LOCUS       NM_028696               2838 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus nucleic acid binding protein 1 (Nabp1), transcript
            variant 1, mRNA.
ACCESSION   NM_028696
VERSION     NM_028696.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2838)
  AUTHORS   Pfeifer,M., Brem,R., Lippert,T.P., Boulianne,B., Ho,H.N.,
            Robinson,M.E., Stebbing,J. and Feldhahn,N.
  TITLE     SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the
            Genomes of B Cell Precursors
  JOURNAL   J Immunol 202 (12), 3423-3433 (2019)
   PUBMED   31085591
REFERENCE   2  (bases 1 to 2838)
  AUTHORS   Shi,W., Vu,T., Boucher,D., Biernacka,A., Nde,J., Pandita,R.K.,
            Straube,J., Boyle,G.M., Al-Ejeh,F., Nag,P., Jeffery,J.,
            Harris,J.L., Bain,A.L., Grzelak,M., Skrzypczak,M., Mitra,A.,
            Dojer,N., Crosetto,N., Cloonan,N., Becherel,O.J., Finnie,J.,
            Skaar,J.R., Walkley,C.R., Pandita,T.K., Rowicka,M., Ginalski,K.,
            Lane,S.W. and Khanna,K.K.
  TITLE     Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and
            progenitor cells by resolving replicative stress
  JOURNAL   Blood 129 (18), 2479-2492 (2017)
   PUBMED   28270450
REFERENCE   3  (bases 1 to 2838)
  AUTHORS   Boucher,D., Vu,T., Bain,A.L., Tagliaro-Jahns,M., Shi,W., Lane,S.W.
            and Khanna,K.K.
  TITLE     Ssb2/Nabp1 is dispensable for thymic maturation, male fertility,
            and DNA repair in mice
  JOURNAL   FASEB J 29 (8), 3326-3334 (2015)
   PUBMED   25917330
  REMARK    GeneRIF: Ssb1 is likely able to compensate for the loss of Ssb2 in
            mice.
REFERENCE   4  (bases 1 to 2838)
  AUTHORS   Gu,P., Deng,W., Lei,M. and Chang,S.
  TITLE     Single strand DNA binding proteins 1 and 2 protect newly replicated
            telomeres
  JOURNAL   Cell Res 23 (5), 705-719 (2013)
   PUBMED   23459151
REFERENCE   5  (bases 1 to 2838)
  AUTHORS   Shi,W., Bain,A.L., Schwer,B., Al-Ejeh,F., Smith,C., Wong,L.,
            Chai,H., Miranda,M.S., Ho,U., Kawaguchi,M., Miura,Y., Finnie,J.W.,
            Wall,M., Heierhorst,J., Wicking,C., Spring,K.J., Alt,F.W. and
            Khanna,K.K.
  TITLE     Essential developmental, genomic stability, and tumour suppressor
            functions of the mouse orthologue of hSSB1/NABP2
  JOURNAL   PLoS Genet 9 (2), e1003298 (2013)
   PUBMED   23408915
REFERENCE   6  (bases 1 to 2838)
  AUTHORS   Feldhahn,N., Ferretti,E., Robbiani,D.F., Callen,E., Deroubaix,S.,
            Selleri,L., Nussenzweig,A. and Nussenzweig,M.C.
  TITLE     The hSSB1 orthologue Obfc2b is essential for skeletogenesis but
            dispensable for the DNA damage response in vivo
  JOURNAL   EMBO J 31 (20), 4045-4056 (2012)
   PUBMED   22940690
  REMARK    Erratum:[EMBO J. 2021 Jan 15;40(2):e107130. doi:
            10.15252/embj.2020107130.. PMID: 33448440]
REFERENCE   7  (bases 1 to 2838)
  AUTHORS   Kang,H.S., Beak,J.Y., Kim,Y.S., Petrovich,R.M., Collins,J.B.,
            Grissom,S.F. and Jetten,A.M.
  TITLE     NABP1, a novel RORgamma-regulated gene encoding a single-stranded
            nucleic-acid-binding protein
  JOURNAL   Biochem J 397 (1), 89-99 (2006)
   PUBMED   16533169
  REMARK    GeneRIF: NABP1 binds single-stranded nucleic acids, but not
            double-stranded DNA, suggesting that it functions as a
            single-stranded nucleic acid binding protein
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY880264.1.
            
            On Apr 5, 2007 this sequence version replaced NM_028696.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY880264.1, AK167652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2838              AY880264.1         2-2839
FEATURES             Location/Qualifiers
     source          1..2838
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.58 cM"
     gene            1..2838
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /note="nucleic acid binding protein 1"
                     /db_xref="GeneID:109019"
                     /db_xref="MGI:MGI:1923258"
     exon            1..575
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             485..1081
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /note="isoform a is encoded by transcript variant 1; SOSS
                     complex subunit B2; SOSS-B2; sensor of ssDNA subunit B2;
                     oligonucleotide/oligosaccharide-binding fold containing
                     2A; single-stranded DNA-binding protein 2; sensor of
                     single-strand DNA complex subunit B2;
                     oligonucleotide/oligosaccharide-binding fold-containing
                     protein 2A"
                     /codon_start=1
                     /product="SOSS complex subunit B2 isoform a"
                     /protein_id="NP_082972.2"
                     /db_xref="CCDS:CCDS35559.1"
                     /db_xref="GeneID:109019"
                     /db_xref="MGI:MGI:1923258"
                     /translation="MHGVNDPPLFIKDIKAGLKNLNVVFIVLEIGRVTKTKDGHEVRS
                     CKVADRTGSITISVWDEIGGLIQTGDIIRLTRGYASMWKGCLTLYTGRGGELQKIGEF
                     CMVYSEVPNFSEPNPDYRGQQNRGVQNEQKDKLSTNTFGPVGNGDQTGPESRGYHLPY
                     GRSNGPGPISPQLPGTPSSQTVRTTISNARDPRRAFKR"
     exon            576..714
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     exon            715..786
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..862
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..914
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     exon            915..2838
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2808..2813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /note="hexamer: AATAAA"
     polyA_site      2838
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /note="major polyA site"
ORIGIN      
        1 agttgctgct tgggacgcgg gctgcgcggt tggtgaacag ccttgccgtt ttgctgtcac
       61 gtaccttccc tgagcctggg acggaggggg cgcgcgcgtg tgcgtgtgtt gtgtgaggga
      121 cagcgggact cgggcagggc cgtctcctga tcccttttcc cttagcggag gcggcagtgc
      181 gcacgctggt ttgctcgccg cccacttggg agcgggctca gggtgcggag tgcgtcttcg
      241 gttttgtttt ttggtttttt gttttttttg aacttgtgag agtctttttc ccctcccttt
      301 tccattttta ttttcttttg gctccgtgcc tctagggctg gtttacccgg cccctgaatt
      361 accgcttcct gaccccggtc gccaatcttg ccccaggttg ctccccggct ctgcccctgc
      421 ccctccccga gggtgggaag ccttgcctag tgggtctctg aagcgtagcc gcacctgcct
      481 cagtatgcac ggggtcaacg accctccact ttttataaaa gacattaagg ccggactgaa
      541 aaacttaaat gtcgtcttta ttgtcctgga gataggacga gtgaccaaaa ccaaagacgg
      601 ccatgaagtg agatcctgca aagtagctga tagaacggga agcatcacta tttctgtgtg
      661 ggatgagatc ggagggctca tacagacagg ggatattatt cggttgacca gagggtatgc
      721 atcaatgtgg aaaggatgcc tgacacttta tactggaaga ggtggtgaac ttcaaaaaat
      781 tggagaattt tgtatggtgt attcagaagt gccaaatttc agtgagccaa acccagatta
      841 tagaggacag cagaatagag gggtacaaaa tgaacagaag gataaactga gcaccaatac
      901 atttggacca gtgggaaatg gtgatcagac tggccctgaa tctaggggat atcatcttcc
      961 atatggcaga agcaatggtc cgggacctat cagtccacag ctaccaggaa cacctagtag
     1021 tcaaacagtc aggaccacaa taagtaacgc cagagatccg aggagagcct ttaaaagatg
     1081 atctaagcca aagagacaca tgtagttttt aaactacatg acctacttga acacttagtg
     1141 cacttttatt tattcttaac tgtgaaaact ttgtctctta cgggtttcct tttatatttt
     1201 tggtttgttg aaaagagtgg ttggttttta ctgaaaaaac tgttacactg ctcagttaca
     1261 tcctattgaa gaataggaac tctgaaagca ggaacattta ttttttgagc aagaacttac
     1321 tgggtatcac ttgaaaacct gtccctgttt cgagggtgag ttacttaaga caccagctta
     1381 tatatagcct ctgtgagtct ggcttctgca taaactttgt aatgtttgtc ataatgttta
     1441 atggaacttg tcttaaactt gaatattgcc acctgaagca ataaccaccc caagccagaa
     1501 acttggacag cattgtcaac atttttgagt attcctgatc taggaatggc ttgactccct
     1561 agagtgtctg cctgccataa ggattttttc acagacagaa tcagaatcat cctaaactct
     1621 tgtttattga ccagataacc aaattcttca tcagaattat ggaataaaat atgtaatata
     1681 acaagtaatt tttagaagaa aacggtttaa gatgatgctc ttaacatttg ttgcaaacat
     1741 tgaagtttac attgaagaaa aatttacaac tgagtccctg aatgctttat ttttgaagtt
     1801 accatgttaa atattgaagt gtaattggag ggattgaaga gagctataac acctttattg
     1861 gacagtggtc tcattgatac tagttgtatt tttgaggcag ggtctttctc tgtgcagccc
     1921 tggttggttg gaacttgtta tatatatata tatatcaggt gggtctctga actatagatt
     1981 gacctgcctc tctcttcctg gagctgggat taaagttgtg tagcaccaca caaggctaat
     2041 ctgattattt ttaaaaaaat actcatggta gttactatag caaatacaaa tcaaattaaa
     2101 ttcatatagc catgtgacta ccagttgcaa gtagtcgggt agaagtaggc atttcctttc
     2161 ttccaggaat gtgtgtgttt aaagtttttg aacaagtcac atagccttac tagcaaaagt
     2221 taaatggctc aagaagtgat tatacttctg ttgaggtggg atttgtgtga tggaacatca
     2281 cttacagtgg gtgattggta atttttttca ttgttagtat ttgtctctcc ttaaatattg
     2341 tctcttgagt aaaacttgct gtaatgatga catatctacc tacttatttt tactttcagt
     2401 aaacatggag agcccagtcc attttactga agttgtattc atcttcagct tgactgctcc
     2461 ctaactctgt acctgtcatt tctccttacc tcatattgta aaataagtaa gtttctgttc
     2521 aacttgtata gcatttgaat ataatttgtg tcagattttg atctaattca ttttaacaga
     2581 ttttcagtaa gcactgcatt aggctctgtg tggagattat catagcattt tgagaagtca
     2641 caaggaattt ggtttatagg tacagggctt tgacatttgt cattgttcat atattaataa
     2701 ttatagctaa tttggcctta tgattttttg tttacatttc tgaatgtttc aaaaaagtta
     2761 agggttaaga tagcttgtgt tttgtgatta tagatgtttt gaataaaaat aaatgacaaa
     2821 ctaatcttaa aaatttaa
//
