LOCUS       NM_001171615            5305 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus myelin transcription factor 1 (Myt1), transcript
            variant 3, mRNA.
ACCESSION   NM_001171615
VERSION     NM_001171615.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5305)
  AUTHORS   Sun Y, Wang L, Zhu T, Wu B, Wang G, Luo Z, Li C, Wei W and Liu Z.
  TITLE     Single-cell transcriptomic landscapes of the otic neuronal lineage
            at multiple early embryonic ages
  JOURNAL   Cell Rep 38 (12), 110542 (2022)
   PUBMED   35320729
REFERENCE   2  (bases 1 to 5305)
  AUTHORS   Ulmke PA, Sakib MS, Ditte P, Sokpor G, Kerimoglu C, Pham L, Xie Y,
            Mao X, Rosenbusch J, Teichmann U, Nguyen HP, Fischer A, Eichele G,
            Staiger JF and Tuoc T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   3  (bases 1 to 5305)
  AUTHORS   Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q,
            Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS
            and Gu G.
  TITLE     Neurog3-Independent Methylation Is the Earliest Detectable Mark
            Distinguishing Pancreatic Progenitor Identity
  JOURNAL   Dev Cell 48 (1), 49-63 (2019)
   PUBMED   30620902
REFERENCE   4  (bases 1 to 5305)
  AUTHORS   Mayer C, Hafemeister C, Bandler RC, Machold R, Batista Brito R,
            Jaglin X, Allaway K, Butler A, Fishell G and Satija R.
  TITLE     Developmental diversification of cortical inhibitory interneurons
  JOURNAL   Nature 555 (7697), 457-462 (2018)
   PUBMED   29513653
REFERENCE   5  (bases 1 to 5305)
  AUTHORS   Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C,
            Hjerling-Leffler J, Sundstrom E, Pachnis V and Marklund U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   6  (bases 1 to 5305)
  AUTHORS   Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J and
            Sander M.
  TITLE     NKX6 transcription factor activity is required for alpha- and
            beta-cell development in the pancreas
  JOURNAL   Development 132 (13), 3139-3149 (2005)
   PUBMED   15944193
REFERENCE   7  (bases 1 to 5305)
  AUTHORS   Romm E, Nielsen JA, Kim JG and Hudson LD.
  TITLE     Myt1 family recruits histone deacetylase to regulate neural
            transcription
  JOURNAL   J Neurochem 93 (6), 1444-1453 (2005)
   PUBMED   15935060
  REMARK    GeneRIF: The Myt1 family of zinc finger proteins, when bound to a
            neural promoter, can recruit Sin3B. Depending on the relative
            availability of Sin3B isoforms, the Myt1 gene family may favor the
            silencing of genes during neural development.
REFERENCE   8  (bases 1 to 5305)
  AUTHORS   Nielsen JA, Berndt JA, Hudson LD and Armstrong RC.
  TITLE     Myelin transcription factor 1 (Myt1) modulates the proliferation
            and differentiation of oligodendrocyte lineage cells
  JOURNAL   Mol Cell Neurosci 25 (1), 111-123 (2004)
   PUBMED   14962745
  REMARK    GeneRIF: Expression of Myt1 inhibited the differentiation of
            progenitors into oligodendrocytes as assessed by morphology,
            immunostaining, and myelin gene expression. Progenitor
            differentiation was similarly inhibited by expression of Myt1.
REFERENCE   9  (bases 1 to 5305)
  AUTHORS   Matsushita F, Kameyama T and Marunouchi T.
  TITLE     NZF-2b is a novel predominant form of mouse NZF-2/MyT1, expressed
            in differentiated neurons especially at higher levels in newly
            generated ones
  JOURNAL   Mech Dev 118 (1-2), 209-213 (2002)
   PUBMED   12351189
  REMARK    GeneRIF: in embryonic mouse nervous system, the expression of
            NZF-2b starts as early as at 9.5 days post-coitum (dpc) in newly
            differentiated neurons in the central nervous system (CNS) and the
            peripheral nervous system (PNS)
REFERENCE   10 (bases 1 to 5305)
  AUTHORS   Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J and
            Hudson LD.
  TITLE     Myelin transcription factor 1 (Myt1) of the oligodendrocyte
            lineage, along with a closely related CCHC zinc finger, is
            expressed in developing neurons in the mammalian central nervous
            system
  JOURNAL   J Neurosci Res 50 (2), 272-290 (1997)
   PUBMED   9373037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC063252.1, AL845173.4 and
            BM935652.1.
            
            [WARNING] On May 2, 2023 this sequence was replaced by
            NM_001171615.2.
            
            Summary: This gene is a member of the myelin transcription factor 1
            gene family. The encoded protein, a zinc finger DNA-binding
            protein, is involved in regulation of oligodendrocyte
            differentiation and proliferation in the developing central nervous
            system. The gene product has a role in remyelination through
            regeneration of oligodendrocyte lineage cells in response to
            demyelination. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding region, compared to variant 1, resulting in a protein
            (isoform 3) that maintains the reading frame but is longer at the
            N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063252.1, SRR9219380.69075.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3792              BC063252.1         1-3792
            3793-3793           AL845173.4         134874-134874
            3794-5297           BC063252.1         3794-5297
            5298-5305           BM935652.1         1-8                 c
FEATURES             Location/Qualifiers
     source          1..5305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.77 cM"
     gene            1..5305
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /note="myelin transcription factor 1"
                     /db_xref="GeneID:17932"
                     /db_xref="MGI:MGI:1100535"
     exon            1..89
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..3574
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     NZF-2; neural zinc finger factor 2; neural zinc finger
                     transcription factor 2"
                     /codon_start=1
                     /product="myelin transcription factor 1 isoform 3"
                     /protein_id="NP_001165086.1"
                     /db_xref="CCDS:CCDS50856.1"
                     /db_xref="GeneID:17932"
                     /db_xref="MGI:MGI:1100535"
                     /translation="MTLCGSFLENEFRGKLLTQRWTQEDKTSSCRTERHFLCRYNKMS
                     SESDDKRARTRSKTLRGPPETTGADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKR
                     KLEDAETEHLVSKRKSHPLRLALDEGYRMDSDGSEDAEVKDVSVSDESEGPLEEAEAE
                     MSGQEEIHHPQTAEGKSLIKPHFDSNPTSSPSGFSKSSYSSYQGIIATSLLNLGQIAE
                     EALVKEDSVSVAKLSPTVVHQLQDEAAMGVNSDEGEKDLFIQPEDVEEVIEVTSERSQ
                     EPCPQSLKDMVSEESSKQKGVLGHEEEGEEEEEDEEEEDEEEEEEGEEGEEEEEEEEE
                     EEEEEDEEEEEEEEEAAPNVIFGEDTSHTSVQKASPEFRGPELSSPKPEYSVIVEVRS
                     DDDKDEDSRSQKSAVTDESEMYDMMTRGNLGLLEQAIALKAEQVRAVCESGCPPAEQG
                     HLGPGEPGKMAKPLDVVRKSCYSKDPSRVEKREIKCPTPGCDGTGHVTGLYPHHRSLS
                     GCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSH
                     EKQQLQTGDPPKNNSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKF
                     SKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSHDAEAAHMAATAILNLST
                     RCWEMPENLSTKPQDLPSKAVDIEVDENGTLDLSMHKHRKRENTFPSSSSCSSSPGVK
                     SPDVSQRQSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHS
                     FASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHIT
                     GNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPR
                     AKKSGLKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGA
                     LNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDE
                     ILSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEE
                     ENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVNTLTDMYSNQD
                     CYQNPENKGLLETIKQAVRGIQV"
     exon            90..190
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            191..245
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            246..276
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..339
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..587
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..1487
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1622
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1713
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1827
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2042
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2167
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2437
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2592
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2655
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2724
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2787
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2871
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3093
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3185
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3289
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3433
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..5305
                     /gene="Myt1"
                     /gene_synonym="Nzf2; Nzf2a; Nzf2b; Nztf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttttccag catgaagtga cttgcatcca ggctccagag aagaggttca tccatcttgc
       61 caggatgacg ctctgcggga gcttcctgga aaatgagttc cggggcaaac ttctgaccca
      121 gaggtggaca caggaagaca agactagtag ctgcagaact gagagacatt tcctgtgtag
      181 atacaacaag atgagctcag aaagtgatga caagcgagcc cgcacacggt ccaagaccct
      241 ccgaggaccc ccagagacca caggtgcaga cctcagttgt cctaccccag gatgtactgg
      301 ttcaggacat gtgcggggca agtactccag acatcgaagc ttacagagtt gccctctggc
      361 caagaagaga aaactggagg atgctgagac tgagcacctg gtatccaaga ggaagtcaca
      421 ccctctgagg ctggctctgg atgagggtta ccgcatggac agtgatggca gtgaggatgc
      481 tgaagtgaag gacgtctctg tttcagatga atcagaagga cccctggagg aggctgaggc
      541 tgagatgtca ggacaggagg agattcatca cccacagaca gctgaaggaa aaagcctcat
      601 caagccccat tttgactcca accccacaag cagcccttct ggcttctcca agagcagcta
      661 cagtagctac caggggatca ttgcaacttc cctcctaaat ctgggccaaa ttgctgaaga
      721 ggcccttgtg aaggaggatt ccgtctcagt agctaagttg agccccactg ttgttcatca
      781 gcttcaggat gaggctgcaa tgggggtcaa cagtgacgag ggtgaaaagg acctctttat
      841 acagccagaa gatgtggagg aggtcattga agtcacaagt gaacgttccc aggagccatg
      901 cccccagtct ctgaaggata tggttagtga agagtcaagt aagcagaaag gagtcctagg
      961 tcatgaggag gagggagagg aggaggaaga agatgaagaa gaagaggatg aggaggagga
     1021 ggaggaggga gaggaaggag aagaagaaga ggaggaggag gaggaagaag aggaggagga
     1081 agatgaagag gaagaggagg aggaggagga agcagctcca aatgttatct ttggggaaga
     1141 cacctcccat acctctgtcc agaaggcgtc tcctgagttc cgaggcccag agctatctag
     1201 tcctaaacct gagtactcag tcatcgtgga ggttcgctct gatgatgaca aggatgagga
     1261 ttcacgctcc cagaagtcag cagtcacaga tgaatcagaa atgtatgaca tgatgacccg
     1321 tgggaattta ggccttctgg aacaggccat tgccctgaag gctgagcagg tgcgagcggt
     1381 ctgtgagtct ggctgtccac ctgctgagca gggccatctg ggcccaggag agccagggaa
     1441 aatggcaaag cccctggacg tggtgaggaa gagctgctac agcaaagatc cttccagggt
     1501 ggagaagcgt gaaatcaagt gtccgacacc tggctgtgat ggcactggcc atgttactgg
     1561 attgtaccct catcaccgca gcctgtctgg ctgtccccac aaggatagaa tccctccaga
     1621 gatcttggcc atgcatgaaa atgtactgaa gtgccctact cctggctgca cgggccaagg
     1681 ccatgtgaac agcaaccgca atactcacag aagtttatct ggatgtccca ttgctgctgc
     1741 tgaaaaatta gccaaatctc atgagaagca gcaattgcag acaggagatc ctcccaaaaa
     1801 taactccaat tcagatcgga tcctcaggcc catgtgtttt gtgaagcagc ttgaggttcc
     1861 accttatggg agctacagac ccaatgtggc tcccgccacg cccagggcca acttggccaa
     1921 ggagctggag aagttctcca aagtcacctt tgactacgca agttttgatg ctcaggtttt
     1981 tggcaaacgt atgcttgccc caaagattca gaccagcgaa acctcaccca aagccttcca
     2041 atgcttcgat tactctcatg atgctgaggc tgcacacatg gctgccacag ccatcctgaa
     2101 cctctccact cgatgttggg agatgccaga gaacctcagc acaaagccac aggacctccc
     2161 cagcaaggct gtggacattg aggtagatga aaatggaact ctggacttga gcatgcataa
     2221 acatcgcaag cgggaaaaca ctttccccag cagtagcagc tgcagtagca gccctggtgt
     2281 caagtctcct gatgtctctc aacgtcagag cagtaccagt gcccccagca gctctatgac
     2341 ctcaccccag tccagccagg cctctcgcca ggatgagtgg gaccgtcctc tagactacac
     2401 caaacctagt cggcttcgag aggaagagcc tgaggagtca gagccagcag cacactcttt
     2461 tgcttcttct gaagcagatg atcaggaggt gtcagaagag aactttgagg agcggaagta
     2521 tccaggggaa gtcaccctaa ccaactttaa gctgaagttt ctttccaagg acataaagaa
     2581 ggaacttctc acctgtccca cccccggctg tgacggcagt ggccatatca ccgggaacta
     2641 tgcctcccat cgcagcctct ctggttgccc tcttgctgac aagagcctca gaaacctcat
     2701 ggctgcccac tctgctgacc tcaagtgccc cacacctggc tgtgatggct ctggccacat
     2761 aacagggaac tatgcttcac accggagttt gtcaggctgc ccacgtgcca agaagagtgg
     2821 actcaaggtg gcgcctacca aggatgacaa ggaggacccc gagttgatga agtgcccagt
     2881 tccaggctgt gtggggctcg gccacatcag cggcaaatat gcctctcaca ggagtgcttc
     2941 tggctgccca ctggctgctc ggaggcagaa agagggagct ctcaatggtt catctttctc
     3001 gtggaagtcg ctgaagaatg agggccctac ttgccccacc ccaggttgcg acggctctgg
     3061 ccatgccaac ggcagtttcc tcacccaccg aagtttgtct ggctgtccca gagcaacctt
     3121 tgctggaaag aaaggaaaac tctcagggga tgagattctc agcccaaagt tcaagacaag
     3181 tgatgtgctg gagaatgatg aggagatcaa gcagctaaat caggagatac gagacttaaa
     3241 tgagtccaat tcggaaatgg aggctgccat ggtgcagctg cagtctcaga tctcgtccat
     3301 ggagaagaac ctgaagaaca tcgaggagga gaacaagctc attgaggagc agaatgaggc
     3361 cctgtttctg gaattgtccg ggcttagcca agccctcatc caaagtcttg ccaatattcg
     3421 ccttccacac atggaaccaa tatgtgaaca gaattttgac gcctatgtga acaccctcac
     3481 tgacatgtac tccaatcagg actgctacca gaatccggag aacaaaggcc ttctggaaac
     3541 gatcaagcaa gctgtgaggg gcattcaggt ctaggctgca ctgcacacag gagtctgctc
     3601 tgctcctcac agcaaggacc ctgacttcta gctacttcta attggaagcc tgggtgcagc
     3661 cttgtgcagc ttacccaaag gggagcctgg gaatcagtgt ctcctatgat gtcctcatta
     3721 ggcccaggca tgaagacctc tctgtgtgag tgcctgggga cactgaagta ttgcaaagtg
     3781 acttattttt gtttttgttc tttgtttttt gtttttttaa aagaagtctg aagagcagct
     3841 caaagtctcc ggtggaagct catggacaag gttctcactc agggaagttt tggagtttgc
     3901 agccacagta ttccattgtt tgtcaaggtt gggagggcag ccatggccct gctgggtgtt
     3961 agtctcagca ggagggcatg cctaggtttc tgactatgct cactgaagcc cacatgacaa
     4021 gtatgttttg tgttttcatt taattcaact ttgtgttaaa ggtgcacaat actctgcttc
     4081 agaggtgaat ctaggaacag gcttcccaga tggcagtcta cacagttgat gagcatcata
     4141 gaaagtcagc tggaggtttt tttttgtttt cagttggagg ccctgaaaaa tcggccactt
     4201 acttgggcag cagatgcctt taagctgtgc agatctgctt tctcctggct ccagttttta
     4261 acccctggct tgggctctaa gtccaagacc actgggccaa acctctggtt tccgtacctc
     4321 catccaggtg ctggacccat cattgtatct tttcctgcat aggtttgctc cttgtatcca
     4381 aggtgactgc agtggggcag gagaccagtg gtaaattgtt acagggagac caccaagatt
     4441 tcacttcttt ataggttcat ttaagatgtg aaaaggataa attttaattt aatgtgttaa
     4501 aaacacaatg ttcttactgt gtaaatagag tccaagtcaa ttgtgactgc aattccaaat
     4561 tagtatttaa aagtagagaa attgcacttc ctggaagaca ctgaaagtag ttagtttatt
     4621 ctgtaaatta tttaattttg tcataagtat ttatattctt accctcttat gttaatgttt
     4681 gctatttatt atttttattt atttatttta tactatatca actagatgac acactagggc
     4741 accataagag ttaaataagt taaattgaaa caaaaacatt tatttgacta taagataggc
     4801 cacaaagaat cttgatataa cttctagtta taattttgat gcaaccgagt tattttttat
     4861 atattttgtt atttattctt ttaataatgg aattttttaa aaaagtattt tgtaactgaa
     4921 gaattttgat aatttgggtt tttctcccca ttggtccacc agagagaaag gtgtttggtt
     4981 ttctttttcc ctttgggttc cttttgtcag gccaataaca gcaaatggaa ttctgtattt
     5041 attattattt aagtgtagtg cagatgtgtg tgctctggtg tttcttgtgt tgcatttgtg
     5101 gaggttctca tggatgattc atgttgctgt gagggagtgc tggccatggt cagttctagg
     5161 caatggactc gctggccaag ctgcccagga tcttgatacc ccaatactgt gaccctcctt
     5221 cctcaggaaa cacgttggac tcacagtacc tcgtggtgtg tttggagggt gatttctaat
     5281 aaaagtctca ctgtgcatag gtgct
//
