LOCUS       NM_027257               1123 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus nucleic acid binding protein 2 (Nabp2), transcript
            variant 1, mRNA.
ACCESSION   NM_027257
VERSION     NM_027257.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1123)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1123)
  AUTHORS   Pfeifer,M., Brem,R., Lippert,T.P., Boulianne,B., Ho,H.N.,
            Robinson,M.E., Stebbing,J. and Feldhahn,N.
  TITLE     SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the
            Genomes of B Cell Precursors
  JOURNAL   J Immunol 202 (12), 3423-3433 (2019)
   PUBMED   31085591
REFERENCE   3  (bases 1 to 1123)
  AUTHORS   Shi,W., Vu,T., Boucher,D., Biernacka,A., Nde,J., Pandita,R.K.,
            Straube,J., Boyle,G.M., Al-Ejeh,F., Nag,P., Jeffery,J.,
            Harris,J.L., Bain,A.L., Grzelak,M., Skrzypczak,M., Mitra,A.,
            Dojer,N., Crosetto,N., Cloonan,N., Becherel,O.J., Finnie,J.,
            Skaar,J.R., Walkley,C.R., Pandita,T.K., Rowicka,M., Ginalski,K.,
            Lane,S.W. and Khanna,K.K.
  TITLE     Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and
            progenitor cells by resolving replicative stress
  JOURNAL   Blood 129 (18), 2479-2492 (2017)
   PUBMED   28270450
REFERENCE   4  (bases 1 to 1123)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1123)
  AUTHORS   Yu,H., Su,Y., Shin,J., Zhong,C., Guo,J.U., Weng,Y.L., Gao,F.,
            Geschwind,D.H., Coppola,G., Ming,G.L. and Song,H.
  TITLE     Tet3 regulates synaptic transmission and homeostatic plasticity via
            DNA oxidation and repair
  JOURNAL   Nat Neurosci 18 (6), 836-843 (2015)
   PUBMED   25915473
REFERENCE   6  (bases 1 to 1123)
  AUTHORS   Shi,W., Bain,A.L., Schwer,B., Al-Ejeh,F., Smith,C., Wong,L.,
            Chai,H., Miranda,M.S., Ho,U., Kawaguchi,M., Miura,Y., Finnie,J.W.,
            Wall,M., Heierhorst,J., Wicking,C., Spring,K.J., Alt,F.W. and
            Khanna,K.K.
  TITLE     Essential developmental, genomic stability, and tumour suppressor
            functions of the mouse orthologue of hSSB1/NABP2
  JOURNAL   PLoS Genet 9 (2), e1003298 (2013)
   PUBMED   23408915
REFERENCE   7  (bases 1 to 1123)
  AUTHORS   Feldhahn,N., Ferretti,E., Robbiani,D.F., Callen,E., Deroubaix,S.,
            Selleri,L., Nussenzweig,A. and Nussenzweig,M.C.
  TITLE     The hSSB1 orthologue Obfc2b is essential for skeletogenesis but
            dispensable for the DNA damage response in vivo
  JOURNAL   EMBO J 31 (20), 4045-4056 (2012)
   PUBMED   22940690
  REMARK    GeneRIF: Obfc2b deficiency does not affect initiation of DNA damage
            checkpoints, Atm activation, or the maintenance of genomic
            stability in B lymphocytes & primary fibroblasts. Its role in
            embryogenesis limited to cell types contributing to bone formation.
            Erratum:[EMBO J. 2021 Jan 15;40(2):e107130. doi:
            10.15252/embj.2020107130.. PMID: 33448440]
REFERENCE   8  (bases 1 to 1123)
  AUTHORS   Kang,H.S., Beak,J.Y., Kim,Y.S., Petrovich,R.M., Collins,J.B.,
            Grissom,S.F. and Jetten,A.M.
  TITLE     NABP1, a novel RORgamma-regulated gene encoding a single-stranded
            nucleic-acid-binding protein
  JOURNAL   Biochem J 397 (1), 89-99 (2006)
   PUBMED   16533169
REFERENCE   9  (bases 1 to 1123)
  AUTHORS   Osipovich,A.B., Singh,A. and Ruley,H.E.
  TITLE     Post-entrapment genome engineering: first exon size does not affect
            the expression of fusion transcripts generated by gene entrapment
  JOURNAL   Genome Res 15 (3), 428-435 (2005)
   PUBMED   15741512
REFERENCE   10 (bases 1 to 1123)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY250791.1, BX519720.1, CX238225.1 and BE988804.1.
            
            On Dec 15, 2017 this sequence version replaced NM_027257.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026942.1, CB193295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BY250791.1         26-70
            46-577              BX519720.1         2-533
            578-902             CX238225.1         433-757
            903-1123            BE988804.1         1-221               c
FEATURES             Location/Qualifiers
     source          1..1123
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.55 cM"
     gene            1..1123
                     /gene="Nabp2"
                     /gene_synonym="2610036N15Rik; Obfc2b; SSB1"
                     /note="nucleic acid binding protein 2"
                     /db_xref="GeneID:69917"
                     /db_xref="MGI:MGI:1917167"
     exon            1..115
                     /gene="Nabp2"
                     /gene_synonym="2610036N15Rik; Obfc2b; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            116..217
                     /gene="Nabp2"
                     /gene_synonym="2610036N15Rik; Obfc2b; SSB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..777
                     /gene="Nabp2"
                     /gene_synonym="2610036N15Rik; Obfc2b; SSB1"
                     /note="isoform 1 is encoded by transcript variant 1; SOSS
                     complex subunit B1; SOSS-B1; sensor of ssDNA subunit B1;
                     single-stranded DNA-binding protein 1; sensor of
                     single-strand DNA complex subunit B1;
                     oligonucleotide/oligosaccharide-binding fold-containing
                     protein 2B; oligonucleotide/oligosaccharide-binding fold
                     containing 2B"
                     /codon_start=1
                     /product="SOSS complex subunit B1 isoform 1"
                     /protein_id="NP_081533.1"
                     /db_xref="CCDS:CCDS24276.1"
                     /db_xref="GeneID:69917"
                     /db_xref="MGI:MGI:1917167"
                     /translation="MTTETFVKDIKPGLKNLNLIFIVLETGRVTKTKDGHEVRTCKVA
                     DKTGSINISVWDDVGNLIQPGDIIRLTKGYASVFKGCLTLYTGRGGDLQKIGEFCMVY
                     SEVPNFSEPNPEYNTQQAPNKSVQNNDNSPTAPQATTGPPAASPASENQNGNGLSTQL
                     GPVGGPHPSHTPSHPPSTRITRSQPNHTPSGPPGPSSNPVSNGKETRRSSKR"
     exon            218..356
                     /gene="Nabp2"
                     /gene_synonym="2610036N15Rik; Obfc2b; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..428
                     /gene="Nabp2"
                     /gene_synonym="2610036N15Rik; Obfc2b; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..510
                     /gene="Nabp2"
                     /gene_synonym="2610036N15Rik; Obfc2b; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..577
                     /gene="Nabp2"
                     /gene_synonym="2610036N15Rik; Obfc2b; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..1106
                     /gene="Nabp2"
                     /gene_synonym="2610036N15Rik; Obfc2b; SSB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1089..1094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nabp2"
                     /gene_synonym="2610036N15Rik; Obfc2b; SSB1"
                     /note="hexamer: AATAAA"
     polyA_site      1106
                     /gene="Nabp2"
                     /gene_synonym="2610036N15Rik; Obfc2b; SSB1"
                     /note="major polyA site"
ORIGIN      
        1 gtttccggga atgtaagcgc tccggcgttc ctctccgcag catccggcgg cagccagccc
       61 cctggctccc cctgcgggtg gctcggcggt gtgcacagtc cggcctgctg gctggcgggg
      121 tgccacggct cgggaagcat gacgaccgag accttcgtga aggatatcaa gcccgggctc
      181 aagaatctga atcttatctt cattgtactg gagacaggcc gggtgaccaa gacaaaggac
      241 ggacacgagg ttcggacctg taaagtggca gacaaaacgg gcagcatcaa catctcagta
      301 tgggacgatg tgggcaacct gatccaacct ggggacatta tccgactcac caaagggtat
      361 gcttcagtgt tcaaaggttg tctgacactg tacactggcc gtgggggcga tctgcagaag
      421 attggagaat tctgtatggt ttattccgaa gtccctaatt tcagtgagcc caatccagag
      481 tataacacgc agcaggcgcc caacaaatcg gtgcagaaca atgacaacag ccctactgcc
      541 ccacaagcga ccacgggacc ccctgctgcc tctccagctt ccgagaacca gaacggaaat
      601 ggactgagca cccagctagg tcctgtgggt ggcccccatc cttctcacac cccctcacat
      661 ccccccagca cccgaatcac tcgaagtcaa cccaaccaca cgccttccgg ccctcctggc
      721 ccctccagca accctgtcag caacggcaaa gaaacccgaa gaagcagcaa gagatagcaa
      781 gagatgagtc tctccttcct tccaccacaa ccatgatcca ggcgtctctg ccagagaaca
      841 agacagtctt ctatcaggct gctggctttg ggattagagg ataaagtagc tgtgttttag
      901 ccactaaatt tccctggagg ggttggaagc agcagcctta tccacctcaa actcacgccc
      961 caccccaccc ctgtcctgct gatgctgtct atcccctggg atccagggtc ctctgcctgc
     1021 cctcctttgg aaaagacagt gtggtttttg tgtgggaaat aagggtctaa ctgaaatccc
     1081 tccttcctaa taaatgttcc cactcaaaaa aaaaaaaaaa aaa
//
