LOCUS       NM_145819               3497 bp    mRNA    linear   ROD 17-JAN-2022
DEFINITION  Mus musculus myeloid zinc finger 1 (Mzf1), transcript variant 1,
            mRNA.
ACCESSION   NM_145819
VERSION     NM_145819.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3497)
  AUTHORS   Liang X, Yan Z, Wang P, Liu Y, Ao X, Liu Z, Wang D, Liu X, Zhu M,
            Gao S, Xie D, Zhou P and Gu Y.
  TITLE     Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and
            Promote Epithelial-Mesenchymal Transition (EMT) in
            Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug
  JOURNAL   Int J Mol Sci 22 (21), 11309 (2021)
   PUBMED   34768749
  REMARK    GeneRIF: Irradiation Activates MZF1 to Inhibit miR-541-5p
            Expression and Promote Epithelial-Mesenchymal Transition (EMT) in
            Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3497)
  AUTHORS   Zhang S, Shi W, Ramsay ES, Bliskovsky V, Eiden AM, Connors D,
            Steinsaltz M, DuBois W and Mock BA.
  TITLE     The transcription factor MZF1 differentially regulates murine Mtor
            promoter variants linked to tumor susceptibility
  JOURNAL   J Biol Chem 294 (45), 16756-16764 (2019)
   PUBMED   31548308
  REMARK    GeneRIF: MZF1 down-regulates Mtor expression in pristane-induced
            plasmacytomas in mice
REFERENCE   3  (bases 1 to 3497)
  AUTHORS   Wu L, Han L, Zhou C, Wei W, Chen X, Yi H, Wu X, Bai X, Guo S, Yu Y,
            Liang L and Wang W.
  TITLE     TGF-beta1-induced CK17 enhances cancer stem cell-like properties
            rather than EMT in promoting cervical cancer metastasis via the
            ERK1/2-MZF1 signaling pathway
  JOURNAL   FEBS J 284 (18), 3000-3017 (2017)
   PUBMED   28703907
  REMARK    GeneRIF: TGF-beta1-induced CK17 enhances cancer stem cell-like
            properties rather than epithelial-mesenchymal transition in
            promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling
            pathway.
REFERENCE   4  (bases 1 to 3497)
  AUTHORS   Doppler SA, Werner A, Barz M, Lahm H, Deutsch MA, Dressen M,
            Schiemann M, Voss B, Gregoire S, Kuppusamy R, Wu SM, Lange R and
            Krane M.
  TITLE     Myeloid zinc finger 1 (Mzf1) differentially modulates murine
            cardiogenesis by interacting with an Nkx2.5 cardiac enhancer
  JOURNAL   PLoS One 9 (12), e113775 (2014)
   PUBMED   25436607
  REMARK    GeneRIF: Findings implicate a novel, temporal-specific role of Mzf1
            in embryonic heart development and show that Mzf1 bounds directly
            to the Nkx2.5 during murine embryonic stem cell differentiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3497)
  AUTHORS   Kan A and Tabin CJ.
  TITLE     c-Jun is required for the specification of joint cell fates
  JOURNAL   Genes Dev 27 (5), 514-524 (2013)
   PUBMED   23475960
REFERENCE   6  (bases 1 to 3497)
  AUTHORS   Murai K, Murakami H and Nagata S.
  TITLE     Myeloid-specific transcriptional activation by murine myeloid
            zinc-finger protein 2
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3461-3466 (1998)
   PUBMED   9520388
REFERENCE   7  (bases 1 to 3497)
  AUTHORS   Murai K, Murakami H and Nagata S.
  TITLE     A novel form of the myeloid-specific zinc finger protein (MZF-2)
  JOURNAL   Genes Cells 2 (9), 581-591 (1997)
   PUBMED   9413999
REFERENCE   8  (bases 1 to 3497)
  AUTHORS   Kim J, Ashworth L, Branscomb E and Stubbs L.
  TITLE     The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc
            finger gene-rich region of human chromosome 19q13.4
  JOURNAL   Genome Res 7 (5), 532-540 (1997)
   PUBMED   9149948
REFERENCE   9  (bases 1 to 3497)
  AUTHORS   Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE,
            Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM and
            Ashworth LK.
  TITLE     Detailed comparative map of human chromosome 19q and related
            regions of the mouse genome
  JOURNAL   Genomics 35 (3), 499-508 (1996)
   PUBMED   8812484
REFERENCE   10 (bases 1 to 3497)
  AUTHORS   Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P,
            Hagen FS and Kaushansky K.
  TITLE     A retinoic acid-responsive human zinc finger gene, MZF-1,
            preferentially expressed in myeloid cells
  JOURNAL   J Biol Chem 266 (22), 14183-14187 (1991)
   PUBMED   1860835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121301.8 and BC129905.1.
            
            [WARNING] On Apr 28, 2023 this sequence was replaced by
            NM_145819.3.
            
            On Apr 28, 2009 this sequence version replaced NM_145819.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145014.1, AB088478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC121301.8         130045-130294       c
            251-2309            BC129905.1         1-2059
            2310-3497           AC121301.8         117833-119020       c
FEATURES             Location/Qualifiers
     source          1..3497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 7.73 cM"
     gene            1..3497
                     /gene="Mzf1"
                     /gene_synonym="Mzf-2; Mzf2; Zfp121; Zfp98; Znf42"
                     /note="myeloid zinc finger 1"
                     /db_xref="GeneID:109889"
                     /db_xref="MGI:MGI:107457"
     exon            1..284
                     /gene="Mzf1"
                     /gene_synonym="Mzf-2; Mzf2; Zfp121; Zfp98; Znf42"
                     /inference="alignment:Splign:2.1.0"
     exon            285..723
                     /gene="Mzf1"
                     /gene_synonym="Mzf-2; Mzf2; Zfp121; Zfp98; Znf42"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..2532
                     /gene="Mzf1"
                     /gene_synonym="Mzf-2; Mzf2; Zfp121; Zfp98; Znf42"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Myeloid zinc finger protein 2; Myeloid zinc finger protein
                     1; zinc finger protein 98; zinc finger protein 121;
                     myeloid-specific retinoic acid-responsive zinc finger
                     protein"
                     /codon_start=1
                     /product="myeloid zinc finger 1 isoform 1"
                     /protein_id="NP_665818.2"
                     /db_xref="CCDS:CCDS20826.1"
                     /db_xref="GeneID:109889"
                     /db_xref="MGI:MGI:107457"
                     /translation="MRPTVLGSSGCAPPENEPALVKLEDSDSDDEREDILWDPGLEAA
                     RLRFRCFRYEDAIGPQEALAQLRELCHQWLRPEVHSKEQVLELLVLEQFLGALPPEIQ
                     AQVQGQWPGSPEEAAALVDRLRWELDGPRKWVTVQVQGKEVLSEKMEPSSFQPRPHIK
                     LQTPDPGAETPQGAMQELPLNLPMKEETELLGNPELLESGPLPAAQEAAATLLPKETQ
                     GHGTTLDQTSPHSDTEPDVPPWSEDPMPLWHEEVGGIFSPGFTLQMDSITAEPDMMSP
                     HLHVPWDLDMASLSGQIQSPTTEGGFAHALVLPSDPGGEQDPACEDPCPSVGPALVAT
                     RWHAPRGRSQSHPRSGTGAMRGGRCDVCGKVFSQRSNLLRHQKIHTGERPFVCGECGR
                     SFSRSSHLLRHQLTHTEERPFVCRDCGQGFVRSARLEEHRRVHTGEQPFRCTECGQSF
                     RQRSNLLQHQRIHGDPPGPAPSILPLAGVPEPPGPFPCSECCESFPRRAVLLEHQAVH
                     TGDKSFGCVECGERFGRRSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQHQRIHTG
                     ERPFACAECGKTFRQRPTLTQHLRVHTGEKPFACPECGQRFSQRLKLTRHQRTHTGEK
                     PYCCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHANLTQHRRIHTGERPY
                     ACPECGKAFRQRPTLTQHLRTHRHEKPFACQDCGRRFNQSTKLIQHQRVHSTE"
     exon            724..907
                     /gene="Mzf1"
                     /gene_synonym="Mzf-2; Mzf2; Zfp121; Zfp98; Znf42"
                     /inference="alignment:Splign:2.1.0"
     exon            908..978
                     /gene="Mzf1"
                     /gene_synonym="Mzf-2; Mzf2; Zfp121; Zfp98; Znf42"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1099
                     /gene="Mzf1"
                     /gene_synonym="Mzf-2; Mzf2; Zfp121; Zfp98; Znf42"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..3497
                     /gene="Mzf1"
                     /gene_synonym="Mzf-2; Mzf2; Zfp121; Zfp98; Znf42"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacggggaga cggcgtccta gtgagagcgg tgattggtgc agaaccctgc aaatccctgg
       61 aaggccggta gagaactgac atttaaaaaa aaaaaaaaaa aaaaaaagtg gtgggggcat
      121 gcgcagtctg gaaggtggtg cttgaatccg ttgccccccg agaggattgt gcacgtcgtc
      181 ggggccctga cgcctgaatt cgtggccggg agtgtgggaa gagacgtcca ggagtgcgag
      241 ctgattattg caaccagcgc aatcccctag ggacgggaag aaggggacag acactggcct
      301 caaagaccgg atctggtact cctgatgaga cccactgtgc tgggctcctc gggctgtgca
      361 cccccagaaa atgagcctgc tctggtgaag ctggaggact ctgacagcga cgatgagaga
      421 gaagatatat tgtgggaccc aggccttgag gctgcacgtc tacgcttccg gtgcttccgg
      481 tatgaggatg caataggtcc tcaggaagcc ctggcccagc tccgagaact gtgtcaccag
      541 tggctacgcc cagaagtaca ttccaaggaa caggtgctag agctcttggt gctggagcag
      601 ttcctgggtg cactgccccc tgagatccag gcccaagtgc aagggcagtg gccaggcagc
      661 cctgaagagg ctgctgcctt ggttgacaga cttcgatggg agcttgatgg acctcggaaa
      721 tgggtcacag tccaggtgca gggcaaggag gtcctatcag agaagatgga accctccagc
      781 ttccagccaa gacctcacat caagcttcag actccagacc ctggggctga gactccccaa
      841 ggagccatgc aggaattgcc actgaaccta ccaatgaaag aggagacaga gttgttgggg
      901 aatccagagc tcctggaatc tgggcctctt cctgctgctc aagaggctgc agccactctc
      961 ctacctaagg agacccaggg ccatgggaca acactggacc agacctctcc tcatagcgac
     1021 actgagcctg atgtgccccc atggagtgag gaccctatgc ccctgtggca tgaggaagta
     1081 gggggcatct tttcaccagg gtttacgctg cagatggaca gcatcacggc agagccagat
     1141 atgatgagcc cccacctcca tgtcccctgg gatctggaca tggctagcct ctctggacag
     1201 atacagtccc ctaccacgga aggtggcttt gcccatgccc ttgtactccc cagcgaccca
     1261 ggaggtgaac aggaccctgc ctgcgaggat ccctgcccca gtgtgggccc agcattggtg
     1321 gcgactcgat ggcatgcccc aaggggccgg agccagagcc accctcgctc ggggactgga
     1381 gccatgcgag gcggccgctg cgacgtgtgt ggcaaggtgt tcagccagcg aagcaatctg
     1441 ctgcggcacc agaagatcca cacaggcgag agaccgttcg tgtgtggcga gtgtggccgc
     1501 agcttcagcc gcagctctca cctactgcgc caccagctca cgcatactga ggaacggcct
     1561 ttcgtgtgcc gcgactgtgg ccagggcttc gtgcgcagcg cccgcctgga ggagcaccgg
     1621 cgtgtacaca cgggcgagca gccgttccgc tgcacagagt gtggccagag ctttcggcag
     1681 cgctccaacc tactgcagca ccagcgcatc cacggcgatc cgcctggtcc agcgccatcc
     1741 atcctgcccc tcgccggagt cccggagccc ccgggcccct tcccatgcag cgagtgctgc
     1801 gagagcttcc cacgacgcgc cgtgctgcta gagcaccagg cggtgcacac cggggacaag
     1861 tccttcggat gcgtggagtg cggcgagcgc ttcggccgcc gttcggtgct gttgcagcac
     1921 cggcgcgtgc acagcggcga acggcccttc gcctgtgccg agtgcggcca aagcttccgg
     1981 cagcgctcta atctcaccca gcaccagcgc atccacactg gagagcggcc cttcgcctgc
     2041 gccgaatgtg gcaagacctt ccgccagcgg cccacgctca cgcagcacct gcgtgtgcat
     2101 acgggtgaga agcccttcgc gtgccccgag tgcggccagc gcttcagcca gcgactcaag
     2161 ctcacgcgcc accaaaggac ccatactggc gagaagccct actgctgcgg tgagtgcggc
     2221 ctcggcttca cgcaggtgtc tcggctcacc gagcaccagc gcatccacac aggtgagcgg
     2281 cccttcgcct gtcccgaatg tggccagagt ttccggcagc acgccaacct cacccagcac
     2341 cggcgcatcc atacgggcga gcgaccctac gcgtgtcccg aatgtggcaa ggcctttcgc
     2401 cagcggccca cgctcacgca gcacctgcgc actcaccggc acgaaaagcc cttcgcctgc
     2461 caggactgtg gccgacgctt caaccagagc accaagctca tccagcacca gcgtgtccac
     2521 agcactgagt agttgtacag cactgagctg tgaaaacact tcacaaggtt gttgtgaggc
     2581 aggcatctcc caacaggccc cagtaaagcc tgggcttcag gaggtgctca ataaacacat
     2641 gatgtctccc caacctgcac atttcttctg cccactttac cgctgtttcc atgctggtat
     2701 aagctatgca aacacggctt ccaggggagg ctccacaccc ccttccacag tagcacacct
     2761 gctttcttgt gggatatact ctgtagcata cctctggctt atacagaggg gatgcccagc
     2821 ctcagatggg gaagagtagc cacattcaca aaggaggaaa gggttctcca cggctgccat
     2881 gggtctagtc aagagagagg tctaccaact atgtcactgg taggtgactg aaaagggtag
     2941 tccagctggc tgtgatggta cacacgtgta accccagcgt tcaggaagct taggcaagag
     3001 gattgcagag agtttgagtt cagtctgggc gacatcataa gctgttattt caaaagcaca
     3061 cattgagtgt ggtggcacac tcagttgggg gacagagaga caagataatt gccaaaagtt
     3121 cagcaggtta gtttatgtaa caagttcctg gacagccaga attagtgaga acctatcaag
     3181 caaaaactcc tggcagagac ataaaataca aacgcggtgg tgtggtgcat gccttgtgac
     3241 cgtcctagct attcaggagg ctgacataaa tggactgcta gctatttcca ggactgcttg
     3301 gaggccaggg ctttgcagta ggatggttca gaggtaaaac cccttgtcat caaggtcaaa
     3361 ctgatgacct gactttgatc cctggaaccc acatgttgga aggagacaac caattcctga
     3421 aagttgtcct ctgatctcca caatctgtgt tttctgggtt atgtttgcac gtgcacatac
     3481 acaagtaaat aagtagg
//
