LOCUS       NM_001310548            2362 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus nucleic acid binding protein 1 (Nabp1), transcript
            variant 2, mRNA.
ACCESSION   NM_001310548 XM_006495621
VERSION     NM_001310548.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2362)
  AUTHORS   Pfeifer,M., Brem,R., Lippert,T.P., Boulianne,B., Ho,H.N.,
            Robinson,M.E., Stebbing,J. and Feldhahn,N.
  TITLE     SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the
            Genomes of B Cell Precursors
  JOURNAL   J Immunol 202 (12), 3423-3433 (2019)
   PUBMED   31085591
REFERENCE   2  (bases 1 to 2362)
  AUTHORS   Shi,W., Vu,T., Boucher,D., Biernacka,A., Nde,J., Pandita,R.K.,
            Straube,J., Boyle,G.M., Al-Ejeh,F., Nag,P., Jeffery,J.,
            Harris,J.L., Bain,A.L., Grzelak,M., Skrzypczak,M., Mitra,A.,
            Dojer,N., Crosetto,N., Cloonan,N., Becherel,O.J., Finnie,J.,
            Skaar,J.R., Walkley,C.R., Pandita,T.K., Rowicka,M., Ginalski,K.,
            Lane,S.W. and Khanna,K.K.
  TITLE     Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and
            progenitor cells by resolving replicative stress
  JOURNAL   Blood 129 (18), 2479-2492 (2017)
   PUBMED   28270450
REFERENCE   3  (bases 1 to 2362)
  AUTHORS   Boucher,D., Vu,T., Bain,A.L., Tagliaro-Jahns,M., Shi,W., Lane,S.W.
            and Khanna,K.K.
  TITLE     Ssb2/Nabp1 is dispensable for thymic maturation, male fertility,
            and DNA repair in mice
  JOURNAL   FASEB J 29 (8), 3326-3334 (2015)
   PUBMED   25917330
  REMARK    GeneRIF: Ssb1 is likely able to compensate for the loss of Ssb2 in
            mice.
REFERENCE   4  (bases 1 to 2362)
  AUTHORS   Gu,P., Deng,W., Lei,M. and Chang,S.
  TITLE     Single strand DNA binding proteins 1 and 2 protect newly replicated
            telomeres
  JOURNAL   Cell Res 23 (5), 705-719 (2013)
   PUBMED   23459151
REFERENCE   5  (bases 1 to 2362)
  AUTHORS   Shi,W., Bain,A.L., Schwer,B., Al-Ejeh,F., Smith,C., Wong,L.,
            Chai,H., Miranda,M.S., Ho,U., Kawaguchi,M., Miura,Y., Finnie,J.W.,
            Wall,M., Heierhorst,J., Wicking,C., Spring,K.J., Alt,F.W. and
            Khanna,K.K.
  TITLE     Essential developmental, genomic stability, and tumour suppressor
            functions of the mouse orthologue of hSSB1/NABP2
  JOURNAL   PLoS Genet 9 (2), e1003298 (2013)
   PUBMED   23408915
REFERENCE   6  (bases 1 to 2362)
  AUTHORS   Feldhahn,N., Ferretti,E., Robbiani,D.F., Callen,E., Deroubaix,S.,
            Selleri,L., Nussenzweig,A. and Nussenzweig,M.C.
  TITLE     The hSSB1 orthologue Obfc2b is essential for skeletogenesis but
            dispensable for the DNA damage response in vivo
  JOURNAL   EMBO J 31 (20), 4045-4056 (2012)
   PUBMED   22940690
  REMARK    Erratum:[EMBO J. 2021 Jan 15;40(2):e107130. doi:
            10.15252/embj.2020107130.. PMID: 33448440]
REFERENCE   7  (bases 1 to 2362)
  AUTHORS   Kang,H.S., Beak,J.Y., Kim,Y.S., Petrovich,R.M., Collins,J.B.,
            Grissom,S.F. and Jetten,A.M.
  TITLE     NABP1, a novel RORgamma-regulated gene encoding a single-stranded
            nucleic-acid-binding protein
  JOURNAL   Biochem J 397 (1), 89-99 (2006)
   PUBMED   16533169
  REMARK    GeneRIF: NABP1 binds single-stranded nucleic acids, but not
            double-stranded DNA, suggesting that it functions as a
            single-stranded nucleic acid binding protein
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125518.3, BY089463.1, BB609822.1, AK167652.1 and AY880264.1.
            
            On Jul 15, 2015 this sequence version replaced XM_006495621.1.
            
            Transcript Variant: This variant (2) uses an alternate splice
            junction in the 5' end compared to variant 1, which results in
            translation from a downstream AUG. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 2 and 3
            both encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.943158.1,
                                           SRR7345562.4615158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC125518.3         168226-168226       c
            2-342               BY089463.1         3-343
            343-756             BB609822.1         273-686
            757-2346            AK167652.1         1235-2824
            2347-2362           AY880264.1         2824-2839
FEATURES             Location/Qualifiers
     source          1..2362
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.58 cM"
     gene            1..2362
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /note="nucleic acid binding protein 1"
                     /db_xref="GeneID:109019"
                     /db_xref="MGI:MGI:1923258"
     exon            1..99
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     exon            100..238
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     exon            239..310
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..605
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /note="isoform b is encoded by transcript variant 2; SOSS
                     complex subunit B2; SOSS-B2; sensor of ssDNA subunit B2;
                     oligonucleotide/oligosaccharide-binding fold containing
                     2A; single-stranded DNA-binding protein 2; sensor of
                     single-strand DNA complex subunit B2;
                     oligonucleotide/oligosaccharide-binding fold-containing
                     protein 2A"
                     /codon_start=1
                     /product="SOSS complex subunit B2 isoform b"
                     /protein_id="NP_001297477.1"
                     /db_xref="CCDS:CCDS78580.1"
                     /db_xref="GeneID:109019"
                     /db_xref="MGI:MGI:1923258"
                     /translation="MWKGCLTLYTGRGGELQKIGEFCMVYSEVPNFSEPNPDYRGQQN
                     RGVQNEQKDKLSTNTFGPVGNGDQTGPESRGYHLPYGRSNGPGPISPQLPGTPSSQTV
                     RTTISNARDPRRAFKR"
     exon            311..386
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     exon            387..438
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..2362
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2332..2337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /note="hexamer: AATAAA"
     polyA_site      2362
                     /gene="Nabp1"
                     /gene_synonym="4930434H03Rik; 4930442A21Rik;
                     4930488J04Rik; 4933440J18Rik; 5830411E10Rik; Nbp1; Obfc2a;
                     Ssb2"
                     /note="major polyA site"
ORIGIN      
        1 agttgctgct tgggacgcgg gctgcgcggt tggtgaacag ccttgccgtt ttgctgtcac
       61 gtaccttccc tgagcctggg acggaggggg cgcgcgcgtg acgagtgacc aaaaccaaag
      121 acggccatga agtgagatcc tgcaaagtag ctgatagaac gggaagcatc actatttctg
      181 tgtgggatga gatcggaggg ctcatacaga caggggatat tattcggttg accagagggt
      241 atgcatcaat gtggaaagga tgcctgacac tttatactgg aagaggtggt gaacttcaaa
      301 aaattggaga attttgtatg gtgtattcag aagtgccaaa tttcagtgag ccaaacccag
      361 attatagagg acagcagaat agaggggtac aaaatgaaca gaaggataaa ctgagcacca
      421 atacatttgg accagtggga aatggtgatc agactggccc tgaatctagg ggatatcatc
      481 ttccatatgg cagaagcaat ggtccgggac ctatcagtcc acagctacca ggaacaccta
      541 gtagtcaaac agtcaggacc acaataagta acgccagaga tccgaggaga gcctttaaaa
      601 gatgatctaa gccaaagaga cacatgtagt ttttaaacta catgacctac ttgaacactt
      661 agtgcacttt tatttattct taactgtgaa aactttgtct cttacgggtt tccttttata
      721 tttttggttt gttgaaaaga gtggttggtt tttactgaaa aaactgttac actgctcagt
      781 tacatcctat tgaagaatag gaactctgaa agcaggaaca tttatttttt gagcaagaac
      841 ttactgggta tcacttgaaa acctgtccct gtttcgaggg tgagttactt aagacaccag
      901 cttatatata gcctctgtga gtctggcttc tgcataaact ttgtaatgtt tgtcataatg
      961 tttaatggaa cttgtcttaa acttgaatat tgccacctga agcaataacc accccaagcc
     1021 agaaacttgg acagcattgt caacattttt gagtattcct gatctaggaa tggcttgact
     1081 ccctagagtg tctgcctgcc ataaggattt tttcacagac agaatcagaa tcatcctaaa
     1141 ctcttgttta ttgaccagat aaccaaattc ttcatcagaa ttatggaata aaatatgtaa
     1201 tataacaagt aatttttaga agaaaacggt ttaagatgat gctcttaaca tttgttgcaa
     1261 acattgaagt ttacattgaa gaaaaattta caactgagtc cctgaatgct ttatttttga
     1321 agttaccatg ttaaatattg aagtgtaatt ggagggattg aagagagcta taacaccttt
     1381 attggacagt ggtctcattg atactagttg tatttttgag gcagggtctt tctctgtgca
     1441 gccctggttg gttggaactt gttatatata tatatatatc aggtgggtct ctgaactata
     1501 gattgacctg cctctctctt cctggagctg ggattaaagt tgtgtagcac cacacaaggc
     1561 taatctgatt atttttaaaa aaatactcat ggtagttact atagcaaata caaatcaaat
     1621 taaattcata tagccatgtg actaccagtt gcaagtagtc gggtagaagt aggcatttcc
     1681 tttcttccag gaatgtgtgt gtttaaagtt tttgaacaag tcacatagcc ttactagcaa
     1741 aagttaaatg gctcaagaag tgattatact tctgttgagg tgggatttgt gtgatggaac
     1801 atcacttaca gtgggtgatt ggtaattttt ttcattgtta gtatttgtct ctccttaaat
     1861 attgtctctt gagtaaaact tgctgtaatg atgacatatc tacctactta tttttacttt
     1921 cagtaaacat ggagagccca gtccatttta ctgaagttgt attcatcttc agcttgactg
     1981 ctccctaact ctgtacctgt catttctcct tacctcatat tgtaaaataa gtaagtttct
     2041 gttcaacttg tatagcattt gaatataatt tgtgtcagat tttgatctaa ttcattttaa
     2101 cagattttca gtaagcactg cattaggctc tgtgtggaga ttatcatagc attttgagaa
     2161 gtcacaagga atttggttta taggtacagg gctttgacat ttgtcattgt tcatatatta
     2221 ataattatag ctaatttggc cttatgattt tttgtttaca tttctgaatg tttcaaaaaa
     2281 gttaagggtt aagatagctt gtgttttgtg attatagatg ttttgaataa aaataaatga
     2341 caaactaatc ttaaaaattt aa
//
