LOCUS       NM_013608               1118 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus nascent polypeptide-associated complex alpha
            polypeptide (Naca), transcript variant 2, mRNA.
ACCESSION   NM_013608
VERSION     NM_013608.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1118)
  AUTHORS   Song,D., Peng,K., Palmer,B.E. and Lee,F.S.
  TITLE     The ribosomal chaperone NACA recruits PHD2 to cotranslationally
            modify HIF-alpha
  JOURNAL   EMBO J 41 (22), e112059 (2022)
   PUBMED   36219563
  REMARK    GeneRIF: The ribosomal chaperone NACA recruits PHD2 to
            cotranslationally modify HIF-alpha.
REFERENCE   2  (bases 1 to 1118)
  AUTHORS   St-Arnaud,R., Pellicelli,M., Ismail,M., Arabian,A., Jafarov,T. and
            Zhou,C.J.
  TITLE     NACA and LRP6 Are Part of a Common Genetic Pathway Necessary for
            Full Anabolic Response to Intermittent PTH
  JOURNAL   Int J Mol Sci 23 (2), 940 (2022)
   PUBMED   35055125
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1118)
  AUTHORS   de Groot,N.E., van den Hoogenhof,M.M.G., Najafi,A., van der
            Made,I., van der Velden,J., Beqqali,A., Pinto,Y.M. and
            Creemers,E.E.
  TITLE     Heterozygous loss of Rbm24 in the adult mouse heart increases
            sarcomere slack length but does not affect function
  JOURNAL   Sci Rep 10 (1), 7687 (2020)
   PUBMED   32376900
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1118)
  AUTHORS   Berkholz,J., Eberle,R., Boller,K. and Munz,B.
  TITLE     siRNA-mediated inhibition of skNAC and Smyd1 expression disrupts
            myofibril organization: Immunofluorescence and electron microscopy
            study in C2C12 cells
  JOURNAL   Micron 108, 6-10 (2018)
   PUBMED   29499397
  REMARK    GeneRIF: The data suggest that skNAC and Smyd1 might be major
            players in the processes of myofibrillogenesis and
            sarcomerogenesis, probably specifically at later stages.
REFERENCE   5  (bases 1 to 1118)
  AUTHORS   Pellicelli,M., Hariri,H., Miller,J.A. and St-Arnaud,R.
  TITLE     Lrp6 is a target of the PTH-activated alphaNAC transcriptional
            coregulator
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1861 (2), 61-71 (2018)
   PUBMED   29413898
  REMARK    GeneRIF: Data show that reduction of alpha chain of nascent
            polypeptide associated complex (alphaNAC) levels decreased basal
            expression of Low density lipoprotein receptor-Related Protein 6
            (Lrp6) by 30%.
REFERENCE   6  (bases 1 to 1118)
  AUTHORS   Munz,B., Wiedmann,M., Lochmuller,H. and Werner,S.
  TITLE     Cloning of novel injury-regulated genes. Implications for an
            important role of the muscle-specific protein skNAC in muscle
            repair
  JOURNAL   J Biol Chem 274 (19), 13305-13310 (1999)
   PUBMED   10224091
REFERENCE   7  (bases 1 to 1118)
  AUTHORS   Moreau,A., Yotov,W.V., Glorieux,F.H. and St-Arnaud,R.
  TITLE     Bone-specific expression of the alpha chain of the nascent
            polypeptide-associated complex, a coactivator potentiating
            c-Jun-mediated transcription
  JOURNAL   Mol Cell Biol 18 (3), 1312-1321 (1998)
   PUBMED   9488446
REFERENCE   8  (bases 1 to 1118)
  AUTHORS   Yotov,W.V., Moreau,A. and St-Arnaud,R.
  TITLE     The alpha chain of the nascent polypeptide-associated complex
            functions as a transcriptional coactivator
  JOURNAL   Mol Cell Biol 18 (3), 1303-1311 (1998)
   PUBMED   9488445
REFERENCE   9  (bases 1 to 1118)
  AUTHORS   Yotov,W.V. and St-Arnaud,R.
  TITLE     Differential splicing-in of a proline-rich exon converts alphaNAC
            into a muscle-specific transcription factor
  JOURNAL   Genes Dev 10 (14), 1763-1772 (1996)
   PUBMED   8698236
REFERENCE   10 (bases 1 to 1118)
  AUTHORS   Yotov,W.V. and St-Arnaud,R.
  TITLE     Fine mapping of the alpha-NAC gene (Naca) to the distal end (D2-D3)
            of mouse chromosome 10
  JOURNAL   Mamm Genome 7 (3), 240 (1996)
   PUBMED   8833254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN840834.1, BC083340.1 and U48364.1.
            
            [WARNING] On Mar 20, 2024 this sequence was replaced by
            NM_013608.4.
            
            On Dec 29, 2007 this sequence version replaced NM_013608.2.
            
            Transcript Variant: This variant (2) lacks an internal in-frame
            large exon in the coding region, compared to variant 1. The
            resulting isoform (b) lacks an internal segment, compared to
            isoform a. Variants 2 and 3 encode the same isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U22151.1, SRR1660817.516851.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               CN840834.1         4-318
            316-1114            BC083340.1         1-799
            1115-1118           U48364.1           6742-6745
FEATURES             Location/Qualifiers
     source          1..1118
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.39 cM"
     gene            1..1118
                     /gene="Naca"
                     /gene_synonym="Gm1878; mKIAA0363; skNAC"
                     /note="nascent polypeptide-associated complex alpha
                     polypeptide"
                     /db_xref="GeneID:17938"
                     /db_xref="MGI:MGI:106095"
     exon            1..338
                     /gene="Naca"
                     /gene_synonym="Gm1878; mKIAA0363; skNAC"
                     /inference="alignment:Splign:2.1.0"
     exon            339..410
                     /gene="Naca"
                     /gene_synonym="Gm1878; mKIAA0363; skNAC"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..988
                     /gene="Naca"
                     /gene_synonym="Gm1878; mKIAA0363; skNAC"
                     /EC_number="5.3.99.3"
                     /note="isoform b is encoded by transcript variant 2;
                     nascent polypeptide-associated complex alpha subunit;
                     nascent polypeptide-associated complex subunit alpha,
                     muscle-specific form; alpha-NAC/1.9.2; alpha-NAC,
                     muscle-specific form"
                     /codon_start=1
                     /product="nascent polypeptide-associated complex subunit
                     alpha isoform b"
                     /protein_id="NP_038636.2"
                     /db_xref="CCDS:CCDS24258.1"
                     /db_xref="GeneID:17938"
                     /db_xref="MGI:MGI:106095"
                     /translation="MPGEATETVPATEQELPQPQAETGSGTESDSDESVPELEEQDST
                     QTATQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNI
                     LFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTP
                     TVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM"
     exon            411..496
                     /gene="Naca"
                     /gene_synonym="Gm1878; mKIAA0363; skNAC"
                     /inference="alignment:Splign:2.1.0"
     exon            497..574
                     /gene="Naca"
                     /gene_synonym="Gm1878; mKIAA0363; skNAC"
                     /inference="alignment:Splign:2.1.0"
     exon            575..721
                     /gene="Naca"
                     /gene_synonym="Gm1878; mKIAA0363; skNAC"
                     /inference="alignment:Splign:2.1.0"
     exon            722..850
                     /gene="Naca"
                     /gene_synonym="Gm1878; mKIAA0363; skNAC"
                     /inference="alignment:Splign:2.1.0"
     exon            851..973
                     /gene="Naca"
                     /gene_synonym="Gm1878; mKIAA0363; skNAC"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1118
                     /gene="Naca"
                     /gene_synonym="Gm1878; mKIAA0363; skNAC"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1117
                     /gene="Naca"
                     /gene_synonym="Gm1878; mKIAA0363; skNAC"
ORIGIN      
        1 aaagaggaaa cccggacgcc gtcctaaaca gctgtagctg tttcgcatac ggtcttggcg
       61 cgtccctcgg ggtcaaggcc atgacggggc ggcccctacc gccccagcca ggcccgcgcg
      121 tcctcttcgg aattcatagc cttatttaga ccgcgccacc gccgtgcccg tgagaacagc
      181 tgctcggctg gctacaggaa gtagaggccc gcgcgcctga cccggaagcg catgctggtc
      241 ccgccctctc ggcgcccggc ttccttctgc aacaggcgtg ggtcacgggc tcgctcgttc
      301 tctttctgcc gccatcttgg ttccgtgatc tccgcacaaa atgcccggtg aagccacaga
      361 aaccgtccct gctacagagc aggagttgcc acagcctcag gctgagacag gatcgggaac
      421 agagtctgac agtgatgagt cagtaccaga gctcgaggaa caagactcca cacagacggc
      481 cacgcagcaa gcccagctgg cagccgcagc agagatcgat gaagaacctg ttagtaaagc
      541 caagcagagt cgaagtgaga agaaggcaag gaaggctatg tccaaactgg gtcttcgaca
      601 ggttacaggg gttacgagag tcactatccg aaaatctaaa aatatcctct ttgtcatcac
      661 aaaacccgat gtctacaaga gcccagcttc agacacctac atagtgtttg gggaagccaa
      721 gattgaagat ttgtctcagc aagcacagtt agcagctgct gagaaattca aagttcaagg
      781 tgaagctgtt tcaaacattc aggaaaacac tcagactcca accgtccaag aggagagtga
      841 agaagaggag gttgatgaga cgggtgtgga agttaaggac atagaactgg tcatgtcgca
      901 agcaaacgta tcaagagcaa aggctgttcg agccctgaaa aacaacagta atgatattgt
      961 aaatgctatt atggaattaa caatgtaact atttgacagc gaagacaact ccccctttcc
     1021 cccctttttg gtgtttgaaa agtggaacta cagcttggtt taaaatttgt actgtttcta
     1081 tcactaataa agttgtggct tcttgttgga tggactca
//
