LOCUS       NP_082972                198 aa            linear   ROD 10-FEB-2025
DEFINITION  SOSS complex subunit B2 isoform a [Mus musculus].
ACCESSION   NP_082972
VERSION     NP_082972.2
DBSOURCE    REFSEQ: accession NM_028696.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 198)
  AUTHORS   Pfeifer,M., Brem,R., Lippert,T.P., Boulianne,B., Ho,H.N.,
            Robinson,M.E., Stebbing,J. and Feldhahn,N.
  TITLE     SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the
            Genomes of B Cell Precursors
  JOURNAL   J Immunol 202 (12), 3423-3433 (2019)
   PUBMED   31085591
REFERENCE   2  (residues 1 to 198)
  AUTHORS   Shi,W., Vu,T., Boucher,D., Biernacka,A., Nde,J., Pandita,R.K.,
            Straube,J., Boyle,G.M., Al-Ejeh,F., Nag,P., Jeffery,J.,
            Harris,J.L., Bain,A.L., Grzelak,M., Skrzypczak,M., Mitra,A.,
            Dojer,N., Crosetto,N., Cloonan,N., Becherel,O.J., Finnie,J.,
            Skaar,J.R., Walkley,C.R., Pandita,T.K., Rowicka,M., Ginalski,K.,
            Lane,S.W. and Khanna,K.K.
  TITLE     Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and
            progenitor cells by resolving replicative stress
  JOURNAL   Blood 129 (18), 2479-2492 (2017)
   PUBMED   28270450
REFERENCE   3  (residues 1 to 198)
  AUTHORS   Boucher,D., Vu,T., Bain,A.L., Tagliaro-Jahns,M., Shi,W., Lane,S.W.
            and Khanna,K.K.
  TITLE     Ssb2/Nabp1 is dispensable for thymic maturation, male fertility,
            and DNA repair in mice
  JOURNAL   FASEB J 29 (8), 3326-3334 (2015)
   PUBMED   25917330
  REMARK    GeneRIF: Ssb1 is likely able to compensate for the loss of Ssb2 in
            mice.
REFERENCE   4  (residues 1 to 198)
  AUTHORS   Gu,P., Deng,W., Lei,M. and Chang,S.
  TITLE     Single strand DNA binding proteins 1 and 2 protect newly replicated
            telomeres
  JOURNAL   Cell Res 23 (5), 705-719 (2013)
   PUBMED   23459151
REFERENCE   5  (residues 1 to 198)
  AUTHORS   Shi,W., Bain,A.L., Schwer,B., Al-Ejeh,F., Smith,C., Wong,L.,
            Chai,H., Miranda,M.S., Ho,U., Kawaguchi,M., Miura,Y., Finnie,J.W.,
            Wall,M., Heierhorst,J., Wicking,C., Spring,K.J., Alt,F.W. and
            Khanna,K.K.
  TITLE     Essential developmental, genomic stability, and tumour suppressor
            functions of the mouse orthologue of hSSB1/NABP2
  JOURNAL   PLoS Genet 9 (2), e1003298 (2013)
   PUBMED   23408915
REFERENCE   6  (residues 1 to 198)
  AUTHORS   Feldhahn,N., Ferretti,E., Robbiani,D.F., Callen,E., Deroubaix,S.,
            Selleri,L., Nussenzweig,A. and Nussenzweig,M.C.
  TITLE     The hSSB1 orthologue Obfc2b is essential for skeletogenesis but
            dispensable for the DNA damage response in vivo
  JOURNAL   EMBO J 31 (20), 4045-4056 (2012)
   PUBMED   22940690
  REMARK    Erratum:[EMBO J. 2021 Jan 15;40(2):e107130. doi:
            10.15252/embj.2020107130.. PMID: 33448440]
REFERENCE   7  (residues 1 to 198)
  AUTHORS   Kang,H.S., Beak,J.Y., Kim,Y.S., Petrovich,R.M., Collins,J.B.,
            Grissom,S.F. and Jetten,A.M.
  TITLE     NABP1, a novel RORgamma-regulated gene encoding a single-stranded
            nucleic-acid-binding protein
  JOURNAL   Biochem J 397 (1), 89-99 (2006)
   PUBMED   16533169
  REMARK    GeneRIF: NABP1 binds single-stranded nucleic acids, but not
            double-stranded DNA, suggesting that it functions as a
            single-stranded nucleic acid binding protein
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY880264.1.
            
            On Mar 8, 2007 this sequence version replaced NP_082972.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY880264.1, AK167652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..198
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.58 cM"
     Protein         1..198
                     /product="SOSS complex subunit B2 isoform a"
                     /note="SOSS complex subunit B2; SOSS-B2; sensor of ssDNA
                     subunit B2; oligonucleotide/oligosaccharide-binding fold
                     containing 2A; single-stranded DNA-binding protein 2;
                     sensor of single-strand DNA complex subunit B2;
                     oligonucleotide/oligosaccharide-binding fold-containing
                     protein 2A"
                     /calculated_mol_wt=21617
     Region          10..102
                     /region_name="Ob-fold"
     Region          22..99
                     /region_name="SoSSB_OBF"
                     /note="A subfamily of OB folds similar to the OB fold of
                     the crenarchaeote Sulfolobus solfataricus single-stranded
                     (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB
                     fold, and it physically and functionally interacts with
                     RNA polymerase. In vitro, SSoSSB...; cd04491"
                     /db_xref="CDD:239937"
     Site            order(22,71,73,75,97)
                     /site_type="active"
                     /note="generic binding surface II [active]"
                     /db_xref="CDD:239937"
     Site            order(27..29,44..47,49,55..57,59,70,78..80,87..89)
                     /site_type="active"
                     /note="generic binding surface I [active]"
                     /db_xref="CDD:239937"
     Region          114..198
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGW5.1)"
     CDS             1..198
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /coded_by="NM_028696.3:485..1081"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS35559.1"
                     /db_xref="GeneID:109019"
                     /db_xref="MGI:MGI:1923258"
ORIGIN      
        1 mhgvndpplf ikdikaglkn lnvvfivlei grvtktkdgh evrsckvadr tgsitisvwd
       61 eiggliqtgd iirltrgyas mwkgcltlyt grggelqkig efcmvysevp nfsepnpdyr
      121 gqqnrgvqne qkdklstntf gpvgngdqtg pesrgyhlpy grsngpgpis pqlpgtpssq
      181 tvrttisnar dprrafkr
//
