LOCUS       NM_030563               6469 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus NEDD4 binding protein 1 (N4bp1), mRNA.
ACCESSION   NM_030563 XM_894155 XM_988455
VERSION     NM_030563.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6469)
  AUTHORS   Gitlin,A.D., Maltzman,A., Kanno,Y., Heger,K., Reja,R.,
            Schubert,A.F., Wierciszewski,L.J., Pantua,H., Kapadia,S.B.,
            Harris,S.F., Webster,J.D., Newton,K. and Dixit,V.M.
  TITLE     N4BP1 coordinates ubiquitin-dependent crosstalk within the IkappaB
            kinase family to limit Toll-like receptor signaling and
            inflammation
  JOURNAL   Immunity 57 (5), 973-986 (2024)
   PUBMED   38697117
  REMARK    GeneRIF: N4BP1 coordinates ubiquitin-dependent crosstalk within the
            IkappaB kinase family to limit Toll-like receptor signaling and
            inflammation.
REFERENCE   2  (bases 1 to 6469)
  AUTHORS   Ma,Z., Zeng,Y., Wang,M., Liu,W., Zhou,J., Wu,C., Hou,L., Yin,B.,
            Qiang,B., Shu,P. and Peng,X.
  TITLE     N4BP1 mediates RAM domain-dependent notch signaling turnover during
            neocortical development
  JOURNAL   EMBO J 42 (22), e113383 (2023)
   PUBMED   37807845
  REMARK    GeneRIF: N4BP1 mediates RAM domain-dependent notch signaling
            turnover during neocortical development.
REFERENCE   3  (bases 1 to 6469)
  AUTHORS   Gou,C., Ni,W., Ma,P., Zhao,F., Wang,Z., Sun,R., Wu,Y., Wu,Y.,
            Chen,M., Chen,H., Zhang,J., Shen,Y., Xiao,M., Lu,C., Mao,R. and
            Fan,Y.
  TITLE     The endoribonuclease N4BP1 prevents psoriasis by controlling both
            keratinocytes proliferation and neutrophil infiltration
  JOURNAL   Cell Death Dis 12 (5), 488 (2021)
   PUBMED   33990547
  REMARK    GeneRIF: The endoribonuclease N4BP1 prevents psoriasis by
            controlling both keratinocytes proliferation and neutrophil
            infiltration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6469)
  AUTHORS   Shi,H., Sun,L., Wang,Y., Liu,A., Zhan,X., Li,X., Tang,M.,
            Anderton,P., Hildebrand,S., Quan,J., Ludwig,S., Moresco,E.M.Y. and
            Beutler,B.
  TITLE     N4BP1 negatively regulates NF-kappaB by binding and inhibiting NEMO
            oligomerization
  JOURNAL   Nat Commun 12 (1), 1379 (2021)
   PUBMED   33654074
  REMARK    GeneRIF: N4BP1 negatively regulates NF-kappaB by binding and
            inhibiting NEMO oligomerization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6469)
  AUTHORS   Gitlin,A.D., Heger,K., Schubert,A.F., Reja,R., Yan,D., Pham,V.C.,
            Suto,E., Zhang,J., Kwon,Y.C., Freund,E.C., Kang,J., Pham,A.,
            Caothien,R., Bacarro,N., Hinkle,T., Xu,M., McKenzie,B.S., Haley,B.,
            Lee,W.P., Lill,J.R., Roose-Girma,M., Dohse,M., Webster,J.D.,
            Newton,K. and Dixit,V.M.
  TITLE     Integration of innate immune signalling by caspase-8 cleavage of
            N4BP1
  JOURNAL   Nature 587 (7833), 275-280 (2020)
   PUBMED   32971525
  REMARK    GeneRIF: Integration of innate immune signalling by caspase-8
            cleavage of N4BP1.
REFERENCE   6  (bases 1 to 6469)
  AUTHORS   Lopez,R.G., Garcia-Silva,S., Moore,S.J., Bereshchenko,O.,
            Martinez-Cruz,A.B., Ermakova,O., Kurz,E., Paramio,J.M. and
            Nerlov,C.
  TITLE     C/EBPalpha and beta couple interfollicular keratinocyte
            proliferation arrest to commitment and terminal differentiation
  JOURNAL   Nat Cell Biol 11 (10), 1181-1190 (2009)
   PUBMED   19749746
REFERENCE   7  (bases 1 to 6469)
  AUTHORS   Oberst,A., Malatesta,M., Aqeilan,R.I., Rossi,M., Salomoni,P.,
            Murillas,R., Sharma,P., Kuehn,M.R., Oren,M., Croce,C.M.,
            Bernassola,F. and Melino,G.
  TITLE     The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the
            E3 ligase Itch
  JOURNAL   Proc Natl Acad Sci U S A 104 (27), 11280-11285 (2007)
   PUBMED   17592138
  REMARK    GeneRIF: May have a role in regulating tumor progression and the
            response of cancer cells to chemotherapy.
REFERENCE   8  (bases 1 to 6469)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 6469)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 6469)
  AUTHORS   Murillas,R., Simms,K.S., Hatakeyama,S., Weissman,A.M. and
            Kuehn,M.R.
  TITLE     Identification of developmentally expressed proteins that
            functionally interact with Nedd4 ubiquitin ligase
  JOURNAL   J Biol Chem 277 (4), 2897-2907 (2002)
   PUBMED   11717310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ134294.1, AK147522.1, AA444325.1, BC089324.1, BM951093.1,
            CX240926.1 and CX122841.1.
            
            On or before Jun 27, 2009 this sequence version replaced
            XM_988455.1, XM_894155.2, NM_030563.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147522.1, AK172981.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CJ134294.1         45-49
            6-516               AK147522.1         7-517
            517-517             AA444325.1         205-205
            518-2249            AK147522.1         519-2250
            2250-3244           BC089324.1         1415-2409
            3245-3750           AK147522.1         3246-3751
            3751-4045           BM951093.1         277-571
            4046-5024           AK147522.1         4047-5025
            5025-5338           CX240926.1         4-317
            5339-5645           CX122841.1         312-618
            5646-6469           AK147522.1         5647-6470
FEATURES             Location/Qualifiers
     source          1..6469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 42.1 cM"
     gene            1..6469
                     /gene="N4bp1"
                     /note="NEDD4 binding protein 1"
                     /db_xref="GeneID:80750"
                     /db_xref="MGI:MGI:2136825"
     exon            1..437
                     /gene="N4bp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..2921
                     /gene="N4bp1"
                     /codon_start=1
                     /product="NEDD4-binding protein 1"
                     /protein_id="NP_085040.2"
                     /db_xref="CCDS:CCDS52625.1"
                     /db_xref="GeneID:80750"
                     /db_xref="MGI:MGI:2136825"
                     /translation="MAARVVLDEFTAPAEKAALLERSRGRIEALFGVGLAVLGALGAE
                     EPLPARIWLQLRGAQEAVHSAKEYIKGICEPELEEKECYPKAMHCIFVGAQSLFLKSL
                     IQDTCADLCVLDTGLLGIRGSAEAVVMARSHIQQFVKLFESNENLPSNQRESEIKREF
                     RQFVEAHADSYTMDLLILPTSLKKELLSLTQGEESLFETDDDVITVGDVRPPEYTQSA
                     ATGPSSARDEVVVQEDSRNKARTPVSELTKHMDTVFSSSPDVLFVPVNGLSPDEDALS
                     KDRVCHKRRSSDTEERHTKKQFSLENVPEGELLPDGKGSAGNEVIDLSDPASNSTNLS
                     PDGKDTTEEMEYNILVNFFKTMGYSQEIVEKVIREYGPSTEPLLLLEEIEKENKRLQE
                     DRDFPPCTVYPDASQSRNAGVGSTTNELTADSTPKKAQSHTEQSMVERFSQLPFKDSK
                     HCTSNCKVNSFRTVPVGQKQEIWGSKQNSSCTVDLETDGHSASAASASPKDISFVSRG
                     ASGHQQRNPAFPENGFQQQTEPLLPNNTKPACEKRSGSCSSPQPKPNYPPLSPPLPLP
                     QLLPSVTEARLGGSSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRADLKHIVIDGSN
                     VAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTRRDPNITEQHFLTQLQEL
                     GILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVTESVSWREIITKR
                     LLQYTFVGDIFMVPDDPLGRNGPRLEEFLRKEAFLRHMQPLLNALPSVGTFDPGFRSP
                     STQVANNSHQPPPRIQTSSSPWLPQQSHFTALATLPSMQQNPPLPAQRSSAETSELRE
                     ALLKIFPDSEQKLKIDQILAAHPYMKDLNALSALVLD"
     exon            438..2122
                     /gene="N4bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2253
                     /gene="N4bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2350
                     /gene="N4bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2458
                     /gene="N4bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2566
                     /gene="N4bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..6469
                     /gene="N4bp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcggcgg cggcggcggc cgtggcgggg cagcggggca gcggggcagc ggggtggcgg
       61 ggagtctctg cccgcagttg ctaagctgcg gcggccgtgt cgtgatggtg tagcggggcc
      121 tgcgggcggg cgaggaggcc ggcacggccc acgcctcctg agcggctcgg tgcagcggcg
      181 gcacgctgag ggggcgtcgc cgccgctggc ccccggcgcc ccgggaggcc gcgcccgcca
      241 tggcggcccg ggtggtgctg gatgagttca cggcgcccgc ggagaaggcg gcgctgctgg
      301 agcggagccg cgggcgcatc gaggctctgt tcggggtggg cttggccgtg ctcggcgccc
      361 tcggggcgga ggagccgctg cccgcgcgta tctggctgca actccgcggc gcgcaggagg
      421 cggtgcacag cgccaaggag tatatcaagg ggatctgcga gccggagctg gaggagaaag
      481 agtgctaccc caaggccatg cactgcattt ttgtcggggc acaaagcctc tttttgaaga
      541 gcttaattca ggatacgtgt gctgacctct gtgttttaga tactgggctt cttggcatcc
      601 gaggaagcgc tgaagctgtg gtcatggcca ggagtcacat tcagcagttt gtgaagctct
      661 ttgagagcaa cgagaacctc cccagtaatc agagagagtc ggaaatcaaa cgggaattca
      721 gacagtttgt tgaagcccac gcagacagtt atacaatgga cctgttgatt ctgcctactt
      781 ccttgaagaa ggaactactg agtctcacac aaggggaaga gagtctgttt gaaacagatg
      841 atgatgtcat tactgttgga gatgtacggc caccagagta cacacagagt gctgccacag
      901 gaccgagtag tgctagagat gaagttgttg tacaggaaga ttctagaaat aaagctagga
      961 cccctgtttc tgagcttaca aaacacatgg acacagtctt ctctagttca ccagatgtgc
     1021 tttttgttcc ggtgaatggc ctaagtccag acgaagatgc tctttccaaa gacagagttt
     1081 gtcacaagag gagatcttct gatacggaag aaaggcacac caagaagcag ttttccttgg
     1141 agaatgttcc agaaggggag cttttgccag atggtaaggg gtcagctgga aatgaagtta
     1201 ttgacctgtc tgatcctgct tcaaactcta caaatctaag ccccgatgga aaagacacta
     1261 cagaagaaat ggaatacaat atccttgtta acttctttaa aaccatgggc tattcccaag
     1321 agattgttga aaaggtcatt agggagtatg ggccttctac agaaccgtta ctgctcttag
     1381 aggaaattga aaaagaaaat aaaaggctcc aagaagaccg agactttcca ccttgtactg
     1441 tgtatccaga tgccagtcag agcagaaatg caggggttgg gagcaccaca aatgagctca
     1501 cagcagactc cacgccaaag aaagcacaga gtcacacaga gcaaagtatg gtggagagat
     1561 tctcgcagtt accgttcaaa gactctaaac actgtacctc aaattgcaaa gttaattctt
     1621 tcagaacagt gccagtagga caaaaacagg aaatctgggg ttcaaagcag aactcaagtt
     1681 gtactgtcga cctggaaact gatggccact cggcctctgc cgcctctgcc agccctaaag
     1741 acatcagttt tgtttcaagg ggagcttcag ggcaccaaca gagaaaccca gcttttcctg
     1801 aaaatggttt tcaacagcaa acagaacctt tgcttccaaa taatacgaag cctgcctgtg
     1861 aaaagcgttc tggctcctgt agctctcctc agcctaagcc aaattatccc ccactttctc
     1921 caccactgcc gctgccccag ctgctacctt cagttactga ggctcgattg ggagggtcct
     1981 ctgaccatat cgattcctca gttacagggg ttcaaagatt tcgagatacc ttaaaaatac
     2041 catacaagct ggaattaaaa aacgaaccag gacgagcaga tttgaagcat attgttatag
     2101 atggaagtaa tgttgcaatt acccacggtc tgaaaaagtt ctttagttgc cgtggaatag
     2161 caattgcagt tgagtatttt tggaagctcg gcaacaggaa catcactgtg tttgtcccac
     2221 agtggagaac aagacgggat cctaatatca cagaacagca cttcttaacc cagctccagg
     2281 agcttggaat attatcttta actcctgccc ggatggtctt tggagaaaga attgcttctc
     2341 atgatgacag gtttctactg cacttagcgg acaagactgg gggtataatt gtaacaaacg
     2401 ataacttcag agagtttgtg accgagtcgg tgtcctggag agaaattatt accaaaagac
     2461 tgcttcagta cacgttcgtg ggggacatat ttatggttcc tgatgaccct ctgggaagaa
     2521 acggacctcg gctagaagaa tttcttcgaa aggaggcctt tcttagacac atgcagccgc
     2581 tactcaatgc cctgccaagt gtgggcacat ttgaccctgg cttccggagt cccagcacgc
     2641 aggtagccaa caacagccac cagcctccac cccggatcca gacctcttca agcccttggc
     2701 ttccccagca gtcccacttc acagctctgg ccacccttcc cagtatgcag cagaacccac
     2761 ccctgccagc acagagatct tctgcagaga ccagcgagct gagggaggcg ctgctaaaga
     2821 tcttccctga ctctgagcaa aagctgaaga tcgaccagat cctggcagct catccgtaca
     2881 tgaaagacct gaatgccctg tcggccctgg tgttggactg acggctgggc tggagcccac
     2941 tgatgctggg gaactgccaa ccgtgggatg gaccataacg tgaagaagcc ttcccggaaa
     3001 gcattgctgt gttgtataga aaaaggaggg aaatgtttta tgtatacaaa agtctggggt
     3061 ttcaaagcca gcttttttct atatataaat tatgctgcta ttacagactt aacgttttct
     3121 gtaaaaggaa agtactcttt ctgcctgttc agaactgttt aatagcagtt actcttgagt
     3181 gtatttacag ttttatgttt tttaaactat tttccttaaa gctgaagaaa aaatgacaaa
     3241 taaatatggt tagcctttct aaataaaatt ttaaaaaaaa attaagaaaa aaaaaggagt
     3301 tgcttcctta aggaaagcaa gacttcttaa agtctatttt cttgaggtaa tttgtcctgt
     3361 tcactaaaca tggcgtgtgc tcccctgcct tcatccctag agtgggcctg ctctgctctt
     3421 gtggggcctt ctcagcgagc cattatgaga gtgaagaagt ggagccacta gatggcatct
     3481 gacacccggg ctgtcaccag tggccagaca aagtcagact gaggagcagg tgggaagtct
     3541 tagaggacgt acagccccag catgctccct gactggcgta gctccgtagt gcactcacca
     3601 gccatggccg ccatgctccc accctggctc cacagctacc ttagcctcag aagacaaggt
     3661 aggcactgaa gcctctggtg aggagacccc ccccccccca tgtggcgttt gtacagcttt
     3721 gccaaaaagt tttctattct caaggatgac ccaagccaat aaatagcatt agtcctttca
     3781 gaagggcctc aaagcccctg catttccctt cttttgtcta cttagaggtt tcttagcagc
     3841 aattcctgag tctttcagaa ccagttatct cagtattgtc tcttctcggt gtagcttgaa
     3901 gtctgtgtct gtgaaccccc tcctggtcat tcttagtgtc ttggctctca cctggacctt
     3961 caaagggctt tgtgttctcc atccatgcag tctccaggcc cttgtggtta aattcactgc
     4021 cctgtggatt gttgttctcc cggtcccgca ggtaaccgtg gacttggtgc tggtttgtta
     4081 tccgtagtgc agggactgtg tagatcacag aatgctgcca ccatgccgtg tcttggttca
     4141 tttggtccct gcacccatca ggagatgaac agagccttct aggtggccat acttacgtga
     4201 tctctcctga atttgttgat gatccagcct gctgggaagc tgtttgtcat ctgtccctag
     4261 ggggtttcag acctgcaggc tgtgtgagta cagaacagag acttctggcc agccccagga
     4321 gttgacccac cacagtcccc cacccagtgc ctcagcttgg gagcacagca aaggtgccaa
     4381 ggtggagctg tctccagggc ttcctggtgt ggtcaatccc agcccagcac tgctgggaac
     4441 caggagagcc gggagtactc catagctgcc tcagcctgat gctggcctga ggagcacagg
     4501 ctctcaaagg cccttcggct agcctgatct ttgagttgtg tgcctctgtg ttcttagtat
     4561 tgtttctgag agatacctgc ccatttcccc ttgccccata taggagggag gaaaaagctg
     4621 gaggaaacca aaaggcatta attactttgt agattataat gtgaaatata attctagatt
     4681 ctttgtgaaa tctgtcacat ttaggtataa catttacagc ccagttatcc agccactgaa
     4741 gaaagctcac aacttgcttc tttgcctcat ccaaagctct gttgctgcta ggtgcttgta
     4801 gatgcttgac ctccatccct ccagtgcctc ctcagtgaac ttgggagcgt cttggaattc
     4861 ctccctgtgt ggagtgcctc tgcctcctgt gtatcctggc atttggttga ggcggccagt
     4921 gcagctaagg ctgatacctt tggtcattgg acaaggtgtc gtgtgtgtgt gtgtgtgtgt
     4981 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt cctggtccag tgtggttgac aggctcagct
     5041 gtatttctag gacatgttag gcatgaaaga gagctccacc tctccttgcc agtcccaagt
     5101 acctagccct ccccctggga ggggcatcta ctgcaggccc tctgcaccag gctcacccag
     5161 gcccttgcct gctccccata cctctccagg gctgtccctc ctcagcattc tgagccacct
     5221 cagctgggtc catcagttgc actgttcgcc cgaatcgtta cttggttcct ctgatccctt
     5281 tagttaaaac acccttcgtt ctgttgctaa tgcttctctc tggcttccca ctttcccctc
     5341 ccagatttgg aaacttggct tctgcccacc acatgggagt agcctgggaa atcactggtt
     5401 gccatttcat cattaatgga gtagctacag acagcaaagc cattggcctc cctttctctg
     5461 ttttccttct tgaagcgctc cattcctttc ttcttgaagg cctagcctta attcagtttc
     5521 tcagcaggtg gctctcaagg tgaaccaccc cttgggctta cagagaaaag ggcaaccctt
     5581 gctacccttg ctaaaaggca ggctgtcaat ctgtcaccgc cctgagggat ggactcagtg
     5641 ctttagagga aagctggtgg cttgtcactg ccacacgcct tgagtgcagg gccctggtag
     5701 gtggtctgga actggacttc cttaggagtc gccactctcc tgactaccct ccactctgtg
     5761 acaccagtcc tctcactaac cctgtgggat cttggctccc agaacctcag cctgcatcct
     5821 gccatctctc acctaactct gaggtccctt aaatccttct tggcccttgg cttgctactg
     5881 cctaccacct gttcccacaa tcctccgtga caccgttccc tccctcattg gctaccttac
     5941 agctcttccc tctccctaat tccaggggac tccaagttca tctagagggc cattttgcat
     6001 catcctcttc ctctgtgatc ttcgaccaga gcatcacgtt cctaccctct gagccatgtg
     6061 tccgcggctg ctgccccatg gccgcacttg actgtctgct ttctcttgcc atgatcctta
     6121 ctccagccac ccagatctag gttccccata ggccctgttc atgtttcttc ctctcataga
     6181 catgcccttc ttccctacag cctgcctcct caaaggccca gccctgagtt ctctttgtgt
     6241 tcagagcaga agcagctcta tgctattctg tggccccatg gcaatttggt gtcttgcttc
     6301 tggctcttac cactctggcc ggtgtagctg cagccaactg tgtactgtgt tgcctccctc
     6361 tagactgtga gctcctcgtg ggcagggacc atatggtcac tctgtatctc ttgtggcacc
     6421 taaaagtgcc ttgcacttgg taggtgctca ataaatgtct gttcaagtg
//
