LOCUS       NM_019870                965 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus N(alpha)-acetyltransferase 10, NatA catalytic subunit
            (Naa10), transcript variant 1, mRNA.
ACCESSION   NM_019870
VERSION     NM_019870.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 965)
  AUTHORS   Lyon,G.J., Longo,J., Garcia,A., Inusa,F., Marchi,E., Shi,D.,
            Dorfel,M., Arnesen,T., Aldabe,R., Lyons,S., Nashat,M.A. and
            Bolton,D.
  TITLE     Evaluating possible maternal effect lethality and genetic
            background effects in Naa10 knockout mice
  JOURNAL   PLoS One 19 (5), e0301328 (2024)
   PUBMED   38713657
  REMARK    GeneRIF: Evaluating possible maternal effect lethality and genetic
            background effects in Naa10 knockout mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 965)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 965)
  AUTHORS   Kweon,H.Y., Lee,M.N., Dorfel,M., Seo,S., Gottlieb,L., PaPazyan,T.,
            McTiernan,N., Ree,R., Bolton,D., Garcia,A., Flory,M., Crain,J.,
            Sebold,A., Lyons,S., Ismail,A., Marchi,E., Sonn,S.K., Jeong,S.J.,
            Jeon,S., Ju,S., Conway,S.J., Kim,T., Kim,H.S., Lee,C., Roh,T.Y.,
            Arnesen,T., Marmorstein,R., Oh,G.T. and Lyon,G.J.
  TITLE     Naa12 compensates for Naa10 in mice in the amino-terminal
            acetylation pathway
  JOURNAL   Elife 10, e65952 (2021)
   PUBMED   34355692
  REMARK    GeneRIF: Naa12 compensates for Naa10 in mice in the amino-terminal
            acetylation pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 965)
  AUTHORS   Lee,C.C., Shih,Y.C., Kang,M.L., Chang,Y.C., Chuang,L.M., Devaraj,R.
            and Juan,L.J.
  TITLE     Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through
            N-alpha-acetylation of Pgc1alpha
  JOURNAL   Mol Cell 76 (3), 500-515 (2019)
   PUBMED   31422874
  REMARK    GeneRIF: Naa10p-mediated N-terminal acetylation of Pgc1alpha
            downregulates thermogenic gene expression in beige adipocytes.
REFERENCE   5  (bases 1 to 965)
  AUTHORS   Takekoshi,D., Tokuzawa,Y., Sakanaka,M. and Kato,H.
  TITLE     The N-end rule pathway enzyme Naa10 supports epiblast specification
            in mouse embryonic stem cells by modulating FGF/MAPK
  JOURNAL   In Vitro Cell Dev Biol Anim 55 (5), 355-367 (2019)
   PUBMED   30993557
  REMARK    GeneRIF: we established Naa10 knockout mESCs to test this
            hypothesis. We found that Naa10 deficiency attenuated
            differentiation towards the epiblast lineage, deviating towards
            primitive endoderm.
REFERENCE   6  (bases 1 to 965)
  AUTHORS   Chun,K.H., Cho,S.J., Choi,J.S., Kim,S.H., Kim,K.W. and Lee,S.K.
  TITLE     Differential regulation of splicing, localization and stability of
            mammalian ARD1235 and ARD1225 isoforms
  JOURNAL   Biochem Biophys Res Commun 353 (1), 18-25 (2007)
   PUBMED   17161380
  REMARK    GeneRIF: These results indicate that ARD1(235) and ARD1(225)
            isoforms may have different activities and function in different
            subcellular compartments of mammalian cells.
REFERENCE   7  (bases 1 to 965)
  AUTHORS   Kim,S.H., Park,J.A., Kim,J.H., Lee,J.W., Seo,J.H., Jung,B.K.,
            Chun,K.H., Jeong,J.W., Bae,M.K. and Kim,K.W.
  TITLE     Characterization of ARD1 variants in mammalian cells
  JOURNAL   Biochem Biophys Res Commun 340 (2), 422-427 (2006)
   PUBMED   16376303
  REMARK    GeneRIF: Mouse ortholog (225) of ARD1 strongly decreased the level
            of hypoxia inducible factor (HIF)-1 alpha and increased the extent
            of acetylation, whereas mARD1(235) variants had a much weaker
            effect on HIF-1 alpha stability and acetylation.
REFERENCE   8  (bases 1 to 965)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 965)
  AUTHORS   Sugiura,N., Adams,S.M. and Corriveau,R.A.
  TITLE     An evolutionarily conserved N-terminal acetyltransferase complex
            associated with neuronal development
  JOURNAL   J Biol Chem 278 (41), 40113-40120 (2003)
   PUBMED   12888564
  REMARK    GeneRIF: Biochemical analysis demonstrated that mNAT1 and its
            evolutionarily conserved co-subunit, mARD1, assemble to form a
            functional acetyltransferase.
REFERENCE   10 (bases 1 to 965)
  AUTHORS   Jeong,J.W., Bae,M.K., Ahn,M.Y., Kim,S.H., Sohn,T.K., Bae,M.H.,
            Yoo,M.A., Song,E.J., Lee,K.J. and Kim,K.W.
  TITLE     Regulation and destabilization of HIF-1alpha by ARD1-mediated
            acetylation
  JOURNAL   Cell 111 (5), 709-720 (2002)
   PUBMED   12464182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672002.14.
            
            On May 5, 2010 this sequence version replaced NM_019870.2.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript but encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY183136.1, AK014469.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AL672002.14        40097-40285         c
            190-288             AL672002.14        39613-39711         c
            289-347             AL672002.14        39324-39382         c
            348-393             AL672002.14        38304-38349         c
            394-509             AL672002.14        38095-38210         c
            510-554             AL672002.14        37843-37887         c
            555-639             AL672002.14        36184-36268         c
            640-965             AL672002.14        35211-35536         c
FEATURES             Location/Qualifiers
     source          1..965
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.49 cM"
     gene            1..965
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /note="N(alpha)-acetyltransferase 10, NatA catalytic
                     subunit"
                     /db_xref="GeneID:56292"
                     /db_xref="MGI:MGI:1915255"
     exon            1..189
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..876
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /EC_number="2.3.1.255"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-N-acetyltransferase 1A; N-terminal acetyltransferase
                     complex ARD1 subunit homolog A; Nalpha acetyltransferase
                     10; N(alpha)-acetyltransferase 10, NatA catalytic
                     subunitNalpha acetyltransferase 10; natA catalytic subunit
                     Naa10; ARD1 homolog A, N-acetyltransferase"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 10 isoform 1"
                     /protein_id="NP_063923.1"
                     /db_xref="CCDS:CCDS30217.1"
                     /db_xref="GeneID:56292"
                     /db_xref="MGI:MGI:1915255"
                     /translation="MNIRNARPEDLMNMQHCNLLCLPENYQMKYYFYHGLSWPQLSYI
                     AEDENGKIVGYVLAKMEEDPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENF
                     NAKYVSLHVRKSNRAALHLYSNTLNFQISEVEPKYYADGEDAYAMKRDLTQMADELRR
                     HLELKEKGKHMVLAALENKAENKGNVLLSSGEACREEKGLAAEDSGGDSKDLSEVSET
                     TESTDVKDSSEASDSAS"
     exon            190..288
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /inference="alignment:Splign:2.1.0"
     exon            289..347
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /inference="alignment:Splign:2.1.0"
     exon            348..393
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /inference="alignment:Splign:2.1.0"
     exon            394..509
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..554
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /inference="alignment:Splign:2.1.0"
     exon            555..639
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..965
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      920..925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /note="hexamer: AATAAA"
     polyA_site      960
                     /gene="Naa10"
                     /gene_synonym="2310039H09Rik; Ard1; Ard1a; Te2"
                     /note="major polyA site"
ORIGIN      
        1 agctgggtac ttccgctgca ggcaggtcgg agcggtccgc cttttccgcc gccgtcccag
       61 gatcctggcc ccagtccaag ctcctatcgt cctttccctg cttctaagtg gccgccgagt
      121 gcacgcgttc acgacccaca aggacccgcg agctccgccg ccgccgcgat gaacatccgc
      181 aatgctaggc ccgaagacct gatgaacatg cagcactgca accttctctg cctgccggag
      241 aactaccaga tgaagtacta tttctatcat ggcctctctt ggccccagct ttcttacatt
      301 gctgaggatg agaatgggaa gattgtgggc tacgtcttgg ctaaaatgga agaggaccca
      361 gacgatgtgc cccatggaca tatcacctca ctggctgtga agcgttccca ccggcgcctt
      421 ggcctggctc agaagctgat ggaccaggcc tctcgagcca tgatagagaa cttcaatgcc
      481 aaatacgtct ccctgcatgt caggaagagt aacagggccg ccctgcatct ctattccaac
      541 accctcaact ttcagatcag cgaagtggag cccaaatact atgcagatgg ggaagatgcg
      601 tatgcaatga agcgggacct cacgcagatg gctgatgagc tgaggcggca cctggagctg
      661 aaggaaaagg gcaagcacat ggttctggcg gccttggaga acaaagcgga gaacaaaggc
      721 aacgtgcttc tgagctcagg agaggcctgt cgtgaggaga agggcctggc tgctgaggat
      781 agtggtgggg acagcaagga cctcagtgag gtcagcgaga ccacagagag cacagatgtc
      841 aaagacagct cagaggcctc tgactctgcc tcctagaacc tgccccacct ggtcccaacc
      901 ttgccccatg tgcttttaca ataaatgtca cccagtggcc ttgggaaatt tgtgaatgtg
      961 catag
//
