LOCUS       NM_182992               5246 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus myopalladin (Mypn), mRNA.
ACCESSION   NM_182992 XM_483911 XM_905765
VERSION     NM_182992.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5246)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5246)
  AUTHORS   Filomena,M.C., Yamamoto,D.L., Carullo,P., Medvedev,R., Ghisleni,A.,
            Piroddi,N., Scellini,B., Crispino,R., D'Autilia,F., Zhang,J.,
            Felicetta,A., Nemska,S., Serio,S., Tesi,C., Catalucci,D.,
            Linke,W.A., Polishchuk,R., Poggesi,C., Gautel,M. and Bang,M.L.
  TITLE     Myopalladin knockout mice develop cardiac dilation and show a
            maladaptive response to mechanical pressure overload
  JOURNAL   Elife 10, e58313 (2021)
   PUBMED   34558411
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5246)
  AUTHORS   Filomena,M.C., Yamamoto,D.L., Caremani,M., Kadarla,V.K.,
            Mastrototaro,G., Serio,S., Vydyanath,A., Mutarelli,M., Garofalo,A.,
            Pertici,I., Knoll,R., Nigro,V., Luther,P.K., Lieber,R.L.,
            Beck,M.R., Linari,M. and Bang,M.L.
  TITLE     Myopalladin promotes muscle growth through modulation of the serum
            response factor pathway
  JOURNAL   J Cachexia Sarcopenia Muscle 11 (1), 169-194 (2020)
   PUBMED   31647200
REFERENCE   4  (bases 1 to 5246)
  AUTHORS   Miyatake,S., Mitsuhashi,S., Hayashi,Y.K., Purevjav,E.,
            Nishikawa,A., Koshimizu,E., Suzuki,M., Yatabe,K., Tanaka,Y.,
            Ogata,K., Kuru,S., Shiina,M., Tsurusaki,Y., Nakashima,M.,
            Mizuguchi,T., Miyake,N., Saitsu,H., Ogata,K., Kawai,M., Towbin,J.,
            Nonaka,I., Nishino,I. and Matsumoto,N.
  TITLE     Biallelic Mutations in MYPN, Encoding Myopalladin, Are Associated
            with Childhood-Onset, Slowly Progressive Nemaline Myopathy
  JOURNAL   Am J Hum Genet 100 (1), 169-178 (2017)
   PUBMED   28017374
REFERENCE   5  (bases 1 to 5246)
  AUTHORS   Bang,M.L.
  TITLE     Animal Models of Congenital Cardiomyopathies Associated With
            Mutations in Z-Line Proteins
  JOURNAL   J Cell Physiol 232 (1), 38-52 (2017)
   PUBMED   27171814
  REMARK    Review article
REFERENCE   6  (bases 1 to 5246)
  AUTHORS   Mastrototaro,G., Liang,X., Li,X., Carullo,P., Piroddi,N., Tesi,C.,
            Gu,Y., Dalton,N.D., Peterson,K.L., Poggesi,C., Sheikh,F., Chen,J.
            and Bang,M.L.
  TITLE     Nebulette knockout mice have normal cardiac function, but show
            Z-line widening and up-regulation of cardiac stress markers
  JOURNAL   Cardiovasc Res 107 (2), 216-225 (2015)
   PUBMED   25987543
REFERENCE   7  (bases 1 to 5246)
  AUTHORS   Huby,A.C., Mendsaikhan,U., Takagi,K., Martherus,R., Wansapura,J.,
            Gong,N., Osinska,H., James,J.F., Kramer,K., Saito,K., Robbins,J.,
            Khuchua,Z., Towbin,J.A. and Purevjav,E.
  TITLE     Disturbance in Z-disk mechanosensitive proteins induced by a
            persistent mutant myopalladin causes familial restrictive
            cardiomyopathy
  JOURNAL   J Am Coll Cardiol 64 (25), 2765-2776 (2014)
   PUBMED   25541130
REFERENCE   8  (bases 1 to 5246)
  AUTHORS   Ghiasvand,N.M., Rudolph,D.D., Mashayekhi,M., Brzezinski,J.A. 4th,
            Goldman,D. and Glaser,T.
  TITLE     Deletion of a remote enhancer near ATOH7 disrupts retinal
            neurogenesis, causing NCRNA disease
  JOURNAL   Nat Neurosci 14 (5), 578-586 (2011)
   PUBMED   21441919
REFERENCE   9  (bases 1 to 5246)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 5246)
  AUTHORS   Bang,M.L., Mudry,R.E., McElhinny,A.S., Trombitas,K., Geach,A.J.,
            Yamasaki,R., Sorimachi,H., Granzier,H., Gregorio,C.C. and Labeit,S.
  TITLE     Myopalladin, a novel 145-kilodalton sarcomeric protein with
            multiple roles in Z-disc and I-band protein assemblies
  JOURNAL   J Cell Biol 153 (2), 413-427 (2001)
   PUBMED   11309420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155909.9.
            
            On or before Apr 9, 2009 this sequence version replaced
            XM_905765.2, XM_483911.3, NM_182992.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220521.1, SRR10223971.10283.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AC155909.9         54671-54905
            236-1132            AC155909.9         65340-66236
            1133-1308           AC155909.9         89193-89368
            1309-1360           AC155909.9         91339-91390
            1361-1472           AC155909.9         94999-95110
            1473-1544           AC155909.9         96330-96401
            1545-1686           AC155909.9         105687-105828
            1687-1710           AC155909.9         108577-108600
            1711-1827           AC155909.9         110630-110746
            1828-2200           AC155909.9         112415-112787
            2201-2788           AC155909.9         122328-122915
            2789-2927           AC155909.9         123552-123690
            2928-3149           AC155909.9         127419-127640
            3150-3299           AC155909.9         130846-130995
            3300-3379           AC155909.9         132875-132954
            3380-3506           AC155909.9         135226-135352
            3507-3714           AC155909.9         136514-136721
            3715-3880           AC155909.9         138429-138594
            3881-4014           AC155909.9         140069-140202
            4015-5246           AC155909.9         141597-142828
FEATURES             Location/Qualifiers
     source          1..5246
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.54 cM"
     gene            1..5246
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /note="myopalladin"
                     /db_xref="GeneID:68802"
                     /db_xref="MGI:MGI:1916052"
     exon            1..235
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            236..1132
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..4184
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /codon_start=1
                     /product="myopalladin"
                     /protein_id="NP_892037.2"
                     /db_xref="CCDS:CCDS48584.1"
                     /db_xref="GeneID:68802"
                     /db_xref="MGI:MGI:1916052"
                     /translation="MQEDSIEASTSISQLLRESYLAETRHRGDNERSRAEPSSNPFHF
                     SGPGAAEGGGPEDLPDLSAFLSQEELDESVNLARLAINHDPLERVDEAQARKRLSSDQ
                     TKHASKPSFEPAFHQDSSRGPASPKDSPPETKRPQYSSETQSKKVFLNKAADFIEELS
                     SLFKAHSSKRIRPRACKNHKSKTESQNKVLQENSPTFSDLTERRERASVPIPIPADSR
                     DNELNHAIEQREAKRREAELAAGEAAAGDSTPGSSPSSLYYEEPLGQPPRFTQKLRSR
                     EVPEGSRVQLDCIVVGIPPPQVRWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDT
                     GRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAAI
                     PPAAEAQPLAAQPRVSTVQQCQSPTNYLQGLNGKPIIAAPVFTKMLQNLSASEGQLVV
                     FECRVKGAPSPKVEWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFSEDSG
                     CFTCTASNKYGTVSSIAQLDVRGNEDISDNGALHSANSTTNPAVAEHQPSPLNPQPLS
                     EEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKDMEASSGSGAANTSQTRPNS
                     FPERFNGQEARIPEPSSPIKEPPPVLAKPKLDSTQLQQLHNQVLLEQQQLQNTSPSSP
                     KESLHMSALNSAPPAVTISSKQVKGPAPQMFNLARPKHFFPASSTSTATVSPSSSPVF
                     TLSNTPQTIQRTVSKESLLMAHPSTQGRSPGGLSIQNEPAPPSPAEPAAPPTAAYSIP
                     SGNQFQPHCVSPTPVSPTGRIQNPVAFLSSVLPSLPSIPPTNAMGLPKSAPSVPSQGL
                     MKKTTKAPQAVSDDYIRETKNSVILDLGKKVNFGDVRSHQQEYKISSFEQRLMNEIEF
                     RLERTPVDESDDEIEHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKIVGIPVPKV
                     YWFKDGKQISKRNEHCKMRREGDGTCSLHIESTHGDDDGNYTIMAANPQGRISCSGHL
                     MVQGLPIRSRLSPALSHRGRSRMQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLD
                     CKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRDAGTYTCVATNK
                     TGQNSFSLELTVVAKEVKKAPVILEKLQNSGVPEGHPVRLEGRVIGMPPPVFYWKKDN
                     ETIPFTRERISMHQDTTGYVCLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQW
                     HQQIPTPISIRPSGSRYGSLTSKGLDIFSAFSSVESTMLYSCTSRSVVESDEL"
     exon            1133..1308
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1360
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1472
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1544
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1686
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1710
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1827
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2200
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2788
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2927
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3149
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3299
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3379
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..3506
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3714
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..3880
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            3881..4014
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..5246
                     /gene="Mypn"
                     /gene_synonym="1110056A04Rik; 9830112J03; mKIAA4170"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagagctg acaaatgctc tggccgcggc ggtgacggtt gcccagcttc taacagccat
       61 cctcaccaaa actacggtta actcctcgct ctctatggac agccactctc tctctccaag
      121 ggcgtgaaga cttttccctt tctccagcgt tttcatccaa acctgctcct tggataacta
      181 ccgtcacaga agcttgcctg ggttggacat cgttgggtca cctaaaaaaa gaaagcatgc
      241 aagaagacag catagaggca tccacttcca tctctcaact cctgagagaa agttacctgg
      301 ctgaaaccag acatcgtggg gacaacgagc gaagtcgagc tgagccctcc tccaaccctt
      361 tccatttcag tggtcctggg gctgcagagg gaggaggccc agaggacctt ccggaccttt
      421 ctgccttcct gagccaagag gagttagatg aaagtgtcaa tctggcgagg ctggccatca
      481 accacgaccc cttggagaga gtggatgaag ctcaagccag gaagcgtctg tcttccgacc
      541 agacgaagca tgcatccaag ccaagcttcg aacctgcctt ccaccaggac agctcccgag
      601 gtccggccag tcctaaagac agcccgccag agaccaagag gccgcagtac agttctgaaa
      661 cccagtccaa gaaagttttc ctgaacaagg ctgccgattt catcgaagaa ctttcctccc
      721 ttttcaaggc tcacagctcc aagaggatca gacctcgggc ctgcaaaaac cacaagagca
      781 agacggaatc ccaaaacaaa gttctgcagg aaaacagccc cactttctca gatctaacag
      841 aaaggcgaga gagagcatcg gtccccattc ccatccctgc ggacagcagg gataacgagc
      901 tgaaccacgc tattgaacag cgagaagcca agaggaggga agccgagttg gctgcggggg
      961 aggctgcggc tggagacagc acccctggct cttcgccttc atccctatac tacgaagagc
     1021 ctctggggca gcctccccgc ttcacacaaa agttacggag ccgagaagtt ccggaaggca
     1081 gccgagtcca gttggattgt atagtggtag gaattccacc gccccaagta aggtggtatt
     1141 gtgaaggcaa ggagcttgaa aactctccag atatccacat tgtgcaggca ggaaaccttc
     1201 actcactgac catcgccgag gccttcgaag aggacacagg acgatactca tgctttgctt
     1261 ccaacattta tgggacagat tcaacttccg ctgagattta catagaagga gtctcttcct
     1321 ctgactcaga aggggaccct aacaaagaag agatgaatcg aatccagaag ccaaatgagg
     1381 tgtcctcacc tcccaccacc tctgcagcca ttcctccagc agcagaagcc cagcctttgg
     1441 cggcccagcc cagagtgtcc accgtccagc agtgtcagag tcctaccaac tatttgcaag
     1501 gcctgaacgg gaagcccatc attgcagcgc cagtgtttac gaagatgctg cagaacttgt
     1561 cagcctctga ggggcagctg gttgtctttg agtgcagagt gaaaggggcc ccatctccga
     1621 aagtcgagtg gtacagagaa gggacattaa tagaagactc tcccgacttc aggatcttac
     1681 agaagaaacc tcgatccatg gcagaaccag aggagatctg cacgttagtc attgctgagg
     1741 tgttttcgga agactcggga tgcttcacgt gcaccgcaag caacaaatat ggcaccgtgt
     1801 ctagcatcgc acagttagac gtgagaggaa atgaagacat cagtgataat ggagctcttc
     1861 actcagcaaa ttcaaccacc aacccggctg tggctgagca ccagccttcc ccactcaacc
     1921 cacagcctct ttcagaggag cagcccccaa aacccaaact tgaaggggtt ctggtgaacc
     1981 ataatgagcc ccggtccagc tccaggattg ggctacgggt gcacttcaac ctaccggaag
     2041 acgacaaaga tatggaggca tcctctggga gcggtgcggc caataccagc cagactagac
     2101 cgaattcctt ccccgagagg ttcaatggac aggaagccag aatcccagag ccttcctcac
     2161 ctatcaagga gccccctccg gtcctggcca aacccaaact tgactccact cagttacaac
     2221 agcttcataa ccaagtgtta ctggaacagc agcaactgca aaacacatct ccttcatcac
     2281 ccaaggagtc tcttcacatg agtgccttga actcggctcc cccggcagtg accatctcca
     2341 gcaagcaggt gaagggtcct gcgcctcaga tgttcaacct ggcccggccg aagcacttct
     2401 tccccgcttc aagcacttcc acagcaaccg tgtccccatc cagctccccg gtgttcacct
     2461 tgagcaatac tcctcaaaca attcagagga cagtcagcaa agaaagcctc ttaatggccc
     2521 acccctccac acaaggcaga tctcctggcg ggctctccat ccaaaatgag ccagctcctc
     2581 caagcccagc agagccagca gcgccaccaa cagccgccta ttccatccct agcggaaacc
     2641 agtttcagcc tcactgcgta tcccccactc ctgtctcccc taccggtcgg attcagaacc
     2701 cggtggcttt tcttagctct gttctgcctt ctctcccttc cattccaccc accaacgcca
     2761 tggggctgcc taaaagcgca ccatctgtac catcccaggg tctaatgaag aaaaccacaa
     2821 aggcccctca ggcagtgagt gacgactaca tccgagagac gaagaactca gtgattctag
     2881 acttggggaa gaaagtgaat ttcggtgacg tcagatcaca ccagcaggaa tataaaattt
     2941 ccagctttga gcagaggctg atgaacgaga tagagttccg cctggagcgg actcctgttg
     3001 acgaatctga tgacgagata gaacacgacg aaatccccac gggcaagtgc atcgcgccca
     3061 tctttgacaa aaggctcaag cacttccggg ttaccgaagg ctcaccagtc accttcacct
     3121 gcaaaattgt tgggatacct gttccaaagg tttattggtt caaagacggg aagcagattt
     3181 ctaagagaaa tgagcactgt aaaatgagga gagaagggga tgggacctgc tcactacaca
     3241 ttgagtccac ccacggcgat gatgacggca actacaccat catggccgcc aacccccagg
     3301 ggagaatcag ctgttctggc catttgatgg tacagggttt gcccattcga agccgactca
     3361 gccctgctct gtctcacaga ggaaggtcca gaatgcagga aagagacaaa gagccgctac
     3421 aggaacgctt tttccgacca catttcctgc aggcccctgg ggatatggtg gctcacgagg
     3481 gccgcctctg tcggctggac tgtaaggtga gtggcttacc acccccggag ctgacatggc
     3541 tactcaatgg gcaacctgtg ctacccgacg cctcccacaa gatgctggtc agagagacgg
     3601 gagtccactc tctgctcatc gacccgctca cccaacgaga cgcagggacc tacacgtgcg
     3661 tggctaccaa caaaaccggg cagaattcct ttagtctgga gctcactgtg gtagccaaag
     3721 aggtaaagaa ggcgccagtg atcctggaga aactccagaa cagcggcgtc cctgagggcc
     3781 acccggtgcg actggagggc cgggtcatag gcatgccccc gcctgtgttc tactggaaga
     3841 aagacaacga gaccatcccg ttcactagag agaggatcag catgcaccag gatacaacag
     3901 gctatgtctg cctcctcatc cagccagcca agaagtccga cgctgggtgg tacacactgt
     3961 cagccaagaa cgaagccggc atcgtatcgt gcacagctag gttggatata tatgctcagt
     4021 ggcaccagca aatcccaaca cccatatcta tccggcccag cggcagccgc tacgggtctc
     4081 tcaccagcaa aggcctcgac atcttttctg ccttctcctc cgtggaaagc acgatgctgt
     4141 attcctgtac ttctcggagt gtagtggaga gcgatgaact ttaaggctgc ctgggtgcct
     4201 gctttgtaag agggtggact gtggaggggt aggaagacga ctgaccgtat gcagtggttt
     4261 ccaaacaact ggattggagt gagtttccat cctgcgggac ccgtggcaag aagtgtttta
     4321 agtaagttgg ctggggcttt ttgagccttg gctgagggct gtgcgtcttc aagatgccag
     4381 ccagtagaca atatacccaa accaaagaca ccgcaccacc accaccacag cttttggtgg
     4441 gggataggga gctagcatgc tcccccaccc ggtgtgttag ggatgctagg cccaactagg
     4501 agcaattagg agccatagcg agggctgaga gaagttagca accttaggat agaaacaaag
     4561 gaggaagatg gagagcccgt tgtcaccttt cgtgggttac atccatcccc gtcatcctgg
     4621 tgaattcatt aaatgagccc ctgcttagca ttagaggatc ttgccatacg ccccacccca
     4681 cccccagtgg caaaacactt actttgcatt atcctacctg tggagtcacg taataagaag
     4741 ccaaaatgtg cctgagattt aaagagaaaa caaaaaacaa aacgggagag ggtttcctag
     4801 gacactcaga tttcccactc cgctggttac gtgctcaaag cggttcccgc cagcctatca
     4861 gcgccatttt aggcagaaaa ccacacccac ctccatcccg agtgcctgga tgggtaccga
     4921 gcttaatgga cacctttgaa atagacctgc tgggtaataa ctccgagact gaactaccat
     4981 ttggtgtcta ccgttcttag cctgtccaaa catggccccg gggatggttg tcacagcggc
     5041 ttgctgcagg caagccaggg ctatgaactg gaggcgtctg ttgtcaatcc ctttgctcga
     5101 atctcggatg ttctctgtgc caggtccccc tcaactggca tccttctcaa gtggttttag
     5161 ctggagatag taattgctta gaaaggcgtg aaactttctt tacttcaagg caaggatttc
     5221 cagtttaaaa ataaattcat ttactc
//
