LOCUS       NM_172722               5402 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus N(alpha)-acetyltransferase 25, NatB auxiliary subunit
            (Naa25), mRNA.
ACCESSION   NM_172722
VERSION     NM_172722.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5402)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5402)
  AUTHORS   Alves,S., Neiri,L., Chaves,S.R., Vieira,S., Trindade,D., Manon,S.,
            Dominguez,V., Pintado,B., Jonckheere,V., Van Damme,P., Silva,R.D.,
            Aldabe,R. and Corte-Real,M.
  TITLE     N-terminal acetylation modulates Bax targeting to mitochondria
  JOURNAL   Int J Biochem Cell Biol 95, 35-42 (2018)
   PUBMED   29233735
  REMARK    GeneRIF: The pro-apoptotic protein Bax is main effector of
            mitochondrial permeabilization during apoptosis. Data suggest that
            Bax N-terminal acetylation by NatB is involved in mitochondrial
            targeting of Bax. These studies used cultured embryonic cells from
            knockout, transgenic, and chimeric mice. (Bax = apoptosis regulator
            BAX)
REFERENCE   3  (bases 1 to 5402)
  AUTHORS   Ohyama,K., Yasuda,K., Onga,K., Kakizuka,A. and Mori,N.
  TITLE     Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20
            in the developing mouse brain: implications for co-operative versus
            non-co-operative actions of Mdm20 and Nat5
  JOURNAL   Gene Expr Patterns 12 (1-2), 36-45 (2012)
   PUBMED   22101279
  REMARK    GeneRIF: Mdm20 is highly expressed in the developing mouse brain.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049325.1, AK051815.1, CF742186.1, AK076483.1, AC129215.3 and
            BX521975.1.
            
            On May 19, 2018 this sequence version replaced NM_172722.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.6004.1,
                                           SRR10223970.7987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3092              AK049325.1         15-3106
            3093-3811           AK051815.1         862-1580
            3812-4160           CF742186.1         343-691
            4161-4675           AK076483.1         207-721
            4676-4676           AC129215.3         74844-74844
            4677-5387           AK076483.1         723-1433
            5388-5402           BX521975.1         439-453
FEATURES             Location/Qualifiers
     source          1..5402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.79 cM"
     gene            1..5402
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /note="N(alpha)-acetyltransferase 25, NatB auxiliary
                     subunit"
                     /db_xref="GeneID:231713"
                     /db_xref="MGI:MGI:2442563"
     exon            1..68
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2929
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /note="N-terminal acetyltransferase B complex subunit
                     MDM20; mitochondrial distribution and morphology protein
                     20; natB complex subunit MDM20; N-terminal
                     acetyltransferase B complex subunit NAA25"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 25, NatB auxiliary
                     subunit"
                     /protein_id="NP_766310.2"
                     /db_xref="CCDS:CCDS19633.1"
                     /db_xref="GeneID:231713"
                     /db_xref="MGI:MGI:2442563"
                     /translation="MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDL
                     HCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLY
                     EAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQS
                     ISARDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRG
                     KLGEKLTSEIQSRENKCMAMYKKLSKWPECNALSRRLLLKNSDDWQFYLTYFDSVFRL
                     IEEAWTPPAEGEHSLEGEVHCSAEDAVKFIEDRITEASQSSRHVRGPHLAKLELIRRL
                     RSQGCNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPAAQCTQFINQLLGVV
                     PLSTPTEDKLALPADIRGLQQHLCVVQLTRLLGLYHSMDKSQKLDVVKELMLRYQHGL
                     EFGRSCLKTELQFSDYYCLLAVHVLIDVWREAGEETAVWQALTLLEEGLTHSPSNAQF
                     KLLLVRIYCVLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAASLGQYAAASQSCNFA
                     LRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLE
                     ANISISLAESIKSMNLRPEEDDVPWEDLRDNRDLDVFFSWDPKDRNVSEEHKKLSLEE
                     ETMWLRIRSLTLRLISGLPSLTHPVEPKNSEKMSENGVSSRIDILRLLLQQLEVAVET
                     GKRFIEKEIQYPFLGPVPTRMGRFFSSGCCQCQVQSFHLVSDMYELDTSGLEGTVDIQ
                     ERIENSLASLLELLKGVFSTCKGDLLEVTDGNVKTQPAVLENLVFFVETISVILWVSS
                     YCESVLRPYKLNIQKKKKKKKETSIIMPPIFTSFQDYVTGLQTVISNAVDHIKGLEAH
                     LIALRLEELTLEETSISTEERKFSKTVQGKVQSSYLHSLLETGELLRKRLETTKKLKI
                     "
     exon            69..154
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            155..293
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            294..412
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            413..487
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            488..595
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            596..674
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            675..786
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            787..876
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1046
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1159
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1367
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1457
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1638
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1738
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1890
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2016
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2260
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2384
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2450
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2548
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2659
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2806
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..5388
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3797..3802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /note="hexamer: CATAAA"
     polyA_site      3818
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
     regulatory      5309..5314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /note="hexamer: ATTATA"
     polyA_site      5330
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
     regulatory      5366..5371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /note="hexamer: AATACA"
     polyA_site      5388
                     /gene="Naa25"
                     /gene_synonym="4833422K13Rik; A630046C11; C330023M02Rik;
                     Mdm20"
                     /note="major polyA site"
ORIGIN      
        1 gcttgtcatc atggcgacgc ggggccatgt gcaggaccct aacgaccggc gcctccggcc
       61 catttacgat tatcttgata atggaaataa taaaatggca attcagcaag ctgataaact
      121 gttgaagaaa cacaaagatc ttcactgtgc aaaggttctc aaggccattg gtttacagag
      181 aactggcaag caggaagaag ctttcacctt ggctcaggag gtggctgccc ttgagcccac
      241 agatgacaac tccctgcagg ccctgacgat tctctaccga gagatgcacc ggccggagtt
      301 agtcacaaag ctctatgagg cggctgtgaa gaaagttccc aacagcgagg agtaccactc
      361 tcacctcttc atggcctatg ccagagtggg cgagtacaag aagatgcagc aggctggcat
      421 ggctctgtat aagattgtcc ccaaaaaccc ttactacttt tggtcagtga tgagcttgat
      481 catgcaatct atatccgcac gggatgagaa cctctccaaa accatgtttc tgcccctggc
      541 ggagagaatg gtagagaaga tggtgaagga ggacaagata gaggctgaag ctgaggttga
      601 actttattac atgattctgg agcgcttggg aaagtaccag gaagccctgg atgtcattag
      661 aggaaaatta ggagagaagt tgacaagtga aattcagagt cgggaaaaca aatgcatggc
      721 catgtacaag aagctgagca agtggccgga gtgcaacgcc ctttcccgac gcctccttct
      781 gaaaaactca gatgactggc agttctatct gacttatttc gattctgtct ttcgactgat
      841 tgaggaagcc tggacgccgc ctgctgaggg ggaacactcc ttagaagggg aagtacactg
      901 ctctgcagaa gatgctgtga agtttataga ggacaggata acagaggcat cacaaagctc
      961 tcgacatgtc cgaggcccac acctagctaa gctggagctc atcaggcgct tgcggagcca
     1021 aggctgtaat gacgaataca agctgggtga ccctgaagag ttaatgttcc agtatttcaa
     1081 gaagttcggg gataagccat gctgcttcac agacctgaag gtgttcgttg acctcttgcc
     1141 tgccgcccag tgcacacaat tcattaacca gctccttgga gttgttccat tgtcgacgcc
     1201 gacagaggat aagcttgccc tgccggccga catccgaggc ctgcagcagc atctgtgtgt
     1261 tgtgcagctg acacggctcc ttggcttgta ccacagcatg gataagagtc agaagctgga
     1321 tgtggtcaaa gaactgatgt taaggtacca gcacggactg gagtttgggc gctcttgttt
     1381 gaagacagag ttgcagttct cagactatta ctgcctgctc gctgttcatg tgctcattga
     1441 tgtatggaga gaagcaggtg aggagactgc ggtctggcag gccctgactc tgctggaaga
     1501 aggcttaacc cacagcccat ccaatgctca gttcaaattg ctacttgttc ggatctactg
     1561 cgtgctgggt gcatttgaac cagtggtgga tctctactcc agtctcgatg ctaagcacat
     1621 ccagcacgac accattggct atcttctgac ccgatatgct gcatccctgg gtcagtatgc
     1681 tgctgcctcc cagtcctgta actttgcact caggtttttc cactccaacc agaaagatac
     1741 ctcagaatac attattcaag cttacaaata tggtgcattt gagaagatcc cagagtttat
     1801 cgcttttagg aacaggctga ataattctct ccattttgca caagtacgca ctgagcggat
     1861 gctgttagac cttctacttg aagcaaacat atcaattagc ttggcagaaa gtatcaaatc
     1921 aatgaatctg aggccagagg aagatgatgt tccatgggaa gatttgcgag acaacagaga
     1981 cttggatgtt ttcttcagtt gggatccaaa agacaggaat gtttctgaag agcataagaa
     2041 actctccttg gaggaagaaa ccatgtggtt aagaattcgc tccttaacgt tgaggctgat
     2101 cagtggactt ccaagtctta cccaccctgt ggagcccaag aactcagaga agatgtcaga
     2161 gaacggtgtg tcctcccgga tcgacatcct tcgtttgctc ctccaacagc tagaggtggc
     2221 cgtggagacg gggaagcggt ttattgagaa ggaaattcag taccccttcc ttgggcctgt
     2281 tcccaccagg atgggcaggt tcttcagttc tggctgctgt cagtgccaag tccagtcctt
     2341 ccatctggtc agcgacatgt atgagcttga caccagtggc ttagagggta cagtggatat
     2401 acaggaacga atagaaaata gtcttgcatc tttactagaa ctattgaaag gtgtcttcag
     2461 cacatgtaaa ggggacctct tagaagttac agatggcaat gtgaagaccc agcctgcagt
     2521 cctagagaat ctggtcttct tcgttgagac tatttctgtc atcctttggg tgtccagtta
     2581 ctgtgaaagt gtcttgcgac catacaaatt aaatatccag aaaaagaaaa agaagaaaaa
     2641 agaaacgagc atcatcatgc ctccaatctt caccagtttc caagactacg ttactggact
     2701 tcagactgta atttccaatg ctgtggatca tattaaagga cttgaagcac atctgattgc
     2761 acttagactt gaggagctca cgttagagga aacttctatc tctacggaag aaagaaaatt
     2821 ttcaaagact gtgcagggga aagtccagag cagttacctg cactcacttc tggagacagg
     2881 ggagctgctg agaaaaagac ttgagactac aaagaaacta aaaatttaag gaattctgaa
     2941 ccataaacac cgaaggttcc acagcagaag atgacacacc accttcccca gcaaaaacaa
     3001 catctggctg gcattgttct aatccagaac ttcctcacaa atgcatgaag gactttgatc
     3061 gtgaattaat ttttgaggta ttaaatatat acaacaaatt aaattattgt atataaacca
     3121 gaagcaggac cctcatctgg gtttaccact ctttatacct gtccatacat acaggacagc
     3181 aacaagagca ccccacctca ctcccagctc caggaatggc tggggtggac atttctatac
     3241 aagcagcaat agagaataag tatagcatcg acctcagagc aggtgggttg ctttttcatc
     3301 atgcagtggg agtttgggtt gggtagccca tactgtagcc gtatgaggca aaagcaggtg
     3361 taggagaccc aggagcagga cccttccctc agtggcaggt tccttgtgcc atcccacaga
     3421 accgggatgg acccacagag gctcaaggga gatgtggctg agtacgtgcc accacagggc
     3481 accacacatg accacaggtg ctcagttttg gcttcacagc cccagcagcc aagacatccc
     3541 cagccccgct cctgggagag ctcagcctca gggcagtgag gaagtccaag ttctgcccac
     3601 tttgaggaag aaatctgagc acagcccacc gtgagcttcg taaactgctg agactgagcc
     3661 ccgctggtct tctgggaaag gtggaaaagc tgttggaaga ggttgtacgt ggtgtgtgca
     3721 ggcgagtctg atatttgtgt cgtcattaag tcaccttgtg cagctgattg atgagtcaca
     3781 cacagataca catatgcata aatatgcttg gaaacagatt tactactcta gtgcttttaa
     3841 ggggggcttt gggatggaag gattaaatat gggtttaacc taggttttta agttttaggt
     3901 tgaaaaaggt atgttttata atgggcctga tgttggtgtc ctgttgacac ttaagaactg
     3961 catcagggtg tattcatgtt gttcacctaa ggttggtggc ctgttcccta agcctccagc
     4021 ttaagaggct ggtctgcgag aagatgaaaa ctgctcttga ttatgtcatg ccgagctccg
     4081 acagcgcttt ccgtgactgt tttgtgtctg aatctcctct ctcacttctg ttcttgttcc
     4141 ctgtcacttt attcctgaga gtaactgtaa ggtgaaaaga tgacttggtg aggactggtc
     4201 tttcccatgg actgctccag cagcacacca ttgcattctt tatcgtaact gtctgggatt
     4261 cacaaatcag catagtggtt aactaattta cttgtaagga aatgtgtgca aactactttc
     4321 ttacttgtag gatgtgctgg agcctacatc atggttgcat cagagtatca cgtgctccat
     4381 ccccaaaaaa agggcctttt tgaataagat gggttgaaga ccctgatttt gacttgcctt
     4441 gaacaccacc ttgtggtact gttctgtagt tgtggcctgt ttcccatggg actgggtggg
     4501 cgtttgcttg cactgccctg gctcctggaa taatgtttct tgggatattc aaattgtgct
     4561 gtgtgttcac ggtcacagat gctctaaatc aagctctgtc agctgaccat ggtccgtatg
     4621 gactgcatgg gctggctatg gccctcaggc atagctcctt cctctaatgg tctatcctgt
     4681 cagtctcctg ctctaacatg tagggcctcc actggtcttg ttgacaaata atgtcatggt
     4741 ggggttacac ttcctctgtt acttgctgat tttcttacta aatgtagcat ttcaatcaga
     4801 tctaattctt acattttgag ataactgtaa aaagagtgaa attatgaaat ggccaatatc
     4861 ttttatcagt ctattctttt ggaagctgtc atgcactata cattgtgtac agttaaaagt
     4921 atatatatat atatattctt actgagtgaa cgcctcctct ccccacgcct gtatgtcact
     4981 agcatctaag gagaatgctc aaggcccagt gctgctgctg ctgtggttta tatgggtttt
     5041 gttctgtttt gtttttgtgt ggtaaattga tatttaaaaa caacaaaaac cacgactact
     5101 gtttacagac tgaaaaaaaa caatcactgc tttttatact actgagatcc taagtcaaga
     5161 ctttgcaaag caggaatcgg gttcaagtta cttctttgct gtggacggat agtcctctgt
     5221 agtatctcca catgatggag agtgcacaaa cctaggtgtg ctgccatcaa ttttgtatat
     5281 tttcataatt ttaattgttc gaaattgcat tatattttgc aatcaccaca ttcaatctgt
     5341 atatgtcttt catttcaact ttttcaatac aaaaagggat tcaatttaaa aaaaaaaaaa
     5401 aa
//
