LOCUS       NM_001418169            2491 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus NEDD4 binding protein 3 (N4bp3), transcript variant 2,
            mRNA.
ACCESSION   NM_001418169 XM_006532766
VERSION     NM_001418169.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2491)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2491)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2491)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2491)
  AUTHORS   Murillas,R., Simms,K.S., Hatakeyama,S., Weissman,A.M. and
            Kuehn,M.R.
  TITLE     Identification of developmentally expressed proteins that
            functionally interact with Nedd4 ubiquitin ligase
  JOURNAL   J Biol Chem 277 (4), 2897-2907 (2002)
   PUBMED   11717310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645602.14.
            
            On Mar 15, 2023 this sequence version replaced XM_006532766.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.400407.1,
                                           SRR7345562.4688227.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AL645602.14        54873-55032         c
            161-315             AL645602.14        52203-52357         c
            316-663             AL645602.14        50122-50469         c
            664-1176            AL645602.14        49368-49880         c
            1177-1431           AL645602.14        48470-48724         c
            1432-2491           AL645602.14        47284-48343         c
FEATURES             Location/Qualifiers
     source          1..2491
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.19 cM"
     gene            1..2491
                     /gene="N4bp3"
                     /gene_synonym="C330016O10Rik"
                     /note="NEDD4 binding protein 3"
                     /db_xref="GeneID:212706"
                     /db_xref="MGI:MGI:2442218"
     exon            1..160
                     /gene="N4bp3"
                     /gene_synonym="C330016O10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            161..315
                     /gene="N4bp3"
                     /gene_synonym="C330016O10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            316..663
                     /gene="N4bp3"
                     /gene_synonym="C330016O10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1959
                     /gene="N4bp3"
                     /gene_synonym="C330016O10Rik"
                     /codon_start=1
                     /product="NEDD4-binding protein 3"
                     /protein_id="NP_001405098.1"
                     /db_xref="GeneID:212706"
                     /db_xref="MGI:MGI:2442218"
                     /translation="MATTSGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGSRQPDG
                     LLRKGLGQREFFSYLHLPKKDGKTTKRAPRNEPDYATLYYREHPRAGDFSKTSLPERG
                     RFDKCRIRPSVFKPPVGSGKGFLSMQSLAAHKGQKLWRSNGSLHTLACHPPLSPGPRA
                     SQARAQLLHALSLDEGGPEPSLSDSSSGGSFGRSPGTGPSPFSSSLGHINHLGGSLDR
                     APRSPKESGPLAVLSCLPEPPPPYEFSCPTTEEVAVLPEAREELKRDLGDQDVSNSFT
                     QVLEERQRLWLSELKRLYVERLHEVAQKAERSERNLQLQLFMAQQEQRRLRKELRAQQ
                     GLAPEPRTSGSSMEADPNARPEEEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIF
                     SLKTQLRGSRAQAQAQDAELARLREAVHSLQEQAPREEAPGSCETDDCKSRGLLGEAG
                     GSEAREGAEQLRAELLQERLRGQEQALRFEQERQTWQEEKERVLRYQREIQGSYMDMY
                     RRNQALEHELRLLREPPTSWSPRLESSKI"
     exon            664..1176
                     /gene="N4bp3"
                     /gene_synonym="C330016O10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1431
                     /gene="N4bp3"
                     /gene_synonym="C330016O10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..2491
                     /gene="N4bp3"
                     /gene_synonym="C330016O10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2481..2486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="N4bp3"
                     /gene_synonym="C330016O10Rik"
                     /note="hexamer: AATATA"
     polyA_site      2491
                     /gene="N4bp3"
                     /gene_synonym="C330016O10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggttttccc tccgtctctg gggccagcgg acgagtgtcg cccagtgcgt cctttgcccg
       61 ccgatccggc tcccgcgcgt tcccgaagag cctgggaaga gaaaggttcg agaccgagct
      121 ggggactgca gcgcgcccta ggattcacgg agccagcatg ctcgtcaagg tgaggcagtg
      181 ttgaatgggg agacaaggtg accaggtcaa attcttttga ttgtgggtga catcctgagt
      241 cctcctagac acttggcagt cctggtggtg ctcggatccc gtgagtcttc atcatgacca
      301 gttctgtgac cttagaatca gctgcccgag ccctgttgaa ccttcatggc cacaacctca
      361 ggccctgctg gcattgccat gggcagcgta ggtagcctgt tggaacggca agacttttcc
      421 cctgaagaac ttcgggccgc actggctggc tcccggggct cccggcagcc cgatgggctc
      481 ctccggaaag gcttgggcca acgagagttc ttcagctacc tgcatctccc caagaaagat
      541 ggcaagacca ccaagcgagc ccctcggaac gagccagact atgccaccct ctactaccgg
      601 gagcatcctc gggctggtga cttcagcaag acttccctgc ctgagcgggg tcgctttgac
      661 aagtgccgaa tccgtccttc tgtgttcaag cctcctgtgg gctctgggaa aggcttcttg
      721 tccatgcaaa gcctggcagc ccacaagggc cagaagttgt ggcgaagcaa cggcagcctg
      781 cacactctgg cctgtcaccc acccctgagc cctgggcctc gggccagtca ggcccgtgca
      841 cagttgcttc acgctctcag cctagatgaa ggtggccctg agcccagcct gtcggactct
      901 tccagcgggg gtagttttgg ccgtagtcca ggtactggcc ccagcccctt cagctcctcc
      961 ttgggccaca ttaatcacct tggaggctcc ctggaccgtg ctccaaggag ccccaaggag
     1021 tctggacctc tggcggtcct gagctgcctg cccgaaccac ctccccccta tgagttctcc
     1081 tgccccacta ctgaagaggt cgccgtgttg cctgaggccc gtgaagagct caagagggac
     1141 ctcggtgacc aggatgtttc taactccttt actcaggtgc tagaggagcg ccagcggttg
     1201 tggttgtctg agctgaagcg tctgtatgtg gaacgacttc atgaggtggc ccagaaagct
     1261 gagcgcagcg agcgcaacct ccaactgcag ctgtttatgg ctcaacagga gcagcggcgc
     1321 ctgcgcaagg agctgcgggc tcagcagggc ctggccccag agcctcggac gtctgggtcc
     1381 tccatggagg ctgaccccaa tgctcggcca gaggaagaag cccgatggga ggtgtgccag
     1441 aagaccgcgg agatcagtct gttgaaacag cagctccggg aagcccaggc ggagctggca
     1501 cagaagctgg cagagatctt cagtttgaag acgcaacttc ggggcagccg ggcacaagcc
     1561 caggctcagg acgctgagct agccaggctg cgggaggcag tgcacagcct gcaggagcag
     1621 gcaccgcggg aggaagcccc aggcagctgc gagacagatg actgcaagag cagaggactg
     1681 ctgggggagg caggaggcag tgaagccaga gaaggggccg agcagctgag ggcagagctg
     1741 ctgcaagagc ggcttagggg ccaggagcag gctctgcgct ttgagcagga gaggcagact
     1801 tggcaggagg aaaaggagag ggtgctgcgc taccagcgag aaatccaagg gagctacatg
     1861 gacatgtacc gccgcaacca ggcacttgaa cacgagctgc ggctgctgcg ggagcctcct
     1921 acatcctgga gtccccggct ggagtcctcc aagatctgag gctcgccaag tgtgctgaca
     1981 gtgggcatac tgtcagaaga taccctgaga tggcaggctc ctcccttgca ctggttggag
     2041 gcagaatctg tagaggccag atcagggatg ggacgcccgc cccgtggagg gctccagcgg
     2101 gcaatgggat ggatagggta cctgctcccg aagctgtggc aaagtcttgc tagcagcgaa
     2161 ccacacccag ggagggtcta gccctgcttc caacagtggg tgtggcctgg taaagtaggt
     2221 tggagccgtc caagcttcag ccccacgatg cagaagagca ggagaggagg agggtggcat
     2281 gtgacctggc ctgaggtctt cctccatgga aggagccagg gttgggaaga ttggccacct
     2341 ccagaataaa aagcacgttt ttatgaggag gcctagttga taagattgtc cttggcctga
     2401 ggccagaggc tcctggatgg tcagtgctcc aggccttgga cctaggctgt agttccttct
     2461 atgttcccaa caatggaaag aatatacccc a
//
