LOCUS       NM_027222                928 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus marginal zone B and B1 cell-specific protein 1 (Mzb1),
            mRNA.
ACCESSION   NM_027222
VERSION     NM_027222.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 928)
  AUTHORS   Tang,Y., Feng,X., Lu,Q., Cui,C., Yu,M., Wen,Z., Luan,Y., Dong,L.,
            Hu,Z., Zhang,R., Lu,C., Liu,J., Shinkura,R., Hase,K. and Wang,J.Y.
  TITLE     MZB1-mediated IgA secretion suppresses the development and
            progression of colorectal cancer triggered by gut inflammation
  JOURNAL   Mucosal Immunol 17 (3), 450-460 (2024)
   PUBMED   38101774
  REMARK    GeneRIF: MZB1-mediated IgA secretion suppresses the development and
            progression of colorectal cancer triggered by gut inflammation.
REFERENCE   2  (bases 1 to 928)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 928)
  AUTHORS   Zhang,L., Wang,Y.N., Ju,J.M., Shabanova,A., Li,Y., Fang,R.N.,
            Sun,J.B., Guo,Y.Y., Jin,T.Z., Liu,Y.Y., Li,T.Y., Shan,H.L.,
            Liang,H.H. and Yang,B.F.
  TITLE     Mzb1 protects against myocardial infarction injury in mice via
            modulating mitochondrial function and alleviating inflammation
  JOURNAL   Acta Pharmacol Sin 42 (5), 691-700 (2021)
   PUBMED   32759964
  REMARK    GeneRIF: Mzb1 protects against myocardial infarction injury in mice
            via modulating mitochondrial function and alleviating inflammation.
REFERENCE   4  (bases 1 to 928)
  AUTHORS   Kapoor,T., Corrado,M., Pearce,E.L., Pearce,E.J. and Grosschedl,R.
  TITLE     MZB1 enables efficient interferon alpha secretion in stimulated
            plasmacytoid dendritic cells
  JOURNAL   Sci Rep 10 (1), 21626 (2020)
   PUBMED   33318509
  REMARK    GeneRIF: MZB1 enables efficient interferon alpha secretion in
            stimulated plasmacytoid dendritic cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 928)
  AUTHORS   Xiong,E., Li,Y., Min,Q., Cui,C., Liu,J., Hong,R., Lai,N., Wang,Y.,
            Sun,J., Matsumoto,R., Takahashi,D., Hase,K., Shinkura,R.,
            Tsubata,T. and Wang,J.Y.
  TITLE     MZB1 promotes the secretion of J-chain-containing dimeric IgA and
            is critical for the suppression of gut inflammation
  JOURNAL   Proc Natl Acad Sci U S A 116 (27), 13480-13489 (2019)
   PUBMED   31127044
  REMARK    GeneRIF: promotes secretion of J-chain-containing dimeric IgA and
            is critical for suppression of gut inflammation
REFERENCE   6  (bases 1 to 928)
  AUTHORS   Zhang,H., Chen,X. and Sairam,M.R.
  TITLE     Novel hormone-regulated genes in visceral adipose tissue: cloning
            and identification of proinflammatory cytokine-like mouse and human
            MEDA-7: implications for obesity, insulin resistance and the
            metabolic syndrome
  JOURNAL   Diabetologia 54 (9), 2368-2380 (2011)
   PUBMED   21688198
REFERENCE   7  (bases 1 to 928)
  AUTHORS   Flach,H., Rosenbaum,M., Duchniewicz,M., Kim,S., Zhang,S.L.,
            Cahalan,M.D., Mittler,G. and Grosschedl,R.
  TITLE     Mzb1 protein regulates calcium homeostasis, antibody secretion, and
            integrin activation in innate-like B cells
  JOURNAL   Immunity 33 (5), 723-735 (2010)
   PUBMED   21093319
  REMARK    GeneRIF: Mzb1 helps to diversify peripheral B cell functions by
            regulating Ca(2+) stores, antibody secretion, and integrin
            activation.
REFERENCE   8  (bases 1 to 928)
  AUTHORS   Shimizu,Y., Meunier,L. and Hendershot,L.M.
  TITLE     pERp1 is significantly up-regulated during plasma cell
            differentiation and contributes to the oxidative folding of
            immunoglobulin
  JOURNAL   Proc Natl Acad Sci U S A 106 (40), 17013-17018 (2009)
   PUBMED   19805157
  REMARK    GeneRIF: Data suggest that pERp1 is either a unique type of
            oxidoreductase or a previously unidentified class of molecular
            chaperone that is dedicated to enhancing the oxidative folding of
            Ig precursors.
REFERENCE   9  (bases 1 to 928)
  AUTHORS   van Anken,E., Pena,F., Hafkemeijer,N., Christis,C., Romijn,E.P.,
            Grauschopf,U., Oorschot,V.M., Pertel,T., Engels,S., Ora,A.,
            Lastun,V., Glockshuber,R., Klumperman,J., Heck,A.J., Luban,J. and
            Braakman,I.
  TITLE     Efficient IgM assembly and secretion require the plasma cell
            induced endoplasmic reticulum protein pERp1
  JOURNAL   Proc Natl Acad Sci U S A 106 (40), 17019-17024 (2009)
   PUBMED   19805154
REFERENCE   10 (bases 1 to 928)
  AUTHORS   Tumes,D.J., Connolly,A. and Dent,L.A.
  TITLE     Expression of survivin in lung eosinophils is associated with
            pathology in a mouse model of allergic asthma
  JOURNAL   Int Immunol 21 (6), 633-644 (2009)
   PUBMED   19395375
  REMARK    GeneRIF: In a mouse model of asthma 2010001M09Rik (Mzb1) was
            unaltered 24 hours after allergen exposure, however, by 72 hours a
            marked increase in 2010001M09Rik mRNA was detected in lung tissue
            from disease-susceptible C57BL/6 and BALB/c mice.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008016.1, BC064044.1 and AA866731.1.
            
            On Sep 9, 2009 this sequence version replaced NM_027222.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064044.1, AK008016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK008016.1         2-29
            29-903              BC064044.1         16-890
            904-928             AA866731.1         528-552
FEATURES             Location/Qualifiers
     source          1..928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.19 cM"
     gene            1..928
                     /gene="Mzb1"
                     /gene_synonym="2010001M09Rik; PACAP; pERp1"
                     /note="marginal zone B and B1 cell-specific protein 1"
                     /db_xref="GeneID:69816"
                     /db_xref="MGI:MGI:1917066"
     exon            1..208
                     /gene="Mzb1"
                     /gene_synonym="2010001M09Rik; PACAP; pERp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..601
                     /gene="Mzb1"
                     /gene_synonym="2010001M09Rik; PACAP; pERp1"
                     /note="proapoptotic caspase adapter protein; plasma
                     cell-induced resident endoplasmic reticulum protein;
                     plasma cell-induced ER protein 1; plasma cell-induced
                     resident ER protein; marginal zone B- and B1-cell-specific
                     protein"
                     /codon_start=1
                     /product="marginal zone B- and B1-cell-specific protein
                     precursor"
                     /protein_id="NP_081498.2"
                     /db_xref="CCDS:CCDS29145.1"
                     /db_xref="GeneID:69816"
                     /db_xref="MGI:MGI:1917066"
                     /translation="MRLPLPLLLLFGCRAILGSAGDRVSLSASAPTLDDEEKYSAHMP
                     AHLRCDACRAVAFQMGQRLAKAEAKSHTPDASGLQELSESTYTDVLDQTCSQNWQSYG
                     VHEVNQMKRLTGPGLSKGPEPRISVMISGGPWPNRLSKTCFHYLGEFGEDQIYEAYRQ
                     GQANLEALLCGGTHGPCSQEILAQREEL"
     exon            209..333
                     /gene="Mzb1"
                     /gene_synonym="2010001M09Rik; PACAP; pERp1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..444
                     /gene="Mzb1"
                     /gene_synonym="2010001M09Rik; PACAP; pERp1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..906
                     /gene="Mzb1"
                     /gene_synonym="2010001M09Rik; PACAP; pERp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      884..889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mzb1"
                     /gene_synonym="2010001M09Rik; PACAP; pERp1"
                     /note="hexamer: AATAAA"
     polyA_site      906
                     /gene="Mzb1"
                     /gene_synonym="2010001M09Rik; PACAP; pERp1"
                     /note="major polyA site"
ORIGIN      
        1 acagcctgtg ctccaagaag taagttcaga ggccatgaga ctgcctctgc cactgttgct
       61 actgttcggg tgcagggcta tcctggggag cgccggggat agggtttccc tctcggcttc
      121 ggctcccaca ctggatgatg aagagaagta ctcggctcat atgccggctc acctgcgctg
      181 cgatgcctgc cgggctgtgg ccttccagat ggggcaacgt ctggcgaaag cagaggctaa
      241 atctcacact ccagacgcca gtggattgca ggagctgagt gaatccacgt acacagatgt
      301 cctggaccag acctgctctc agaactggca gtcctatgga gttcatgaag tgaaccagat
      361 gaagcgtctc acgggcccag gacttagcaa ggggccagag ccaagaatca gcgtgatgat
      421 ttctgggggt ccctggccca ataggctctc caagacgtgt ttccactacc tgggtgagtt
      481 tggagaggac cagatctatg aagcctaccg ccaaggccaa gcgaatctgg aggcgctgct
      541 ctgtgggggc acccatgggc cctgctcaca ggagatcctg gcccagagag aagagcttta
      601 gtccaacctg ctgcacttct ggatcttctc taattttatt attattaatg gctgattaga
      661 ggcaggctct catcatgtag gccaggctgg ccttaaactt gtcatcctgc tcagcctcga
      721 aagtgctgca tttaagtcct gagccttttt gtgcttgacc ctcctatata attttttcaa
      781 ctgtggtggt ggggagggga cagggaagcc tgactctagc tgtcaatctt ctccctccac
      841 ctctcgatgg ggtactggga ctgaggctgc ctttctactt tcaaataaag ctttgaaaga
      901 ctttgaaaaa aaaaaaaaaa aaaaaaaa
//
