LOCUS       NM_001141965            1167 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus N(alpha)-acetyltransferase 20, NatB catalytic subunit
            (Naa20), transcript variant 1, mRNA.
ACCESSION   NM_001141965
VERSION     NM_001141965.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1167)
  AUTHORS   Qiao,L., Dong,C., Jia,W. and Ma,B.
  TITLE     NAA20 recruits Rin2 and promotes triple-negative breast cancer
            progression by regulating Rab5A-mediated activation of EGFR
            signaling
  JOURNAL   Cell Signal 112, 110922 (2023)
   PUBMED   37827343
  REMARK    GeneRIF: NAA20 recruits Rin2 and promotes triple-negative breast
            cancer progression by regulating Rab5A-mediated activation of EGFR
            signaling.
REFERENCE   2  (bases 1 to 1167)
  AUTHORS   Elurbide,J., Carte,B., Guedes,J. and Aldabe,R.
  TITLE     NatB Catalytic Subunit Depletion Disrupts DNA Replication
            Initiation Leading to Senescence in MEFs
  JOURNAL   Int J Mol Sci 24 (10), 8724 (2023)
   PUBMED   37240070
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1167)
  AUTHORS   Ohyama,K., Yasuda,K., Onga,K., Kakizuka,A. and Mori,N.
  TITLE     Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20
            in the developing mouse brain: implications for co-operative versus
            non-co-operative actions of Mdm20 and Nat5
  JOURNAL   Gene Expr Patterns 12 (1-2), 36-45 (2012)
   PUBMED   22101279
  REMARK    GeneRIF: Mdm20 is not necessarily co-expressed with Nat5 in the
            developing mouse brain.
REFERENCE   4  (bases 1 to 1167)
  AUTHORS   Kuo,H.P., Lee,D.F., Chen,C.T., Liu,M., Chou,C.K., Lee,H.J., Du,Y.,
            Xie,X., Wei,Y., Xia,W., Weihua,Z., Yang,J.Y., Yen,C.J., Huang,T.H.,
            Tan,M., Xing,G., Zhao,Y., Lin,C.H., Tsai,S.F., Fidler,I.J. and
            Hung,M.C.
  TITLE     ARD1 stabilization of TSC2 suppresses tumorigenesis through the
            mTOR signaling pathway
  JOURNAL   Sci Signal 3 (108), ra9 (2010)
   PUBMED   20145209
  REMARK    GeneRIF: ARD1 functions as an inhibitor of the mTOR pathway and
            that dysregulation of the ARD1-TSC2-mTOR axis may contribute to
            cancer development
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1167)
  AUTHORS   Ametzazurra,A., Larrea,E., Civeira,M.P., Prieto,J. and Aldabe,R.
  TITLE     Implication of human N-alpha-acetyltransferase 5 in cellular
            proliferation and carcinogenesis
  JOURNAL   Oncogene 27 (58), 7296-7306 (2008)
   PUBMED   18794801
REFERENCE   6  (bases 1 to 1167)
  AUTHORS   Arnesen,T., Anderson,D., Torsvik,J., Halseth,H.B., Varhaug,J.E. and
            Lillehaug,J.R.
  TITLE     Cloning and characterization of hNAT5/hSAN: an evolutionarily
            conserved component of the NatA protein N-alpha-acetyltransferase
            complex
  JOURNAL   Gene 371 (2), 291-295 (2006)
   PUBMED   16507339
REFERENCE   7  (bases 1 to 1167)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 1167)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009229.1, AK005143.1 and CO802916.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001141965.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009229.1, BC009157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AK009229.1         4-43
            41-41               AK005143.1         14-14
            42-1033             AK009229.1         44-1035
            1034-1167           CO802916.1         577-710
FEATURES             Location/Qualifiers
     source          1..1167
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 71.28 cM"
     gene            1..1167
                     /gene="Naa20"
                     /gene_synonym="1500004D14Rik; 2900026I01Rik; D2Ertd186e;
                     Nat5"
                     /note="N(alpha)-acetyltransferase 20, NatB catalytic
                     subunit"
                     /db_xref="GeneID:67877"
                     /db_xref="MGI:MGI:1915127"
     exon            1..122
                     /gene="Naa20"
                     /gene_synonym="1500004D14Rik; 2900026I01Rik; D2Ertd186e;
                     Nat5"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..606
                     /gene="Naa20"
                     /gene_synonym="1500004D14Rik; 2900026I01Rik; D2Ertd186e;
                     Nat5"
                     /EC_number="2.3.1.254"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae);
                     N-terminal acetyltransferase B complex catalytic subunit
                     NAT5; natB complex subunit NAT5; N-terminal
                     acetyltransferase B complex catalytic subunit NAA20; natB
                     catalytic subunit; methionine N-acetyltransferase"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 20 isoform 1"
                     /protein_id="NP_001135437.1"
                     /db_xref="CCDS:CCDS50735.1"
                     /db_xref="GeneID:67877"
                     /db_xref="MGI:MGI:1915127"
                     /translation="MTTLRAFTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFI
                     VAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISER
                     KGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYDMRKALSRDT
                     EKKSIIPLPHPVRPEDIE"
     exon            123..147
                     /gene="Naa20"
                     /gene_synonym="1500004D14Rik; 2900026I01Rik; D2Ertd186e;
                     Nat5"
                     /inference="alignment:Splign:2.1.0"
     exon            148..238
                     /gene="Naa20"
                     /gene_synonym="1500004D14Rik; 2900026I01Rik; D2Ertd186e;
                     Nat5"
                     /inference="alignment:Splign:2.1.0"
     exon            239..374
                     /gene="Naa20"
                     /gene_synonym="1500004D14Rik; 2900026I01Rik; D2Ertd186e;
                     Nat5"
                     /inference="alignment:Splign:2.1.0"
     exon            375..520
                     /gene="Naa20"
                     /gene_synonym="1500004D14Rik; 2900026I01Rik; D2Ertd186e;
                     Nat5"
                     /inference="alignment:Splign:2.1.0"
     exon            521..1142
                     /gene="Naa20"
                     /gene_synonym="1500004D14Rik; 2900026I01Rik; D2Ertd186e;
                     Nat5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1122..1127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naa20"
                     /gene_synonym="1500004D14Rik; 2900026I01Rik; D2Ertd186e;
                     Nat5"
                     /note="hexamer: TATAAA"
     polyA_site      1142
                     /gene="Naa20"
                     /gene_synonym="1500004D14Rik; 2900026I01Rik; D2Ertd186e;
                     Nat5"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcgagt acttccggta gtgcgggcgc ggggtcgcgc cgagcgggtt ggaggctggc
       61 ggcggcgcaa tgaccacgct ccgggccttc acctgcgacg acctgttccg cttcaacaac
      121 attaacttgg atccacttac agaaacttat gggattcctt tttacttaca gtaccttgcg
      181 cactggccag agtatttcat cgtcgctgaa gcacctggcg gagaactaat gggttatatt
      241 atgggcaaag cagaaggctc ggtagctagg gaagaatggc atggacatgt cacagctctc
      301 tctgtcgccc ctgaattccg ccgtcttggc ttggctgcta aacttatgga gttactagaa
      361 gaaatttcag aaagaaaagg tggatttttt gttgatctct tcgtaagagt atccaatcaa
      421 gttgccgtca acatgtacaa gcagttgggt tacagtgtct acaggacagt catagagtac
      481 tactcagcca gcaatgggga gcctgatgag gatgcctatg atatgaggaa agcactttcc
      541 agggacactg agaagaaatc catcatccca ttacctcatc ccgtgaggcc tgaggacatt
      601 gaataaccat aggcagtggt tcttaggcag gtgttccaga cagtttgtgg acatactact
      661 ttcataggat gatcttggag ctctattagg aggaaagtaa gcatttaagt cttaaagact
      721 tcaaaaaatg caggctataa acttcaaatc tcatccttcc aatgagcaat agcatacatg
      781 ttcgaactgt ttgccatagt aaaattcaat caaggcagct aagtcagaag gactcgttcc
      841 actatcatgg ttgacagtac atgccaagaa aagactccct ccatcctcct cctaaatcct
      901 gtgcctgaga accactgctg cacatatata aatatatata tattttattt tgtattgatc
      961 tgttaattga agctttaaaa gcatatatga aatgtataaa tctgagatgt atagtaaaac
     1021 attgttgact atgaatgttt tctggaagtt tgttgtcttt taatcaaaat tatggacgga
     1081 tctttgttta ggatgtggtg cctcttgttt tgactttttt atataaaacc tttttaaatg
     1141 caaaaaaaaa aaaaaaaaaa aaaaaaa
//
