LOCUS       NP_085040                893 aa            linear   ROD 11-DEC-2024
DEFINITION  NEDD4-binding protein 1 [Mus musculus].
ACCESSION   NP_085040 XP_899248 XP_993549
VERSION     NP_085040.2
DBSOURCE    REFSEQ: accession NM_030563.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 893)
  AUTHORS   Gitlin,A.D., Maltzman,A., Kanno,Y., Heger,K., Reja,R.,
            Schubert,A.F., Wierciszewski,L.J., Pantua,H., Kapadia,S.B.,
            Harris,S.F., Webster,J.D., Newton,K. and Dixit,V.M.
  TITLE     N4BP1 coordinates ubiquitin-dependent crosstalk within the IkappaB
            kinase family to limit Toll-like receptor signaling and
            inflammation
  JOURNAL   Immunity 57 (5), 973-986 (2024)
   PUBMED   38697117
  REMARK    GeneRIF: N4BP1 coordinates ubiquitin-dependent crosstalk within the
            IkappaB kinase family to limit Toll-like receptor signaling and
            inflammation.
REFERENCE   2  (residues 1 to 893)
  AUTHORS   Ma,Z., Zeng,Y., Wang,M., Liu,W., Zhou,J., Wu,C., Hou,L., Yin,B.,
            Qiang,B., Shu,P. and Peng,X.
  TITLE     N4BP1 mediates RAM domain-dependent notch signaling turnover during
            neocortical development
  JOURNAL   EMBO J 42 (22), e113383 (2023)
   PUBMED   37807845
  REMARK    GeneRIF: N4BP1 mediates RAM domain-dependent notch signaling
            turnover during neocortical development.
REFERENCE   3  (residues 1 to 893)
  AUTHORS   Gou,C., Ni,W., Ma,P., Zhao,F., Wang,Z., Sun,R., Wu,Y., Wu,Y.,
            Chen,M., Chen,H., Zhang,J., Shen,Y., Xiao,M., Lu,C., Mao,R. and
            Fan,Y.
  TITLE     The endoribonuclease N4BP1 prevents psoriasis by controlling both
            keratinocytes proliferation and neutrophil infiltration
  JOURNAL   Cell Death Dis 12 (5), 488 (2021)
   PUBMED   33990547
  REMARK    GeneRIF: The endoribonuclease N4BP1 prevents psoriasis by
            controlling both keratinocytes proliferation and neutrophil
            infiltration.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 893)
  AUTHORS   Shi,H., Sun,L., Wang,Y., Liu,A., Zhan,X., Li,X., Tang,M.,
            Anderton,P., Hildebrand,S., Quan,J., Ludwig,S., Moresco,E.M.Y. and
            Beutler,B.
  TITLE     N4BP1 negatively regulates NF-kappaB by binding and inhibiting NEMO
            oligomerization
  JOURNAL   Nat Commun 12 (1), 1379 (2021)
   PUBMED   33654074
  REMARK    GeneRIF: N4BP1 negatively regulates NF-kappaB by binding and
            inhibiting NEMO oligomerization.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 893)
  AUTHORS   Gitlin,A.D., Heger,K., Schubert,A.F., Reja,R., Yan,D., Pham,V.C.,
            Suto,E., Zhang,J., Kwon,Y.C., Freund,E.C., Kang,J., Pham,A.,
            Caothien,R., Bacarro,N., Hinkle,T., Xu,M., McKenzie,B.S., Haley,B.,
            Lee,W.P., Lill,J.R., Roose-Girma,M., Dohse,M., Webster,J.D.,
            Newton,K. and Dixit,V.M.
  TITLE     Integration of innate immune signalling by caspase-8 cleavage of
            N4BP1
  JOURNAL   Nature 587 (7833), 275-280 (2020)
   PUBMED   32971525
  REMARK    GeneRIF: Integration of innate immune signalling by caspase-8
            cleavage of N4BP1.
REFERENCE   6  (residues 1 to 893)
  AUTHORS   Lopez,R.G., Garcia-Silva,S., Moore,S.J., Bereshchenko,O.,
            Martinez-Cruz,A.B., Ermakova,O., Kurz,E., Paramio,J.M. and
            Nerlov,C.
  TITLE     C/EBPalpha and beta couple interfollicular keratinocyte
            proliferation arrest to commitment and terminal differentiation
  JOURNAL   Nat Cell Biol 11 (10), 1181-1190 (2009)
   PUBMED   19749746
REFERENCE   7  (residues 1 to 893)
  AUTHORS   Oberst,A., Malatesta,M., Aqeilan,R.I., Rossi,M., Salomoni,P.,
            Murillas,R., Sharma,P., Kuehn,M.R., Oren,M., Croce,C.M.,
            Bernassola,F. and Melino,G.
  TITLE     The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the
            E3 ligase Itch
  JOURNAL   Proc Natl Acad Sci U S A 104 (27), 11280-11285 (2007)
   PUBMED   17592138
  REMARK    GeneRIF: May have a role in regulating tumor progression and the
            response of cancer cells to chemotherapy.
REFERENCE   8  (residues 1 to 893)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (residues 1 to 893)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 893)
  AUTHORS   Murillas,R., Simms,K.S., Hatakeyama,S., Weissman,A.M. and
            Kuehn,M.R.
  TITLE     Identification of developmentally expressed proteins that
            functionally interact with Nedd4 ubiquitin ligase
  JOURNAL   J Biol Chem 277 (4), 2897-2907 (2002)
   PUBMED   11717310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ134294.1, AK147522.1, AA444325.1, BC089324.1, BM951093.1,
            CX240926.1 and CX122841.1.
            
            On or before Jun 27, 2009 this sequence version replaced
            XP_993549.1, XP_899248.2, NP_085040.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147522.1, AK172981.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..893
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 42.1 cM"
     Protein         1..893
                     /product="NEDD4-binding protein 1"
                     /calculated_mol_wt=99016
     Region          8..73
                     /region_name="KH-I_N4BP1_like_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of NEDD4-binding protein 1 (N4BP1);
                     cd09032"
                     /db_xref="CDD:411808"
     Region          75..142
                     /region_name="KH-I_N4BP1"
                     /note="type I K homology (KH) RNA-binding domain found in
                     NEDD4-binding protein 1 (N4BP1) and similar proteins;
                     cd22476"
                     /db_xref="CDD:411904"
     Site            order(86,88..90,92..96,99..100,103..104,109..112)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411904"
     Site            200..201
                     /site_type="cleavage"
                     /note="Cleavage, by CASP8.
                     /evidence=ECO:0000269|PubMed:32971525; propagated from
                     UniProtKB/Swiss-Prot (Q6A037.2)"
     Region          213..243
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A037.2)"
     Site            241
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75113; propagated from
                     UniProtKB/Swiss-Prot (Q6A037.2)"
     Site            257
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75113; propagated from
                     UniProtKB/Swiss-Prot (Q6A037.2)"
     Site            269
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6A037.2)"
     Region          273..339
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A037.2)"
     Site            299
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6A037.2)"
     Site            325..326
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000269|PubMed:32971525;
                     propagated from UniProtKB/Swiss-Prot (Q6A037.2)"
     Region          394..433
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A037.2)"
     Region          472..564
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A037.2)"
     Site            488..489
                     /site_type="cleavage"
                     /note="Cleavage, by CASP8.
                     /evidence=ECO:0000269|PubMed:32971525; propagated from
                     UniProtKB/Swiss-Prot (Q6A037.2)"
     Site            507..508
                     /site_type="cleavage"
                     /note="Cleavage, by MALT1.
                     /evidence=ECO:0000250|UniProtKB:O75113; propagated from
                     UniProtKB/Swiss-Prot (Q6A037.2)"
     Site            560
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6A037.2)"
     Region          618..744
                     /region_name="PIN_N4BP1-like"
                     /note="PRORP-like PIN domain of NEDD4 binding protein 1
                     and related proteins; cd18728"
                     /db_xref="CDD:350295"
     Region          793..820
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A037.2)"
     Region          846..893
                     /region_name="CoCUN.
                     /evidence=ECO:0000250|UniProtKB:O75113"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A037.2)"
     CDS             1..893
                     /gene="N4bp1"
                     /coded_by="NM_030563.2:240..2921"
                     /db_xref="CCDS:CCDS52625.1"
                     /db_xref="GeneID:80750"
                     /db_xref="MGI:MGI:2136825"
ORIGIN      
        1 maarvvldef tapaekaall ersrgrieal fgvglavlga lgaeeplpar iwlqlrgaqe
       61 avhsakeyik gicepeleek ecypkamhci fvgaqslflk sliqdtcadl cvldtgllgi
      121 rgsaeavvma rshiqqfvkl fesnenlpsn qreseikref rqfveahads ytmdllilpt
      181 slkkellslt qgeeslfetd ddvitvgdvr ppeytqsaat gpssardevv vqedsrnkar
      241 tpvseltkhm dtvfssspdv lfvpvnglsp dedalskdrv chkrrssdte erhtkkqfsl
      301 envpegellp dgkgsagnev idlsdpasns tnlspdgkdt teemeynilv nffktmgysq
      361 eivekvirey gpstepllll eeiekenkrl qedrdfppct vypdasqsrn agvgsttnel
      421 tadstpkkaq shteqsmver fsqlpfkdsk hctsnckvns frtvpvgqkq eiwgskqnss
      481 ctvdletdgh sasaasaspk disfvsrgas ghqqrnpafp engfqqqtep llpnntkpac
      541 ekrsgscssp qpkpnyppls pplplpqllp svtearlggs sdhidssvtg vqrfrdtlki
      601 pyklelknep gradlkhivi dgsnvaithg lkkffscrgi aiaveyfwkl gnrnitvfvp
      661 qwrtrrdpni teqhfltqlq elgilsltpa rmvfgerias hddrfllhla dktggiivtn
      721 dnfrefvtes vswreiitkr llqytfvgdi fmvpddplgr ngprleeflr keaflrhmqp
      781 llnalpsvgt fdpgfrspst qvannshqpp priqtssspw lpqqshftal atlpsmqqnp
      841 plpaqrssae tselreallk ifpdseqklk idqilaahpy mkdlnalsal vld
//
