LOCUS       NM_001033208            2283 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus myocardial zonula adherens protein (Myzap), mRNA.
ACCESSION   NM_001033208
VERSION     NM_001033208.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2283)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2283)
  AUTHORS   Rangrez,A.Y., Eden,M., Poyanmehr,R., Kuhn,C., Stiebeling,K.,
            Dierck,F., Bernt,A., Lullmann-Rauch,R., Weiler,H., Kirchof,P.,
            Frank,D. and Frey,N.
  TITLE     Myozap Deficiency Promotes Adverse Cardiac Remodeling via
            Differential Regulation of Mitogen-activated Protein
            Kinase/Serum-response Factor and beta-Catenin/GSK-3beta Protein
            Signaling
  JOURNAL   J Biol Chem 291 (8), 4128-4143 (2016)
   PUBMED   26719331
REFERENCE   3  (bases 1 to 2283)
  AUTHORS   Frank,D., Rangrez,A.Y., Poyanmehr,R., Seeger,T.S., Kuhn,C.,
            Eden,M., Stiebeling,K., Bernt,A., Grund,C., Franke,W.W. and Frey,N.
  TITLE     Mice with cardiac-restricted overexpression of Myozap are
            sensitized to biomechanical stress and develop a
            protein-aggregate-associated cardiomyopathy
  JOURNAL   J Mol Cell Cardiol 72, 196-207 (2014)
   PUBMED   24698889
  REMARK    GeneRIF: Cardiac overexpression of Myozap results in cardiomyopathy
            with hypertrophy and left ventricular dilation.
REFERENCE   4  (bases 1 to 2283)
  AUTHORS   Takase,H., Matsumoto,K., Yamadera,R., Kubota,Y., Otsu,A.,
            Suzuki,R., Ishitobi,H., Mochizuki,H., Kojima,T., Takano,S.,
            Uchida,K., Takahashi,S. and Ema,M.
  TITLE     Genome-wide identification of endothelial cell-enriched genes in
            the mouse embryo
  JOURNAL   Blood 120 (4), 914-923 (2012)
   PUBMED   22535667
REFERENCE   5  (bases 1 to 2283)
  AUTHORS   Seeger,T.S., Frank,D., Rohr,C., Will,R., Just,S., Grund,C.,
            Lyon,R., Luedde,M., Koegl,M., Sheikh,F., Rottbauer,W., Franke,W.W.,
            Katus,H.A., Olson,E.N. and Frey,N.
  TITLE     Myozap, a novel intercalated disc protein, activates serum response
            factor-dependent signaling and is required to maintain cardiac
            function in vivo
  JOURNAL   Circ Res 106 (5), 880-890 (2010)
   PUBMED   20093627
  REMARK    GeneRIF: Reveal myozap as a previously unrecognized component of a
            Rho-dependent signaling pathway that links the intercalated disc to
            cardiac gene regulation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107662.9 and AC160560.2.
            
            On Oct 19, 2007 this sequence version replaced NM_001033208.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146889.1, BC139077.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC107662.9         65323-65493         c
            172-258             AC107662.9         52744-52830         c
            259-414             AC160560.2         207887-208042       c
            415-507             AC160560.2         204432-204524       c
            508-621             AC160560.2         202325-202438       c
            622-774             AC160560.2         199062-199214       c
            775-900             AC160560.2         195716-195841       c
            901-1029            AC160560.2         193656-193784       c
            1030-1109           AC160560.2         192201-192280       c
            1110-1215           AC160560.2         190146-190251       c
            1216-1299           AC160560.2         168259-168342       c
            1300-1400           AC160560.2         158546-158646       c
            1401-2283           AC160560.2         147824-148706       c
FEATURES             Location/Qualifiers
     source          1..2283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 39.85 cM"
     gene            1..2283
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /note="myocardial zonula adherens protein"
                     /db_xref="GeneID:102371"
                     /db_xref="MGI:MGI:2142908"
     exon            1..171
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1497
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /note="GRINL1A complex locus protein 1"
                     /codon_start=1
                     /product="myocardial zonula adherens protein precursor"
                     /protein_id="NP_001028380.1"
                     /db_xref="CCDS:CCDS23327.1"
                     /db_xref="GeneID:102371"
                     /db_xref="MGI:MGI:2142908"
                     /translation="MLRSTSTVTLFSGGGAKSPGTPSRRANVCRLRLTVPPENPVPQQ
                     TEKKIERKDQPPELSNGESTKRLPQGVVYGVVRRSDPNQQKEMVVYGWSTNQLKEEMN
                     YIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQDLSVSHAQQDYLDSHIQAQASALDSF
                     NAMNAALASDSVGLQKTLVDVTLENSHIKDQIRHLQQTYEASMDKLREKQRQLEAAQM
                     ENQLLKMRVESSQEANAEVMREMTRKLYSQYEEKLQEAQRKHSAEKEVLLEETNSFLK
                     AIEEANKKMEAAELSLEEKDQKIGELDRLIERMEKERHQLQLQLLEHETEMSGEMADS
                     DKNRYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLL
                     EKISFLEGENNELQSRLDYLTETQPKTEVETREIGVGCDLLPSPTGRTREITMPSRSY
                     TPYTRVLELSSKKTLT"
     exon            172..258
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     exon            259..414
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     exon            415..507
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     exon            508..621
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     exon            622..774
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     exon            775..900
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1029
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1109
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1215
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1299
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1400
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..2283
                     /gene="Myzap"
                     /gene_synonym="Gcom1; Gm20502; Gm640; Grinl1a7; Myozap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtctgag cctcccccgc gtagggtgcg ccccgcacgc ttatcctgcc ccggagcagc
       61 gcgggcaccc agcccttgct ccacagccgc tgcgagatgc tgcgctccac gtccactgtc
      121 accctgttct caggtggcgg cgccaagtcg cctggaacgc ccagtagaag ggcaaatgtc
      181 tgcagactgc ggctgactgt gccccctgag aatccagtgc cacagcaaac agaaaagaag
      241 atcgaaagga aagatcagcc tccagaacta agcaatggag aatctaccaa gaggctccct
      301 cagggtgttg tctatggtgt ggtgcgaaga tcagatccca accagcagaa ggaaatggtc
      361 gtgtatggct ggtccaccaa tcagctgaaa gaagagatga attacatcaa agacgtgagg
      421 gccacactgg agaaagtgag gaagcggatg tatggagact atgatgagat gagacagaag
      481 atccgacagc tcacccagga cctgtcggtg tcccatgctc agcaggacta tctagacagt
      541 cacatccaag cccaggcatc ggccctggat agcttcaatg ccatgaatgc ggcattggca
      601 tcagactctg ttggcttaca gaaaaccctt gtggacgtga ctttggaaaa tagccatatc
      661 aaggatcaaa tccgacatct gcaacagacc tatgaagcat ccatggacaa gctgcgggag
      721 aagcagaggc agttagaggc tgctcagatg gaaaaccagc tcctaaagat gagggtggag
      781 tcatcgcaag aagccaatgc tgaggtgatg cgggagatga cgagaaagct gtacagccag
      841 tatgaggaga aactgcagga ggcacagcgc aagcacagtg cggagaagga ggtgctcctg
      901 gaagaaacca atagctttct gaaggccatc gaagaggcca ataagaagat ggaggcagct
      961 gagctcagcc tggaggagaa agaccagaag atcggggaac tggacaggct gattgaacgc
     1021 atggagaagg aacggcatca gctccagctc cagctccttg agcatgagac agaaatgtca
     1081 ggggagatgg cagattctga caagaacagg taccagcagc tggaggaggc gtcggccagc
     1141 ctccgggagc ggatcagaca cctggatgac atggtgcact gccagcagaa gaaagtcaag
     1201 cagatggttg aggagattga gtcattaaag aaaaaagtgc aacagaagca gctcctgata
     1261 ctgcagcttt tagaaaaaat ctctttcctg gaaggagaga ataatgaact acaaagcagg
     1321 ttggactatt tgacagaaac ccagcccaag actgaagtgg aaacaagaga aattggagtg
     1381 gggtgtgatc ttcttcccag cccaacaggc aggactcgtg aaatcacaat gccttccagg
     1441 agttacaccc cgtacacgag agtcctggag ttatcctcaa agaaaacgct gacttaggca
     1501 ctcagagaca tacgcctctt gcggatgctg caaagccctg gaagcctgtg acttaaaagt
     1561 ccggagaggg tggcaattgc ttcctcgaag acatggtgtc accttgaata ggaatctcag
     1621 gcaatcgaga cagagagagc cagcaagggc tggtacctga ggtcatattt cagacaccca
     1681 cctgaccctg ccactcacag ccgtcgtttg ttttccatgg atgcagaagt ccaggtttca
     1741 ccatctattt tctgttttac tcgattttgg tttggaggga aaagggcatt agtttaaaat
     1801 gtcgtttttg ttacagcaca aaggttttgt ttacccgtca agtattagca gcagtatttc
     1861 tcccacacgg agaagcctgt gcacaagtag catgggcacc tggaaaactt gaacctggaa
     1921 ggaaagattc ccagcatgca gtgctctctc ctccagggag gagaatgtgt gctgggctat
     1981 gggagccatg ttcagagatt tgtgtgtgtg tgccagagta gctgcattct gattcactaa
     2041 tccctcattt taatgtgtgc cttatgcctt gaatggacca gctgagatca ctatatttat
     2101 tcaagctgtg attgttttct ttctcactca aaaaagaatt ttgtatgttg tggcatttaa
     2161 tcatttcatg ttcagtaaca aatgatattt ttgttaaatg gacgaggagt ccattcacgc
     2221 acgctctact ttgatattaa aacccacata acatatattt aataaattct atctattttg
     2281 ttc
//
