LOCUS       NM_025972               2424 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus N-acylethanolamine acid amidase (Naaa), transcript
            variant 1, mRNA.
ACCESSION   NM_025972
VERSION     NM_025972.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2424)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2424)
  AUTHORS   Fotio,Y., Mabou Tagne,A., Squire,E., Lee,H.L., Phillips,C.M.,
            Chang,K., Ahmed,F., Greenberg,A.S., Villalta,S.A., Scarfone,V.M.,
            Spadoni,G., Mor,M. and Piomelli,D.
  TITLE     NAAA-regulated lipid signaling in monocytes controls the induction
            of hyperalgesic priming in mice
  JOURNAL   Nat Commun 15 (1), 1705 (2024)
   PUBMED   38402219
  REMARK    GeneRIF: NAAA-regulated lipid signaling in monocytes controls the
            induction of hyperalgesic priming in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2424)
  AUTHORS   Palese,F., Pontis,S., Realini,N., Torrens,A., Ahmed,F., Assogna,F.,
            Pellicano,C., Bossu,P., Spalletta,G., Green,K. and Piomelli,D.
  TITLE     Targeting NAAA counters dopamine neuron loss and symptom
            progression in mouse models of parkinsonism
  JOURNAL   Pharmacol Res 182, 106338 (2022)
   PUBMED   35781057
REFERENCE   4  (bases 1 to 2424)
  AUTHORS   Xie,X., Li,Y., Xu,S., Zhou,P., Yang,L., Xu,Y., Qiu,Y., Yang,Y. and
            Li,Y.
  TITLE     Genetic Blockade of NAAA Cell-specifically Regulates Fatty Acid
            Ethanolamides (FAEs) Metabolism and Inflammatory Responses
  JOURNAL   Front Pharmacol 12, 817603 (2022)
   PUBMED   35069223
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2424)
  AUTHORS   Fotio,Y., Jung,K.M., Palese,F., Obenaus,A., Tagne,A.M., Lin,L.,
            Rashid,T.I., Pacheco,R., Jullienne,A., Ramirez,J., Mor,M.,
            Spadoni,G., Jang,C., Hohmann,A.G. and Piomelli,D.
  TITLE     NAAA-regulated lipid signaling governs the transition from acute to
            chronic pain
  JOURNAL   Sci Adv 7 (43), eabi8834 (2021)
   PUBMED   34678057
REFERENCE   6  (bases 1 to 2424)
  AUTHORS   Alhouayek,M., Bottemanne,P., Subramanian,K.V., Lambert,D.M.,
            Makriyannis,A., Cani,P.D. and Muccioli,G.G.
  TITLE     N-Acylethanolamine-hydrolyzing acid amidase inhibition increases
            colon N-palmitoylethanolamine levels and counteracts murine colitis
  JOURNAL   FASEB J 29 (2), 650-661 (2015)
   PUBMED   25384424
  REMARK    GeneRIF: NAAA inhibition increases palmitoylethanolamide levels in
            the colon and reduces colon inflammation and systemic inflammation
REFERENCE   7  (bases 1 to 2424)
  AUTHORS   Sasso,O., Moreno-Sanz,G., Martucci,C., Realini,N., Dionisi,M.,
            Mengatto,L., Duranti,A., Tarozzo,G., Tarzia,G., Mor,M.,
            Bertorelli,R., Reggiani,A. and Piomelli,D.
  TITLE     Antinociceptive effects of the N-acylethanolamine acid amidase
            inhibitor ARN077 in rodent pain models
  JOURNAL   Pain 154 (3), 350-360 (2013)
   PUBMED   23218523
  REMARK    GeneRIF: NAAA regulates peripheral pain initiation by interrupting
            endogenous fatty acid ethanolamide signaling at PPAR-alpha.
REFERENCE   8  (bases 1 to 2424)
  AUTHORS   Zhao,L.Y., Tsuboi,K., Okamoto,Y., Nagahata,S. and Ueda,N.
  TITLE     Proteolytic activation and glycosylation of
            N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme
            involved in the endocannabinoid metabolism
  JOURNAL   Biochim Biophys Acta 1771 (11), 1397-1405 (2007)
   PUBMED   17980170
REFERENCE   9  (bases 1 to 2424)
  AUTHORS   Sun,Y.X., Tsuboi,K., Zhao,L.Y., Okamoto,Y., Lambert,D.M. and
            Ueda,N.
  TITLE     Involvement of N-acylethanolamine-hydrolyzing acid amidase in the
            degradation of anandamide and other N-acylethanolamines in
            macrophages
  JOURNAL   Biochim Biophys Acta 1736 (3), 211-220 (2005)
   PUBMED   16154384
  REMARK    GeneRIF: Results suggest that N-acylethanolamine-hydrolyzing acid
            amidase and fatty acid amide hydrolase cooperatively degrade
            anandamide and other N-acylethanolamines in macrophages.
REFERENCE   10 (bases 1 to 2424)
  AUTHORS   Tsuboi,K., Sun,Y.X., Okamoto,Y., Araki,N., Tonai,T. and Ueda,N.
  TITLE     Molecular characterization of N-acylethanolamine-hydrolyzing acid
            amidase, a novel member of the choloylglycine hydrolase family with
            structural and functional similarity to acid ceramidase
  JOURNAL   J Biol Chem 280 (12), 11082-11092 (2005)
   PUBMED   15655246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008776.1, AB162194.1, AK133485.1 and AC125542.4.
            
            On Aug 8, 2009 this sequence version replaced NM_025972.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133485.1, AK008776.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AK008776.1         3-36
            35-1159             AB162194.1         1-1125
            1160-1850           AK133485.1         1145-1835
            1851-1851           AC125542.4         176562-176562       c
            1852-2424           AK133485.1         1837-2409
FEATURES             Location/Qualifiers
     source          1..2424
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 46.35 cM"
     gene            1..2424
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /note="N-acylethanolamine acid amidase"
                     /db_xref="GeneID:67111"
                     /db_xref="MGI:MGI:1914361"
     exon            1..270
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1138
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /EC_number="3.5.1.23"
                     /EC_number="3.5.1.60"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; N-acylethanolamine-hydrolyzing acid amidase;
                     ASAH-like protein; acylsphingosine deacylase NAAA"
                     /codon_start=1
                     /product="N-acylethanolamine-hydrolyzing acid amidase
                     isoform 1 precursor"
                     /protein_id="NP_080248.2"
                     /db_xref="CCDS:CCDS19428.1"
                     /db_xref="GeneID:67111"
                     /db_xref="MGI:MGI:1914361"
                     /translation="MGTLATRAACHGAHLALALLLLLSLSGPWLSAVVPGTPPLFNVS
                     LDAAPEQRWLPMLRHYDPDFLRTAVAQVIGDRVPQWVLGMVGEIVSKVESFLPQPFTD
                     EIRSICDSLNLSLADGILVNLAYEASAFCTSIVAQDSQGHIYHGRNLDYPFGKILRKL
                     TANVQFIKNGQIAFTGTTFVGYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGH
                     SPISWLIRKTLSESESFEAAVYTLAKTPLIADVYYIVGGTSPKEGVVITRDRGGPADI
                     WPLDPLNGEWFRVETNYDHWKPAPKVDDRRTPAIKALNATGQAHLNLETLFQVLSLFP
                     VYNNYTIYTTVMSAAEPDKYLTMIRNPS"
     exon            271..435
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            436..562
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            563..653
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            654..730
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            731..903
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            904..966
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1033
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1062
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1140
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..2424
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1747..1752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /note="hexamer: AATAAA"
     polyA_site      1792
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /note="major polyA site"
     regulatory      2200..2205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /note="hexamer: AATAAG"
     polyA_site      2228
                     /gene="Naaa"
                     /gene_synonym="2210023K21Rik; 3830414F09Rik; Asahl"
                     /note="major polyA site"
ORIGIN      
        1 aggacagcaa agattcattg gtccggtggt ggcctcagaa gccggagcta tggggaccct
       61 agccaccagg gccgcgtgcc atggggcaca cctggccctg gctctgttgc tgctactgtc
      121 gctgtccggt ccctggctgt cggctgtcgt ccccgggact ccgcctctct tcaacgtcag
      181 tctggacgcg gccccggagc agcgctggct gccgatgctg cggcactacg acccagactt
      241 cttgcgcacc gcggtggcgc aggtcattgg cgacagggtt ccccagtggg tactcgggat
      301 ggtcggagaa attgtgtcga aggtggagag cttcctgcct cagcccttca ccgacgagat
      361 ccgcagcatc tgtgactcgc tcaacctcag cctggctgac ggtatcttgg tcaacctggc
      421 ctacgaggct tccgcattct gcaccagtat tgtggcccaa gactcccaag gccatattta
      481 ccacggccgg aacctggact atccttttgg aaaaatctta cgaaagctga cagcgaacgt
      541 gcagtttata aagaatgggc agattgcatt cactgggacc acttttgttg gctatgtagg
      601 actgtggaca ggccaaagtc cacacaagtt tacaatttct ggtgatgaac gagataaagg
      661 ctggtggtgg gagaatatga tcgcggcgct ttctctggga cactccccca tcagctggct
      721 tatccgcaaa accctgagtg agtcagaaag cttcgaagca gctgtctaca cgctggccaa
      781 gactcccctc attgctgacg tttattacat tgttgggggt acatcgccca aggagggagt
      841 agtcatcacc agggaccgag gtggcccggc agacatttgg cctcttgacc ctctgaatgg
      901 agagtggttc cgagttgaga caaattatga ccattggaag cctgcaccca aggtggatga
      961 ccgaagaaca ccagccatca aagccctaaa tgctacaggg caagctcacc tcaatctgga
     1021 gaccctcttc caggttttat ccctgtttcc tgtttataac aactacacaa tttatactac
     1081 agtgatgagc gctgccgagc ccgacaagta cctgaccatg atcagaaacc cgagctgaag
     1141 gtgatgtatt gtcaaaaagc tgcatttaga agtctaagac tggaaggact gtcccgtttc
     1201 ctgagcaacg caggctccct ccccacagag cgtttctgcc tgtggaggaa gaggagcgca
     1261 gcctgctgtc ttggtcctcc tgacttcctg gtccccttga gcttcactaa cagcccacct
     1321 tggcttgaac aactcatata actggtctca gaggtcaggc tgcacccaac cagtcacaag
     1381 tgtcctgtga ttctgtgttc acactcctgc ttgtccactg aagaagggac aggacaagat
     1441 ggctgtcatg tggacaaacc caggtttctc ctaaggctgg gtgaggctta gtggcagggt
     1501 ttgcaccgat agatagatag atgatagata gatagataga tagatagata gatagataga
     1561 tagatagata atagatagaa agatagatag acaaatgaga gttttctctg aagagcagag
     1621 acctctaatt tgagtaaaat tttcttaaag ctatgaactc tgacttttga ttttgtgttt
     1681 ccatttagta gaaactcatt ttttgtaaac ttctaatgta tttttttaaa tgtaagcctt
     1741 attaaaaata aaactacttt cttactactt ttgaaaaata tatgacacca aataatatcc
     1801 tgtcatcgtt tgttaataaa atgtcaaaaa aaaaaatgct agctgtgaag agaaaactta
     1861 taattttggg tcttatagca ttgtggtatc taagctcaag aaattcaggg ctgaagaata
     1921 gacccaggcg gatccaggca cagccagatc caccctgtag ctaagaatgt ccggccataa
     1981 aagataaaaa agaaagtgca ggaactagcc agggctatca ggaccaaatg gccatctggc
     2041 aggatggcgc ctcccgggtg gcacctccct atagcccacc ataaatcata tactgaccag
     2101 gtgtcctgct gacctcgaga agtccaagcc tttgtgcccc cctacacctt aactagcatg
     2161 tactgccctg ttaatttgta atcacctcgc cgacatttaa ataagccaat catgtgtaac
     2221 ctcgcaaatt ccttcggctc cctccctttt tggtttgtgg tttttgcctt tataagcctg
     2281 taagaagttt gggccggggt cgaactcccc tgccccctgc gcagtgcatg agtttcgacc
     2341 ccagcatgct ggcttgagtg ctcttttgtt gtttgtgtgt gtgtgtgtgt gtgtgtgtgc
     2401 cattaaaagc ctgttgttac aacg
//
