LOCUS       NM_008668               2593 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Ngfi-A binding protein 2 (Nab2), transcript variant 1,
            mRNA.
ACCESSION   NM_008668
VERSION     NM_008668.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2593)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2593)
  AUTHORS   Accogli,A., Lu,S., Musante,I., Scudieri,P., Rosenfeld,J.A.,
            Severino,M., Baldassari,S., Iacomino,M., Riva,A., Balagura,G.,
            Piccolo,G., Minetti,C., Roberto,D., Xia,F., Razak,R., Lawrence,E.,
            Hussein,M., Chang,E.Y., Holick,M., Cali,E., Aliberto,E.,
            De-Sarro,R., Gambardella,A., Network,U.D., Group,S.S., Emrick,L.,
            McCaffery,P.J.A., Clagett-Dame,M., Marcogliese,P.C., Bellen,H.J.,
            Lalani,S.R., Zara,F., Striano,P. and Salpietro,V.
  TITLE     Loss of Neuron Navigator 2 Impairs Brain and Cerebellar Development
  JOURNAL   Cerebellum 22 (2), 206-222 (2023)
   PUBMED   35218524
  REMARK    GeneRIF: Loss of Neuron Navigator 2 Impairs Brain and Cerebellar
            Development.
REFERENCE   3  (bases 1 to 2593)
  AUTHORS   LaVallee,J., Grant,T., D'Angelo-Early,S., Kletsov,S., Berry,N.A.,
            Abt,K.M., Bloch,C.P., Muscedere,M.L. and Adams,K.W.
  TITLE     Refining the nuclear localization signal within the Egr
            transcriptional coregulator NAB2
  JOURNAL   FEBS Lett 593 (1), 107-118 (2019)
   PUBMED   30411343
  REMARK    GeneRIF: Study characterized sequences in NAB2 that mediate its
            nuclear localization and determined that the KKXK motif that aligns
            with the NAB1 KRXK motif is necessary for NAB2 nuclear
            localization, while the K(X2)R motif situated 11 residues upstream
            is not.
REFERENCE   4  (bases 1 to 2593)
  AUTHORS   Wang,Y., Terrell,A.M., Riggio,B.A., Anand,D., Lachke,S.A. and
            Duncan,M.K.
  TITLE     beta1-Integrin Deletion From the Lens Activates Cellular Stress
            Responses Leading to Apoptosis and Fibrosis
  JOURNAL   Invest Ophthalmol Vis Sci 58 (10), 3896-3922 (2017)
   PUBMED   28763805
REFERENCE   5  (bases 1 to 2593)
  AUTHORS   Hastings,K.T., Elizalde,D., Muppana,L., Levine,S., Kamel,C.M.,
            Ingram,W.M., Kirkpatrick,J.T., Hu,C., Rausch,M.P. and
            Gallitano,A.L.
  TITLE     Nab2 maintains thymus cellularity with aging and stress
  JOURNAL   Mol Immunol 85, 185-195 (2017)
   PUBMED   28282643
  REMARK    GeneRIF: These findings indicate a requirement for Nab2 in
            maintaining thymocyte number in male mice with age and in response
            to stress.
REFERENCE   6  (bases 1 to 2593)
  AUTHORS   Le,N., Nagarajan,R., Wang,J.Y., Svaren,J., LaPash,C., Araki,T.,
            Schmidt,R.E. and Milbrandt,J.
  TITLE     Nab proteins are essential for peripheral nervous system
            myelination
  JOURNAL   Nat Neurosci 8 (7), 932-940 (2005)
   PUBMED   16136673
  REMARK    GeneRIF: Nab1 and Nab2 proteins are necessary for Schwann cells to
            exit the cell cycle, downregulate suppressed cAMP-inducible protein
            (SCIP) expression and upregulate expression of critical myelination
            genes.
REFERENCE   7  (bases 1 to 2593)
  AUTHORS   Mechta-Grigoriou,F., Garel,S. and Charnay,P.
  TITLE     Nab proteins mediate a negative feedback loop controlling Krox-20
            activity in the developing hindbrain
  JOURNAL   Development 127 (1), 119-128 (2000)
   PUBMED   10654606
REFERENCE   8  (bases 1 to 2593)
  AUTHORS   Svaren,J., Apel,E.D., Simburger,K.S., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.A. and Milbrandt,J.
  TITLE     The Nab2 and Stat6 genes share a common transcription termination
            region
  JOURNAL   Genomics 41 (1), 33-39 (1997)
   PUBMED   9126479
REFERENCE   9  (bases 1 to 2593)
  AUTHORS   Svaren,J., Sevetson,B.R., Apel,E.D., Zimonjic,D.B., Popescu,N.C.
            and Milbrandt,J.
  TITLE     NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by
            proliferative and differentiative stimuli
  JOURNAL   Mol Cell Biol 16 (7), 3545-3553 (1996)
   PUBMED   8668170
REFERENCE   10 (bases 1 to 2593)
  AUTHORS   Russo,M.W., Sevetson,B.R. and Milbrandt,J.
  TITLE     Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated
            transcription
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 6873-6877 (1995)
   PUBMED   7624335
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY160550.1 and BC045139.1.
            
            On Apr 1, 2008 this sequence version replaced NM_008668.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045139.1, AK171180.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               BY160550.1         8-123
            117-2593            BC045139.1         1-2477
FEATURES             Location/Qualifiers
     source          1..2593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.6 cM"
     gene            1..2593
                     /gene="Nab2"
                     /note="Ngfi-A binding protein 2"
                     /db_xref="GeneID:17937"
                     /db_xref="MGI:MGI:107563"
     exon            1..328
                     /gene="Nab2"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1823
                     /gene="Nab2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NGFI-A-binding protein 2; EGR-1-binding protein 2; NGFI-A
                     binding protein 2 (EGR-1 binding protein 2)"
                     /codon_start=1
                     /product="NGFI-A-binding protein 2 isoform 1"
                     /protein_id="NP_032694.2"
                     /db_xref="CCDS:CCDS24247.1"
                     /db_xref="GeneID:17937"
                     /db_xref="MGI:MGI:107563"
                     /translation="MHRAPSPTAEQPPGRGDNTRRTPQPRFKASAPAMALPRTLGELQ
                     LYRVLQRANLLSYYETFIQQGGDDVQQLCEAGEEEFLEIMALVGMATKPLHVRRLQKA
                     LREWATNPGLFSQPVPAVPVSSIPLFKISETAGTRKGSMSNGHGSPGEKAGSARSFSP
                     KSPLELGEKLSPLPGGPGAGDPRIWPGQSTPESDVGAGGEEEAGSPPFSPPAGGGVSE
                     GPGVGGVAAGGAGGGPDRLEPEMVRMVVESVERIFRSFPRGDTGEIASLLKLNKKLAR
                     SVGHIFEMDDHDAQKEEEIRKYSVIYGRLDSKRREGKQLSLHELTINEAAAQFCMRDN
                     TLLLRRVELFSLSRQVARESTYLSSLKGSRLHSEELGGPPLKKLKQEVGEQSHNEIQQ
                     PPPGPESYAPPYRPSLEEDSASLSGESLDGHLQAVGSCPRLTPPPADLPLALPAHGLW
                     SRHILQQTLMDEGLRLARLVSHDRVGRLSPCVPAKPPLAEFEEGLLDRCPAPGPHPAL
                     VEGRRSSVKVEAEASRQ"
     exon            329..1202
                     /gene="Nab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1336
                     /gene="Nab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1388
                     /gene="Nab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1521
                     /gene="Nab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1713
                     /gene="Nab2"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..2575
                     /gene="Nab2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nab2"
                     /note="hexamer: AATAAA"
     polyA_site      2575
                     /gene="Nab2"
                     /note="major polyA site"
ORIGIN      
        1 agcgcagcgc cgggcctcgc tccctgtgcg tcctgcgggg gaggaggcgc ggagaggcgg
       61 caagcgcagc cggggaggtg ggggcagagg cacagacaga ggcgcggagg ctccgagaga
      121 gaagacgtgg agggagggac ggagcctgga cagcggtgga cccgggccgc gcgcgccagg
      181 caaagagcag cgcgcagcag gcgccgggca ccgagagggg aggcactggt gatctctggc
      241 cgtccatgca cagagctccc tctcccacag cggaacagcc acctggcaga ggggataaca
      301 cacgccggac cccgcaaccc agattcaagg caagtgcccc agccatggca ctgcctcgga
      361 cactgggtga gctacagctg tatcgggtcc tgcaacgcgc caacctcctc tcttactacg
      421 agaccttcat ccagcaggga ggagatgatg tacagcagct gtgtgaggct ggcgaggagg
      481 agttcctgga aatcatggca ctcgtgggca tggccaccaa accactccat gtccgacgtc
      541 tacagaaggc tctgagagaa tgggccacca atccagggct cttcagccaa ccagtgcctg
      601 ctgtgcccgt ctccagcatc ccacttttca agatctctga gacagctggt acccggaaag
      661 ggagcatgag caatgggcac ggcagcccag gagaaaaggc gggcagtgct cgaagcttta
      721 gccccaagag tcccctcgaa cttggagaga agttgtcgcc actccctgga ggacctgggg
      781 caggggatcc ccggatctgg ccaggccaga gcactccaga atctgatgtt ggagcagggg
      841 gagaagagga ggccgggtct ccccctttct ccccacctgc agggggagga gtctctgaag
      901 ggcctggggt tgggggggtg gcagctggtg gtgcaggggg tggtccagac cgcctggaac
      961 cagagatggt gcgaatggtg gtggagagtg tggagaggat cttccggagt ttccccaggg
     1021 gtgacactgg agagatcgca tccctgttga agctgaataa gaagctggcg cggagcgtgg
     1081 ggcacatctt tgagatggac gatcatgacg cccagaagga agaggagatc cggaagtaca
     1141 gcgtcatcta cggccgcctg gactccaaaa ggcgggaggg caaacagctt agcttgcatg
     1201 agctgaccat caacgaggct gctgcccagt tctgcatgag ggacaacact cttttactgc
     1261 gaagggtaga actcttctca ctgtcccgac aagtagcccg agagagcacc tatctttctt
     1321 ccttgaaggg atccaggctt cactctgaag aattgggagg cccaccactg aagaaactga
     1381 aacaagaggt tggagaacag agtcacaatg aaatccagca gcctcctcca ggccctgagt
     1441 cctatgcacc cccataccgc cccagcctag aggaggacag cgccagtctg tctggggaga
     1501 gcctggatgg ccacttgcag gctgtggggt cgtgcccaag gctgacgccg ccccctgctg
     1561 acctgcccct ggcattgcca gcgcatgggc tatggagccg ccacatcttg cagcagacac
     1621 tgatggatga ggggctgcgg ctcgcccgcc tcgtctccca tgatcgtgtg ggccgcctca
     1681 gcccctgtgt gcctgcgaag ccgcctctcg cagagttcga ggaggggttg ctggaccgct
     1741 gccctgcccc gggacctcat cctgctctgg tggagggccg caggagcagc gttaaagtgg
     1801 aggcagaagc cagccggcag tgaaagtggg ggaagtctca gacccaggac ccagacttct
     1861 ggctcactta gacccccaca ttctccatcc ttgcactcgc cactacccta gaaggatcct
     1921 tctgctgccc tctgcctccc atccgcccca tgggcacagg actatggggc ttcaagcaat
     1981 aacaggcagg ggcctggcca gaggacacaa ggacggtgca aggtgtgccc tcacccggct
     2041 taggggcacg gactttgcct ccagcctgct ggggctctcc tttctctcat accacacaca
     2101 cacacacaca cacacacaca cacacacaca cacacacata ttctccaggt ggccagcagt
     2161 ggtgtgagca gctgaactac ttcacttgga cacggagaaa gaacttcccc aggaaggtct
     2221 agcgacttac agtggaacct tcactctgag actgggggct tgggaaaact gggtctcccc
     2281 tccccatccc catttttcgt gcttctagtt tgtttcttta atttaacaag tgctgcagtt
     2341 tgcccacccg ttcttatctc ccccctcccc gcagaccttt ctctcagcac tgtgtgggag
     2401 ggtgccccga agttccctcc accagcccct tagaggcctg ggttggaccc tgggcctcct
     2461 cagccggcag gactgcagca cctgtcgaac acttagcgtg tctttctttt cagattgtgt
     2521 acagtagatt atttattttg ttattttgga ataaaattta ttttatggct taggaaaaaa
     2581 aaaaaaaaaa aaa
//
