain Res 187 (1), 48-55 (2008)
   PUBMED   17945361
  REMARK    GeneRIF: these data indicate involvement of NAC1 in the acute
            behavioral and neurochemical responses to psychomotor stimulants
REFERENCE   7  (bases 1 to 4332)
  AUTHORS   Shen,H., Korutla,L., Champtiaux,N., Toda,S., LaLumiere,R.,
            Vallone,J., Klugmann,M., Blendy,J.A., Mackler,S.A. and Kalivas,P.W.
  TITLE     NAC1 regulates the recruitment of the proteasome complex into
            dendritic spines
  JOURNAL   J Neurosci 27 (33), 8903-8913 (2007)
   PUBMED   17699672
REFERENCE   8  (bases 1 to 4332)
  AUTHORS   Tateossian,H., Powles,N., Dickinson,R., Ficker,M. and Maconochie,M.
  TITLE     Determination of downstream targets of FGF signalling using gene
            trap and cDNA subtractive approaches
  JOURNAL   Exp Cell Res 292 (1), 101-114 (2004)
   PUBMED   14720510
REFERENCE   9  (bases 1 to 4332)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4332)
  AUTHORS   Mackler,S.A., Homan,Y.X., Korutla,L., Conti,A.C. and Blendy,J.A.
  TITLE     The mouse nac1 gene, encoding a cocaine-regulated Bric-a-brac
            Tramtrac Broad complex/Pox virus and Zinc finger protein, is
            regulated by AP1
  JOURNAL   Neuroscience 121 (2), 355-361 (2003)
   PUBMED   14521994
  REMARK    GeneRIF: The mouse Nac1 gene consist of six exons, with exon 2
            containing an alternative splice donor, providing a molecular
            explanation of the splice variants observed in mouse and rat.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054800.1.
            
            On Nov 19, 2009 this sequence version replaced NM_025788.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054800.1, BC052706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4332              BC054800.1         1-4332
FEATURES             Location/Qualifiers
     source          1..4332
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.02 cM"
     gene            1..4332
                     /gene="Nacc1"
                     /gene_synonym="2010001H03Rik; 4930511N13Rik; Btbd14b;
                     Nac1"
                     /note="nucleus accumbens associated 1, BEN and BTB (POZ)
                     domain containing"
                     /db_xref="GeneID:66830"
                     /db_xref="MGI:MGI:1914080"
     exon            1..188
                     /gene="Nacc1"
                     /gene_synonym="2010001H03Rik; 4930511N13Rik; Btbd14b;
                     Nac1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..1100
                     /gene="Nacc1"
                     /gene_synonym="2010001H03Rik; 4930511N13Rik; Btbd14b;
                     Nac1"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1741
                     /gene="Nacc1"
                     /gene_synonym="2010001H03Rik; 4930511N13Rik; Btbd14b;
                     Nac1"
                     /note="BTB (POZ) domain containing 14B; transcriptional
                     repressor NAC1; NAC-1; BTB/POZ domain-containing protein
                     14B"
                     /codon_start=1
                     /product="nucleus accumbens-associated protein 1"
                     /protein_id="NP_080064.3"
                     /db_xref="CCDS:CCDS22475.1"
                     /db_xref="GeneID:66830"
                     /db_xref="MGI:MGI:1914080"
                     /translation="MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAH
                     RAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTFCYTGRLSMNMGDQFLLIY
                     TAGFLQIQEIMEKGTEFFLKVSSPSCDSQGLHPEEAPSSEPQSPVAQTLGWPACSTPL
                     PLVSRVKTEQELDSVQCTPMAKRLWDSSQKEAGGSGGNNGSRKMAKFSTPDLALNRMP
                     QPLSMATATAAVAVVAVGGCVSGPSMSERTSPGTSSAYTSDSPSSYHNEEDEEEDAGE
                     EGTDEQYRQICNMYTMYSMLNVGQTAEKVEALPEQVVLESRSRIRVRQDLASLPAELI
                     NQIGNRCHPKLYDEGDPSEKLELVTGTNVYITRAQLMNCHVSAGTRHKVLLRRLLASF
                     FDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMNAIAADMC
                     TNARRVVRKSWLPKTKPLHLVEGDNYSSFISDTCKIEPDMMSMEHSFETASHDGEAGP
                     SAEVLQ"
     exon            1101..1274
                     /gene="Nacc1"
                     /gene_synonym="2010001H03Rik; 4930511N13Rik; Btbd14b;
                     Nac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1380
                     /gene="Nacc1"
                     /gene_synonym="2010001H03Rik; 4930511N13Rik; Btbd14b;
                     Nac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1478
                     /gene="Nacc1"
                     /gene_synonym="2010001H03Rik; 4930511N13Rik; Btbd14b;
                     Nac1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..4304
                     /gene="Nacc1"
                     /gene_synonym="2010001H03Rik; 4930511N13Rik; Btbd14b;
                     Nac1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4285..4290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nacc1"
                     /gene_synonym="2010001H03Rik; 4930511N13Rik; Btbd14b;
                     Nac1"
                     /note="hexamer: AACAAG"
     polyA_site      4304
                     /gene="Nacc1"
                     /gene_synonym="2010001H03Rik; 4930511N13Rik; Btbd14b;
                     Nac1"
                     /note="major polyA site"
ORIGIN      
        1 cggctggggc ggcctggccc acaatgaatg gccgccgcgg ctaccactgc tgctgaggcg
       61 gaggccgcgg aggccgcaga ggcggaggcc gaggccgagg cgcagggagg cgcgccccgg
      121 gcccaggccc ggccccagct gccgctgcgg agcccgccgg gaggccccgg agcgcggcca
      181 cagcgcagct gctgccatgg cgcagacctt acagatggag attccaaact tcggcaacag
      241 catccttgag tgcctcaatg agcagcggct acagggacta tactgtgacg tgtcagtagt
      301 ggtgaagggc catgccttca aagcccaccg tgctgtgctg gccgctagta gctcttactt
      361 ccgggacctc ttcaacagca gccgcagtgc tgtggtagaa ctgccggccg ctgtgcagcc
      421 acagtcattc cagcagatcc tcacattttg ttacacaggc cggctgagca tgaacatggg
      481 agaccagttt ctgctcatct acacagccgg cttcctgcag atccaggaga tcatggagaa
      541 aggcactgag ttcttcctca aagttagctc tccaagttgc gactcccagg gcctgcaccc
      601 ggaggaggcc ccatcctcag agcctcagag tcctgtagcg cagacattgg ggtggccagc
      661 ctgtagcacg ccactgcccc ttgtgtcacg ggtcaagaca gaacaggagt tggactcagt
      721 gcaatgcaca cccatggcca agaggctgtg ggacagcagc cagaaggagg ctggaggcag
      781 tggtggcaac aacggcagcc gcaagatggc caagttctcc acgccagacc tggcccttaa
      841 ccggatgcct cagccactct caatggccac agctacagca gcagtggctg tggttgcagt
      901 agggggatgt gtgagtgggc ccagcatgtc agagcggacc agtccaggta cctccagtgc
      961 ttacaccagt gacagcccca gctcctacca caatgaagag gacgaagaag aagatgcagg
     1021 tgaggagggc acagatgagc agtaccgtca gatctgcaat atgtatacaa tgtacagtat
     1081 gttgaacgtt ggccagacag ctgagaaggt agaggccctt cctgagcagg tggtccttga
     1141 gtcccgcagt cgcattcgag tgcggcaaga cctggcatct ctcccagctg aacttatcaa
     1201 ccagattggc aatcgttgcc acccaaagct ctacgatgaa ggtgacccct cagagaagct
     1261 ggagctcgtg acaggcacca atgtatacat cacaagggca cagcttatga actgccacgt
     1321 cagtgcaggc acgcggcaca aggtcttgct gcggcggctt ctggcttcct tctttgaccg
     1381 gaatacactg gccaatagct gtggcaccgg catccgttct tccaccaatg accccagacg
     1441 aaagccactg gacagtcgtg tcctccatgc tgtcaagtac tactgccaga acttcgcccc
     1501 caacttcaag gagagcgaga tgaatgccat tgcagctgac atgtgcacca atgcccgccg
     1561 agtggtacgt aaaagctggc tgcccaagac taagccgctg cacctggtgg agggtgataa
     1621 ctacagcagc ttcatcagcg acacttgcaa gatagaaccg gacatgatga gcatggaaca
     1681 cagcttcgag acagccagcc acgatggcga ggctggccct tcagctgagg ttctccagta
     1741 acatacatgt gacaccccct tactggatgt cacactcccc tcctatcaca ccctcaccta
     1801 tcacctacct ggtcacgatc tactgtctgt ccctccccag gacctgtgag gggctgctcc
     1861 atgccctcta tccggatgca agagctggct gacaaggcca aaccactgta cctaggagag
     1921 ggcagtgcct acaacagctt tctcagtgac catgaggaag agcagaactt gataggcata
     1981 gaatacagct ttcacacaga cagccccctc agcgaaggtc ctccaatacc tgcccaggac
     2041 ccttccatgg atgtcacact cccctcctgt cacatacata cccccaccac cttagtcacg
     2101 agctactgtc tgtccctccc cagaacctgc aggggtgctg catgctccca gcccctctgc
     2161 ctccctgtca tcccacacct tttccccaaa gcaagctggg ctgggtcaag agaggacagg
     2221 catcaggtgg gatctgtgac cttcctcaac actcacgggg agccctggtt ccccttcctc
     2281 ttaggcattt cccagcacca ggcccggcta ggggacgggc aggactcaac aagagcctgc
     2341 ccctcactgt ggctgcttgg gactccacgg gcccaggggt cttctggacc cctcccacca
     2401 tcccccagtg cttccatgtc tccaaaagcg ccttcctgtc cctctcgtct gtccctgcac
     2461 cttggggctg gggtaggtgg ggccaagagg gactgtctac tttacaaact gaggaaacaa
     2521 gcccaaaagg cttagagaaa ctctagaact gaccctctgt gacagcctcc atcacgcccc
     2581 ttttagtccc accctgctct gcctctgtgg gccccctcag cccaagaggt cattccaaga
     2641 gagcagtgct cctatgggca ggtgagggtc tcaggacagg tttccagtct ggcagaattt
     2701 gtgggtgtgc gtgcgtgcgt gtgtgcgtgc gtgcctgcgt agagtgtttg cttttaaaaa
     2761 catgaagatc aagaggcagc aagaccaggg tcggaaccag ggagcaggct gggagactgc
     2821 tgcccttctc ccatccgacc ctgggcaggg ctcccagccc ccaccccctg tacataactt
     2881 tttgaaacat ttttttagcg aatgaaatat tgaagtataa gatttccttt tatttttcaa
     2941 atcaatggga atgtgtctga ggttccctgg gtccctgggc tgtggaaggc aggatgcagg
     3001 gaagactgaa tgtgtgtgtg tgtggactgt gggtgcatgt ttccacaggg gcccagtccc
     3061 agtgccccag gactcctgtg gatccaacca gcttcctctc ccccgggact aaagttttag
     3121 ggtgttcaca ggtcccagtt agctgagccc actcctgggg gatgaggcag ggcagggtcc
     3181 gcatccattg ttactggttt gcggagctta tctctggccg cactcctttc cactctagct
     3241 ctccaggagc agtcttttgg gtgtcttgag tttgacatgt gagcacaggg tttctgttac
     3301 tcccctccat taacgtcctt tcacatctca ctggttctgt tctagccctg acctcccccc
     3361 cctccccaac tctgcattct agctgccttt tcagaggcag gggtttgcag gattggagaa
     3421 ggtgggatgg agccttttga gtcagatctg gagacctgtc tccaggccag cagcaccctc
     3481 taatctgcca tgatccctct taacatctga tggtgtgagg gtggggtgtt gggtctgact
     3541 tggcccccag taccttagcc ctgggtggcc aagtggaggg gagtagacat ccctagctaa
     3601 agcacaagca ccttagtcat accccctccc tccgccctcg ccctggcctg ttacccacct
     3661 cccccagcaa agatcccaaa gcacaatctc ctgataactt ggcgagcagc tgagcctggc
     3721 cgggatgagc gcaggctgtg ctccctgccc aggtttagta agggggcagt tctgtggggc
     3781 ggagagggct tgtagagtgg gcagcagagc ccattggttc caagcacctc aggaggtggc
     3841 cctgactccc ggggcttggg ttgagggaag tataaagcca ggggtgcagg ggagaatact
     3901 actcacttag gagagccaaa gacagggttg tgccttacct caggagccac ccctgcaccc
     3961 ctcctctggc agtcagctgc ttgccctgcc ctcctgagag ctgcatggtc cccaccccaa
     4021 gcacccagga gagtaaaaaa gtaacccact tagcaggaaa gacaagtagg ggcaaaccca
     4081 gtggctaccc tcccacccat ccatgcctct catggggaca ggccatcacc cactggccca
     4141 tgtgaagtgc caatgccctc cccacccaga gccgagcccc cacccttccc aggcccacaa
     4201 gtgagattgc acattaacta ctgtatggag aggagcggtg ttgggaaatg tgaaccctga
     4261 gagtcagtga tgctgataag aataaacaag acgcctttgt aacaaaaaaa aaaaaaaaaa
     4321 aaaaaaaaaa aa
//
