LOCUS       NM_008667               5098 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus Ngfi-A binding protein 1 (Nab1), mRNA.
ACCESSION   NM_008667
VERSION     NM_008667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5098)
  AUTHORS   Kearney SJ, Delgado C, Eshleman EM, Hill KK, O'Connor BP and Lenz
            LL.
  TITLE     Type I IFNs downregulate myeloid cell IFN-gamma receptor by
            inducing recruitment of an early growth response 3/NGFI-A binding
            protein 1 complex that silences ifngr1 transcription
  JOURNAL   J Immunol 191 (6), 3384-3392 (2013)
   PUBMED   23935197
  REMARK    GeneRIF: These data suggest that type I IFN stimulation induces a
            rapid recruitment of a repressive Egr3/Nab1 complex that silences
            transcription from the ifngr1 promoter.
REFERENCE   2  (bases 1 to 5098)
  AUTHORS   Herriges JC, Yi L, Hines EA, Harvey JF, Xu G, Gray PA, Ma Q and Sun
            X.
  TITLE     Genome-scale study of transcription factor expression in the
            branching mouse lung
  JOURNAL   Dev Dyn 241 (9), 1432-1453 (2012)
   PUBMED   22711520
REFERENCE   3  (bases 1 to 5098)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 5098)
  AUTHORS   Baloh RH, Strickland A, Ryu E, Le N, Fahrner T, Yang M, Nagarajan R
            and Milbrandt J.
  TITLE     Congenital hypomyelinating neuropathy with lethal conduction
            failure in mice carrying the Egr2 I268N mutation
  JOURNAL   J Neurosci 29 (8), 2312-2321 (2009)
   PUBMED   19244508
REFERENCE   5  (bases 1 to 5098)
  AUTHORS   Desmazieres A, Decker L, Vallat JM, Charnay P and
            Gilardi-Hebenstreit P.
  TITLE     Disruption of Krox20-Nab interaction in the mouse leads to
            peripheral neuropathy with biphasic evolution
  JOURNAL   J Neurosci 28 (23), 5891-5900 (2008)
   PUBMED   18524893
REFERENCE   6  (bases 1 to 5098)
  AUTHORS   Mechta-Grigoriou F, Garel S and Charnay P.
  TITLE     Nab proteins mediate a negative feedback loop controlling Krox-20
            activity in the developing hindbrain
  JOURNAL   Development 127 (1), 119-128 (2000)
   PUBMED   10654606
REFERENCE   7  (bases 1 to 5098)
  AUTHORS   Svaren J, Sevetson BR, Golda T, Stanton JJ, Swirnoff AH and
            Milbrandt J.
  TITLE     Novel mutants of NAB corepressors enhance activation by Egr
            transactivators
  JOURNAL   EMBO J 17 (20), 6010-6019 (1998)
   PUBMED   9774344
REFERENCE   8  (bases 1 to 5098)
  AUTHORS   Svaren J, Apel ED, Simburger KS, Jenkins NA, Gilbert DJ, Copeland
            NA and Milbrandt J.
  TITLE     The Nab2 and Stat6 genes share a common transcription termination
            region
  JOURNAL   Genomics 41 (1), 33-39 (1997)
   PUBMED   9126479
REFERENCE   9  (bases 1 to 5098)
  AUTHORS   Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC and
            Milbrandt J.
  TITLE     NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by
            proliferative and differentiative stimuli
  JOURNAL   Mol Cell Biol 16 (7), 3545-3553 (1996)
   PUBMED   8668170
REFERENCE   10 (bases 1 to 5098)
  AUTHORS   Russo MW, Sevetson BR and Milbrandt J.
  TITLE     Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated
            transcription
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 6873-6877 (1995)
   PUBMED   7624335
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164428.4 and AI607440.1.
            
            [WARNING] On Apr 28, 2023 this sequence was replaced by
            NM_008667.4.
            
            On Aug 11, 2009 this sequence version replaced NM_008667.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005627.1, U47008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC164428.4         154523-154761       c
            240-1074            AC164428.4         144234-145068       c
            1075-1208           AC164428.4         135184-135317       c
            1209-1260           AC164428.4         133551-133602       c
            1261-1350           AC164428.4         121203-121292       c
            1351-1513           AC164428.4         119098-119260       c
            1514-1630           AC164428.4         116401-116517       c
            1631-4829           AC164428.4         110421-113619       c
            4830-5098           AI607440.1         1-269               c
FEATURES             Location/Qualifiers
     source          1..5098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.99 cM"
     gene            1..5098
                     /gene="Nab1"
                     /note="Ngfi-A binding protein 1"
                     /db_xref="GeneID:17936"
                     /db_xref="MGI:MGI:107564"
     exon            1..239
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            240..1074
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1719
                     /gene="Nab1"
                     /note="EGR-1-binding protein 1"
                     /codon_start=1
                     /product="NGFI-A-binding protein 1"
                     /protein_id="NP_032693.2"
                     /db_xref="CCDS:CCDS14944.1"
                     /db_xref="GeneID:17936"
                     /db_xref="MGI:MGI:107564"
                     /translation="MATALPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEA
                     GEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFNQPLTSLPVSSIPIYKLPEG
                     SPTWLGISCNSYERSSSSREPHLKIPKCAATTCVQSLGQGKSEVGSLALQSVSDSRLW
                     QGHHATESEHSLSPADLGSPASPKESSEALDAAAALSVAECVERMAPTLPKSDLSEVK
                     ELLKNNKKLAKMIGHIFEMSDEDPHKEEEIRKYSAIYGRFDSKRKDGKHLTLHELTVN
                     EAAAQLCVKDNALLTRRDELFALARQVSREVTYKYTYRTTRLKCGERDELSPKRIKIE
                     DGFPDFQESVPTLFQQARAKSEELAGLGSQQAEKGMAKQMELLCAQAGYERLQQERRL
                     TAGLYRQSSGEQSPDGGLPSDSSDGQGERPLNLRIPSVQNRQPHHFVVDGELSRLYSS
                     EAKSHSSESLGILKDYPHSAFTLEKKVIKTEPEDSR"
     exon            1075..1208
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1260
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1350
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1513
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1630
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..5088
                     /gene="Nab1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgaggga ggggcggcgg gagaggccta gggagggcgc ccggggccgc cgccgcccgc
       61 ctccgcccga gcctccgccc gcgcgaccga gcgagcgccg tcggggcggg cgggggacgg
      121 agcgcgcgcc caccgcgtcc ctgcccccct cgatgggcgc gggggcgtcc cggccgccgc
      181 agccgccgca ggagcccggc agagccgtcg tcgcggagcg cgccgcagct gcgggccgcg
      241 ttaagcccat ccacagtaat ggccacagcc ttacctagga ccctggggga gctgcagctg
      301 tatagaatat tgcaaaaagc caacctgctt tcttactttg atgcctttat ccaacaaggt
      361 ggtgatgatg tccagcaact gtgtgaagct ggagaagagg aatttttgga aataatggca
      421 cttgtgggca tggcaagcaa gccccttcac gttagaaggc ttcagaaggc tttgagagac
      481 tgggttacaa atcctggcct tttcaatcag ccattgactt cacttcctgt cagtagcata
      541 cccatctata aattaccaga gggatcgcca acatggctgg ggatatcctg caatagttat
      601 gaaaggagta gcagctcccg agagccacat ttaaaaatcc ctaaatgtgc cgccaccacc
      661 tgtgtgcaga gcttgggtca gggcaagtca gaagtgggaa gtttagcact gcagagtgtc
      721 agcgattcca gactctggca aggacatcat gccactgaaa gcgagcatag tctctcccca
      781 gcagacctgg gctccccggc ctctccaaag gaaagcagcg aagccctgga tgctgcagct
      841 gcactctctg tggccgagtg tgtggagcgg atggccccca cactgcccaa aagtgacttg
      901 agtgaagtga aggagctgct gaagaacaat aagaagttgg ccaaaatgat cggtcacata
      961 tttgagatga gtgacgaaga cccacacaaa gaggaggaga ttagaaagta cagcgccatc
     1021 tatgggcgat ttgactccaa aagaaaggat ggcaaacacc ttacattgca tgagctcact
     1081 gttaatgagg cagccgctca gctgtgtgtg aaggacaatg ccctgctgac aagaagagat
     1141 gagctttttg ccctggccag gcaggtttct cgagaagtta cctacaagta cacttacagg
     1201 accaccaggt taaaatgtgg tgaaagagat gaattatctc caaagagaat taaaatagag
     1261 gatggatttc ccgacttcca ggaatctgtg ccaacactct tccagcaggc cagagccaag
     1321 agcgaggagc ttgcagggct cggttcacag caggctgaaa aggggatggc gaagcagatg
     1381 gagctcctgt gtgcccaggc cgggtatgag aggctgcagc aggagaggag actcacggcc
     1441 gggctctaca ggcagagctc cggcgagcag agccctgatg gcggcctgcc ttctgatagc
     1501 tctgatggac aaggagaaag acctttgaat ctccgaattc cgagtgtgca gaaccgacag
     1561 ccccatcatt ttgtggtgga tggggagctg agtaggcttt actccagtga ggccaagtcc
     1621 cactcctcag agagccttgg gattctaaaa gactatcctc actctgcatt caccttggaa
     1681 aagaaagtta ttaaaacaga gcctgaagac tcaagatagc tgagatgctc ctactgttct
     1741 ctggaaatgg caccagattc aaggataatg ctccatcata gattaagcct taataaccag
     1801 tgttgcctca ttcagctcac agaccatagc caaagcataa gaacccacac agtagtctgt
     1861 ggacatcagg acaaaacaac aaccacagaa gagggaatca agagagcatt gcaatgtaac
     1921 agacactgac cacttacctt cctgtgtaag ctgcttgtgt ggaaaggctc aatattgtag
     1981 gcattcacta tttaagaatg tacaacatgt ctttgtaatt tatagaaaca agtctaggtg
     2041 ttgatacctt gtggtctaat agatgtggat accattcatt ttacttgaaa ttttgttgtc
     2101 tactttaagt gtatttgcca taaatgttac tcgtcagcaa ttagaacttt tgcaatcata
     2161 gaaagaaagt ctgggcaatg tagttattgg caaggtgact ggagaaagat ggaagataaa
     2221 tacacaattt acaccaagga gaagactgtg tgtttaatac ttgataacat tgattttgat
     2281 taataggaaa tatgtagctg tcgctaaata atgtcacctt cattggttta atcaatgcac
     2341 aaattaaaaa ttggagtaac attcccaaaa tgaggtaggc tatatttatg gcagctgctt
     2401 aagatgtaac aaaggttgga cagaggacat gaaataaatg ggttattgtg taaaagcctt
     2461 gacttaaaaa cattgatatt tcagaatatg ttaaacaaat taaggcatag taagatagcc
     2521 ctaaatgtga taaagatgat ggatgatgtg ggtgaatgga catggaatgt gtgtcttgtt
     2581 ttcagttctg ctttagatca tgctgttata gatatgagtt cctaatctgt tatactgaaa
     2641 tctgttggcc agatgttagg tgagatgtgt gcaccaccac aggctctaag cagtcacata
     2701 gatagtcact tttcaatttg atctgtagaa gagttctaca gtagaaacac cagtaaacag
     2761 ctttactaca actacaaggc ttttcccttc ctagatgatt ctattggacc atagcacctt
     2821 gcccactaaa aactatctta gggaccatgt gcctctgttt ctaccgtgag gttgattatt
     2881 gtggtctcac tgtccactgt gtgtagagct agtgtgatac catttaaata gaatgttcag
     2941 tttttaatat tagccacagc actggatatt atccctatac tttcatgaac cgtttcctgt
     3001 gttccttaat ctattttgag aaattttgtg gtcctttttc ttttaaaaaa aaaaaaaaac
     3061 aaaaacgaaa aacaaaaaaa ctatgtctta cagttcaagt tcgtagattt taacattgca
     3121 agttataaaa gatgcagtag tcttccagct gatatatatc tgtctctcct ggacctagaa
     3181 cctgcatttt taaatccaga agaaagtctc cttaagtagc atacttttct gacttccaag
     3241 cttagagata gagaagaagc acacacacac acacacacac acacacacac acacacacac
     3301 acacacacaa attttcagta gaatacaatt tttatcttgt gaacactaat gtattaaact
     3361 tgctatacat taaagcaaat aatatatatt tttatttgaa tggtatatat aaattagatg
     3421 ttataactag tggggtgttc ttcatttcat ttaagatact tccactgaac aaggtcaatt
     3481 ggttacctca gtattacagc caatataacc caagggacca tttctcccta agtctgtgtt
     3541 attctttatt gtgtgaattc tgcatttttg tgattcctaa aactgttgaa gagatgagtg
     3601 aacttgcttc ccgtggcaat aaaggatttc tctgcctcac aaatccttgc ttagagtgct
     3661 ttgcatagca catgatgttc gtctatactg cctcccttac cgcatgtcgg gacaggatgc
     3721 gcttctcttt tttcctgtga cactgagagt tgaacccaga ggctctacca ctgataggcc
     3781 cagcactcat gttacttttt tattctgaga caggcttcct aacttgccgc agctggcctt
     3841 gaactcactc tgtagaccac acaggtggtg gtcacctggg gagacctttc ctagcctggg
     3901 cttcatacat ttcacttttg aaagggcaga gtacttctga ctcagcacca tgttgtttgt
     3961 gacattgatg ctgctctgaa tcttcaaaag aaaaccaacc aggttgtcaa cccaatgaga
     4021 gcaggagccc tggtagattc aagagattac aacagcaaat atttgatgaa agccctcttc
     4081 tgacccagcg ctgtgcaagg gttggttctg gggatccaag aacgtgtatt tgctgttatc
     4141 tctgggcgtt ctcatgaatg acattctcca gtggccttca agttaacaaa ggatgactca
     4201 gtgtccactg ttattgaaaa cacacattga tgacaactgt ttccatagca accgtgcaag
     4261 acaaacattc ccgacaccta agagatcaga agccgacact gtgataatgc tttcaattct
     4321 gaatgtgtgg tggctaaatc gtccaggtca cccctggatt ctgctttggc tgacttacgg
     4381 aaatgaagaa aacaatcact tgttcttgtg cagaaaatat gaaatcataa tttaagttca
     4441 taattctttt aaattagtct tatgttctac ttacacatat ttttctgtct atttttttta
     4501 ccatagcttt agaaagaatg ataaataata gctggttttg ttataaattc attagaactc
     4561 cttccttctt tcatattttc atagctgcta ggccacacga ttcttgagca ctacagtatt
     4621 cttttgaatt ctggtctctt ggcagtgcct gattctttgg tcataatttc taagactgtt
     4681 cttttgactg ctccatttat gtccagatct cacttgtaag acataaaagg gctcatttct
     4741 gccagttcac cctcaaccaa aggaaaagtt taatattgtt gtagtgattt aatatgatgt
     4801 ctagaacaga agcatttaaa aataactcac caagcactaa actcgatttt ttagcattca
     4861 catgacatgc tacttaccat tagctttctc tttttatttt taaaatattt cattgatttt
     4921 ctatttttaa agtagttaat tgggccagtg tgatgatgcc cacttttaat tagtccttga
     4981 aggttgaggt ggggcaactg tagtttgagt ttggcctaca caggaagact cagttgcaaa
     5041 aggaaaagac attaattggt aaataaaaat ggtacatatt caagtgtaaa aaaaaaaa
//
