LOCUS       NM_053089               6090 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus N(alpha)-acetyltransferase 15, NatA auxiliary subunit
            (Naa15), mRNA.
ACCESSION   NM_053089
VERSION     NM_053089.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6090)
  AUTHORS   Kweon,H.Y., Lee,M.N., Dorfel,M., Seo,S., Gottlieb,L., PaPazyan,T.,
            McTiernan,N., Ree,R., Bolton,D., Garcia,A., Flory,M., Crain,J.,
            Sebold,A., Lyons,S., Ismail,A., Marchi,E., Sonn,S.K., Jeong,S.J.,
            Jeon,S., Ju,S., Conway,S.J., Kim,T., Kim,H.S., Lee,C., Roh,T.Y.,
            Arnesen,T., Marmorstein,R., Oh,G.T. and Lyon,G.J.
  TITLE     Naa12 compensates for Naa10 in mice in the amino-terminal
            acetylation pathway
  JOURNAL   Elife 10, e65952 (2021)
   PUBMED   34355692
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6090)
  AUTHORS   Monestier,O., Landemaine,A., Bugeon,J., Rescan,P.Y. and
            Gabillard,J.C.
  TITLE     Naa15 knockdown enhances c2c12 myoblast fusion and induces defects
            in zebrafish myotome morphogenesis
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 228, 61-67 (2019)
   PUBMED   30502388
  REMARK    GeneRIF: Taken together, these results show that Naa15 regulates
            myotome formation and myogenesis
REFERENCE   3  (bases 1 to 6090)
  AUTHORS   Qun,L., Wenda,X., Weihong,S., Jianyang,M., Wei,C., Fangzhou,L.,
            Zhenyao,X. and Pingjin,G.
  TITLE     miRNA-27b modulates endothelial cell angiogenesis by directly
            targeting Naa15 in atherogenesis
  JOURNAL   Atherosclerosis 254, 184-192 (2016)
   PUBMED   27755984
  REMARK    GeneRIF: decreased miRNA-27b regulates the activity of the
            CCL20/CCR6 axis by targeting Naa15, and promotes plaque stability
            in atherosclerosis
REFERENCE   4  (bases 1 to 6090)
  AUTHORS   Laurieri,N., Dairou,J., Egleton,J.E., Stanley,L.A., Russell,A.J.,
            Dupret,J.M., Sim,E. and Rodrigues-Lima,F.
  TITLE     From arylamine N-acetyltransferase to folate-dependent acetyl CoA
            hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and
            its homologue (MOUSE)NAT2
  JOURNAL   PLoS One 9 (5), e96370 (2014)
   PUBMED   24823794
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6090)
  AUTHORS   Gendron,R.L., Laver,N.V., Good,W.V., Grossniklaus,H.E.,
            Miskiewicz,E., Whelan,M.A., Walker,J. and Paradis,H.
  TITLE     Loss of tubedown expression as a contributing factor in the
            development of age-related retinopathy
  JOURNAL   Invest Ophthalmol Vis Sci 51 (10), 5267-5277 (2010)
   PUBMED   20463314
REFERENCE   6  (bases 1 to 6090)
  AUTHORS   Willis,D.M., Loewy,A.P., Charlton-Kachigian,N., Shao,J.S.,
            Ornitz,D.M. and Towler,D.A.
  TITLE     Regulation of osteocalcin gene expression by a novel Ku antigen
            transcription factor complex
  JOURNAL   J Biol Chem 277 (40), 37280-37291 (2002)
   PUBMED   12145306
REFERENCE   7  (bases 1 to 6090)
  AUTHORS   Paradis,H., Liu,C.Y., Saika,S., Azhar,M., Doetschman,T., Good,W.V.,
            Nayak,R., Laver,N., Kao,C.W., Kao,W.W. and Gendron,R.L.
  TITLE     Tubedown-1 in remodeling of the developing vitreal vasculature in
            vivo and regulation of capillary outgrowth in vitro
  JOURNAL   Dev Biol 249 (1), 140-155 (2002)
   PUBMED   12217325
  REMARK    GeneRIF: tbdn-1 inhibits capillary-like formation in vitro and may
            serve to dampen vitreal blood vessel formation preceding the
            regression of the vitreal vasculature during development.
REFERENCE   8  (bases 1 to 6090)
  AUTHORS   Saika,S., Saika,S., Liu,C.Y., Azhar,M., Sanford,L.P.,
            Doetschman,T., Gendron,R.L., Kao,C.W. and Kao,W.W.
  TITLE     TGFbeta2 in corneal morphogenesis during mouse embryonic
            development
  JOURNAL   Dev Biol 240 (2), 419-432 (2001)
   PUBMED   11784073
REFERENCE   9  (bases 1 to 6090)
  AUTHORS   Sugiura,N., Patel,R.G. and Corriveau,R.A.
  TITLE     N-methyl-D-aspartate receptors regulate a group of transiently
            expressed genes in the developing brain
  JOURNAL   J Biol Chem 276 (17), 14257-14263 (2001)
   PUBMED   11297529
REFERENCE   10 (bases 1 to 6090)
  AUTHORS   Gendron,R.L., Adams,L.C. and Paradis,H.
  TITLE     Tubedown-1, a novel acetyltransferase associated with blood vessel
            development
  JOURNAL   Dev Dyn 218 (2), 300-315 (2000)
   PUBMED   10842358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX241349.1, BQ887090.1, CA327064.1, AB221683.1 and AC102860.13.
            
            On Mar 21, 2009 this sequence version replaced NM_053089.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.89454.1, AF510858.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CX241349.1         1-11
            12-118              BQ887090.1         7-113
            119-307             CA327064.1         96-284
            308-2905            AB221683.1         1-2598
            2906-6090           AC102860.13        12364-15548
FEATURES             Location/Qualifiers
     source          1..6090
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 22.47 cM"
     gene            1..6090
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /note="N(alpha)-acetyltransferase 15, NatA auxiliary
                     subunit"
                     /db_xref="GeneID:74838"
                     /db_xref="MGI:MGI:1922088"
     exon            1..361
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..2905
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /note="N-terminal aceyltransferase 1; tubedown; NMDA
                     receptor-regulated protein 1; protein tubedown-1;
                     N-terminal acetyltransferase 1; NMDA receptor-regulated
                     gene 1"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 15, NatA auxiliary
                     subunit"
                     /protein_id="NP_444319.3"
                     /db_xref="CCDS:CCDS17340.1"
                     /db_xref="GeneID:74838"
                     /db_xref="MGI:MGI:1922088"
                     /translation="MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAE
                     HGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKC
                     YRNALKWDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHL
                     LEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEK
                     QICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPENWAYYKGLEKALKPANMLER
                     LKIYEEAWTKYPRGLVPRRLPLNFLSGEKFKECLDRFLRMNFSKGCPPVFNTLRSLYR
                     DKEKVAIVEELVVGYETSLKSCRLFNPNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSI
                     ALEYINTAIESTPTLIELFLVKAKIYKHAGNIKEAARWMDEAQALDTADRFINSKCAK
                     YMLKANLIKEAEEMCSKFTREGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKC
                     HEIERHFIEITDDQFDFHTYCMRKITLRSYVDLLKLEDVLRQHPFYFKAARIAIEIYL
                     KLHDNPLTDENKEHEADTANMSDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQ
                     KKKKDDDDEEIGGPKEELIPEKLAKVETPLEEAIKFLTPLKNLVKNKIETHLFAFEIY
                     FRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFHSVCESKDLPETVRTVLKQEMNRL
                     FGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDSSSQKRAIELATTLDGSLTNRNL
                     QTCMEVLEALCDGSLGDCKEAAEAYRASCHKLFPYALAFMPPGYEEDMKITVNGDSSA
                     ETEELANEI"
     exon            362..446
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..551
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..709
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..844
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..998
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1118
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1214
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1321
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1394
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1564
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1717
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1846
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2060
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2254
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2363
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2462
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2606
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2704
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..6090
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4116..4121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /note="hexamer: AATAAA"
     polyA_site      4136
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /note="major polyA site"
     regulatory      5542..5547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /note="hexamer: AATAAA"
     polyA_site      5563
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
     regulatory      6066..6071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
                     /note="hexamer: AATAAA"
     polyA_site      6090
                     /gene="Naa15"
                     /gene_synonym="5730450D16Rik; 6330400I15; ASTBDN; mNAT1;
                     Narg1; Tbdn-1"
ORIGIN      
        1 gtcggtcttt tcagttacca cgtgaaccgc cgacggagac ccgggagggg ggaggtggcg
       61 gcggcgttaa gtgagaaagg gggaaaagga ggagagagag agagagagag aaaaaaaaga
      121 aaagaaaaaa aaaaagaggc gaagggagtg tcaggacagg gcgggcgcgg cgaccccgga
      181 ggcctagtgg cggcggagtg aaggcttcaa ggctgaagtg agctcgggaa cggcagtggc
      241 ggcggcgggc ggacaaacgg actgagcgag ccgggcggtg gcgggagccg cgggaggagc
      301 cggaaccatg ccggccgtga gcctcccgcc caaggagaac gcgctcttca agcggatctt
      361 gagatgttat gaacataaac agtatagaaa tggattgaag ttctgtaaac aaatcctttc
      421 caatcccaaa tttgcagagc atggagaaac cctggctatg aaaggattaa cgttgaactg
      481 tttgggaaaa aaggaagaag cttatgaatt ggttcgcaga ggtttgagaa atgacttaaa
      541 gagtcatgtg tgttggcatg tttatggcct tcttcaaagg tcagacaaga agtatgatga
      601 agccattaag tgctacagaa atgcactgaa atgggataaa gacaatcttc agatcttaag
      661 agatctttcc ttactgcaga ttcaaatgcg agatcttgag ggctataggg aaacaagata
      721 ccagttgctt cagcttcggc ctgcacagag agcatcatgg attggttatg ctattgctta
      781 ccatttatta gaagactatg aaatggcagc aaaaatttta gaagagttta ggaaaacaca
      841 gcagacatct cctgataaag tggattatga atatagtgaa ctcctcttat atcagaatca
      901 agttcttcgg gaagcaggtc tttatagaga agccctggaa catctttgta cctatgaaaa
      961 gcagatttgt gataaacttg ctgttgaaga aaccaaaggg gaacttctgt tgcagttgtg
     1021 tcgtttggaa gatgctgctg acgtttatag aggattacaa gagaggaatc ctgaaaattg
     1081 ggcctattac aaaggcttag aaaaagcact gaagccagct aatatgttag aacggctaaa
     1141 aatatatgag gaagcctgga ctaaataccc caggggactc gtgccaagaa ggctgccctt
     1201 aaacttttta tctggagaga agtttaagga gtgtttggat aggttcctaa ggatgaattt
     1261 cagcaagggc tgtccacctg tcttcaatac cttgaggtct ttatacagag ataaagagaa
     1321 ggtggcaatc gtagaagaac tagtagttgg ttatgaaact tctctaaaaa gttgtcgcct
     1381 atttaacccc aatgatgatg gaaaggagga acctccaacc acattacttt gggtccagta
     1441 ctatttggca cagcattatg ataaaattgg tcagccatcc attgctctgg aatacataaa
     1501 tactgcaatt gaaagtacac caacattgat agaactcttt cttgtaaaag ctaaaatcta
     1561 taagcatgct gggaatatta aagaagctgc caggtggatg gatgaagccc aggccctgga
     1621 cacagcagac agatttatta attccaagtg tgcaaaatac atgttaaaag ccaacctgat
     1681 taaagaggct gaagaaatgt gttccaagtt tacgagggaa ggaacttcag cggtagagaa
     1741 cctgaatgaa atgcagtgta tgtggttcca gacagagtgt gctcaggcat acaaagcaat
     1801 gaacaaattt ggtgaagcac ttaagaaatg tcatgaaatt gagagacatt ttatagaaat
     1861 caccgatgac cagtttgact ttcatacata ctgtatgagg aagatcaccc ttagatcata
     1921 tgtggactta ttaaaactag aagatgtact tcgacagcat ccattttact tcaaagcagc
     1981 gaggattgct attgagatct atttgaagct tcatgacaac cctctgacag atgagaacaa
     2041 agaacacgag gctgatacag caaacatgtc tgacaaagag ctaaagaaac tgcgtaataa
     2101 acaaagaaga gctcaaaaga aagcccagat agaagaagag aaaaaaaatg cagaaaaaga
     2161 aaagcagcaa cggaatcaga aaaagaaaaa ggatgatgat gacgaagaaa ttggaggccc
     2221 caaagaagag cttatccctg agaaactggc caaggttgaa actccattgg aagaagctat
     2281 taagttttta acaccattga agaacttggt gaagaacaag atagaaactc atctttttgc
     2341 ctttgagatc tactttagga aagaaaagtt tcttttgatg ctacaatcag taaagcgggc
     2401 atttgctatt gattctagtc atccctggct tcatgagtgc atgattcgac tctttcattc
     2461 tgtgtgtgaa agtaaagact tacccgaaac agttagaaca gtattaaaac aagaaatgaa
     2521 tcgtcttttt ggagcaacaa atccaaagaa ttttaatgaa acctttctga aaaggaattc
     2581 tgattcattg ccacatagat tatcagctgc caaaatggta tattatttag attcttctag
     2641 tcaaaaacga gcaatagagc tggcgacaac acttgatgga tccctcacca acagaaacct
     2701 tcagacttgc atggaggtgt tggaagcctt gtgtgatggt agcctaggag actgtaaaga
     2761 agctgccgaa gcctacagag caagttgtca taagcttttc ccttatgctt tggctttcat
     2821 gcctcctgga tacgaagagg atatgaagat cacagtgaac ggagatagtt ctgcagaaac
     2881 ggaagaactg gccaatgaaa tctgaacatc attaaacaag caaatggaat gactttggac
     2941 catatctagt gtataatatt tttgtcacgc acctgctgca ttgctcttac ttacacagaa
     3001 tgagaggagt aaatgttctt gccttcaaat agtcttacgt tttttatcct gctgaaaact
     3061 atatataaaa tatctaacat tacaggatat aggttcagtt tcttaaaaaa ttaaaagctg
     3121 ctaaaattga ggggtttaaa agaaaaaaaa aatccgtatc ctattcctac cttcccttcc
     3181 catgttttta actaatttat ataaaatctg gaggctataa cagctaacat agcaggtgtg
     3241 tggcagaaat attactttaa atttgtcttg tgagattttg ctatatctca gacagcataa
     3301 ataaatgctg ttttagcact ggattctttc actgagcaca aagagttgtt ggggctttag
     3361 catctgcctg attctgttac ggggttggtg attgaccata ggaagtatgc aatgtgaatc
     3421 actgtgtaca gagccgtcta caacacatgc ttgacgttgt agagactggg acacatagct
     3481 accaagcgga ttaagtgaaa cctagaaggt gttcagtacg tgtgttgtgt ttccaaaatt
     3541 cactgtacat gatcagtttg gtgttcttgt accacagttt ttaaccgaag gaaccagttg
     3601 gaacaatctc aatttaacta aaacttgaag aactaaaata acaatgcaaa cctttagcat
     3661 tgttttggcc aaacttgtta aaactgtaat gcaagaacca aatgcactgt gatgtggcac
     3721 caactaatta gcaagcatga atttttcacc tgagagtgaa aaaagaaaac tctaccatgg
     3781 cttgaagtta cagagcagaa ctcctgacta ccattctatg actgatgaag agactaatag
     3841 ctaaaacctc agcaggcctt gttcacgata tgcagaaaag tgctgcagtt tagatacctc
     3901 tggaactttt ccacagtgtc acaggtttgt aatacttgaa gcccttcatt tctaagaata
     3961 tatttctcgc tcagttgttt caggcaagcc caagactttg taatttttaa agggcccaag
     4021 attttttttt caataacaga ccagcttctt tttcctgcag ttacaaatgt aatttctttt
     4081 tttttttgtt gtcaaacata aggtaccaaa tatgcaataa attgttttga aaaacagttg
     4141 tgtgaatatt tccactaacc tgagttgggc ttctgtgaaa tgcacaggtg gaaacagagg
     4201 ttgcaagcca gaggcaatga aacacactgt agggctagta tagaggggag cttttagagc
     4261 cggctaagtg gtggtgtcag gaaagttcca gaactaagca gaatgctgct cctttgttca
     4321 gatttcactg aggctaggat ggtggcagat cctgtgaatg taattcaaat cagaaaggaa
     4381 aagtaaacat gaccatttgg attgggaaac cgagccttaa acaagtcaaa cctgtacact
     4441 gagaacgagc ctcaggctta atatttcttt atgtttgcaa ggtctgagca attaagttca
     4501 atgaattaag tgtatataaa atagaacttt tgtagtattt tagttataca tagtacatac
     4561 actaaaggga attttcagaa gatcagatcc ttttatttca tagtacatga tctgcattcc
     4621 acatcccagt ctagcaggtt agtgatgcaa agatacttcc agtctgaact tcagtgctta
     4681 cacaggccct gtctcaggaa catcttaaca gatggcaaaa aaaagtgagc agactttacg
     4741 aatttttctc ctatgagtgg caactaaggt tcctgttgtt tggaaaaaac actagtggta
     4801 tgtccgctac taattcagtg ttggaggagg caccagccat atagtagggg tgtgtgtgtg
     4861 tgtgtgtgtg tgtgcgcgcg cgcgcgcgcg tgtgtatttg tttaaattct actgtatatc
     4921 accatgaaat ctgtctgttt gtcttgacaa tgtttaaatg atgtagattg tcttagaatg
     4981 aatactcaga agtactcaga actccgattc cgatgccacc cgagaggagt cagactcctg
     5041 tcatgtatat tgtattccaa ccaatttact ggaactattg aataaatctt tattttcttt
     5101 caggtttatt tgacagtgga tacattgtct ggtgtcacag gaccttgact gggttcacct
     5161 aaaacattgt actttactct gagtatatat ttatttcaac tggatcattt cacatttacc
     5221 ccgttgatat tcagttaatt atcagtgata ctgtggggga aaacagggtt agataaacaa
     5281 gttggaaaaa tgcagtgtga tgttgtaatc taaacaagtg ccttatgttt attgctaaga
     5341 actggtgtta tcaacccttt tactaagaag ggtccctcgg cctgtattca tgtaggaaag
     5401 tgaagagcct tctgttttct tcatagtcac ttactgtcat gtctcattga aagttacaat
     5461 ctgacgagct tagtttactt agctttaatt agataggtga gtcatacatt ttcaccattt
     5521 tttcctgtat ttattatgca caataaaatg atctctaata gcatgactaa aagtagtgcc
     5581 gatgttgctg gaaagctttc tgggtcgtac gaggccctgt tttttcaccg tgattgtacc
     5641 gcatgctcta ctactctcag ctgtgaagtg aaagctgtga atgtatgaag agctcagaaa
     5701 accatggagt gttgtgacaa actcacatcc tttctaatca attggtaaga ctttctgttg
     5761 ccgggcatag catctgtttg gggaaagcta aaagggaaat actgaaaatg ctaggcattt
     5821 gttattttag ataattactg tccttggatt ctgcaggtcg accttcctga tgggaggagt
     5881 cttcctatct gcatcgtgct cctggttctt acatttaagg attcttacta ccgttttgct
     5941 gttgtctaag ctttgctgaa cccattgtta agtctaagac acaaacccat gaaatggctg
     6001 tgttgcgcca taggaagcag aaatggtttc agtttctgct ggttgaaaat tgaacaactt
     6061 gtagcaataa aaagcttttg gaaaaggtta
//
